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公开(公告)号：US11117958B2
公开(公告)日：2021-09-14
申请号：US16616172
申请日：2018-05-25
Inventor： Charles D. Surh , Jun-Young Lee
IPC: C07K16/24 , A61P35/00 , A61K39/395 , C07K16/28 , A61K39/00
Abstract: Provided is an antibody that binds to human interleukin-2 (hIL-2), and more particularly to an anti-hIL-2 antibody that binds specifically to a particular epitope of hIL-2, thereby inhibiting the binding of the hIL-2 to CD25.
The anti-hIL-2 antibody of the subject matter binds specifically to a particular epitope of hIL-2, thereby inhibiting the binding of the hIL-2 to CD25, thereby minimizing expansion of Treg cells. In addition, it stimulates the CD8+ T cells and NK cells that exhibit anti-tumor activity. Thus, the anti-hIL-2 antibody of the present invention is useful as a new anticancer therapeutic agent.-
公开(公告)号：US20210260269A1
公开(公告)日：2021-08-26
申请号：US17253050
申请日：2019-06-18
Inventor： Taeghwan HYEON , Hyekjin KWON , Dokyoon KIM
Abstract: A blood cleansing system is provided. The blood cleansing system comprises a blood circulation part to circulate blood of a body by discharging the blood to the outside of the body and injecting the blood into the body, a nanoparticle structure supply part connected to the blood circulation part to supply a nanoparticle structure to the blood circulation part, and a nanoparticle structure recovery part connected to the blood circulation part to retrieve the nanoparticle structure. The nanoparticle structure comprises a core comprising first nanoparticles and a shell located on a surface of the core and comprising second nanoparticles.
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公开(公告)号：US10767174B2
公开(公告)日：2020-09-08
申请号：US15347871
申请日：2016-11-10
Applicant: INSTITUTE FOR BASIC SCIENCE
Inventor： Jin-Soo Kim , So Jung Kim
Abstract: Provided are a composition for ribonucleoprotein delivery, comprising a guide RNA free of 5′-terminal phosphates, and a method for ribonucleoprotein delivery, using the same.
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254.发明授权公开(公告)号：US10577465B2
公开(公告)日：2020-03-03
申请号：US15760135
申请日：2016-09-12
Inventor： Sukbok Chang , Seewon Joung , Dongwook Kim , Jeung Gon Kim
Abstract: The present invention relates to a silicon polymer production method using a non-transition-metal-catalyst method of hydrosilylation, and more specifically relates to a production method for a silicon polymer using a non-transition-metal-catalyst method of hydrosilylation, wherein an environmentally friendly silicon polymer is produced by using hydrosilylation using a non-transition metal as a catalyst, thereby avoiding the use of platinum, palladium and rhodium or other expensive platinum group catalysts and so achieving outstanding economic viability and making it possible to prevent residues of heavy metals.
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255.发明授权公开(公告)号：US10564043B2
公开(公告)日：2020-02-18
申请号：US15982303
申请日：2018-05-17
Inventor： Kyung-Taec Kim , Chang-Hee Nam , Seung-Beom Park , Wo-Sik Cho , Kyung-Seung Kim
Abstract: The present invention relates to a apparatus and method for measuring a waveform of a light wave. A light wave measurement apparatus according to an embodiment of the present invention includes a pulse separation unit to separate an input light wave into a fundamental pulse and a signal pulse, a time delay adjustment unit to adjust a time delay between the fundamental pulse and the signal pulse, a focusing unit to focus the fundamental pulse and the signal pulse whose time delay is adjusted on an ionization material, and an ionization yield measurement unit to measure an ionization yield from electrons and/or ions generated by the focused fundamental pulse and signal pulse. The waveform of the input light wave is obtained by obtaining an ionization yield modulation changed by the signal pulse as a function of the time delay.
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Patent Agency Ranking
公开(公告)号：US10517963B2
公开(公告)日：2019-12-31
申请号：US15337252
申请日：2016-10-28
Inventor： Won Jong Kim , Jinhwan Kim
Abstract: Provided is a gene delivery including a polymer network formed by binding phenylboronic acid, sugar, and a low-molecular weight branched polymer. The gene delivery may be stably maintained in vivo and efficiently deliver a gene specifically to cancer cells, such that the gene delivery system may be usefully used as a gene delivery system for chemotherapy.
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公开(公告)号：US20190333858A1
公开(公告)日：2019-10-31
申请号：US16225432
申请日：2018-12-19
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , INSTITUTE FOR BASIC SCIENCE , ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Seong Keun KIM , Woo Chul LEE , Sang Tae KIM , Hyun Cheol SONG , Seung Hyub BAEK , Ji Won CHOI , Jin Sang KIM , Chong Yun KANG , Christopher W. BIELAWSKI , Jung Hwan YUM , Eric S. LARSEN
IPC: H01L23/532 , H01L49/02 , H01L27/108
Abstract: Provided is a dielectric layer that has a rock salt structure in a room temperature stable phase. The dielectric layer is made of a compound having a chemical formula of BexM1-xO, where M includes one of alkaline earth metals and x has a value greater than 0 and less than 0.5.
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公开(公告)号：US20190153530A1
公开(公告)日：2019-05-23
申请号：US15526528
申请日：2015-11-13
Applicant: INSTITUTE FOR BASIC SCIENCE
Inventor： Jin Soo Kim , Dae Sik Kim , Sang Su Bae
IPC: C12Q1/6874 , C12N9/22 , C12Q1/6806 , C12Q1/686
Abstract: The present disclosure relates to a method for detecting off-target sites of a programmable nuclease in a genome, and specifically, to a method for detecting off-target sites through data analysis by subjecting the genome isolated in vitro to programmable nucleases to cleave the genome and then performing whole genome sequencing or deep sequencing, and to a method for selecting on-target sites of a programmable nuclease, which minimizes the off-target effect, using this method. The Digenome-seq of the present disclosure can detect the off-target sites of a programmable nuclease on the genomic scale at a high degree of reproducibility, and thus can be used in the manufacture of programmable nucleases having high target specificity and the study thereof.
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公开(公告)号：US10219779B2
公开(公告)日：2019-03-05
申请号：US14741155
申请日：2015-06-16
Applicant: Institute for Basic Science
Inventor： Chi Young Ahn , Ki Wan Jeon , Sang Woon Yun
Abstract: An apparatus for generating a 3D left ventricle image includes: an ultrasonic sensor transmitting ultrasonic waves to the heart and receiving echoes thereof, an image processor acquiring a plurality of 2D left ventricle images based on the echoes of the ultrasonic waves and extracting sets of left ventricle boundary coordinates from the plurality of 2D images, respectively and a controller calculating a position of the left ventricle in 3D space through transformation of the sets of left ventricle boundary coordinates extracted by the image processor and generating a 3D left ventricle image based on the position of the left ventricle in 3D space.
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公开(公告)号：US20180363055A1
公开(公告)日：2018-12-20
申请号：US15736949
申请日：2016-06-17
Inventor： Kee Tae KIM , Hong Gil NAM , Chand Parvez DANK MOHAMMED
IPC: C12Q1/6883 , G01N33/68 , C12N15/113 , G01N33/50
Abstract: The present invention relates to a method for determining a decrease in the functions of the hippocampus by using the correlation between a micro RNA (miRNA) and an N-methyl-D-aspartate receptor (NMDAR), a method for inhibiting the decrease in the functions, and a method for screening for inhibitors of the decrease in the functions. The present invention confirms that miR-204, among miRNAs up-regulated in an aged hippocampus, decreases the expression of EphB2, by accurately targeting EphB2, which is an important regulatory receptor, resulting in a decrease in the neuronal surface expression of an NR1 subunit of an NMDAR in hippocampal nerves and a decrease in the density of dendrites, thereby having an effect of determining whether the functions of the hippocampus are decreased, by using the correlation between a miRNA and an NMDAR, and furthermore, has an effect of providing a method for inhibiting the decrease in the functions of the hippocampus, and a method for screening for inhibitors of the decrease in the functions.
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