公开(公告)号：WO2004093642A3

公开(公告)日：2004-11-04

申请号：PCT/US2004/011847

申请日：2004-04-16

Applicant: NEW ENGLAND MEDICAL CENTER HOSPITALS, INC. ,  BERGETHON, Peter

Inventor： BERGETHON, Peter

IPC: A61B05/00

Abstract: In one aspect, a method of detecting ischemia within the brain of a patient. The method includes assigning a first value to a first signal generated by a tissue on the right-hand side of the body and assigning a second value to a second signal generated by a tissue on the left-hand side of the body. The method also includes comparing the first value and the second value. The difference between the first value and the second value indicates that ischemia is present within the patient’s brain.

公开(公告)号：WO2003067216A3

公开(公告)日：2003-08-14

申请号：PCT/US2003/003472

申请日：2003-02-05

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  GEORGE, Steven, C. ,  CONDORELLI, Peter

Inventor： GEORGE, Steven, C. ,  CONDORELLI, Peter

IPC: A61B05/00

Abstract: Parametric characterization of nitric oxide (NO) gas exchange using a two-compartment model of the lungs (65, 70) is a non-invasive technique to characterize inflammatory lung diseases. The technique applies the two-compartment (65, 70) model to parametric characterization of NO gas exchange from a tidal breathing pattern. The model (65, 70) is used to estimate up to six flow-independent parameters, and to study alternate breathing patterns.

公开(公告)号：WO2003022128A3

公开(公告)日：2003-03-20

申请号：PCT/US2002/028017

申请日：2002-09-04

Applicant: MEDTRONIC MINIMED, INC.

Inventor： LEBEL, Ronald, J. ,  SHAH, Rajiv ,  ZHANG, Yanan ,  CHERNOFF, Edward ,  MONTALVO, Rudolph, A.

IPC: A61B05/00

Abstract: A sensing apparatus (10) with a connector (16), a sensor lead (12) and a sensor module (20) with a spacer (50) placed over electrodes (36) that have been deposited on a substrate (30). The spacer (50) may have a space for receiving an enzyme. End portions of the sensor module (20) may be encapsulated, such as with molded beads (22). A sensor lead (12) may attach to the sensor module (20) and may have an outer tubing that passes over the module and attaches to the beads (22) at the end of the sensor module (20). The sensor lead (12) may also attach to the connector (16) such that the sensing apparatus may be electrically coupled to a pump, electronics, or other devices. The sensing apparatus (10) may be implanted into a vein or artery.

公开(公告)号：WO1998053733A1

公开(公告)日：1998-12-03

申请号：PCT/JP1997001755

申请日：1997-05-26

Applicant: HITACHI, LTD. ,  SONEHARA, Tsuyoshi ,  MIYAHARA, Yuji ,  SUGA, Masao

Inventor： HITACHI, LTD.

IPC: A61B05/00

CPC classification number: G01N21/45 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/7257 ,  G01J2003/4538

Abstract: An inspection apparatus uses an optical interferometer comprising optical branching/multiplexing means (3) for branching light from a light source (1) into an irradiating light (41) irradiating a sample and a reference light (40) and multiplexing a signal light, which is scattered or reflected by a sample (7, 42), with the reference light, a modulator (4, 5, 10) for phase modulation of the reference light, and a photodetector (9) for detecting light, multiplexed by the optical branching/multiplexing means (3). The inspection apparatus uses the optical interferometer further comprising first means (12-1) for detecting an amplitude of a first signal component which is included in a signal from the photodetector (9) and has a frequency odd multiples of a basic modulation frequency of the modulator, second means (12-2) for separatingly detecting an amplitude of a second signal component which is included in the signal from the photodetector and has a frequency even multiples of the basic modulating frequency of the modulator, and means (14) for finding an intensity of the signal light using amplitudes of the first and second signal components, the optical interferometer providing a high signal stability and a high signal versus noise ratio. In measurement of a sample such as an organism, in which light is largely scattered or attenuated, it is possible to highly accurately measure refractive indexes and distribution of absorption coefficients up to a region of large depth.

Abstract translation: 检查装置使用包括光分支/多路复用装置（3）的光学干涉仪，用于将来自光源（1）的光分散到照射样品和参考光（40）的照射光（41）中并复用信号光， 由具有参考光的样品（7,42）散射或反射，用于参考光的相位调制的调制器（4,5,10）和用于检测光的光检测器（9），通过光学分支复用 /多路复用装置（3）。 检查装置使用光干涉仪，其还包括第一装置（12-1），用于检测包含在来自光电检测器（9）的信号中的第一信号分量的幅度，并且具有基本调制频率的频率奇数倍 调制器，用于分离地检测来自光电检测器的信号中包含的具有调制器的基本调制频率的偶数倍的第二信号分量的振幅的第二装置（12-2），以及用于发现 信号光的强度使用第一和第二信号分量的幅度，光学干涉仪提供高信号稳定性和高信噪比。 在光被大量散射或衰减的诸如生物体的样品的测量中，可以高度精确地测量折射率和吸收系数的分布直到大深度区域。

公开(公告)号：WO1998042249A1

公开(公告)日：1998-10-01

申请号：PCT/IB1997000287

申请日：1997-03-21

Applicant: NELLCOR PURITAN BENNETT INC.

Inventor： NELLCOR PURITAN BENNETT INC. ,  BAKER, Clark, R., Jr. ,  YORKEY, Thomas, J.

IPC: A61B05/00

CPC classification number: A61B5/14551

Abstract: A method of reducing noise effects in a system for measuring a physiological parameter, comprises the steps of: (a) generating a plurality of measurements derived from at least one wavelength of electromagnetic energy transmitted through living tissue; (b) comparing selected measurements with at least one expected measurement characteristic; (c) assigning one of a plurality of variable weights to each selected measurement based on the comparing step thereby generating a plurality of differently weighted measurements; and (d) averaging a plurality of the differently weighted measurements to obtain a filtered measurement for use in estimating the physiological parameter.

Abstract translation: 一种减少用于测量生理参数的系统中的噪声影响的方法，包括以下步骤：（a）产生从透过活体组织的电磁能的至少一个波长衍生的多个测量值; （b）将所选择的测量与至少一个期望的测量特征进行比较; （c）基于所述比较步骤为每个所选择的测量分配多个可变权重中的一个，从而生成多个不同加权的测量; 和（d）对多个不同加权的测量进行平均以获得用于估计生理参数的滤波测量值。

公开(公告)号：WO1998037800A1

公开(公告)日：1998-09-03

申请号：PCT/US1997011043

申请日：1997-06-25

Applicant: MINNESOTA MINING AND MANUFACTURING COMPANY

Inventor： MINNESOTA MINING AND MANUFACTURING COMPANY ,  HACKER, Thomas, G. ,  FRANTA, David, J.

IPC: A61B05/00

CPC classification number: A61B5/14557 ,  G01N21/05

Abstract: A cassette (12) for tonometric calibration especially useful for systems that measure one or more blood parameters includes a cassette (16) having an elongated fluid chamber (18). In one embodiment of the invention, the fluid chamber (18) includes an expansion region (25) that reduces the likelihood of bubble coalescence of the calibration gas. In another embodiment, inner wall sections of the chamber (18) are provided with a hydrophilic surface. Optionally, a fitting (56) is non-releasably coupled to a casing (16)of the cassette (12) and is movable between a first position for closing a calibration gas outlet port and a second position for venting the calibration gas outlet port. In another embodiment, the cassette (12) includes an elongated sparging tube (72) that extends in a direction generally parallel to the longitudinal axis of the chamber (18).

Abstract translation: 特别适用于测量一个或多个血液参数的系统的用于校准校准的盒（12）包括具有细长流体腔（18）的盒（16）。 在本发明的一个实施例中，流体室（18）包括膨胀区域（25），其减少校准气体的气泡聚结的可能性。 在另一个实施例中，腔室（18）的内壁部分设置有亲水表面。 可选地，配件（56）不可释放地联接到盒（12）的壳体（16），并且可在用于关闭校准气体出口的第一位置和用于排出校准气体出口的第二位置之间移动。 在另一个实施例中，盒（12）包括在大致平行于腔室（18）的纵向轴线的方向上延伸的细长的喷射管（72）。

公开(公告)号：WO1998026709A1

公开(公告)日：1998-06-25

申请号：PCT/US1997023605

申请日：1997-12-12

Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

Inventor： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  WILSON, David, F.

IPC: A61B05/00

CPC classification number: A61B5/14539 ,  A61B5/14542 ,  A61B5/1459

Abstract: Methods and apparatus for the measurement of oxygen, pH and CO2 in human and animal tissue is provided in which the compounds preferably comprise a chromophore and/or fluorphor capable of absorbing an amount of energy and subsequently releasing the energy as phosphorescent and/or fluorescent light, and wherein the phosphorescence is quenched by molecular oxygen according to the Stern-Volmer relationship. CO2 is measured by a fluorphor which alters fluorescence with pH. The apparatus includes an optical fiber (2) for transmitting light to a probe (70) that includes a gas permeable film (10) enclosing a portion (12) of the distal end of the optical fiber to form a reservoir (14) of a solution of the oxygen quenchable phosphorescent compound and/or the fluorescence emitting compound. The apparatus also includes a light source (36) and a light detector (34).

Abstract translation: 提供了用于测量人和动物组织中氧，pH和CO 2的方法和装置，其中化合物优选包含能够吸收一定量的能量并随后释放能量作为磷光和/或荧光的发色团和/或荧光素 ，并且其中根据斯特恩 - 沃尔默关系，磷光被分子氧猝灭。 二氧化碳通过荧光测量，其荧光改变pH。 该装置包括用于将光传送到探针（70）的光纤（2），探针（70）包括封闭光纤远端部分（12）的透气膜（10），以形成一个 氧可淬磷光化合物和/或荧光发射化合物的溶液。 该装置还包括光源（36）和光检测器（34）。

公开(公告)号：WO1998025514A1

公开(公告)日：1998-06-18

申请号：PCT/US1997022808

申请日：1997-12-10

Applicant: ALLIANCE PHARMACEUTICAL CORP.

Inventor： ALLIANCE PHARMACEUTICAL CORP. ,  FAITHFULL, Nicholas, Simon ,  RHOADES, Glenn

IPC: A61B05/00

CPC classification number: A61B5/412 ,  A61B5/0215 ,  A61B5/029 ,  A61B5/145 ,  A61B5/14539 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/742

Abstract: Systems and methods are described for calculating, in real-time, various oxygenation parameters including total oxygen transport (DO 2), mixed venous blood oxygen tension (RO 2) and mixed venous blood oxyhemoglobin saturation (SvO 2) in a patient. The system preferably uses a computer (140), an arterial pressure line (160) and a blood chemistry monitor (150) to assist a physician in accurately determining when to give a patient a blood transfusion or otherwise alter the clinical management of the patient.

Abstract translation: 描述了用于实时计算患者中各种氧合参数的系统和方法，包括总氧气输送（DO 2），混合静脉血氧压力（RO 2）和混合静脉血氧血红蛋白饱和度（SvO 2）。 系统优选地使用计算机（140），动脉压力管线（160）和血液化学监测器（150）来帮助医生准确地确定何时给予患者输血或以其他方式改变患者的临床管理。

公开(公告)号：WO1998020791A1

公开(公告)日：1998-05-22

申请号：PCT/US1996017774

申请日：1996-11-13

Applicant: KABAL, John

IPC: A61B05/00

CPC classification number: A61B5/029 ,  A61B5/022 ,  A61B5/0295 ,  A61B5/4884

Abstract: This invention is a noninvasive method for calculating hemodynamic parameters of a patient using computerized algorithms. The method is implemented in a continuous, noninvasive hemodynamic analyzer (1-9) which computes a complete real time hemodynamic profile with twelve parameters, in both rest and exercise modes. Inputs are received by the analyzer (1-9) and a cascade of algorithms are used to calculate the parameters. The analyzer (1-9) displays or prints a summary in graphical form.

Abstract translation: 本发明是使用计算机化算法计算患者的血液动力学参数的非侵入性方法。 该方法在连续的无创血液动力学分析仪（1-9）中实现，其在休息和运动模式中计算具有十二个参数的完整实时血流动力学特征。 输入由分析仪（1-9）接收，并且使用级联的算法来计算参数。 分析仪（1-9）以图形形式显示或打印摘要。

公开(公告)号：WO1998006323A1

公开(公告)日：1998-02-19

申请号：PCT/US1997013075

申请日：1997-07-22

Applicant: NELLCOR PURITAN BENNETT INCORPORATED

Inventor： NELLCOR PURITAN BENNETT INCORPORATED ,  LEVINSON, Mitchell ,  WARRING, Jessica ,  NIERLICH, Steven, L. ,  PALMER, Phillip, S.

IPC: A61B05/00

CPC classification number: A61B5/1464 ,  A61B5/14542 ,  A61B5/6859 ,  A61B5/6882 ,  A61B5/6885 ,  A61B2503/02

Abstract: A presenting part fetal pulse oximeter sensor which does not penetrate the fetus' skin, and does not rely on a vacuum for attachment is provided. The fetal sensor (10) of the present invention is held in place by pressure applied to the fetus by a number of different mechanisms. In one embodiment, the sensor is held in place against the fetus by a rigid rod (12), with the pressure being applied by the physician or technican's hand on the rod. This type of sensor is useful for spot-checking, where continuous monitoring is not needed. In another embodiment, a pre-loaded spring (24) is coupled between the rod and the sensor head to prevent too much pressure being applied by the user.

Abstract translation: 提供了不穿透胎儿皮肤并且不依赖于真空附件的呈现部分胎儿脉搏血氧计传感器。 本发明的胎儿传感器（10）通过多种不同的机构施加到胎儿的压力保持在适当位置。 在一个实施例中，传感器通过刚性杆（12）保持在与胎儿相对的位置，其中压力由医师或技术人员的手施加在杆上。 这种类型的传感器可用于不需要连续监测的点检。 在另一个实施例中，预加载的弹簧（24）联接在杆和传感器头之间以防止使用者施加过大的压力。