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1.发明申请
公开(公告)号：WO2020068058A1
公开(公告)日：2020-04-02
申请号：PCT/US2018/052759
申请日：2018-09-25
Applicant: ACADEMIA SINICA , YANG, An-Suei
Inventor： YANG, An-Suei , HSIEH, Shie-Liang , TSAI, Tsung-Yu , YU, Chung-Ming , PENG, Cheng-Yuan
IPC: A61K39/395 , C07K16/08 , C12P21/08 , G01N33/576
Abstract: Disclosed herein is a novel monoclonal antibody exhibiting binding affinity to Siglec-3 receptor. According to the embodiment, the monoclonal antibody is capable of reversing HBV-induced immunosuppression. Accordingly, also disclosed herein are the uses thereof in the treatment and/or prophylaxis of hepatitis B virus (HBV) infection.
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公开(公告)号：WO2021257539A1
公开(公告)日：2021-12-23
申请号：PCT/US2021/037390
申请日：2021-06-15
Applicant: ACADEMIA SINICA
Inventor： WANG, Andrew H.-J. , KUO, Wen-Chih , LEE, Cheng-Chung , YANG, An-Suei
IPC: C07K16/24 , A61K39/395 , A61K39/00
Abstract: Disclosed herein are anti-IL-1β antibodies capable of binding to human IL-1β and blocking its biological activities. Also provided herein are pharmaceutical compositions comprising the anti-IL-1β antibodies and therapeutic and diagnostic uses of such antibodies.
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公开(公告)号：WO2020069050A3
公开(公告)日：2020-04-02
申请号：PCT/US2019/053042
申请日：2019-09-25
Applicant: ACADEMIA SINICA , YANG, An-Suei
Inventor： YANG, An-Suei , HSIEH, Shie-Liang , SUNG, Pei-Shan , HUANG, Ming-Ting , YU, Chung-Ming
IPC: A61K39/395 , A61P25/28 , C07K16/28
Abstract: Provided herein is a method for treating neurodegenerative diseases, such as Alzheimer's disease (AD), by use of monoclonal antibody, which exhibits a binding affinity to Siglec-3 receptor. According to some embodiments of the present disclosure, the monoclonal antibody is capable of enhancing phagocytosis of neurotoxic peptides by immune cells thereby providing a neuroprotective effect to a subject in need thereof.
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公开(公告)号：WO2016137992A2
公开(公告)日：2016-09-01
申请号：PCT/US2016/019128
申请日：2016-02-23
Applicant: YANG, An-Suei , ACADEMIA SINICA
Inventor： YANG, An-Suei , CHEN, Hong-Sen , CHEN, Ing-Chien , TUNG, Chao-Ping , HOU, Shin-Chen , YU, Chung-Ming , YANG, Chi-Kai , CHIU, Yi-Kai
CPC classification number: C07K16/005 , C07K16/1018 , C07K16/18 , C07K16/22 , C07K16/245 , C07K16/2803 , C07K16/2827 , C07K16/2863 , C07K16/2887 , C07K16/32 , C07K2317/34 , C07K2317/622 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N15/1037
Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1 ) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.
Abstract translation: 本文公开了噬菌体展示的单链可变片段（scFv）文库，其包含多个噬菌体展示的scFv，其特征在于（1）特定的CS组合; （2）每个CDR中芳香族残基的特定分布; 和（3）每个CDR中的特定序列。 本发明的scFv文库可用于有效产生对不同抗原具有结合亲和力的不同抗体。 因此，本公开提供了根据实验研究和/或临床应用中的需要，迅速产生不同抗原特异性抗体的潜在手段。
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公开(公告)号：WO2020069050A2
公开(公告)日：2020-04-02
申请号：PCT/US2019/053042
申请日：2019-09-25
Applicant: ACADEMIA SINICA , YANG, An-Suei
Inventor： YANG, An-Suei , HSIEH, Shie-Liang , SUNG, Pei-Shan , HUANG, Ming-Ting , YU, Chung-Ming
IPC: A61K39/395
Abstract: Provided herein is a method for treating neurodegenerative diseases, such as Alzheimer's disease (AD), by use of monoclonal antibody, which exhibits a binding affinity to Siglec-3 receptor. According to some embodiments of the present disclosure, the monoclonal antibody is capable of enhancing phagocytosis of neurotoxic peptides by immune cells thereby providing a neuroprotective effect to a subject in need thereof.
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Patent Agency Ranking
公开(公告)号：WO2011019827A2
公开(公告)日：2011-02-17
申请号：PCT/US2010/045184
申请日：2010-08-11
Applicant: ACADEMIA SINICA , YANG, An-Suei , LEE, Yu-Ching , CHEN, Ing-Chien , YU, Chung-Ming , HSU, Hung-Ju , HUANG, Yi-Jen , CHANG, Hung-Ju , TSAI, Keng-Chang , PENG, Hung-Pin
Inventor： YANG, An-Suei , LEE, Yu-Ching , CHEN, Ing-Chien , YU, Chung-Ming , HSU, Hung-Ju , HUANG, Yi-Jen , CHANG, Hung-Ju , TSAI, Keng-Chang , PENG, Hung-Pin
IPC: C40B40/02 , C40B40/06 , C07H21/04 , C12N1/00 , C12N7/00 , C12P21/00 , C40B40/10 , C07K14/00 , C07H21/00
CPC classification number: C07K16/005 , C07K16/1018 , C07K16/22 , C07K2317/622 , C07K2317/624 , C07K2319/02 , C12N15/1037 , C12N15/1051 , C12N15/73 , C12N2795/00022 , C40B40/08 , C40B50/06
Abstract: Disclosed are nucleic acid libraries for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and for facilitating production of a disulfide-stabilized single chain antibody. Also disclosed are host cell libraries and phage libraries including the nucleic acid libraries. Further disclosed are methods for identifying a signal peptide that facilitates production of disulfide- stabilized single chain antibody, and methods for producing a disulfide-stabilized single chain antibody and non-fusion form thereof.
Abstract translation: 公开了用于鉴定促进二硫键稳定的单链抗体的产生并促进二硫键稳定的单链抗体的产生的信号肽的核酸文库。 还公开了宿主细胞文库和包括核酸文库的噬菌体文库。 进一步公开了用于鉴定促进二硫键稳定的单链抗体的产生的信号肽的方法，以及用于制备二硫键稳定的单链抗体及其非融合形式的方法。
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7.发明申请
公开(公告)号：WO2022261261A2
公开(公告)日：2022-12-15
申请号：PCT/US2022/032746
申请日：2022-06-08
Applicant: ACADEMIA SINICA , LIU, Fu-tong
Inventor： YANG, An-Suei , HSU, Hung-Ju , TUNG, Chao-Ping , YU, Chung-Ming , CHEN, Chi-Yung , CHEN, Hong-Sen , HUANG, Yu-Chuan , TSAI, Pei-Hsun , LIN, Szu-Yu , PENG, Hung-Pin
Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, which comprises a plurality of phage-displayed scFvs characterized with a specific sequence in each CDR. The present phage-displayed scFv library is useful in selecting an antibody fragment exhibiting a binding affinity and specificity to mesothelin (MSLN). Also disclosed herein are a recombinant antibody specific to MSLN, an immunoconjugate comprising the recombinant antibody, and uses thereof in treating cancers.
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公开(公告)号：WO2011130332A1
公开(公告)日：2011-10-20
申请号：PCT/US2011/032192
申请日：2011-04-12
Applicant: ACADEMIA SINICA , WONG, Chi-Huey , WU, Chung-Yi , LIANG, Chi-Hui , YANG, An-Suei
Inventor： WONG, Chi-Huey , WU, Chung-Yi , LIANG, Chi-Hui , YANG, An-Suei
CPC classification number: G01N33/56983 , G01N33/53 , G01N33/54346 , G01N2333/11 , G01N2400/00 , G01N2400/38 , G01N2458/00
Abstract: Glycan arrays that can detect and distinguish between various sub-types and strains of influenza virus are provided. Methods for using the glycan arrays with assays using nanoparticle amplification technique are disclosed. Sandwich assays using gold nanoparticles conjugated to phage particles comprising influenza virus-specific antibodies for detecting multiple serotypes using a single reaction are provided. Plurality of glycans directed to specific target HA of influenza virus comprises the array. Detector molecules comprising noble metals conjugated to (a) phage display particles expressing antibodies against hemagglutinin and (b) neuraminidase binding agents are disclosed.
Abstract translation: 提供了可以检测和区分各种亚型和流感病毒株的糖阵列。 公开了使用纳米颗粒扩增技术的测定法使用聚糖阵列的方法。 提供使用与包含用于使用单个反应检测多种血清型的流感病毒特异性抗体的噬菌体颗粒缀合的金纳米颗粒的三明治测定。 针对流感病毒的特定目标HA的多种聚糖包括阵列。 公开了包含与（a）噬菌体缀合的贵金属的检测分子，其显示表达针对血凝素的抗体的颗粒和（b）神经氨酸酶结合剂。
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9.发明公开
公开(公告)号：EP3856242A1
公开(公告)日：2021-08-04
申请号：EP18934688.5
申请日：2018-09-25
Applicant: Academia Sinica
Inventor： HSIEH, Shie-Liang , TSAI, Tsung-Yu , YANG, An-Suei , YU, Chung-Ming , PENG, Cheng-Yuan
IPC: A61K39/395 , C07K16/08 , C12P21/08 , G01N33/576
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10.发明公开
公开(公告)号：EP4161556A2
公开(公告)日：2023-04-12
申请号：EP21822857.5
申请日：2021-06-07
Applicant: Academia Sinica
Inventor： YANG, An-Suei , YU, Chung-Ming , CHEN, Ing-Chien , TUNG, Chao-Ping , PENG, Hung-Pin
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