公开(公告)号：WO2021257539A1

公开(公告)日：2021-12-23

申请号：PCT/US2021/037390

申请日：2021-06-15

Applicant: ACADEMIA SINICA

Inventor： WANG, Andrew H.-J. ,  KUO, Wen-Chih ,  LEE, Cheng-Chung ,  YANG, An-Suei

IPC: C07K16/24 ,  A61K39/395 ,  A61K39/00

Abstract: Disclosed herein are anti-IL-1β antibodies capable of binding to human IL-1β and blocking its biological activities. Also provided herein are pharmaceutical compositions comprising the anti-IL-1β antibodies and therapeutic and diagnostic uses of such antibodies.

公开(公告)号：WO2021113440A2

公开(公告)日：2021-06-10

申请号：PCT/US2020/063007

申请日：2020-12-03

Applicant: CHINA MEDICAL UNIVERSITY ,  ACADEMIA SINICA ,  SHIH, Ming-Che

Inventor： HUNG, Shih-Chieh ,  WU, Han-Chung ,  LIN, Chin-Yu ,  CHI, Yi-Hsuan

IPC: A61K38/08

Abstract: The present disclosure relates to an oligopeptide. The oligopeptide includes an amino acid sequence having at least 50% identity with at least one of full-length amino acid sequences of SEQ ID NO. 1, SEQ ID NO. 2, SEQ ID NO. 3 or SEQ ID NO. 4. The present disclosure also relates to a testing kit including the oligopeptide and a medical composition including the oligopeptide.

公开(公告)号：WO2021055587A1

公开(公告)日：2021-03-25

申请号：PCT/US2020/051247

申请日：2020-09-17

Applicant: ACADEMIA SINICA ,  NATIONAL CENTRAL UNIVERSITY ,  SHIH, Ming-Che

Inventor： YU, Su-May ,  CHEN, Yi-Shih ,  LU, Chung-An ,  HO, Tuan-Hua David

IPC: C12N15/87 ,  A01H9/00 ,  A01H5/00 ,  C12N5/00 ,  C12N15/82 ,  C12N15/00 ,  C07H21/04

Abstract: Provided herein is a method for improving growth, stress tolerance and productivity of a plant. Also provided herein is a method for increasing seed quality of a plant. Specifically, the disclosure provides a method for improving growth, stress tolerance and productivity of a plant, comprising: providing a transgenic plant, which includes a reduced expression on an MYBS2 gene as relative to its wild-type counterpart; and a method for increasing seed quality of a plant, comprising: providing a seed from a transgenic plant, which overexpresses a full-length MYBS2 gene or a mutant MYBS2 gene as relative to its wild-type counterpart.

公开(公告)号：WO2021042082A1

公开(公告)日：2021-03-04

申请号：PCT/US2020/048854

申请日：2020-09-01

Applicant: ACADEMIA SINICA ,  SHIH, Ming-Che ,  NATIONAL CHIAOTUNG UNIVERSITY

Inventor： HSIAO, Michael ,  CHAN, Ming-Hsien ,  CHEN, Nelson, G. ,  LIU, Ru-Shi

IPC: A61B6/00 ,  A61K49/00 ,  A61K49/18 ,  A61B8/481 ,  A61K41/0057 ,  A61K49/225 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N5/06 ,  A61N5/0625 ,  A61P35/00

Abstract: Disclosed herein is a nanocomposite particle comprising a core-shell-shell nanoparticle, an encapsulated nanorod linked with the core-shell-shell nanoparticle, and a lipid layer encapsulating the core-shell-shell nanoparticle and the encapsulated nanorod. The core-shell nanoparticle comprises a phosphor core, an inner shell layer, an outer shell layer, and a cationic polymer. The encapsulated nanorod comprises a nanorod, and a mesoporous scaffold. According to embodiments of the present disclosure, the encapsulated nanorod is linked with the core-shell -shell nanoparticle via an electrostatic interaction between the cationic polymer and the mesoporous scaffold. Also disclosed are the uses of the nanocomposite in treating diseases, for example, cancers.

公开(公告)号：WO2021026176A1

公开(公告)日：2021-02-11

申请号：PCT/US2020/044914

申请日：2020-08-05

Applicant: ACADEMIA SINICA ,  SHIH, Ming-Che

Inventor： HSIAO, Michael ,  HSIEH, Ming-Che ,  BAO, Zhen ,  CHAN, Ming-Hsien ,  LIU, Ru-Shi ,  WANG, An-Bang ,  CHU, Chia-Chih

IPC: B01J19/00 ,  B01J19/02

Abstract: Disclosed herein is a micro-reactor for synthesizing a molecule, for example, compound, a nanoparticle, or a quantum dot. According to embodiments of the present disclosure, the apparatus comprises a processor, a storage unit, a reaction unit, a detector, and a collector, in which the storage unit and the reaction unit are independently controlled by the process. Optionally, the present micro-reactor further comprises a diagnostic device for performing a diagnostic test on a biological sample by use of the molecule. Also disclosed wherein are methods of diagnosing and treating a disease in a subject with the aid of the present micro-reactor.

公开(公告)号：WO2021021861A1

公开(公告)日：2021-02-04

申请号：PCT/US2020/043963

申请日：2020-07-29

Applicant: HU, Che-ming, Jack ,  ACADEMIA SINICA

Inventor： HU, Che-ming, Jack ,  LIN, Chien-wei ,  LIN, Jung-chen ,  PAI, Chen-hsueh

IPC: B82Y5/00 ,  A61K49/18 ,  C07K19/00

Abstract: A carrier system that includes a nanocarrier and a peptide non-covalently associated with the nanocarrier. The peptide contains an adaptor peptide sequence fused to the N-terminus of a target peptide, the adaptor peptide sequence being designed to facilitate the association to the nanocarrier. Also disclosed is a method for improving the immunogenicity of a peptide antigen by fusing it to an adaptor peptide sequence to form an immunizing peptide and contacting the immunizing peptide with a compatible nanocarrier. Further, a method is provided for treating a condition by immunization with a target peptide that has been fused to an adaptor peptide sequence and thereby associated with a nanocarrier. The method induces an immune response against the target peptide for treating cancer, viral infection, bacterial infection, parasitic infection, autoimmunity, or undesired immune responses to a biologies treatment.

公开(公告)号：WO2020237010A1

公开(公告)日：2020-11-26

申请号：PCT/US2020/033929

申请日：2020-05-21

Applicant: ACADEMIA SINICA ,  CHIU, Kuo-Ping

Inventor： CHIU, Kuo-Ping ,  SHIAU, Hsin-Chieh ,  GOH, Zee Hong

IPC: A61K31/713 ,  C07H21/02 ,  C07H21/04 ,  C12N15/10 ,  C12N15/11 ,  C12N15/113

Abstract: The present invention relates to a method for amplifying and detecting ribonucleic acid (RNA) fragments. In particular, the method of the present invention comprises conversion of RNA fragments to cDNA and DNA amplification. The present invention also provides a kit for performing the method as described herein.

公开(公告)号：WO2020139914A1

公开(公告)日：2020-07-02

申请号：PCT/US2019/068528

申请日：2019-12-26

Applicant: ACADEMIA SINICA ,  LU, Joyce Jean

Inventor： LU, Joyce Jean ,  CHEN, Wei-Ju

IPC: C12N5/02 ,  C12N5/10 ,  C12N15/63 ,  C12N15/64

Abstract: The present invention relates to a method for regulating potency of pluripotent stem cells (PSCs) by modulating expression of podocalyxin-like protein 1 (PODXL) and applications thereof.

公开(公告)号：WO2020081765A1

公开(公告)日：2020-04-23

申请号：PCT/US2019/056657

申请日：2019-10-17

Applicant: ACADEMIA SINICA ,  SHIH, Ming-Che

Inventor： CHAO, Yu-Chan ,  LIAO, Lin-Li ,  LIAO, Chuan-yu ,  TSAI, Chih-Hsuan ,  HSU, Paul Wei-che

IPC: C12N9/18 ,  C12Q1/46 ,  G01N21/78

Abstract: This disclosure provides a method and a kit for pesticide detection. By expressing acetylcholinesterases on cell surface, rapid pesticide screening, identification and quantification of pesticides or insecticides may be achieved.

公开(公告)号：WO2020072586A1

公开(公告)日：2020-04-09

申请号：PCT/US2019/054205

申请日：2019-10-02

Applicant: ACADEMIA SINICA ,  SHIH, Ming-Che

Inventor： HSIEH, Patrick, C.H. ,  LUNDY, David

IPC: A61K38/18 ,  A61K9/127 ,  A61K9/51 ,  A61K9/00 ,  A61K31/704 ,  A61K45/06 ,  A61P25/00

Abstract: A method of facilitating the delivery of an agent across the blood-brain barrier (BBB) of a subject, the method involving the use of a low dose of vascular endothelial growth factor (VEGF) polypeptide. In some embodiments, the VEGF polypeptide can be given to the subject before and after administration of the agent at multiple doses.