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    FC DOMAIN IMAGING PROBES AND METHODS OF USE THEREOF
    251.
    发明申请
    FC DOMAIN IMAGING PROBES AND METHODS OF USE THEREOF 审中-公开

    公开(公告)号：WO2023035082A1

    公开(公告)日：2023-03-16

    申请号：PCT/CA2022/051359

    申请日：2022-09-12

    Applicant: UNIVERSITY OF SASKATCHEWAN

    Inventor： GEYER, Clarence Ronald ,  BERNHARD, Wendy Lynn

    IPC: A61K49/00 ,  A61B5/00 ,  A61B6/00 ,  C07D403/12 ,  C07D471/04 ,  C09K11/06

    Abstract: The disclosure relates to a method of detecting the presence of tumor infiltrating Fc receptor-expressing immune cells in a mammalian subject afflicted with a cancer or detecting the presence of one or more site(s) of inflammation characterized by Fc receptor-expressing immune cells in a mammalian subject afflicted with an inflammatory disease or disorder, the method comprising administering a non-specific imaging probe comprising one or more Fc domain(s) labeled with a detectable moiety to the subject; subjecting the subject to imaging; and identifying one or more tumor(s) or sites of inflammation comprising infiltrating Fc receptor-expressing immune cells.

    ANTIBODIES TO IGF2R AND METHODS
    254.
    发明申请
    ANTIBODIES TO IGF2R AND METHODS 审中-公开

    公开(公告)号：WO2022178642A1

    公开(公告)日：2022-09-01

    申请号：PCT/CA2022/050273

    申请日：2022-02-25

    Applicant: UNIVERSITY OF SASKATCHEWAN

    Inventor： UPPALAPATI, Maruti ,  DADACHOVA, Ekaterina

    IPC: C07K16/28 ,  A61K39/395 ,  A61K47/68 ,  A61K49/00 ,  A61K51/10 ,  A61P35/00

    Abstract: The disclosure relates to antibodies that bind human, murine, and canine IGF2R, and methods of using said antibodies. Provided herein are antibodies having specific CDRs identified herein, including functional variants of specific variable domains and IgGs having the specified CDR sequences, and immunoconjugates of said antibodies and uses thereof. Also provided herein are compositions and kits comprising said antibodies, and methods and uses of said antibodies, immunoconjugates, compositions, and kits. Also provided herein are the use of said antibodies for radioimmunotherapy (RIT) for cancer including osteosarcoma.

    3'-UNSATURATED ABSCISIC ACID DERIVATIVES AS ABA ANTAGONISTS
    257.
    发明申请
    3'-UNSATURATED ABSCISIC ACID DERIVATIVES AS ABA ANTAGONISTS 审中-公开

    公开(公告)号：WO2020102892A1

    公开(公告)日：2020-05-28

    申请号：PCT/CA2019/051650

    申请日：2019-11-19

    Applicant: UNIVERSITY OF SASKATCHEWAN

    Inventor： ABRAMS, Suzanne R. ,  LAI, Leon ,  DIDDI, Naveen

    IPC: C07C59/90 ,  A01N37/42 ,  A01P21/00 ,  C07C69/732

    Abstract: The present application relates to novel 3'-unsaturated abscisic acid (ABA) derivatives of Formula (I) as ABA antagonists. For example, the present application relates to methods of using compounds of Formula (I) for reducing adverse effects of an ABA response in plants such as lentil and promoting germination. (I) The present application also relates to methods of using 3'-phenyl abscisic acid (ABA) derivatives of Formula (II) as ABA antagonists, for example, for reducing adverse effects of an ABA response in plants such as lentil and promoting germination. (II)

    EGFR-BINDING AGENTS AND USES THEREOF
    258.
    发明申请
    EGFR-BINDING AGENTS AND USES THEREOF 审中-公开

    公开(公告)号：WO2018152634A1

    公开(公告)日：2018-08-30

    申请号：PCT/CA2018/050202

    申请日：2018-02-22

    Applicant: UNIVERSITY OF SASKATCHEWAN ,  THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

    Inventor： SIDHU, Sachdev ,  MIERSCH, Shane ,  GEYER, Clarence

    IPC: C07K16/28 ,  A61K47/68 ,  A61K49/00 ,  A61P35/00

    Abstract: An Epidermal Growth Factor Receptor (EGFR, HER1, ErbB1)-binding agent has a heavy chain and a light chain, wherein the dimerization loop from EGFR's Domain II is grafted within complementarity determining region 3 (CDR3) of the heavy chain, and the binding agent is affinity matured. The graft directs the binding agent to bind EGFR at its dimerization region, to thereby inhibit EGFR dimerization and activation. In another embodiment, an EGFR-binding agent is panned out of Library F, a Fab library. The binding agents are for detecting and/or quantifying EGFR expression, for targeting EGFR-expressing cells, and for decreasing levels of EGFR in EGFR-expressing cells.

    TELEMETERED COMBINED PRESSURE AND EMG DEVICE TO ASSESS PELVIC FLOOR MUSCLE FUNCTION
    259.
    发明申请
    TELEMETERED COMBINED PRESSURE AND EMG DEVICE TO ASSESS PELVIC FLOOR MUSCLE FUNCTION 审中-公开
    TELEMETERED组合压力和EMG装置评估PELVIC地板肌功能

    公开(公告)号：WO2018007898A1

    公开(公告)日：2018-01-11

    申请号：PCT/IB2017/053810

    申请日：2017-06-26

    Applicant: UNIVERSITY OF SASKATCHEWAN

    Inventor： MADILL, Stephanie

    IPC: A61B5/0488 ,  A61B5/22 ,  A61B1/303

    CPC classification number: A61B5/20 ,  A61B5/04882 ,  A61B5/0492 ,  A61B5/07 ,  A61B5/1107

    Abstract: Various embodiments are described herein for a vaginal probe for measuring at least one physiological activity (i.e. at least one property) of a female user's urinary continence system. The probe comprises a semi-enlarged section at a distal portion thereof, the semi-enlarged section having a head portion with a height and a width that is larger than the height, and a transitional portion having a first end adjacent to the semi-enlarged section and an opposite second end, the transitional portion having a similar height as the head portion and a width that that is tapered from the first end to the second end; a cylindrical section at a proximal portion of the probe, the cylindrical section having a first end adjacent to the second end of the transitional portion of the semi-enlarged section; and sensors for recording data to measure the at least one physiological activity of the female user's urinary continence system.

    Abstract translation: 这里描述了用于测量女性用户的尿控制系统的至少一种生理活动（即，至少一种性质）的阴道探针的各种实施例。 探针包括在其远端部分处的半扩大部分，半扩大部分具有高度和宽度大于高度的头部，以及具有与半扩大相邻的第一端的过渡部分 所述过渡部分具有与所述头部相似的高度以及从所述第一端到所述第二端逐渐变细的宽度; 在所述探头的近端部分处的圆柱形部分，所述圆柱形部分具有与所述半扩大部分的所述过渡部分的所述第二端相邻的第一端; 以及用于记录数据以测量女性用户的尿控制系统的至少一种生理活动的传感器。

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