公开(公告)号：US07474398B2

公开(公告)日：2009-01-06

申请号：US11434605

申请日：2006-05-15

Applicant: David Nilson ,  Brad Rice ,  Tamara Troy

Inventor： David Nilson ,  Brad Rice ,  Tamara Troy

IPC: G01J3/30 ,  G01N21/25

CPC classification number: G01N21/6456 ,  G01N2021/1787 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0227 ,  G01N2201/0826

Abstract: A fluorescence illumination system is provided for use with an imaging apparatus that defines a light-tight imaging compartment. The fluorescence illumination system includes a trans-illumination component configured to direct excitation light into a first surface of the specimen wherein diffused light emanates from a second surface thereof for receipt through the view port to acquire fluorescence data of the specimen. Further, the fluorescence illumination system includes an epi-illumination component configured to direct excitation light onto a third surface of the specimen wherein the diffused light exits the third surface thereof for receipt through the view port to acquire fluorescence data of the specimen.

Abstract translation: 荧光照明系统被提供用于与定义不透光成像室的成像装置一起使用。 荧光照明系统包括反射照明部件，其被配置为将激发光引导到样品的第一表面，其中散射光从其第二表面发出，以通过视口接收，以获取样品的荧光数据。 此外，荧光照明系统包括被配置为将激发光引导到样本的第三表面上的外照明部件，其中扩散的光离开其第三表面以通过视口接收以获取样本的荧光数据。

公开(公告)号：US20080280331A1

公开(公告)日：2008-11-13

申请号：US12093132

申请日：2007-02-07

Applicant: Mark Davies ,  Tara Dalton

Inventor： Mark Davies ,  Tara Dalton

IPC: C12P19/34 ,  C12M1/02

CPC classification number: B01L7/525 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2300/0838 ,  B01L2300/0867 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/185 ,  B01L2400/0487 ,  C12Q1/686 ,  G01N21/6428 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A thermal cycling device (3) device a number of fixed thermal zones (11, 12, 13) and a fixed conduit (10) passing through the thermal zones. A controller maintains each thermal zone including its section of conduit (10) at a constant temperature. A series of droplets flows through the conduit (10) so that each droplet is thermally cycled, and a detection system detects fluorescence from droplets at all of the thermal cycles. The conduit is in a single plane, and so a number of thermal cycling devices may be arranged together to achieve parallelism. The flow conduit comprises a channel (17) and a capillary tube (10) inserted into the channel. The detection system may perform scans along a direction to detect radiation from a plurality of cycles in a pass.

Abstract translation: 热循环装置（3）装置设有多个固定热区（11,12,13）和通过热区的固定导管（10）。 控制器将每个热区域保持在其恒定温度下的导管（10）部分。 一系列液滴流过导管（10），使得每个液滴热循环，并且检测系统在所有热循环中检测来自液滴的荧光。 导管处于单个平面中，因此可以将多个热循环装置布置在一起以实现平行。 流动管道包括插入通道中的通道（17）和毛细管（10）。 检测系统可以沿着一个方向执行扫描，以检测通过中多个周期的辐射。

公开(公告)号：US20080063426A1

公开(公告)日：2008-03-13

申请号：US11931339

申请日：2007-10-31

Applicant: TZYY-SHUH CHANG ,  DANIEL GUTCHESS ,  HSUN-HAU HUANG

Inventor： TZYY-SHUH CHANG ,  DANIEL GUTCHESS ,  HSUN-HAU HUANG

IPC: G03G21/00

CPC classification number: G01N21/952 ,  G01N2201/0826 ,  G01N2201/084 ,  H04N7/18

Abstract: The present invention is directed to solving the problems associated with the detection of surface defects on metal bars as well as the problems associated with applying metal flat inspection systems to metal bars for non-destructive surface defects detection. A specially designed imaging system, which is comprised of a computing unit, line lights and high data rate line scan cameras, is developed for the aforementioned purpose. The target application is the metal bars (1) that have a circumference/cross-section-area ratio equal to or smaller than 4.25 when the cross section area is unity for the given shape, (2) whose cross-sections are round, oval, or in the shape of a polygon, and (3) are manufactured by mechanically cross-section reduction processes. The said metal can be steel, stainless steel, aluminum, copper, bronze, titanium, nickel, and so forth, and/or their alloys. The said metal bars can be at the temperature when they are being manufactured. A removable cassette includes various mirrors. A protection tube isolates the moving metal bar from the line light assembly and image acquisition camera. A contaminant reduction mechanism applies a vacuum to remove airborne contaminants.

Abstract translation: 本发明旨在解决与检测金属棒表面缺陷相关的问题以及将金属平面检查系统应用于金属棒以用于非破坏性表面缺陷检测相关的问题。 为了上述目的开发了一种专门设计的成像系统，由计算单元，线路灯和高数据速率线扫描摄像机组成。 目标应用是当给定形状的横截面积为1时，具有等于或小于4.25的圆周/横截面积比的金属棒（1），（2）横截面为圆形，椭圆形 ，或多边形的形状，（3）通过机械截面缩小工艺制造。 所述金属可以是钢，不锈钢，铝，铜，青铜，钛，镍等，和/或它们的合金。 所述金属棒可以处于制造时的温度。 可拆卸的盒子包括各种镜子。 保护管将移动的金属棒与线路灯组件和图像采集相机隔离。 污染物减少机制应用真空去除空气污染物。

公开(公告)号：US20070276257A1

公开(公告)日：2007-11-29

申请号：US11381443

申请日：2006-05-03

Applicant: John HEANUE ,  Joseph Heanue ,  Brian Wilfley ,  Augustus Lowell

Inventor： John HEANUE ,  Joseph Heanue ,  Brian Wilfley ,  Augustus Lowell

IPC: A61B6/00

CPC classification number: A61B5/0059 ,  A61B5/415 ,  A61B5/418 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/4406 ,  G01N21/6408 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A system and method for optical lymph node mapping. The system is useful for guiding sentinel lymph node biopsy surgeries. A contrast agent that includes a fluorescent dye is injected near the site of a malignancy. The contrast agent drains into the lymphatic system, collecting in a sentinel node or nodes. The system utilizes one or more low-power continuous-wave lasers or light-emitting diodes modulated with a digital code sequence to probe the tissue suspected of containing the sentinel node. When the light is incident near the sentinel node, it will excite fluorescence from the dye. A portion of the scattered fluorescent light is captured with one or more photo-detectors. A correlation of the photo-detector signal and the digital code sequence is calculated to produce an estimate of the distribution of flight times for photons traveling from a given source to a given detector. The flight time distributions are used along with the measured amplitudes to reconstruct a map of contrast agent location within the tissue.

Abstract translation: 一种用于光学淋巴结图谱的系统和方法。 该系统可用于引导前哨淋巴结活检。 包含荧光染料的造影剂在恶性肿瘤部位附近注射。 造影剂排入淋巴系统，收集在前哨节点或节点。 该系统利用一个或多个低功率连续波激光器或用数字代码序列调制的发光二极管来探测怀疑含有前哨节点的组织。 当光在哨兵节点附近入射时，它会激发染料的荧光。 一部分散射的荧光被一个或多个光电探测器捕获。 计算光检测器信号和数字码序列的相关性，以产生从给定源到给定检测器的光子的飞行时间分布的估计。 飞行时间分布与测量的振幅一起使用以重建组织内造影剂位置的图。

公开(公告)号：US20070251337A1

公开(公告)日：2007-11-01

申请号：US11789431

申请日：2007-04-23

Applicant: Michael Reed ,  Steven Geelhood ,  Paul Harris ,  Lynn Barker ,  Perry Hargrave ,  Oliver Nanassy

Inventor： Michael Reed ,  Steven Geelhood ,  Paul Harris ,  Lynn Barker ,  Perry Hargrave ,  Oliver Nanassy

IPC: G01N33/00

CPC classification number: G01N33/84 ,  C12Q1/04 ,  C12Q1/22 ,  C12Q1/54 ,  G01N21/6428 ,  G01N21/77 ,  G01N21/80 ,  G01N33/492 ,  G01N33/542 ,  G01N33/582 ,  G01N33/66 ,  G01N2021/6421 ,  G01N2021/6434 ,  G01N2021/6484 ,  G01N2021/7786 ,  G01N2201/062 ,  G01N2201/068 ,  G01N2201/0826 ,  G01N2201/084 ,  G01N2400/00

Abstract: System and method for detecting and measuring chemical perturbations in a sample. The system and method are useful for non-invasive pH monitoring of blood or blood products sealed in storage bags.

Abstract translation: 用于检测和测量样品中化学扰动的系统和方法。 该系统和方法可用于密封在储存袋中的血液或血液制品的非侵入性pH监测。

公开(公告)号：US07220034B2

公开(公告)日：2007-05-22

申请号：US10888302

申请日：2004-07-09

Applicant: Falai Li

Inventor： Falai Li

IPC: G02B6/04

CPC classification number: H01L21/67288 ,  G01N21/8806 ,  G01N21/9501 ,  G01N2021/8822 ,  G01N2201/08 ,  G01N2201/0826

Abstract: A fiber optic darkfield ring light with many angled fiber optic light lines with direct illumination in a very small package. The fiber optic darkfield ring light includes a base with multiple light heads and multiple light covers attached thereto, a main cover, an optional cord grip, and an optional hood. It incorporates multiple fiber optic line arrays positioned at low angle and used in conjunction with a strobe light source.

Abstract translation: 一种光纤暗场环形灯，具有许多成角度的光纤光线，具有非常小的封装中的直接照明。 光纤暗场环形灯包括具有多个光头的基座和附接到其上的多个灯罩，主盖，可选的绳把和可选的罩。 它集成了多个光栅线阵列，它们以低角度定位并与闪光灯光源一起使用。

公开(公告)号：US20060103846A1

公开(公告)日：2006-05-18

申请号：US11280546

申请日：2005-11-15

Applicant: Josep Pages Pinyol

Inventor： Josep Pages Pinyol

IPC: G01J3/51 ,  G01N21/25

CPC classification number: G01J3/02 ,  G01J3/0213 ,  G01J3/0218 ,  G01J3/12 ,  G01J3/2803 ,  G01N21/03 ,  G01N21/13 ,  G01N21/253 ,  G01N21/272 ,  G01N21/274 ,  G01N2201/0461 ,  G01N2201/082 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: Apparatus for measuring the optical absorbency of samples of liquids, method and reaction container for its implementation. The apparatus comprises a receiving body for receiving the reaction containers carrying the samples to be analyzed, with means for causing each of the reaction containers to be passed through by a luminous signal of controlled wavelength, having means for conducting it to a scanning head where the luminous signals are picked up by a single CCD sensor, constituting a digital processing system for evaluating the absorbency of the corresponding sample.

公开(公告)号：US06961125B2

公开(公告)日：2005-11-01

申请号：US10250956

申请日：2001-12-18

Applicant: John Gordon Rushbrooke ,  Claire Elizabeth Hooper

Inventor： John Gordon Rushbrooke ,  Claire Elizabeth Hooper

IPC: G01N21/64 ,  G01N21/25

CPC classification number: G01N21/6452 ,  G01N21/6456 ,  G01N21/76 ,  G01N2021/6484 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A fiber optic epi-fluorescence imaging system in which the optical fibers are rearranged so that the system can be used for measuring luminescence samples. The system comprises at least two optical fibers (32, 46) or bundles of fibers which lead to a CCD camera (74), the fibers or bundles of fibers from all samples being arranged in two sets, a first set which are formed from a non-fluorescing material and a second set which are formed from a material which may fluoresce but enables the fibers formed therefrom to have a higher numerical aperture than those of the first set.

Abstract translation: 光纤外延荧光成像系统，其中光纤被重新排列，使得该系统可用于测量发光样品。 该系统包括通向CCD照相机（74）的至少两根光纤（32,46）或纤维束，来自所有样品的纤维或纤维束被布置成两组，第一组由 非荧光材料和第二组，其由可以发荧光但使得由其形成的纤维具有比第一组更高的数值孔径的材料形成。

公开(公告)号：US20050231711A1

公开(公告)日：2005-10-20

申请号：US10827655

申请日：2004-04-19

Applicant: Jeffrey Benoit ,  Wayde Schmidt ,  Thomas Vanderspurt

Inventor： Jeffrey Benoit ,  Wayde Schmidt ,  Thomas Vanderspurt

IPC: F21V8/00 ,  G01N21/00 ,  G02B6/14

CPC classification number: G06F17/5045 ,  G01N2201/0826 ,  G02B6/001 ,  G02B6/14

Abstract: A system and method that redistributes light from a light source. The controller can redistribute light to make an irradiance profile of the light source more uniform or make the irradiance profile match a fluid flow profile. The irradiance profile may be controlled by modifying light leakage from a plurality of waveguides or changing the light-directing properties of reflectors and/or lenses.

Abstract translation: 从光源重新分配光的系统和方法。 控制器可以重新分配光，使光源的辐照度分布更均匀，或使辐照度轮廓匹配流体流动分布。 可以通过修改来自多个波导的光泄漏或改变反射器和/或透镜的导光性能来控制辐照度分布。

公开(公告)号：US06950546B2

公开(公告)日：2005-09-27

申请号：US10331050

申请日：2002-12-27

Applicant: Tzyy-Shuh Chang ,  Daniel Gutchess ,  Hsun-Hau Huang

Inventor： Tzyy-Shuh Chang ,  Daniel Gutchess ,  Hsun-Hau Huang

IPC: G01B20060101 ,  G01B11/30 ,  G01N21/88 ,  G01N21/95 ,  G01N21/952 ,  G06K9/00 ,  H04N7/18 ,  H04N9/47

CPC classification number: H04N7/18 ,  G01N21/952 ,  G01N2201/0826 ,  G01N2201/084

Abstract: The present invention is directed to solving the problems associated with the detection of surface defects on metal bars as well as the problems associated with applying metal flat inspection systems to metal bars for non-destructive surface defects detection. A specially designed imaging system, which is comprised of a computing unit, line lights and high data rate line scan cameras, is developed for the aforementioned purpose. The target application is the metal bars (1) that have a circumference/cross-section-area ratio equal to or smaller than 4.25 when the cross section area is unity for the given shape, (2) whose cross-sections are round, oval, or in the shape of a polygon, and (3) are manufactured by mechanically cross-section reduction processes. The said metal can be steel, stainless steel, aluminum, copper, bronze, titanium, nickel, and so forth, and/or their alloys. The said metal bars can be at the temperature when they are being manufactured.

Abstract translation: 本发明旨在解决与检测金属棒表面缺陷相关的问题以及将金属平面检查系统应用于金属棒以用于非破坏性表面缺陷检测相关的问题。 为了上述目的开发了一种专门设计的成像系统，由计算单元，线路灯和高数据速率线扫描摄像机组成。 目标应用是当给定形状的横截面积为1时，具有等于或小于4.25的圆周/横截面积比的金属棒（1），（2）其横截面为圆形，椭圆形 ，或多边形的形状，（3）通过机械截面缩小工艺制造。 所述金属可以是钢，不锈钢，铝，铜，青铜，钛，镍等，和/或它们的合金。 所述金属棒可以处于制造时的温度。