公开(公告)号：US20180206772A1

公开(公告)日：2018-07-26

申请号：US15414197

申请日：2017-01-24

Applicant: David R. Hall ,  Dan Allen

Inventor： David R. Hall ,  Dan Allen

IPC: A61B5/20 ,  G01N33/493 ,  A61B5/145 ,  A61B10/00 ,  A61B5/1477 ,  A61B5/1455

CPC classification number: A61B5/201 ,  A61B5/14507 ,  A61B5/1455 ,  A61B5/1477 ,  A61B5/207 ,  A61B10/007 ,  A61B2562/0271 ,  A61B2562/0295 ,  G01N33/493

Abstract: We disclose an in-toilet urinalysis system which includes a system for collection urine and applying the urine to a urine test strip. The system may include an orifice within a toilet bowl which leads into a channel. The channel may be connected to a capillary which has an orifice at each end. Urine may pass through the orifice, into the channel, then may be moved by capillary action through the capillary. A urine test strip dispenser may move reaction pads on a urine test strip to the distal end of the capillary to load the reaction pads with urine. The reaction pads may absorb the urine from the most distal orifice of the capillary. A measurable chemical reaction may occur in the reaction pads in response to urine analytes.

公开(公告)号：US09861315B2

公开(公告)日：2018-01-09

申请号：US14427889

申请日：2013-09-04

Applicant: Lohmann GmbH & Co. KG ,  Norbert Gretz ,  Daniel Schock-Kusch

Inventor： Norbert Gretz ,  Daniel Schock-Kusch ,  Michael Herbertz ,  Ralf Nittenwilm

IPC: A61B5/1455 ,  A61B5/00 ,  A61B5/20 ,  C09J7/02 ,  A61B5/02 ,  A61B5/145 ,  C08K3/04 ,  C09J133/08

CPC classification number: A61B5/6832 ,  A61B5/0071 ,  A61B5/02 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/201 ,  A61B5/4244 ,  A61B5/425 ,  A61B5/6833 ,  A61B2560/0285 ,  A61B2562/12 ,  C08K3/04 ,  C09J7/22 ,  C09J7/38 ,  C09J7/381 ,  C09J133/08 ,  C09J2201/134 ,  C09J2201/606 ,  C09J2205/102 ,  C09J2400/22 ,  C09J2421/00 ,  C09J2433/00 ,  C09J2467/006 ,  C09J2483/00 ,  C09J2483/005

Abstract: The present invention pertains to a functional patch to be affixed to the skin, with the aim of measuring metabolic disruptions to organs, and general organ functions, of kidneys, liver, heart, pancreas and muscles (lactate), for example—more particularly it concerns the measurement of the glomerular filtration rate (GFR)—and also to a method for producing a functional patch of this kind.

公开(公告)号：US20170367636A1

公开(公告)日：2017-12-28

申请号：US15536004

申请日：2015-12-21

Applicant: RENALSENSE LTD.

Inventor： Jack Yehoshua MANTINBAND ,  Mor GRINSTEIN ,  Michael ADLER

IPC: A61B5/20 ,  G01N33/493 ,  A61B5/00

CPC classification number: A61B5/201 ,  A61B5/14507 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/208 ,  A61B5/6852 ,  A61B10/007 ,  G01N33/493

Abstract: Described is an apparatus for inline urine analysis comprising a control unit and at least one image capture unit comprising an image sensor and an optical assembly. The apparatus is configured to be coupled with an indwelling urinary catheter or conduit leading from the catheter. Embodiments of the apparatus comprise a dispenser configured to dispense inert or reactive matter into the urine stream to aid in the analysis of properties of the urine and an illumination device configured to illuminate the urine stream. Also described is a system comprising at least one of these apparatuses and at least one image analyzer unit operatively connected to it. The image analyzer unit comprises a processor and software adapted to analyze the captured images to derive information therefrom relating to identification of properties of the urine and/or objects of interest in the urine stream. Embodiments of the system may comprise other peripheral devices.

公开(公告)号：US09820811B2

公开(公告)日：2017-11-21

申请号：US14956350

申请日：2015-12-01

Applicant: SYMAP HOLDING LIMITED

Inventor： Jie Wang

IPC: A61B18/00 ,  A61B18/14 ,  A61B5/00 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/04 ,  A61B5/20 ,  A61B18/18 ,  A61N1/36

CPC classification number: A61B18/1492 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/04001 ,  A61B5/201 ,  A61B5/4833 ,  A61B5/4836 ,  A61B5/4893 ,  A61B5/6853 ,  A61B18/18 ,  A61B2018/00202 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00791 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/1407 ,  A61B2018/1435 ,  A61B2018/1475 ,  A61N1/36117

Abstract: Disclosed herein are systems and methods for locating and identifying nerves innervating the wall of arteries such as the renal artery. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve. The methods includes evaluating a change in physiological parameters after energy is delivered to an arterial wall; and determining the type of nerve that the energy was directed to (sympathetic or parasympathetic or none) based on the evaluated results. The system includes at least a device for delivering energy to the wall of blood vessel; sensors for detecting physiological signals from a subject; and indicators to display results obtained using said method. Also provided are catheters for performing the mapping and ablating functions.

公开(公告)号：US09814788B2

公开(公告)日：2017-11-14

申请号：US14062123

申请日：2013-10-24

Applicant: PHARMACOPHOTONICS, INC.

Inventor： Exing Wang ,  Daniel Meier ,  Robert Bunch ,  Bruce Molitoris ,  Ruben Sandoval ,  Matthew Rubin

IPC: A61B10/00 ,  A61B5/00 ,  A61B8/00 ,  A61K49/00 ,  A61B5/20

CPC classification number: A61K49/0043 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/201 ,  A61B5/412 ,  A61K49/0017 ,  A61K49/0054

Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.

公开(公告)号：US09770291B2

公开(公告)日：2017-09-26

申请号：US14421869

申请日：2013-08-23

Applicant: SYMAP MEDICAL (SUZHOU), LTD

Inventor： Jie Wang ,  Chuwu Li ,  Bo Zou ,  Jiancong Wang

IPC: A61B18/14 ,  A61B5/0205 ,  A61B5/20 ,  A61B5/00 ,  A61B5/04 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/053 ,  A61B18/24 ,  A61N7/02 ,  A61B18/00 ,  A61B18/18 ,  A61N1/36 ,  A61N7/00

CPC classification number: A61B18/1492 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/04001 ,  A61B5/0538 ,  A61B5/201 ,  A61B5/4833 ,  A61B5/4836 ,  A61B5/4893 ,  A61B5/6852 ,  A61B5/6853 ,  A61B18/18 ,  A61B18/24 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00708 ,  A61B2018/00791 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61N1/36117 ,  A61N7/02 ,  A61N2007/003 ,  G06F19/00

Abstract: A device for mapping and ablating the renal nerves distributed on the renal artery is provided, said device comprising a guide catheter (11), a mapping-ablation catheter (12), a handle (13) and a connector (15). The guide catheter (11) had at least one lumen and a distal end with adjustable curvature. The mapping-ablation catheter (12) is housed in one of the lumens of the guide catheter (11) and its distal end has one or more electrodes (22) and one or more detecting devices (23). The distal end of the mapping-ablation catheter (12) is curved, rotatable, and can be extended out of or retracted into the guide catheter (11). The handle (13) connects the guide catheter (11) and mapping-ablation catheter (12), and comprises one or more controlling components for controlling the movement of the guide catheter (11) and mapping-ablation catheter (12). The connector (15) is designed to supply energy to the electrodes (22).

公开(公告)号：US09750463B2

公开(公告)日：2017-09-05

申请号：US14101663

申请日：2013-12-10

Applicant: General Electric Company

Inventor： Gokul Swamy ,  Sahika Genc ,  Hariharan Ravishankar ,  Aditya Saha

IPC: A61B5/00 ,  A61B5/08 ,  A61B5/0205 ,  A61B5/145 ,  A61B5/20 ,  A61B5/083 ,  A61B5/021 ,  A61B5/024 ,  A61B5/01

CPC classification number: A61B5/7275 ,  A61B5/002 ,  A61B5/0022 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0816 ,  A61B5/0836 ,  A61B5/14532 ,  A61B5/14542 ,  A61B5/201 ,  A61B5/202 ,  A61B5/7203 ,  A61B5/7246 ,  A61B5/7264 ,  A61B5/746 ,  G06F19/00

Abstract: Embodiments of the disclosure are directed to a system for analysis of respiratory distress in hospitalized patients. The system performs multi-parametric simultaneous analysis of respiration rate (RR) and pulse oximetry (SpO2) data trends in order to gauge patterns of patient instability pertaining to respiratory distress. Three patterns in SpO2 and RR are used along with LOWESS algorithm and Chauvenets criteria for outlier rejection to obtain robust short term and long term trends in RR and SpO2. Pattern analysis detects the presence of any one of three pattern types proposed. Further, a learning paradigm is introduced to find unknown instances of respiratory distress. This algorithm in conjunction with the learning model allows early detection of respiratory distress in hospital ward and ICU patients.

公开(公告)号：US09737232B2

公开(公告)日：2017-08-22

申请号：US14153546

申请日：2014-01-13

Applicant: Tailin Fan

Inventor： Tailin Fan

IPC: A61B5/00 ,  A61B5/05 ,  A61B17/34 ,  A61B5/06 ,  G01R33/00 ,  G01R33/09 ,  A61B34/20 ,  A61B5/20 ,  A61B90/00

CPC classification number: A61B5/05 ,  A61B5/062 ,  A61B5/201 ,  A61B5/6848 ,  A61B17/3403 ,  A61B2034/2051 ,  A61B2090/3954 ,  A61B2560/0223 ,  A61B2562/04 ,  G01R33/0017 ,  G01R33/0029 ,  G01R33/09

Abstract: A surgical locator circuit identifies a surgical target such as a kidney stone by disposing an emitter such as a magnetic source behind or adjacent the surgical target, and employing the circuit to identify an axis to the emitter, thus defining an axis or path to the surgical target. An array of sensors arranged in an equidistant, coplanar arrangement each senses a signal indicative of a distance to the emitter. A magneto resistor sensor generates a variable resistance is responsive to the distance to a magnetic coil emitting a magnetic field. An equal signal from each of the coplanar sensors indicates positioning on an axis passing through a point central to the sensors and orthogonal to the plane. A fixed element and signal conditioner augments and normalizes the signal received from each of the sensors to accommodate subtle differences in magneto resistive response among the plurality of sensors.

公开(公告)号：US09723998B2

公开(公告)日：2017-08-08

申请号：US15195998

申请日：2016-06-28

Applicant: SYMAP HOLDING LIMITED

Inventor： Jie Wang

IPC: A61B5/04 ,  A61B5/0205 ,  A61B5/20 ,  A61B5/00 ,  A61B18/14 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/053 ,  A61B18/24 ,  A61N7/02 ,  A61B18/00 ,  A61B18/18 ,  A61N1/36 ,  A61N7/00

CPC classification number: A61B18/1492 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/04001 ,  A61B5/0538 ,  A61B5/201 ,  A61B5/4833 ,  A61B5/4836 ,  A61B5/4893 ,  A61B5/6852 ,  A61B5/6853 ,  A61B18/18 ,  A61B18/24 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00708 ,  A61B2018/00791 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61N1/36117 ,  A61N7/02 ,  A61N2007/003 ,  G06F19/00

Abstract: System and method for locating and identifying nerves innervating the wall of arteries such as the renal artery are disclosed. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve. The method includes at least the steps to evaluate a change in physiological parameters after energy is delivered to an arterial wall; and to determine the type of nerve that the energy was directed to (none, sympathetic or parasympathetic) based on the evaluated results. The system includes at least a device for delivering energy to the wall of blood vessel; sensors for detecting physiological signals from a subject; and indicators to display results obtained using this method. Also provided are catheters for performing the mapping and ablating functions.

公开(公告)号：US20170157273A1

公开(公告)日：2017-06-08

申请号：US15438047

申请日：2017-02-21

Applicant: NATIONAL UNIVERSITY CORPORATION MIE UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY

Inventor： Katsunori TERANISHI ,  Hitoshi HIRATA ,  Tetsuya ARAI

IPC: A61K49/00 ,  C08B37/16

CPC classification number: A61K49/0054 ,  A61B5/0071 ,  A61B5/0205 ,  A61B5/026 ,  A61B5/0275 ,  A61B5/201 ,  A61B5/415 ,  A61B5/418 ,  A61B5/7275 ,  A61B5/7425 ,  A61B2576/00 ,  A61K49/001 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0093 ,  A61M5/007 ,  C08B37/0012 ,  C08B37/0015 ,  C09B23/0066 ,  C09B23/086 ,  C09B68/41 ,  C09B68/485

Abstract: The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof. Furthermore, found are a method for fluorescence-imaging an organ other than liver by intravenous administration, a method for evaluating biokinetics of the novel indocyanine compound, a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, utilizing the diagnostic composition including the novel indocyanine compound.