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    Pharmaceutical active derivative delivery systems
    222.
    发明公开
    Pharmaceutical active derivative delivery systems 失效
    Abgabesystemfürpharmazeutische Wirkstoffderivate。

    公开(公告)号：EP0408019A2

    公开(公告)日：1991-01-16

    申请号：EP90113294.4

    申请日：1990-07-11

    Applicant: UNION CARBIDE CHEMICALS AND PLASTICS COMPANY, INC.

    Inventor： Partain III, Emmett Malone ,  Brode II, George Lewis

    IPC: A61K9/06 ,  A61K9/70 ,  A61M35/00 ,  A61L15/00 ,  A61K31/52

    CPC classification number: A61K9/7023 ,  A61K9/7015 ,  A61K31/52 ,  A61K47/58

    Abstract: A biocompatible, film-forming delivery system for the delivery of pharmaceutical or therapeutic actives to a desired topical site of a subject, the system including:
    an active derivatized compound, wherein the active derivatized compound is a reaction product of

    (1) a cyclic anhydride moiety-containing. biocompatible, film-forming polymer with
    (2) at least one active selected from the group con­sisting of pharmaceutical actives, therapeutic actives and a combina­tion thereof, wherein the at least one active has a moiety selected from the group consisting of (a) a hydroxyl moiety capable of forming a half-ester reaction product with a cyclic anhydride moiety of the polymer, (b) an amine moiety capable of forming a half-amide reac­tion product with a cyclic anhydride moiety of the polymer, and (c) a combination thereof, and
    wherein the active derivatized compound forms an active derivatized compound film on the site and the active is released from the active derivatized compound while the delivery system is in contact with the site such that the polymer remains thereon as a polymer film and the at least one active is delivered to the site in an absorbable form.

    Abstract translation: 一种生物相容的成膜递送系统，用于将药物或治疗活性物质递送至受试者的期望的局部部位，该系统包括：活性衍生化合物，其中活性衍生化合物是（1）环状酸酐 含部分 - 。 生物相容的成膜聚合物，其中（2）选自药物活性物质，治疗活性物质及其组合中的至少一种活性物质，其中所述至少一种活性物质具有选自以下的部分：（a）羟基 能够与聚合物的环酸酐部分形成半酯反应产物的部分，（b）能够与聚合物的环酸酐部分形成半酰胺反应产物的胺部分，和（c）其组合 ，并且其中所述活性衍生化合物在所述位点上形成活性衍生化合物膜，并且所述活性物质从所述活性衍生化合物释放，同时所述递送系统与所述位点接触，使得所述聚合物保留在其上作为聚合物膜，并且所述至少 一个活跃的是以可吸收的形式运送到现场。 一世

    Process for crosslinking hydrolyzable copolymers
    224.
    发明公开
    Process for crosslinking hydrolyzable copolymers 失效
    Verfahren zur Vernetzung hydrolisierbarer Copolymere。

    公开(公告)号：EP0401540A2

    公开(公告)日：1990-12-12

    申请号：EP90108934.2

    申请日：1990-05-11

    Applicant: UNION CARBIDE CHEMICALS AND PLASTICS COMPANY, INC.

    Inventor： Keogh, Michael John

    IPC: C08L43/04 ,  C08K5/57

    CPC classification number: C08K5/09 ,  C08K5/57 ,  C08L43/04

    Abstract: A process for crosslinking comprising the following steps:

    (a) admixing, in a processing zone, a copolymer containing at least one hydrolyzable silane moiety; a dihydrocarbyltin oxide; and
    (i) a carboxylic acid;
    (ii) a compound bearing at least one carboxylate moiety, which is capable of forming a carboxylic acid when subjected to heat and/or moisture; or
    (iii) mixtures thereof,
    with the proviso that:

    (A) in the event that component (ii) is present, the conditions in the processing zone are such that the carboxylate moiety forms a carboxylate acid;
    (B) the residence time of the mixture in the processing zone is sufficient to at least partially complete the processing of the copolymer, but of sufficient brevity to substantially avoid a reaction of the carboxylic acid with the dihydrocarbyltin oxid; and

    (b) passing the mixture from step (a) into a crosslinking zone under such reaction conditions that the carboxylic acid reacts with the dihydrocarbyltin oxide to form dihydrocarbyltin carboxylate, said crosslinking zone having a moisture content sufficient to crosslink the hydrolyzable copolymer in the presence of the dihydrocarbyltin carboxylate.

    Abstract translation: 一种交联方法，包括以下步骤：（a）在加工区中混合含有至少一个可水解硅烷部分的共聚物; 二烃基氧化锡; 和（i）羧酸; （ii）具有至少一个羧酸酯部分的化合物，当经受热和/或水分时能够形成羧酸; 或（iii）其混合物，条件是：（A）在存在组分（ii）的情况下，处理区中的条件使得羧酸酯部分形成羧酸; （B）混合物在加工区中的停留时间足以至少部分地完成共聚物的加工，但足够的简便性以便基本避免羧酸与二烃基氧化锡的反应; 和（b）在羧酸与二烃基氧化锡反应形成二烃基羧酸锡的反应条件下将步骤（a）的混合物送入交联区，所述交联区具有足够的水分含量，使水解共聚物在存在下交联 的二烃基羧酸锌。

    Precursor coating compositions
    227.
    发明公开
    Precursor coating compositions 失效
    Vorläuferbeschichtungszusammensetzungen。

    公开(公告)号：EP0388923A1

    公开(公告)日：1990-09-26

    申请号：EP90105347.0

    申请日：1990-03-21

    Applicant: UNION CARBIDE CHEMICALS AND PLASTICS COMPANY, INC.

    Inventor： Nielsen, Kenneth Andrew ,  Glancy, Charles William

    IPC: C09D7/00 ,  B05D1/02

    CPC classification number: B05D1/025 ,  B05D2401/90 ,  C09D7/20 ,  Y02P20/544

    Abstract: Disclosed are precursor coating compositions which are particularly suitable for being admixed with at least one supercritical fluid used as a viscosity reduction diluent and then spraying this resultant liquid mixture of supercritical fluid and precursor coating composition onto a substrate to be coated.

    Abstract translation: 公开了前体涂料组合物，其特别适于与用作粘度降低稀释剂的至少一种超临界流体混合，然后将所得到的超临界流体和前体涂料组合物的液体混合物喷涂到待涂布的基材上。

    Aminopolyol stabilizers
    228.
    发明公开
    Aminopolyol stabilizers 失效
    氨基多元-Stabilisatoren。

    公开(公告)号：EP0371323A2

    公开(公告)日：1990-06-06

    申请号：EP89121140.1

    申请日：1989-11-15

    Applicant: UNION CARBIDE CHEMICALS AND PLASTICS COMPANY, INC.

    Inventor： Hoy, Kenneth Look ,  Taylor, Glenn Alfred ,  Lee, Chinsoo

    IPC: C08G18/08 ,  C08G18/50

    CPC classification number: C08G18/6681 ,  C08G18/0876 ,  C08G18/3246 ,  C08G18/3271 ,  C08G18/409

    Abstract: A method is described for producing dispersions of polyurea and the like in polyols of increased stability by polymerizing an amine and an isocyanate in the presence of an aminoalcohol, typically an aminopolyol, having the following formula:
    wherein A and A′ are individually connective atoms which may be same or different, and are selected from the group consisting of carbon and oxygen or combinations thereof with hydrogen atoms or the like satisfying the valences; B is a member selected from the group consisting of nitrogen, NR, R being alkyl or aryl, or CR′, R′ being hydrogen, alkyl or aryl; D is a member selected from the group consisting of (̵OC a H 2a )̵ and

    (̵O- -(CH₂)₄-CH₂)̵ wherein a has a value of one to four; X is a member selected from the group consisting of OH, NH₂ or H; X′ is a member selected from the group consisting of H or NHR′ where R′ is hydrogen, alkyl or aryl; n and d are individually integers of 0 to 10 and the sum of n and d is at least one and does not exceed 10; S is either 0 or 1; y is an integer of 0 to 4; and m is an integer of at least about 16, with the proviso that when B is nitrogen and either n or d is zero, X and X′ are not both H. The dispersions are useful for the production of polyurethane foams.

    Abstract translation: 描述了一种用于通过在具有下式的氨基醇（通常为氨基多元醇）的存在下聚合胺和异氰酸酯在多元醇中生产聚脲等的分散体来提高稳定性的方法：其中A和A min分别为 可以相同或不同的连接原子，并且选自碳和氧或其与氢原子等的化合物，其满足化合价; B为选自氮，NR，R为烷基或芳基或CR min，R min为氢，烷基或芳基的成员; D是选自由＆lparstr＆OCaH2a＆rparstr＆和＆lparstr＆O - - （CH 2）4 -CH 2＆rparstr组成的组的成员，其中a具有1至4的值; X是选自OH，NH 2或H的成员; X min是选自H或NHR min的成员，其中R min是氢，烷基或芳基; n和d分别为0〜10的整数，n和d的和为1以上且不超过10; S为0或1; y为0〜4的整数; 并且m为至少约16的整数，条件是当B为氮且n或d为0时，X和Xmin都不为H.分散体可用于生产聚氨酯泡沫。

    Wet set additives for high resilience foam
    229.
    发明公开
    Wet set additives for high resilience foam 失效
    添加剂ür。。on on on on。。。。。。。。。。。。。。。。

    公开(公告)号：EP0367283A2

    公开(公告)日：1990-05-09

    申请号：EP89120384.6

    申请日：1989-11-03

    Applicant: UNION CARBIDE CHEMICALS AND PLASTICS COMPANY INC. (a New York corporation)

    Inventor： Whitman, Robert Don ,  Argento, Benny John

    IPC: C08G18/48 ,  C08G18/40 ,  C08G18/65

    CPC classification number: C08G18/4072 ,  A61K8/44 ,  A61Q11/00 ,  C08G18/4804 ,  C08G18/4833 ,  C08G18/4841 ,  C08G2101/0008 ,  C08G2101/005 ,  C08G2101/0058

    Abstract: Ethylene oxide (EO) adducts of di- ard tri-functional starters, such as, trimethylolpropane and glycerine, provide unexpected improvements in the "wet compression set" properties of high resilience (HR) urethane foams. Heretofore, wet set improvements have been achieved through the use of EO adducts of tetrols because of the high degree of crosslink density which these materials impart to a urethane polymeric composition. One commercial wet set additive, which is an EO adduct of pentaerythritol and diglycerine, is an effective wet set improver. Surprisingly, EO adducts of di- and tri-functional starters provide improvements in foam wet set properties, which are comparable to those obtained with such commercial wet set additive. Specifically, EO adducts of glycerine in the 500 to 10,000 molecular weight range yield foam wet set improvements equal to those of such commercial wet set additive at as low as 20 percent of the use level on an equivalent weight basis. Moreover, the EO adducts of glycerine yield foams having improved elongation properties and improved processing (stability) characteristics as compared to those observed with such commercial wet set additives. An EO adduct of glycerine having a number average MW of 1,000 is particularly useful in the invention.

    Abstract translation: 二元三官能起始物（如三羟甲基丙烷和甘油）的环氧乙烷（EO）加成物在高弹性（HR）聚氨酯泡沫的“湿压缩永久变形”性能方面提供了意想不到的改进。 迄今为止，由于这些材料赋予氨基甲酸酯聚合物组合物的交联密度高，所以通过使用四元醇的EO加合物已经实现了湿定型改进。 一种商业湿定型添加剂，它是季戊四醇和二甘油的EO加合物，是一种有效的湿定型改良剂。 令人惊讶的是，二官能和三功能起始机的EO加合物提供了泡沫湿固化性能的改进，这与用这种商业湿固定添加剂获得的那些相当。 具体地说，甘油在500至10,000分子量范围内的EO加合物产生等于这种商业湿定型添加剂的泡沫湿固化改进，其用量低于当量重量的20％。 此外，与使用这种商业湿定型添加剂观察到的那些相比，甘油的EO加合物产生具有改善的伸长性能和改进的加工（稳定性）特性的泡沫。 数均分子量为1,000的甘油的EO加成物在本发明中是特别有用的。

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