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公开(公告)号：JP5344466B2
公开(公告)日：2013-11-20
申请号：JP2008545317
申请日：2007-03-27
Applicant: 国立大学法人 香川大学 , 株式会社希少糖生産技術研究所 , 株式会社林原 , 松谷化学工業株式会社
CPC classification number: C12R1/01 , A61K8/60 , A61K2800/86 , A61Q19/00 , C12N9/0006 , C12P19/02
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公开(公告)号：JP5320411B2
公开(公告)日：2013-10-23
申请号：JP2011001909
申请日：2011-01-07
Applicant: 株式会社林原
IPC: C07F15/04 , C07D207/06 , C07D211/04 , C07D231/46 , C07D233/90 , C07D471/04 , C07F15/06 , C09B23/14 , C09B45/14 , C09B45/20 , C09B45/22 , C09B69/02 , G11B7/247 , G11B7/249
CPC classification number: G11B7/2467 , C09B23/145 , G11B7/246 , G11B7/2463 , G11B7/247 , G11B7/2472 , G11B7/2475 , G11B7/2478 , G11B7/248 , G11B7/2495 , G11B7/2531 , G11B7/2533 , G11B7/2534 , G11B7/2536 , G11B7/259 , G11B2007/24612
Abstract: The present invention provides styryl dyes which exert satisfactory recording properties in high-density optical recording media, and uses thereof. These are solved by providing dimethine styryl dyes having specific structures, light absorbents and optical recording media which comprise the dimethine styryl dyes, and a process for producing the dimethine styryl dyes which comprises a step of reacting an aromatic amine compound having an aldehyde group with either a 3,3-dimethylbenzoindolium compound having an active methyl group or a 3,3-dimethylindolium compound having an aminosulfonyl group.
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公开(公告)号：JP2013198476A
公开(公告)日：2013-10-03
申请号：JP2012284745
申请日：2012-12-27
Applicant: Hayashibara Co Ltd , 株式会社林原
Inventor： KUDO NAOKI , SHIBUYA TAKASHI , MIYAKE TOSHIO
IPC: C12N1/20
Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a high-quality preparation of dried microbial fungi by which survival rate from a microbial fungal suspension is improved.SOLUTION: There is provided a method for producing a preparation of dried microbial fungi, including, when producing the preparation of the dried microbial fungi by using a microbial fungal suspension, a step of obtaining a main culture solution by proliferating the microbial fungi in a sterilized liquid medium containing nutrient, a step of obtaining an additional culture liquid by subjecting the microbial fungi obtained in the main culture solution to additional culture in the coexistence of a stabilizing base agent, and a step of collecting the preparation of the dried microbial fungi containing the stabilizing base agent by forming the additional culture liquid into a microbial fungi suspension, and drying the suspension by pulse combustion-type drying or spray drying.
Abstract translation: 要解决的问题：提供一种制备干燥的微生物真菌的高品质制剂的方法，通过该方法可提高微生物真菌悬浮液的存活率。解决方案：提供了一种干燥的微生物真菌制剂的制备方法， 当通过使用微生物真菌悬浮液生产干燥的微生物真菌的制备时，通过在含有营养物的无菌液体培养基中增殖微生物真菌得到主培养液的步骤，通过使微生物真菌 在主培养溶液中获得的，在稳定基剂共存的情况下进行附加培养，以及通过将附加培养液形成微生物真菌悬浮液收集含有稳定基剂的干燥微生物真菌的制备步骤，并干燥 通过脉冲燃烧式干燥或喷雾干燥悬浮。
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公开(公告)号：JPWO2012014805A1
公开(公告)日：2013-09-12
申请号：JP2012526471
申请日：2011-07-22
Applicant: 株式会社林原
IPC: A61K31/4709 , A61K33/00 , A61K45/06 , A61P1/04 , A61P1/18 , A61P9/10 , A61P9/12 , A61P13/12 , A61P19/02 , A61P29/00 , A61P31/12 , A61P37/06
CPC classification number: A61K31/4709 , A61K9/2018 , C07D215/12 , C07D401/14
Abstract: 生体へ安全に適用可能な、ミクログリア細胞を含むマクロファージ系細胞や血管内皮細胞などからの一酸化窒素生成を効果的に調節するための新規な一酸化窒素生成調節剤を提供することを課題とし、下記一般式1で表される三核型ペンタメチン系シアニン色素を有効成分とする一酸化窒素生成調節剤を提供することにより解決する。【化1】一般式1(一般式1においてRは分岐を有することある炭素数が2乃至4のアルキル基を表し、X−は適宜の対アニオンを表す。)
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Patent Agency Ranking
公开(公告)号：JPWO2011158904A1
公开(公告)日：2013-08-19
申请号：JP2012520494
申请日：2011-06-16
Applicant: 株式会社林原
IPC: A61K31/7076 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/10 , A61P13/12 , A61P17/00 , A61P29/00 , A61P31/04 , C07H19/20
CPC classification number: A61K31/7076 , A61K8/602 , A61K31/7052 , A61K31/7056 , A61K31/706 , A61K31/7064 , A61K31/708 , A61K45/06 , A61K2800/10 , A61Q17/04 , A61Q19/00 , A61Q19/007 , A61Q19/08 , C07H19/067 , C07H19/167
Abstract: 効果的で、且つ、安全な敗血症、肝炎又は炎症性腸疾患などの炎症性疾患治療剤を提供することを課題とし、有効成分としてアデノシンN1−オキシド又はその誘導体を含有してなる炎症性疾患治療剤を提供することにより解決する。
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217.发明专利
公开(公告)号：JP2013151556A
公开(公告)日：2013-08-08
申请号：JP2013094927
申请日：2013-04-30
Applicant: Hayashibara Co Ltd , 株式会社林原
Inventor： SHIBUYA TAKASHI , IZAWA SEISUKE , NISHIMOTO TOMOYUKI , FUKUDA SHIGEHARU , MIYAKE TOSHIO
CPC classification number: A61K31/7048 , A61K9/16 , C07H17/04 , C12P19/18 , C12P19/60 , C12Y204/01019
Abstract: PROBLEM TO BE SOLVED: To provide a method for producing an ascorbic acid 2-glucoside anhydrous crystal-containing powder, capable of producing a powder that will not show significant solidification, even when the percentage of ascorbic acid 2-glucoside produced is less than 35 mass%.SOLUTION: A method for producing an ascorbic acid 2-glucoside anhydrous crystal-containing powder comprises: a step in which a solution containing either liquefied starch or dextrin and L-ascorbic acid is exposed to CGTase and then to glucoamylase in order to obtain a solution where the percentage of ascorbic acid 2-glucoside produced is 27 mass% or greater; a step of purifying the resulting solution such that the ascorbic acid 2-glucoside content exceeds 86 mass%; a step of precipitating the ascorbic acid 2-glucoside anhydrous crystals by controlled cooling or semi-controlled cooling; and a step of recovering, aging, and drying the precipitated ascorbic acid 2-glucoside anhydrous crystals.
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218.发明专利METHOD FOR PRODUCING 2-O-α-D-GLUCOSYL-L-ASCORBIC ACID ANHYDROUS CRYSTAL-CONTAINING POWDER 有权生产2-O-α-D-葡萄糖-L-抗坏血酸含水晶体粉末的方法
公开(公告)号：JP2013151555A
公开(公告)日：2013-08-08
申请号：JP2013094917
申请日：2013-04-30
Applicant: Hayashibara Co Ltd , 株式会社林原
Inventor： SHIBUYA TAKASHI , IZAWA SEISUKE , NISHIMOTO TOMOYUKI , FUKUDA SHIGEHARU , MIYAKE TOSHIO
CPC classification number: A61K31/7048 , A61K9/16 , C07H17/04 , C12P19/18 , C12P19/60 , C12Y204/01019
Abstract: PROBLEM TO BE SOLVED: To provide a method for producing an ascorbic acid 2-glucoside anhydrous crystal-containing powder, capable of producing a powder that will not show significant solidification, even when the percentage of ascorbic acid 2-glucoside produced is less than 35 mass%.SOLUTION: A method for producing an ascorbic acid 2-glucoside anhydrous crystal-containing powder comprises: a step in which a solution containing either liquefied starch or dextrin and L-ascorbic acid is exposed to CGTase and then to glucoamylase in order to obtain a solution where the percentage of ascorbic acid 2-glucoside produced is 27 mass% or greater; a step of purifying the resulting solution such that the ascorbic acid 2-glucoside content exceeds 86 mass%; a step of precipitating the ascorbic acid 2-glucoside anhydrous crystals by controlled cooling or semi-controlled cooling; and a step of recovering, aging, and drying the precipitated ascorbic acid 2-glucoside anhydrous crystals.
Abstract translation: 要解决的问题：即使产生的抗坏血酸2-葡萄糖苷的百分比小于35，也可以提供能够生产不显示固化的粉末的抗坏血酸2-葡萄糖苷无水结晶粉末的制造方法 质量％溶液：制备抗坏血酸2-葡萄糖苷无水结晶粉末的方法包括：将含有液化淀粉或糊精和L-抗坏血酸的溶液暴露于CGT酶然后暴露于葡糖淀粉酶的步骤，以便 得到生成的抗坏血酸2-葡萄糖苷的百分比为27质量％以上的溶液; 纯化所得溶液使得抗坏血酸2-葡萄糖苷含量超过86质量％的步骤; 通过控制冷却或半控冷却沉淀出抗坏血酸2-葡萄糖苷无水晶体的步骤; 以及回收，老化和干燥沉淀的抗坏血酸2-葡萄糖苷无水晶体的步骤。
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公开(公告)号：JP5240480B2
公开(公告)日：2013-07-17
申请号：JP2010177117
申请日：2010-08-06
Applicant: 株式会社林原
IPC: A23G9/32 , C12Q1/34 , A23G9/44 , A23G9/52 , A23L1/09 , A23L1/30 , A61K8/00 , A61K8/06 , A61K8/60 , A61K8/73 , A61K9/06 , A61K9/28 , A61K47/26 , A61Q11/00 , C12N1/20 , C12N9/24 , C12P19/00 , C12P19/12 , C12P19/16 , C12P19/20 , C12R1/06
CPC classification number: Y02P20/52
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220.发明专利Alkylresorcinol glycoside, process for production of the same, and use of the same 审中-公开阿奇霉素甘氨酸，其生产方法及其用途
公开(公告)号：JP2013129658A
公开(公告)日：2013-07-04
申请号：JP2013011158
申请日：2013-01-24
Applicant: Hayashibara Co Ltd , 株式会社林原
Inventor： SHIBUYA TAKASHI , NOGUCHI AYAYUKI , TAKAYAMA SATORU , SUEMOTO YASUO , TAKEUCHI MASATO , NAKANO MASAYUKI
IPC: A61K8/60 , A61K31/7034 , A61P17/18 , A61Q19/02
CPC classification number: A61Q19/00 , A61K8/602 , A61K31/7034 , A61Q19/02 , C07H15/203 , C12P19/44
Abstract: PROBLEM TO BE SOLVED: To provide a 4-alkylresorcinol derivative which is excellent in water solubility and stability while overcomining defects inherent to 4-alkylresorcinols, is substantially tasteless, odorless, non-irritating, and free from the concern about toxicity, and can exert its physiological activity in a living body satisfactorily.SOLUTION: There is provided the 4-alkylresorcinol glycoside has a glycosyl group bonded to one or both of hydroxyl groups in a 4-alkylresorcinol.
Abstract translation: 要解决的问题：为了提供水溶性和稳定性优异的4-烷基间苯二酚衍生物，同时过度使用4-烷基间苯二酚固有的缺陷，基本上无味，无臭，无刺激性，并且不受毒性的关注，并且可以发挥 其活体的生理活性令人满意。解决方案：4-烷基间苯二酚糖苷具有与4-烷基间苯二酚中的一个或两个羟基键合的糖基。
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