公开(公告)号：WO2005118773A2

公开(公告)日：2005-12-15

申请号：PCT/US2005018297

申请日：2005-05-24

Applicant: WAFERGEN INC ,  JOSEPH VICTOR ,  HUDA AMJAD ,  SHIVJI ALNOOR ,  ZHOU JIE

Inventor： JOSEPH VICTOR ,  HUDA AMJAD ,  SHIVJI ALNOOR ,  ZHOU JIE

IPC: B01L3/00 ,  B01L7/00 ,  C12M1/00 ,  C12Q1/68 ,  G01N21/03 ,  G01N21/25 ,  G01N21/64 ,  G01N21/76 ,  G01N35/00 ,  G01N35/04

CPC classification number: C12Q1/686 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/52 ,  B01L7/54 ,  B01L2200/0689 ,  B01L2300/044 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/1827 ,  B82Y30/00 ,  C12Q1/6806 ,  C12Q1/6844 ,  G01N21/01 ,  G01N21/0332 ,  G01N21/6408 ,  G01N21/6452 ,  G01N21/76 ,  G01N35/0099 ,  G01N2021/6417 ,  G01N2021/6484 ,  G01N2035/0405 ,  G01N2201/0231 ,  H01L27/1443 ,  H01L31/0203 ,  H01L31/02325 ,  H01L31/024 ,  H01L31/105 ,  H01L31/18 ,  C12Q2565/501

Abstract: The present invention provides miniaturized instruments for conducting chemical reactions where control of the reaction temperature is desired or required. Specifically, this invention provides chips and optical systems for performing and monitoring temperature-dependent chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost amplification of nucleic acids.

Abstract translation: 本发明提供了在需要或需要反应温度的控制下进行化学反应的小型化仪器。 具体地，本发明提供用于执行和监测温度依赖性化学反应的芯片和光学系统。 本发明中体现的装置和方法对于核酸的高通量和低成本扩增特别有用。

公开(公告)号：US12064772B2

公开(公告)日：2024-08-20

申请号：US17176019

申请日：2021-02-15

Applicant: IT-IS INTERNATIONAL LIMITED

Inventor： James Richard Howell ,  Benjamin Masterman Webster

IPC: B01L7/00 ,  B01L9/06 ,  G01N21/03 ,  G01N21/27

CPC classification number: B01L7/52 ,  B01L9/06 ,  G01N21/0332 ,  G01N21/272 ,  B01L2300/02 ,  B01L2300/041 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0681 ,  B01L2300/0832 ,  B01L2300/087 ,  B01L2300/123 ,  B01L2300/1805 ,  B01L2300/1822 ,  B01L2300/1827 ,  G01N2201/0231 ,  G01N2201/0846

Abstract: A chemical and/or biochemical apparatus (10) includes a thermal mount (14) having wells (26) for receiving reaction vessels (12), a thermal module (16) having a first side thermally coupled to the thermal mount (14), a first heat sink (18) thermally coupled to a second side of the thermal module, the heat sink (18) having a body and thermally conductive fins (32) extending outwards from the body of the first heat sink (18), and a printed circuit board (54) having electronic components for controlling at least the thermal module (16), an excitation light source (62), and a light sensor (52). A first set of light waveguides (60) delivers excitation light to a reaction vessel, and a second set of light waveguides (38) receives light from a reaction vessel and delivers the light to the light sensor (52). The printed circuit board (54), the excitation light source (62), the light sensor (52) and the light waveguides (38, 60) are arranged within an interior space (5) of the first heat sink (18).

公开(公告)号：US20240201093A1

公开(公告)日：2024-06-20

申请号：US18140406

申请日：2023-04-27

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Wooram HONG ,  Hyukju KWON ,  Gahee KIM ,  Won Seok OH ,  Hyunjeong JEON ,  Hyun Do CHOI ,  Minsu CHANG ,  Younsuk CHOI

IPC: G01N21/85 ,  G01N21/3577

CPC classification number: G01N21/85 ,  G01N21/3577 ,  G01N2021/8557 ,  G01N2201/0231 ,  G01N2201/061

Abstract: The present disclosure provides optical monitoring devices. In some embodiments, the optical monitoring device includes a heating stirrer, a floating barrel, and a support body arranged to support the floating barrel. The floating barrel includes a barrel body facing the heating stirrer and spaced apart from the heating stirrer by a gap, a cavity provided in the barrel body and configured to accommodate at least one of a vessel and a conduit, an irradiator arranged in the barrel body and configured to radiate light to the cavity, and a light receiver arranged in the barrel body, aligned with the irradiator and the cavity, and configured to receive light from the cavity.

公开(公告)号：US20180335440A1

公开(公告)日：2018-11-22

申请号：US16050340

申请日：2018-07-31

Applicant: PALO ALTO HEALTH SCIENCES, INC.

Inventor： Leslie E. MACE ,  Elizabeth K. SIEGELMAN ,  Debra L. REISENTHEL ,  Simon W.H. THOMAS

IPC: G01N33/84 ,  G16H20/40 ,  G01N21/78 ,  G16H40/67 ,  G16H50/20 ,  G16H40/40 ,  G16H40/63 ,  A61B5/00 ,  A61B5/08 ,  A61B5/083 ,  A61B5/103 ,  A61M21/02 ,  G16H20/30 ,  A61B5/097 ,  A61M16/00 ,  A61M21/00 ,  G01N21/31 ,  G01N21/77 ,  H04M1/725

CPC classification number: G01N33/84 ,  A61B5/0075 ,  A61B5/0816 ,  A61B5/082 ,  A61B5/0836 ,  A61B5/097 ,  A61B5/1032 ,  A61B5/4836 ,  A61B5/486 ,  A61B5/7415 ,  A61B2560/0223 ,  A61M16/0051 ,  A61M16/024 ,  A61M21/02 ,  A61M2021/0027 ,  A61M2021/0088 ,  A61M2205/3303 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2230/432 ,  G01N21/3151 ,  G01N21/78 ,  G01N21/783 ,  G01N2021/7773 ,  G01N2201/0231 ,  G01N2201/062 ,  G01N2201/1211 ,  G16H20/30 ,  G16H20/40 ,  G16H40/40 ,  G16H40/63 ,  G16H40/67 ,  G16H50/20 ,  H04M1/7253

Abstract: Quantitative colorimetric carbon dioxide detection and measurement systems are disclosed. The systems can include a gas conduit, a colorimetric indicator adapted to exhibit a color change in response to exposure to carbon dioxide gas, a temperature controller operatively coupled to the colorimetric indicator and configured to control the temperature of the colorimetric indicator, an electro-optical sensor assembly including a light source or sources adapted to transmit light to the colorimetric indicator, and a photodiode or photodiodes configured to detect light reflected from the colorimetric indicator and to generate a measurement signal, and a processor in communication with the electro-optical sensor assembly. The processor can be configured to receive the measurement signal generated by the electro-optical sensor assembly and to compute a concentration of carbon dioxide based on the measurement signal. Methods for using the systems are also disclosed including providing a breathing therapy to a patient or user.

公开(公告)号：US10036058B2

公开(公告)日：2018-07-31

申请号：US15027797

申请日：2014-10-07

Applicant: Agdia, Inc.

Inventor： Mark B. Baumgartner ,  Cory D. Hodgson ,  Andrew L. Bristow ,  Paul A. Syverson ,  Grant L. Pexsa ,  Christopher T. Davis ,  Rich Schoeneck ,  Duane Brown ,  Darren Cook

IPC: B01L3/00 ,  B01L7/00 ,  B01L9/06 ,  G01N21/64 ,  G01N21/25 ,  C12Q1/6848 ,  G01N21/03 ,  C12Q1/68

CPC classification number: C12Q1/6848 ,  B01L3/50851 ,  B01L7/00 ,  B01L9/06 ,  B01L2200/10 ,  B01L2200/141 ,  B01L2300/021 ,  B01L2300/024 ,  B01L2300/025 ,  B01L2300/041 ,  B01L2300/0654 ,  G01N21/0332 ,  G01N21/253 ,  G01N21/6428 ,  G01N21/645 ,  G01N2021/0325 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2201/0221 ,  G01N2201/0231

Abstract: A portable testing device includes a housing with an integrated touchscreen display and a receptacle in which a sample holder containing a biological sample and reagent mixture can be placed. The portable testing device further includes an optical assembly positioned in the housing, an electronic assembly that is configured to receive data from the optical assembly and transmit it for display on the touchscreen display, and a power supply in the housing to power the portable testing device. The optical assembly includes an excitation filter that extends across the entire optical assembly and an emission filter that extends across the entire optical assembly.

公开(公告)号：US09909995B2

公开(公告)日：2018-03-06

申请号：US15303913

申请日：2015-04-16

Applicant: Vision IO AS

Inventor： Øyvind Hovland ,  André Hognestad

IPC: G01N21/00 ,  G01N21/954 ,  E21B47/00 ,  G01M3/00 ,  G02B23/24 ,  E21B36/00 ,  G01M5/00 ,  G01N17/04

CPC classification number: G01N21/954 ,  E21B36/001 ,  E21B47/0002 ,  G01M3/005 ,  G01M5/0033 ,  G01M5/0075 ,  G01N17/04 ,  G01N2021/9542 ,  G01N2201/0231 ,  G02B23/24 ,  G02B23/2484 ,  G02B23/2492

Abstract: An inspection tool for inspecting oil and/or gas production and/or injection wells and pipes is provided. The tool comprises at least an image sensor, one or more processors or chips and one or more power supplies. The tool further comprises at least a first and a second chamber being insulated from each other. The first chamber comprises the image sensor and is provided with one or more passive cooling means, and the second chamber comprises the one or more processors and is provided with one or more active cooling means. Further, a method for cooling such inspection tool is provided.

公开(公告)号：US09909171B2

公开(公告)日：2018-03-06

申请号：US14857379

申请日：2015-09-17

Applicant: Takara Bio USA, Inc.

Inventor： Victor Joseph ,  Amjad Huda ,  Alnoor Shivji ,  Jie Zhou

IPC: C12Q1/68 ,  B01L3/00 ,  B01L7/00 ,  B82Y30/00 ,  G01N21/03 ,  G01N35/00 ,  G01N21/01 ,  H01L27/144 ,  H01L31/0203 ,  H01L31/0232 ,  H01L31/024 ,  H01L31/105 ,  H01L31/18 ,  G01N21/64 ,  G01N21/76 ,  G01N35/04

CPC classification number: C12Q1/686 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/52 ,  B01L7/54 ,  B01L2200/0689 ,  B01L2300/044 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/1827 ,  B82Y30/00 ,  C12Q1/6806 ,  C12Q1/6844 ,  G01N21/01 ,  G01N21/0332 ,  G01N21/6408 ,  G01N21/6452 ,  G01N21/76 ,  G01N35/0099 ,  G01N2021/6417 ,  G01N2021/6484 ,  G01N2035/0405 ,  G01N2201/0231 ,  H01L27/1443 ,  H01L31/0203 ,  H01L31/02325 ,  H01L31/024 ,  H01L31/105 ,  H01L31/18 ,  C12Q2565/501

Abstract: The present invention provides miniaturized instruments for conducting chemical reactions where control of the reaction temperature is desired or required. Specifically, this invention provides chips and optical systems for performing and monitoring temperature-dependent chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost amplification of nucleic acids.

公开(公告)号：US09575323B2

公开(公告)日：2017-02-21

申请号：US14970430

申请日：2015-12-15

Applicant: NATIONAL PINGTUNG UNIVERSITY OF SCIENCE & TECHNOLOGY

Inventor： Lung-Ming Fu ,  Wei-Jhong Ju

IPC: G02B27/02 ,  G01N21/86 ,  G01N21/78 ,  G01N21/29 ,  G02B7/02 ,  H01L25/16 ,  H01L27/146 ,  H01L31/0216

CPC classification number: G01N21/29 ,  G01N21/78 ,  G01N2021/786 ,  G01N2201/0231 ,  G02B7/021 ,  G02B27/028 ,  H01L25/167 ,  H01L27/14618 ,  H01L31/02162

Abstract: The present invention provides a biochip image-forming system including a case having a cavity, an optical assembly, a chip-holding assembly and an electricity storage assembly. The cavity communicates with a chip inlet for a biochip to be inserted into the cavity through the chip inlet and an image outlet for an image of the biochip to be outputted from the cavity via the image outlet. The optical assembly is received in the cavity and aligned with the image outlet for forming the image of the biochip. The chip-holding assembly is received in the cavity and arranged between the optical assembly and a heating component. The chip-holding assembly aligns with the chip inlet for the biochip to be placed thereon. The electricity storage assembly is electrically connected with the optical assembly and the heating component. As such, a biochip can be analyzed conveniently using said biochip image-forming system.

Abstract translation: 本发明提供一种生物芯片图像形成系统，其包括具有空腔的壳体，光学组件，芯片保持组件和蓄电组件。 空腔与用于生物芯片的芯片入口连通，以通过芯片入口插入空腔，以及用于通过图像出口从空腔输出的用于生物芯片的图像的图像出口。 光学组件容纳在空腔中并与图像出口对齐以形成生物芯片的图像。 芯片保持组件被容纳在空腔中并且布置在光学组件和加热部件之间。 芯片保持组件与待放置在其上的生物芯片的芯片入口对齐。 蓄电组件与光学组件和加热组件电连接。 因此，可以使用所述生物芯片成像系统方便地分析生物芯片。

公开(公告)号：US20170038310A1

公开(公告)日：2017-02-09

申请号：US15303913

申请日：2015-04-16

Applicant: Vision IO AS

Inventor： Øyvind HOVLAND ,  André HOGNESTAD

IPC: G01N21/954 ,  E21B47/00 ,  G02B23/24 ,  G01N17/04

CPC classification number: G01N21/954 ,  E21B36/001 ,  E21B47/0002 ,  G01M3/005 ,  G01M5/0033 ,  G01M5/0075 ,  G01N17/04 ,  G01N2021/9542 ,  G01N2201/0231 ,  G02B23/24 ,  G02B23/2484 ,  G02B23/2492

Abstract: An inspection tool for inspecting oil and/or gas production and/or injection wells and pipes is provided. The tool comprises at least an image sensor, one or more processors or chips and one or more power supplies. The tool further comprises at least a first and a second chamber being insulated from each other. The first chamber comprises the image sensor and is provided with one or more passive cooling means, and the second chamber comprises the one or more processors and is provided with one or more active cooling means. Further, a method for cooling such inspection tool is provided.

Abstract translation: 提供了一种用于检查油和/或天然气生产和/或注入井和管道的检查工具。 该工具至少包括图像传感器，一个或多个处理器或芯片以及一个或多个电源。 所述工具进一步包括彼此绝缘的至少第一和第二室。 第一室包括图像传感器并且设置有一个或多个被动冷却装置，并且第二室包括一个或多个处理器并且设置有一个或多个主动冷却装置。 此外，提供了一种用于冷却这种检查工具的方法。

公开(公告)号：US20170010472A1

公开(公告)日：2017-01-12

申请号：US14970430

申请日：2015-12-15

Applicant: NATIONAL PINGTUNG UNIVERSITY OF SCIENCE & TECHNOLOGY

Inventor： Lung-Ming FU ,  Wei-Jhong JU

IPC: G02B27/02 ,  G01N21/29 ,  G01N21/78

CPC classification number: G01N21/29 ,  G01N21/78 ,  G01N2021/786 ,  G01N2201/0231 ,  G02B7/021 ,  G02B27/028 ,  H01L25/167 ,  H01L27/14618 ,  H01L31/02162

Abstract: The present invention provides a biochip image-forming system including a case having a cavity, an optical assembly, a chip-holding assembly and an electricity storage assembly. The cavity communicates with a chip inlet for a biochip to be inserted into the cavity through the chip inlet and an image outlet for an image of the biochip to be outputted from the cavity via the image outlet. The optical assembly is received in the cavity and aligned with the image outlet for forming the image of the biochip. The chip-holding assembly is received in the cavity and arranged between the optical assembly and a heating component. The chip-holding assembly aligns with the chip inlet for the biochip to be placed thereon. The electricity storage assembly is electrically connected with the optical assembly and the heating component. As such, a biochip can be analyzed conveniently using said biochip image-forming system.

Abstract translation: 本发明提供一种生物芯片图像形成系统，其包括具有空腔的壳体，光学组件，芯片保持组件和蓄电组件。 空腔与用于生物芯片的芯片入口连通，以通过芯片入口插入空腔，以及用于通过图像出口从空腔输出的用于生物芯片的图像的图像出口。 光学组件容纳在空腔中并与图像出口对齐以形成生物芯片的图像。 芯片保持组件被容纳在空腔中并且布置在光学组件和加热部件之间。 芯片保持组件与待放置在其上的生物芯片的芯片入口对齐。 蓄电组件与光学组件和加热组件电连接。 因此，可以使用所述生物芯片成像系统方便地分析生物芯片。