公开(公告)号：US20150247806A1

公开(公告)日：2015-09-03

申请号：US14422886

申请日：2013-08-06

Applicant: Beri Cohen

Inventor： Beri Cohen

IPC: G01N21/76 ,  G01N33/53

CPC classification number: G01N21/76 ,  G01N21/253 ,  G01N33/5302 ,  G01N2201/0221 ,  G01N2201/064 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/084

Abstract: A clam-shell luminometer that, when closed, completely encloses an assay reaction mixture-containing reaction vessel and some portion of a reaction carousel or ring. The luminometer includes first and second portions that are coupled to each other, a photomultiplier tube, and plural fiber optic bundles that are optically coupled to the photomultiplier tube. First ends of the fiber optic bundles are disposed adjacent to the reaction vessel in the second portion so that the fiber optic bundles completely surround the perimeter or periphery of the reaction vessel.

Abstract translation: 一种蛤壳式发光计，当关闭时，完全包含含有测定反应混合物的反应容器和一部分反应转盘或环。 光度计包括彼此耦合的第一和第二部分，光电倍增管和光学耦合到光电倍增管的多个光纤束。 光纤束的第一端在第二部分邻近反应容器设置，使得光纤束完全包围反应容器的周边或周边。

公开(公告)号：US20150138552A1

公开(公告)日：2015-05-21

申请号：US14402948

申请日：2012-11-15

Applicant: KOWA COMPANY, LTD.

Inventor： Taisuke Hirono

IPC: G01N21/49 ,  G01N33/487

CPC classification number: G01N21/49 ,  G01N21/0332 ,  G01N21/51 ,  G01N21/82 ,  G01N33/487 ,  G01N2021/0357 ,  G01N2021/0367 ,  G01N2021/4707 ,  G01N2201/064

Abstract: With regard to the detection of a physiological active substance of biological origin and the measurement of its concentration in a sample, the invention provides a technique for moving gel particles that are produced in the sample without using a mechanical stirring member, and allows a highly accurate detection of the physiological active substance of biological origin and measurement of its concentration with a simple arrangement. By partial heating/cooling of a sample cell, thermal convection is generated within a mixture liquid in the sample cell, and as a result the gel particles that are produced in the mixture liquid are moved. In addition, based on the intensity of forward scattered light, the rate of change in the number of gel particles is measured.

Abstract translation: 关于生物来源的生物活性物质的检测及其在样品中的浓度的测定，本发明提供一种移动在样品中生产的凝胶颗粒而不使用机械搅拌构件的技术，并且允许高精度 检测生物来源的生理活性物质，并用简单的排列测定其浓度。 通过对样品池进行部分加热/冷却，在样品池内的混合液体中产生热对流，结果，在混合液中产生的凝胶粒子移动。 此外，基于前向散射光的强度，测定凝胶粒子数量的变化率。

公开(公告)号：US20140349383A1

公开(公告)日：2014-11-27

申请号：US14457628

申请日：2014-08-12

Applicant: TERUMO KABUSHIKI KAISHA

Inventor： Ryo OTA ,  Atsushi Matsumoto

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  G01N21/645 ,  G01N21/77 ,  G01N2021/6434 ,  G01N2021/6469 ,  G01N2021/6471 ,  G01N2021/7753 ,  G01N2021/7786 ,  G01N2201/064

Abstract: A fluorescent sensor includes a detecting substrate, an indicator, a filter layer, a light blocking layer, and an LED chip. In the detecting substrate, a PD element for converting fluorescence into electric signals is positioned on wall surfaces of a through-hole which penetrates a first main surface and a second main surface. The indicator is arranged inside the through-hole and generates fluorescence of intensity corresponding to analyte density when the indicator receives excitation light. The filter layer covers the PD element, transmits fluorescence and blocks excitation light. The light blocking layer, through which an analyte can pass, covers an opening of the first main surface of the through-hole. The LED chip covers a region just below an opening of the second main surface of the through-hole, and generates excitation light.

Abstract translation: 荧光传感器包括检测基板，指示器，滤光层，遮光层和LED芯片。 在检测基板中，将荧光转换为电信号的PD元件位于穿透第一主表面和第二主表面的通孔的壁表面上。 当指示器接收到激发光时，指示器布置在通孔内部并产生与分析物密度相对应的强度的荧光。 过滤层覆盖PD元件，透射荧光并阻挡激发光。 分析物通过的遮光层覆盖通孔的第一主表面的开口。 LED芯片覆盖刚好在通孔的第二主表面的开口下方的区域，并产生激发光。

公开(公告)号：US20140296671A1

公开(公告)日：2014-10-02

申请号：US14304106

申请日：2014-06-13

Applicant: SEIKO EPSON CORPORATION

Inventor： Hideto YAMASHITA ,  Yoshitaka IIJIMA

IPC: A61B5/024 ,  A61B5/1455

CPC classification number: A61B5/0059 ,  A61B5/02055 ,  A61B5/02427 ,  A61B5/02438 ,  A61B5/02444 ,  A61B5/14552 ,  A61B5/681 ,  A61B5/7278 ,  A61B2562/0219 ,  A61B2562/0238 ,  G01N21/474 ,  G01N21/49 ,  G01N2201/064

Abstract: A biological information detector includes a light-emitting part, a reflecting part, a light-receiving part, a protecting part, and a processing part. The reflecting part has a curve shaped reflecting surface that is configured to reflect light emitted by the light-emitting part. The light-receiving part is configured to receive incident light that is emitted by the light-emitting part and reflected at a detection site of a user. The protecting part is configured to protect the light-emitting part, and the protecting part haw a contact surface adapted to contact with the detection site. The processing part is configured to process a light-receiving signal outputted from the light-receiving part. The light-emitting part has a light-emitting surface substantially in parallel to the contact surface, and a distance between the light-emitting surface and the contact surface is within a range of 0.4 mm to 0.9 mm.

Abstract translation: 生物信息检测器包括发光部，反射部，受光部，保护部和处理部。 反射部具有弯曲形状的反射面，被配置为反射由发光部发射的光。 光接收部被配置为接收由发光部发射并在用户的检测部位反射的入射光。 保护部被配置为保护发光部，保护部具有与检测部位接触的接触面。 处理部被配置为处理从光接收部输出的光接收信号。 发光部具有与接触面大致平行的发光面，发光面与接触面的距离在0.4mm〜0.9mm的范围内。

公开(公告)号：US08823944B2

公开(公告)日：2014-09-02

申请号：US13015210

申请日：2011-01-27

Applicant: Hideto Yamashita ,  Yoshitaka Iijima

Inventor： Hideto Yamashita ,  Yoshitaka Iijima

IPC: G01N21/55 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/024 ,  G01N21/47 ,  G01N21/49

CPC classification number: A61B5/0059 ,  A61B5/02055 ,  A61B5/02427 ,  A61B5/02438 ,  A61B5/02444 ,  A61B5/14552 ,  A61B5/681 ,  A61B5/7278 ,  A61B2562/0219 ,  A61B2562/0238 ,  G01N21/474 ,  G01N21/49 ,  G01N2201/064

Abstract: To reduce the effect of directly reflected light on a contact-surface side of a contact member, a biological information detector includes a light-emitting part, a light-receiving part, a reflecting part, a protecting part for protecting the light-emitting part, and a substrate. The protecting member is formed from a material that is transparent with respect to a wavelength of the light emitted by the light-emitting part and has a contact member provided with a contact surface in contact with the detection site. Light emitted from the light-emitting part is inhibited from reflecting once on a contact-surface side of the contact member of the protecting part and being incident on a light-receiving region of the light-receiving part.

Abstract translation: 为了减少直接反射光对接触构件的接触面侧的影响，生物体信息检测器包括发光部，受光部，反射部，保护发光部的保护部 ，和基材。 保护构件由相对于由发光部发射的光的波长透明的材料形成，并具有设置有与检测部位接触的接触面的接触构件。 从保护部的接触部件的接触面侧抑制从发光部射出的光反射一次，入射到受光部的受光部。

公开(公告)号：US08687185B2

公开(公告)日：2014-04-01

申请号：US13023078

申请日：2011-02-08

Applicant: Martina Daub ,  Jochen Rupp

Inventor： Martina Daub ,  Jochen Rupp

IPC: G01N1/10 ,  G01N21/01 ,  G01N21/00

CPC classification number: G01N21/645 ,  B01L3/5085 ,  B01L2200/026 ,  B01L2200/141 ,  B01L2300/0654 ,  G01N21/0303 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2201/064

Abstract: A device and a method for optical parallel analysis of a sample arrangement. The device includes a system of sample areas provided on and/or in a front face of the carrier substrate for receiving a sample substance; a system of detector areas provided on and/or in a back face of the carrier substrate, each detector area being assigned to a corresponding sample area; and a system of optical devices, each optical system being assigned to a corresponding sample area and being designed in such a way that it deflects light beams, which the corresponding sample area in response to an optical excitation does not emit in the direction of a detector area assigned to it, in the direction of the detector area assigned to it and/or in the direction of a detector-free area on the back face of the carrier substrate.

Abstract translation: 用于样本布置的光学并行分析的装置和方法。 该装置包括：设置在载体基板的正面和/或前表面上的用于接收样品物质的样品区域系统; 设置在载体基板的背面和/或背面的检测器区域的系统，每个检测器区域被分配给相应的样品区域; 以及光学装置系统，每个光学系统被分配给对应的采样区域并且被设计成使得其偏转光束，所述光束响应于光学激发而不在检测器的方向上发射 分配给它的区域，分配给它的检测器区域的方向和/或在载体基板的背面上的无检测器区域的方向上。

公开(公告)号：US20140024126A1

公开(公告)日：2014-01-23

申请号：US13926679

申请日：2013-06-25

Applicant: CANON KABUSHIKI KAISHA

Inventor： Makoto Ogusu

IPC: G01N21/75

CPC classification number: G01N21/75 ,  B01L3/502707 ,  B01L2200/0689 ,  B01L2300/0816 ,  B01L2300/168 ,  G01N21/05 ,  G01N2021/056 ,  G01N2201/064 ,  Y10T436/143333

Abstract: The present invention provides a flow-channel device for detecting light emission, which suppresses a noise originating in unnecessary light emission, and can be simply bonded with the use of an organic material. The flow-channel device having a flow channel is structured by the bonding of at least two substrates, wherein at least any one substrate has a first groove which constitutes the flow channel, and a second groove for arranging an adhesive therein which contains an organic material, and a light-shielding layer is provided on an inner wall of the second groove so as to block a light emitted from the second groove from penetrating into the first groove.

Abstract translation: 本发明提供了一种用于检测发光的流路装置，其抑制源自不必要的发光的噪声，并且可以使用有机材料简单地结合。 具有流动通道的流动通道装置通过至少两个基板的结合而构成，其中至少一个基板具有构成流动通道的第一凹槽，以及用于在其中布置粘合剂的第二凹槽，其中包含有机材料 并且在所述第二槽的内壁上设置有遮光层，以阻挡从所述第二凹槽发射的光穿透到所述第一凹槽中。

公开(公告)号：US08228506B2

公开(公告)日：2012-07-24

申请号：US12670148

申请日：2008-07-17

Applicant: Dominique Maria Bruls ,  Johannes Joseph Hubertina Barbara Schleipen

Inventor： Dominique Maria Bruls ,  Johannes Joseph Hubertina Barbara Schleipen

IPC: G01B9/02 ,  G01N21/00 ,  G01N21/55

CPC classification number: G01N21/552 ,  G01N21/648 ,  G01N27/745 ,  G01N2201/064 ,  G01N2201/0691 ,  G01N2201/0696

Abstract: A microelectronic sensor device and a method for making optical examinations at a carrier for the detection of magnetic particles, for example, at a contact surface of the carrier by frustrated total internal reflection (FTIR), include a light source with a laser modulator for emitting an input light beam into the carrier. The input light beam is modulated such that optical interferences with reflections of the input light beam from the entrance window, or from other components of the carrier, are reduced or minimized. This can be achieved by a pulsed on/off modulation in which the first relaxation minimum of a currently emitted pulse (PN) coincides in the light source with the first relaxation maximum of a reflected pulse (PN-1′). By reducing the effect of interferences, the setup is less prone to disturbances from dimensional variations that are induced by thermal extension, for example.

Abstract translation: 微电子传感器装置和用于在载体处用于检测磁性颗粒的光学检查的方法，例如通过沮丧的全内反射（FTIR）在载体的接触表面处，包括具有用于发射的激光调制器的光源 输入光束进入载体。 输入光束被调制成使得来自入口窗口的输入光束或者来自载体的其它部件的反射的光学干涉被减小或最小化。 这可以通过脉冲开/关调制来实现，其中当前发射的脉冲（PN）的第一弛豫最小值在光源中与反射脉冲（PN-1'）的第一弛豫最大值重合。 通过减少干扰的影响，例如，该设置不容易受到由热延伸引起的尺寸变化的干扰。

公开(公告)号：US20110284765A1

公开(公告)日：2011-11-24

申请号：US12785308

申请日：2010-05-21

Applicant: Sean B. Pieper ,  Ahmed Bouzid ,  Donald T. Lamb ,  Andrew G. Ragatz

Inventor： Sean B. Pieper ,  Ahmed Bouzid ,  Donald T. Lamb ,  Andrew G. Ragatz

IPC: G01N21/64

CPC classification number: G01N21/6456 ,  G01N2201/064 ,  G01N2201/0642

Abstract: A fluorescence imaging system having an enclosure having an optical excitation and detection system and features designed to suppress or reduce background fluorescence. In certain aspects, all or a portion of the interior walls has a material finish and texture that provides a surface that absorbs at least a portion of any impinging excitation light and which has low auto-fluorescing properties. In certain aspects, a baffle structure is provided on the interior of the structure and is configured to mask portions of the interior and reduce the opening through which light impinges on the detector. In certain aspects, a platform having an optically transparent window is located in the interior of the housing structure for holding a sample for excitation by excitation light from an excitation source, wherein a light-trap structure is positioned or located on an opposite side of the platform relative to the excitation source and configured to receive and contain a substantial portion of any scattered or transmitted excitation light.

Abstract translation: 一种荧光成像系统，其具有具有光学激发和检测系统的外壳和被设计为抑制或减少背景荧光的特征。 在某些方面，内壁的全部或一部分具有提供吸收至少一部分任何入射激发光并且具有低自发荧光特性的表面的材料表面和纹理。 在某些方面，挡板结构设置在结构的内部，并且构造成掩盖内部的一部分并且减小光照射在检测器上的开口。 在某些方面，具有光学透明窗口的平台位于壳体结构的内部，用于通过来自激发源的激发光来保持用于激发的样品，其中光阱结构被定位或位于 平台相对于激发源并且被配置为接收和容纳任何散射或透射的激发光的实质部分。

公开(公告)号：US08032205B2

公开(公告)日：2011-10-04

申请号：US11227195

申请日：2005-09-16

Applicant: Nizar A. Mullani

Inventor： Nizar A. Mullani

IPC: A61B6/00

CPC classification number: G01N21/8806 ,  A61B5/0059 ,  G01N21/8803 ,  G01N2201/061 ,  G01N2201/064

Abstract: Transillumination uses light to image tissues and organs, specifically the veins within the tissue. Strong ambient light hinders the imaging of veins and often, transillumination must be done in a dark or dim room. To enhance the capabilities of a transilluminator, a light shield is placed over the viewing area of the transilluminator so that turning off or dimming of ambient light is not necessary. For pediatric care, a frustroconical adapter attached to the bottom of the transilluminator. The adapter reduces the size of the viewing area.

Abstract translation: 透照使用光来对组织和器官进行成像，特别是组织内的静脉。 强烈的环境光阻碍了静脉成像，而且经常需要在黑暗或昏暗的房间进行透照。 为了增强透照器的功能，将遮光板放置在透照器的观察区域上，以便不需要关闭或调暗环境光。 对于儿科护理，连接在透照器底部的截头锥形适配器。 适配器减小了观看区域的大小。