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    AZOXY COMPOUND
    4.
    发明申请
    AZOXY COMPOUND 审中-公开
    AZOXY化合物

    公开(公告)号：WO1994005629A1

    公开(公告)日：1994-03-17

    申请号：PCT/JP1993001295

    申请日：1993-09-10

    Applicant: KOWA COMPANY, LTD. ,  DEUSHI, Takeo ,  TAKAHASHI, Yoshio ,  ISHIWATA, Hiroyuki ,  OKUNO, Yukihiro ,  ODA, Toshiaki ,  SHIRATSUCHI, Masami ,  YAMAMOTO, Katsuhiro

    Inventor： KOWA COMPANY, LTD.

    IPC: C07C291/08

    CPC classification number: C07C291/08 ,  A01N51/00

    Abstract: An azoxy compound represented by general formula (I), which has an excellent fungicidal activity against fungi which infect warm-blooded animals, agrohorticultural crops or fruits, thus being useful as medicine, veterinary drug and agrohorticultural fungicide. In formula (I), R1 represents hydrogen, halogen, hydroxy, lower alkoxy, lower alkoxy-lower alkoxy or X1-C=C-CH2O-, wherein X1 represents hydrogen or halogen; R2 represents hydrogen or lower alkyl; R3 represents hydrogen or lower alkyl; R4 represents hydrogen or X2-C=C-CH2O-, wherein X2 represents hydrogen or halogen; R5 represents hydrogen or lower alkyl; and n represents 0 or 1.

    Abstract translation: 由通式（I）表示的氧化偶氮化合物，其对感染温血动物，农业农作物或水果的真菌具有优异的杀真菌活性，因此可用作药物，兽药和农业园艺杀真菌剂。 在式（I）中，R 1表示氢，卤素，羟基，低级烷氧基，低级烷氧基 - 低级烷氧基或X 1 -C = C-CH 2 O-，其中X 1表示氢或卤素; R2代表氢或低级烷基; R3代表氢或低级烷基; R4表示氢或X2-C = C-CH2O-，其中X2表示氢或卤素; R5代表氢或低级烷基; 并且n表示0或1。

    APPARATUS AND METHOD FOR MEASURING PHYSIOLOGICALLY ACTIVE SUBSTANCE OF BIOLOGICAL ORIGIN
    7.
    发明申请
    APPARATUS AND METHOD FOR MEASURING PHYSIOLOGICALLY ACTIVE SUBSTANCE OF BIOLOGICAL ORIGIN 审中-公开
    用于测量生物原始生理活性物质的装置和方法

    公开(公告)号：WO2013175661A1

    公开(公告)日：2013-11-28

    申请号：PCT/JP2012/080253

    申请日：2012-11-15

    Applicant: KOWA COMPANY, LTD.

    Inventor： HIRONO, Taisuke

    IPC: G01N21/51 ,  G01N21/82 ,  G01N21/03

    CPC classification number: G01N21/49 ,  G01N21/0332 ,  G01N21/51 ,  G01N21/82 ,  G01N33/487 ,  G01N2021/0357 ,  G01N2021/0367 ,  G01N2021/4707 ,  G01N2201/064

    Abstract: With regard to the detection of a physiological active substance of biological origin and the measurement of its concentration in a sample, the invention provides a technique for moving gel particles that are produced in the sample without using a mechanical stirring member, and allows a highly accurate detection of the physiological active substance of biological origin and measurement of its concentration with a simple arrangement. By partial heating/cooling of a sample cell, thermal convection is generated within a mixture liquid in the sample cell, and as a result the gel particles that are produced in the mixture liquid are moved. In addition, based on the intensity of forward scattered light, the rate of change in the number of gel particles is measured.

    Abstract translation: 关于生物来源的生物活性物质的检测及其在样品中的浓度的测定，本发明提供一种移动在样品中生产的凝胶颗粒而不使用机械搅拌构件的技术，并且允许高精度 检测生物来源的生理活性物质，并用简单的排列测定其浓度。 通过对样品池进行部分加热/冷却，在样品池内的混合液体内产生热对流，结果，在混合液中产生的凝胶粒子移动。 此外，基于前向散射光的强度，测定凝胶粒子数量的变化率。

    PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF KIDNEY DISEASES
    8.
    发明申请
    PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF KIDNEY DISEASES 审中-公开
    用于预防和治疗KIDNEY疾病的药物组合物

    公开(公告)号：WO2004028566A1

    公开(公告)日：2004-04-08

    申请号：PCT/JP2003/012472

    申请日：2003-09-30

    Applicant: KOWA COMPANY, LTD.

    Inventor： NAKAGAWA, Takashi ,  ISHIWATA, Hiroyuki ,  TAKIZAWA, Toshiaki ,  KANKE, Toru ,  WADA, Yasushi ,  KAWAGOE, Junichi

    IPC: A61K45/00

    CPC classification number: A61K38/4846 ,  A61K38/08 ,  A61K38/482 ,  A61K38/4826 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2800/347

    Abstract: The present invention relates to a pharmaceutical composition for prevention and treatment of kidney diseases comprising one or more effective component(s) of an activator for PAR-2 which is able to activate PAR-2 and a pharmaceutically acceptable carrier. The present invention further relates to a method for prevention and treatment of kidney diseases comprising administration of a pharmaceutical composition for prevention and treatment of kidney diseases containing an activator for PAR-2 which is able to activate PAR-2 to patients suffering from kidney diseases, and also relates to the use of an activator for PAR-2 which is able to activate PAR-2 for the manufacture of a pharmaceutical composition for prevention and treatment of kidney diseases. The present invention furthermore relates to a method for screening an effective ingredient for prevention and treatment of kidney diseases comprising screening of the activating action of the test substance to PAR-2.

    Abstract translation: 本发明涉及一种用于预防和治疗肾脏疾病的药物组合物，其包含一种或多种能够激活PAR-2的活化剂的有效成分和能够激活PAR-2和药学上可接受的载体。 本发明还涉及一种用于预防和治疗肾脏疾病的方法，包括给予含有PAR-2活化剂的肾脏疾病的预防和治疗药物组合物，所述活化剂能够对患有肾脏疾病的患者激活PAR-2， 并且还涉及能够激活PAR-2用于制备用于预防和治疗肾脏疾病的药物组合物的PAR-2的活化剂的用途。 本发明还涉及筛选用于预防和治疗肾脏疾病的有效成分的方法，其包括将检测物质的活化作用筛选至PAR-2。

    PRODUCTION OF GLYCIDYL ETHER
    9.
    发明申请
    PRODUCTION OF GLYCIDYL ETHER 审中-公开
    生产甘油醚

    公开(公告)号：WO1990007506A1

    公开(公告)日：1990-07-12

    申请号：PCT/JP1989001293

    申请日：1989-12-25

    Applicant: KOWA COMPANY, LTD. ,  KAWAMURA, Kiyoshi ,  OTA, Tomio

    Inventor： KOWA COMPANY, LTD.

    IPC: C07D301/28

    CPC classification number: C07D303/22 ,  C07D407/12

    Abstract: This invention relates to a method for producing a glycidyl ether of general formula (I), wherein A is an optionally substituted aryl or heteroaryl group and the asterisked carbon atom represents an asymmetric carbon atom, comprising reacting an aryl alcohol of the general formula A-OH, wherein A is as defined above, with an epihalohydrin in the presence of a quaternary ammonium salt and, if necessary, treating the reaction product with a base. This method can afford the glycidyl ether of formula (I), which is useful as an intermediate of drugs, especially a β-blocker, in a simplified manner with a high optical purity.

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