公开(公告)号：KR1020090054736A

公开(公告)日：2009-06-01

申请号：KR1020070121572

申请日：2007-11-27

Applicant: (주)아모레퍼시픽

Inventor： 이진영 ,  박준성 ,  김은주 ,  박혜윤 ,  박성일 ,  김연준 ,  김덕희 ,  장이섭 ,  김선영 ,  조현수

IPC: A47J31/00

CPC classification number: A47J31/32

Abstract: An extractor and an extracting method using a pottery are provided to create high pressure inside the extractor body in order to prevent extracts from contacting the extractor body of metal material. An extractor(200) comprises a hollow body(210) made of metal, a cover(220) closing the body, a heating part(230) heating the body from the outside, a pottery(240) placed inside the body, and a gas valve(250) which injects gas into the body or discharges gas from the body.

Abstract translation: 提供使用陶器的提取器和提取方法以在提取器体内产生高压，以防止提取物与金属材料的提取体接触。 提取器（200）包括由金属制成的中空体（210），封闭主体的盖（220），从外部加热身体的加热部（230），放置在身体内的陶器（240），以及 气体阀（250），其将气体注入体内或从身体排出气体。

公开(公告)号：KR1020080052024A

公开(公告)日：2008-06-11

申请号：KR1020060123982

申请日：2006-12-07

Applicant: (주)아모레퍼시픽 ,  크리스탈지노믹스(주) ,  연세대학교 산학협력단

Inventor： 홍용덕 ,  강승현 ,  김연준 ,  변경희 ,  우병영 ,  박미영 ,  주영협 ,  김정주 ,  장두옥 ,  태진성 ,  신동규 ,  김용은 ,  천영훈 ,  이재일 ,  현영란 ,  노성구 ,  조중명

IPC: C07D487/04 ,  A61K31/4162

CPC classification number: C07D487/04

Abstract: Triazolopyridazine derivatives are provided to inhibit acetyl-CoA carboxylase 2(ACC2), so that the compounds are useful for prevention and treatment of obesity, diabetes, hyperlipidemia and metabolic syndrome-related disease. Triazolopyridazine derivatives represented by the formula(1) have inhibitory effects on acetyl-CoA carboxylase 2, wherein X is hydrogen, pyridyl, thiophenyl, furanyl or phenyl optionally substituted by C1-5 alkyl, C1-5 alkoxy, hydroxy or halogen; Y is pyridine, thiophene or NHR2; Z is O, S, NH, methylene, ethylene or -CH(CH3)-; R1 is methyl, hydroxy or hydroxy methyl; R2 is hydrogen, C1-7 alkyl, C3-8 cycloalkyl optionally substituted by hydroxy or C1-7 alkyl, or phenyl optionally substituted by C1-5 alkyl; R3 is hydrogen, hydroxy, C1-5 alkyl, C1-5 alkoxy or halogen; R4 is hydrogen, hydroxy, C1-5 alkyl, C1-5 alkoxy, trifluoromethyl, C1-5 alkoxycarbonyl or halogen; and W is bond, C1-2 alkylene, alkenylene or alkynylene.

Abstract translation: 提供三唑并哒嗪衍生物以抑制乙酰辅酶A羧化酶2（ACC2），使得该化合物可用于预防和治疗肥胖症，糖尿病，高脂血症和代谢综合征相关疾病。 由式（1）表示的三唑并哒嗪衍生物对乙酰辅酶A羧化酶2具有抑制作用，其中X为氢，吡啶基，噻吩基，呋喃基或任选被C 1-5烷氧基，羟基或卤素取代的苯基; Y为吡啶，噻吩或NHR2; Z是O，S，NH，亚甲基，亚乙基或-CH（CH 3） - ; R1是甲基，羟基或羟基甲基; R 2为氢，C 1-7烷基，任选被羟基或C 1-7烷基取代的C 3-8环烷基，或任选被C 1-5烷基取代的苯基; R3是氢，羟基，C1-5烷基，C1-5烷氧基或卤素; R4是氢，羟基，C1-5烷基，C1-5烷氧基，三氟甲基，C1-5烷氧基羰基或卤素; W是键，C1-2亚烷基，亚烯基或亚炔基。

公开(公告)号：KR1020070089302A

公开(公告)日：2007-08-31

申请号：KR1020060019113

申请日：2006-02-28

Applicant: (주)아모레퍼시픽

Inventor： 주희경 ,  김연준 ,  채병근 ,  김한곤

IPC: A61K8/92 ,  A61Q19/00

CPC classification number: A61K8/062 ,  A61K8/92 ,  A61K2800/262 ,  A61Q19/00

Abstract: Provided is an oil in water type cosmetic composition which has transparent external appearance by including water and high viscosity by having oil, and shows excellent phase stability and skin stability. In the transparent oil in water type emulsified cosmetic composition including an aqueous ingredient, an oil ingredient and a surfactant, 2-6 wt.% of water in the aqueous ingredient is contained based on the total weight of the composition. The content of oil having a viscosity of more than 10,000 cps at 25 deg.C in the oil ingredient is 40-90 wt.%, based on the total weight of the composition.

Abstract translation: 本发明提供一种水包油型化妆品组合物，其通过包含水而具有透明的外观，并且通过油具有高粘度，并且显示出优异的相稳定性和皮肤稳定性。 在包含水成分，油成分和表面活性剂的透明油包水型乳化化妆品组合物中，基于组合物的总重量含有2-6重量％的含水成分中的水。 基于组合物的总重量，油成分中在25℃下粘度大于10,000cps的油的含量为40-90重量％。

公开(公告)号：KR1020070082635A

公开(公告)日：2007-08-22

申请号：KR1020060015467

申请日：2006-02-17

Applicant: (주)아모레퍼시픽

Inventor： 주희경 ,  이성일 ,  이종찬 ,  김연준 ,  김한성

IPC: A61K8/97 ,  A61Q19/08

Abstract: An anti-aging composition for external skin application containing the extract of red pine needles is provided to remove free radicals, protect cell membrane damage due to UV(ultraviolet), inhibit production of reactive oxygen species due to UV, restore expression decrease of superoxide dismutase and catalase due to UV, promote production of HSP70(heat shock protein 70) and suppress MMP-2(matrix metal protease-2) biosynthesis. The anti-aging composition for external skin application contains 0.001-10.0 wt.% of the extract of red pine needles which is prepared by extracting freeze-dried red pine needles with 70% ethanol at room temperature for 48 hours, and evaporating ethanol from the extract by using an evaporator, and has a formulation selected from solution, gel, emulsion, suspension, microemulsion, microcapsule, microgranule, dispersion, cream, skin, lotion, powder, ointment, spray or stick.

Abstract translation: 提供含有红松提取物的外用皮肤抗衰老组合物，以除去自由基，保护由紫外线（紫外线）引起的细胞膜损伤，抑制紫外线引起的活性氧的产生，恢复超氧化物歧化酶的表达降低 和由于UV引起的过氧化氢酶，促进HSP70（热休克蛋白70）的产生并抑制MMP-2（基质金属蛋白酶-2）生物合成。 用于外用皮肤的抗衰老组合物含有0.001-10.0重量％的红松针提取物，其通过在室温下用70％乙醇提取冷冻干燥的红松针48小时而制备，并将乙醇从 通过使用蒸发器提取，并且具有选自溶液，凝胶，乳液，悬浮液，微乳液，微胶囊，微粒，分散体，霜剂，皮肤，洗剂，粉末，软膏，喷雾或棒状物的制剂。

公开(公告)号：KR100650043B1

公开(公告)日：2006-11-28

申请号：KR1020060009223

申请日：2006-01-31

Applicant: (주)아모레퍼시픽

Inventor： 김세범 ,  채병근 ,  김연준 ,  김한곤

IPC: A61K8/06 ,  A61K8/34 ,  A61K8/92 ,  A61Q19/08

Abstract: An oil-in-water type emulsified composition is provided to have high temperature stability, show light feeling of use and be able to improve skin elasticity when being applied to skin. The composition comprises 5-10 wt.% of high aliphatic alcohol such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, and cetostearyl alcohol, 2-3 wt.% of a non-ionic surfactant such as alkyl ether-based surfactant and alkyl ester-based surfactant having a linear alkyl with carbon number of more than 16, and 8-20 wt.% of oil selected from the group consisting of ester-based oil, hydrocarbon-based oil and a mixture thereof.

Abstract translation: 本发明提供一种水包油型乳化组合物，该组合物具有高温稳定性，使用感觉轻，并且能够改善施用于皮肤时的皮肤弹性。 该组合物包含5-10重量％的高级脂族醇如月桂醇，鲸蜡醇，硬脂醇，山alcohol醇，肉豆蔻醇和鲸蜡硬脂醇，2-3重量％的非离子表面活性剂如烷基醚 具有碳数超过16的直链烷基的烷基酯类表面活性剂和烷基酯类表面活性剂，和8-20重量％选自酯类油，烃类油及其混合物的油。

公开(公告)号：KR100643514B1

公开(公告)日：2006-11-23

申请号：KR1020050041060

申请日：2005-05-17

Applicant: (주)아모레퍼시픽

Inventor： 백흥수 ,  이찬우 ,  노호식 ,  안수미 ,  김연준 ,  주희경 ,  이해광 ,  김덕희 ,  장이섭

IPC: C07C233/64 ,  A61K8/368

Abstract: Provided are a hydroxybenzoic acid amide compound which suppresses the generation of melanin, its preparation method, and a whitening cosmetic composition containing the compound. The hydroxybenzoic acid amide compound is represented by the formula 1, wherein R1 and R2 are H or OH. The method comprises the steps of dissolving hydroxybenzoic acid in a solvent, adding a catalyst and a base drop by drop, and reacting it with acetic anhydride to prepare an acetylated compound represented by the formula II; dissolving the acetylated compound of the formula II in a solvent and adding a base, ethyl chloroformate and adamantamine to prepare an amide compound represented by the formula III; and reacting the amine compound of the formula III with a base to hydrolyze it (See the reaction scheme 1), wherein R3 and R4 is H or an acetoxy group.

Abstract translation: 本发明提供抑制黑色素生成的羟基苯甲酸酰胺化合物及其制备方法和含有该化合物的美白化妆品组合物。 羟基苯甲酸酰胺化合物由式1表示，其中R 1和R 2是H或OH。 该方法包括以下步骤：将羟基苯甲酸溶解在溶剂中，逐滴加入催化剂和碱，并使其与乙酸酐反应以制备式II表示的乙酰化化合物; 将式II的乙酰化的化合物溶解在溶剂中并加入碱，氯甲酸乙酯和金刚烷胺以制备式III表示的酰胺化合物; 和使式III的胺化合物与碱反应以水解（参见反应方案1），其中R 3和R 4是H或乙酰氧基。