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公开(公告)号：US09398876B2
公开(公告)日：2016-07-26
申请号：US13713189
申请日：2012-12-13
Applicant: PHARMACOPHOTONICS, INC.
Inventor： Exing Wang , Daniel Meier , Robert Bunch , Bruce Molitoris , Ruben Sandoval , Matthew Rubin
CPC classification number: A61B5/201 , A61B1/00154 , A61B1/00165 , A61B5/0071 , A61B5/0084 , A61B5/412 , A61B5/6852 , A61K49/0017 , A61M5/007
Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.
Abstract translation: 用于测量哺乳动物肾脏中肾小球滤过率的方法包括报告物和标记物荧光分子的来源。 将荧光分子引入哺乳动物受试者的血液中。 在一段时间内，测量报告物和标记荧光分子的强度。 计算比例以确定受试者的肾脏的健康状况。 该方法基于标记分子的荧光相对于报告分子的荧光测量血浆分布的体积。
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公开(公告)号：US09814788B2
公开(公告)日：2017-11-14
申请号：US14062123
申请日：2013-10-24
Applicant: PHARMACOPHOTONICS, INC.
Inventor： Exing Wang , Daniel Meier , Robert Bunch , Bruce Molitoris , Ruben Sandoval , Matthew Rubin
CPC classification number: A61K49/0043 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/201 , A61B5/412 , A61K49/0017 , A61K49/0054
Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.
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公开(公告)号：US20170014065A1
公开(公告)日：2017-01-19
申请号：US15218417
申请日：2016-07-25
Inventor： Exing Wang , Daniel Meier , Robert Bunch , Bruce Molitoris , Ruben Sandoval , Matthew Rubin
CPC classification number: A61B5/201 , A61B1/00154 , A61B1/00165 , A61B5/0071 , A61B5/0084 , A61B5/412 , A61B5/6852 , A61K49/0017 , A61M5/007
Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.
Abstract translation: 用于测量哺乳动物肾脏中肾小球滤过率的方法包括报告物和标记物荧光分子的来源。 将荧光分子引入哺乳动物受试者的血液中。 在一段时间内，测量报告物和标记荧光分子的强度。 计算比例以确定受试者的肾脏的健康状况。 该方法基于标记分子的荧光相对于报告分子的荧光测量血浆分布的体积。
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公开(公告)号：US20140369936A1
公开(公告)日：2014-12-18
申请号：US14374259
申请日：2013-02-15
Applicant: PharmacoPhotonics, Inc.
Inventor： Daniel Meier , Bruce Molitoris , Erinn Sheridan , Ruben Sandoval
CPC classification number: A61K49/0017 , A61B5/0071 , A61B5/0088 , A61B5/14535 , A61B5/1455 , A61B5/201 , A61B5/682 , A61K49/0004
Abstract: Methods of measurement of biometric indicators in a mammalian subject are described. Biometric indicators of interest include hematocrit, plasma volume, volume of distribution, and glomerular filtration rate. The methods are especially applicable to subjects with rapid blood loss and to subjects with unstable hematocrits. Hematocrit may be measured by administering an injectate with a dynamic fluorescent marker and a static fluorescent marker, or a single static marker with two fluorescent tags, into the vascular system of the subject, and monitoring the emission intensities of the markers or fluorescent tags over a period of time. Hematocrit may then be calculated using a calibrated spectrometric analyzer by determining the raw ratio of the markers at T0, calculating the apparent hematocrit, and applying a correction factor.
Abstract translation: 描述了哺乳动物受试者中生物特征指示物的测量方法。 感兴趣的生物特征指标包括血细胞比容，血浆体积，分布体积和肾小球滤过率。 该方法特别适用于快速失血的受试者和具有不稳定血细胞比容的受试者。 可以通过将具有动态荧光标记物和静态荧光标记物的注射剂或具有两个荧光标签的单个静态标记物注射到受试者的血管系统中来测量血细胞比容，并且通过对受试者的血管系统监测标记物或荧光标签的发射强度 一段的时间。 然后可以使用校准的光谱分析仪通过确定T0处的标记物的原始比率，计算明显的血细胞比容和应用校正因子来计算血细胞比容。
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公开(公告)号：US20140050667A1
公开(公告)日：2014-02-20
申请号：US14062123
申请日：2013-10-24
Inventor： Exing Wang , Daniel Meier , Robert Bunch , Bruce Molitoris , Ruben Sandoval , Matthew Rubin
IPC: A61K49/00
CPC classification number: A61K49/0043 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/201 , A61B5/412 , A61K49/0017 , A61K49/0054
Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.
Abstract translation: 用于测量哺乳动物肾脏中肾小球滤过率的方法包括报告物和标记物荧光分子的来源。 将荧光分子引入哺乳动物受试者的血液中。 在一段时间内，测量报告物和标记荧光分子的强度。 计算比例以确定受试者的肾脏的健康状况。 该方法基于标记分子的荧光相对于报告分子的荧光测量血浆分布的体积。
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Patent Agency Ranking
公开(公告)号：US11337629B2
公开(公告)日：2022-05-24
申请号：US16692490
申请日：2019-11-22
Applicant: PHARMACOPHOTONICS, INC.
Inventor： Exing Wang , Daniel Meier , Robert Bunch , Bruce Molitoris , Ruben Sandoval , Matthew Rubin
Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.
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公开(公告)号：US20180256755A9
公开(公告)日：2018-09-13
申请号：US15825823
申请日：2017-11-29
Applicant: PharmacoPhotonics, Inc.
Inventor： Daniel Meier , Bruce Molitoris , Erinn Sheridan , Ruben Sandoval
IPC: A61K49/00 , A61B5/00 , A61B5/20 , A61B5/1455 , A61B5/145
Abstract: Methods of measurement of biometric indicators in a mammalian subject are described. Biometric indicators of interest include hematocrit, plasma volume, volume of distribution, and glomerular filtration rate. The methods are especially applicable to subjects with rapid blood loss and to subjects with unstable hematocrits. Hematocrit may be measured by administering an injectate with a dynamic fluorescent marker and a static fluorescent marker, or a single static marker with two fluorescent tags, into the vascular system of the subject, and monitoring the emission intensities of the markers or fluorescent tags over a period of time. Hematocrit may then be calculated using a calibrated spectrometric analyzer by determining the raw ratio of the markers at T0, calculating the apparent hematocrit, and applying a correction factor.
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公开(公告)号：US20130116518A1
公开(公告)日：2013-05-09
申请号：US13713189
申请日：2012-12-13
Inventor： Exing Wang , Daniel Meier , Robert Bunch , Bruce Molitoris , Ruben Sandoval , Matthew Rubin
CPC classification number: A61B5/201 , A61B1/00154 , A61B1/00165 , A61B5/0071 , A61B5/0084 , A61B5/412 , A61B5/6852 , A61K49/0017 , A61M5/007
Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.
Abstract translation: 用于测量哺乳动物肾脏中肾小球滤过率的方法包括报告物和标记物荧光分子的来源。 将荧光分子引入哺乳动物受试者的血液中。 在一段时间内，测量报告物和标记荧光分子的强度。 计算比例以确定受试者的肾脏的健康状况。 该方法基于标记分子的荧光相对于报告分子的荧光测量血浆分布的体积。
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公开(公告)号：US20220354403A1
公开(公告)日：2022-11-10
申请号：US17728026
申请日：2022-04-25
Applicant: PHARMACOPHOTONICS, INC.
Inventor： Exing Wang , Daniel Meier , Robert Bunch , Bruce Molitoris , Ruben Sandoval , Matthew Rubin
Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.
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公开(公告)号：US20180147302A1
公开(公告)日：2018-05-31
申请号：US15825823
申请日：2017-11-29
Applicant: PharmacoPhotonics, Inc.
Inventor： Daniel Meier , Bruce Molitoris , Erinn Sheridan , Ruben Sandoval
IPC: A61K49/00 , A61B5/00 , A61B5/20 , A61B5/1455 , A61B5/145
CPC classification number: A61K49/0017 , A61B5/0071 , A61B5/0088 , A61B5/14535 , A61B5/1455 , A61B5/201 , A61B5/682 , A61K49/0004
Abstract: Methods of measurement of biometric indicators in a mammalian subject are described. Biometric indicators of interest include hematocrit, plasma volume, volume of distribution, and glomerular filtration rate. The methods are especially applicable to subjects with rapid blood loss and to subjects with unstable hematocrits. Hematocrit may be measured by administering an injectate with a dynamic fluorescent marker and a static fluorescent marker, or a single static marker with two fluorescent tags, into the vascular system of the subject, and monitoring the emission intensities of the markers or fluorescent tags over a period of time. Hematocrit may then be calculated using a calibrated spectrometric analyzer by determining the raw ratio of the markers at T0, calculating the apparent hematocrit, and applying a correction factor.
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