公开(公告)号：WO2017011918A1

公开(公告)日：2017-01-26

申请号：PCT/CA2016/050863

申请日：2016-07-22

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： PEREZ-CASAL, Jose ,  POTTER, Andrew ,  GERDTS, Volker ,  WANG, Yejun

IPC: C12N15/31 ,  A61K39/02 ,  A61P31/04 ,  A61P37/04 ,  C07K14/30 ,  C12N15/63 ,  C12N15/70 ,  C12P21/02

CPC classification number: C07K14/30 ,  A61K39/0241 ,  A61K2039/55516 ,  A61K2039/55561 ,  A61K2039/55566 ,  C07K2319/00

Abstract: Mycoplasma bovis antigens for use in subunit vaccine compositions to elicit immune responses against M. bovis , polynucleotides encoding therefor, and use of said compositions to prevent Mycoplasma bovis infections.

Abstract translation: 用于亚单位疫苗组合物中的支原体牛抗原用于引发针对牛枝原体的免疫应答，编码该多核苷酸的多核苷酸以及使用所述组合物来预防牛支原体感染。

公开(公告)号：WO2017011919A1

公开(公告)日：2017-01-26

申请号：PCT/CA2016/050864

申请日：2016-07-22

Applicant: UNIVERSITY OF SASKATCHEWAN ,  KENYA AGRICULTURE AND LIVESTOCK RESEARCH ORGANIZATION (KALRO) ,  INTERNATIONAL LIVESTOCK RESEARCH INSTITUTE (ILRI)

Inventor： POTTER, Andrew ,  GERDTS, Volker ,  PEREZ-CASAL, Jose ,  WANG, Yejun ,  WESONGA, Hezron ,  SOI, Reuben ,  NAESSENS, Jan ,  JORES, Joerg

IPC: C12N15/31 ,  A61K39/02 ,  A61K39/385 ,  A61P31/04 ,  A61P37/04 ,  C07K14/30 ,  C07K19/00 ,  C12N15/62 ,  C12N15/63 ,  C12N15/70

CPC classification number: C07K14/30 ,  A61K39/0241 ,  A61K2039/55516 ,  A61K2039/55561 ,  A61K2039/55566 ,  C07K2319/00

Abstract: Immunogenic proteins comprising Mycoplasma mycoides subsp. mycoides and M. mycoides subsp. capri proteins, encoding polynucleotides, a method for producing said proteins, and use of compositions to prevent M. mycoides subsp. mycoides infections are disclosed.

Abstract translation: 免疫原性蛋白质，包括支原体支原体亚种 金丝桃和M.cocoides subsp。 编码多核苷酸的capri蛋白，用于产生所述蛋白质的方法，以及使用组合物来防止M.mycoides subsp。 披露了金丝雀感染。

公开(公告)号：WO2014176680A1

公开(公告)日：2014-11-06

申请号：PCT/CA2014/000392

申请日：2014-04-30

Applicant: UNIVERSITY OF SASKATCHEWAN ,  MARCINIUK, Kristen ,  TASCHUK, Ryan ,  NAPPER, Scott ,  POTTER, Andrew ,  CASHMAN, Neil

Inventor： MARCINIUK, Kristen ,  TASCHUK, Ryan ,  NAPPER, Scott ,  POTTER, Andrew ,  CASHMAN, Neil

IPC: C07K14/47 ,  A61K39/00 ,  A61K39/395 ,  A61P37/04 ,  C07K16/18 ,  C07K19/00 ,  C07K7/06 ,  C12N15/12 ,  C12N15/85 ,  G01N33/53

CPC classification number: C07K7/06 ,  A61K39/0007 ,  A61K2039/55566 ,  A61K2039/6037 ,  C07K14/001 ,  C07K14/285 ,  C07K14/47 ,  C07K16/18 ,  C07K16/44 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/40 ,  C12N2760/20134 ,  G01N33/6854 ,  G01N33/6896 ,  G01N2333/001 ,  G01N2800/24 ,  G01N2800/2828

Abstract: Prion peptides comprising prion epitopes and fusions thereof, that display enhanced immunogenicity are described. Also described are methods of treating and diagnosing prion disease.

Abstract translation: 描述了包含朊病毒表位和其融合物的朊病毒肽，其显示增强的免疫原性。 还描述了治疗和诊断朊病毒疾病的方法。

公开(公告)号：WO2010043039A1

公开(公告)日：2010-04-22

申请号：PCT/CA2009/001463

申请日：2009-10-15

Applicant: UNIVERSITY OF SASKATCHEWAN ,  THE UNIVERSITY OF BRITISH COLUMBIA ,  DALHOUSIE UNIVERSITY ,  INTERNATIONAL VACCINE INSTITUTE ,  VAN DRUNEN LITTEL-VAN DEN HURK, Sylvia ,  GERDTS, Volker ,  POTTER, Andrew ,  BABIUK, Lorne ,  HANCOCK, Robert ,  HALPERIN, Scott ,  . KOVACS-NOLAN, Jennifer ,  MUTWIRI, George ,  LEE, Song ,  KWEON, Mi-Na ,  KINDRACHUK, Jason ,  ELLIOTT, Melissa

Inventor： VAN DRUNEN LITTEL-VAN DEN HURK, Sylvia ,  GERDTS, Volker ,  POTTER, Andrew ,  BABIUK, Lorne ,  HANCOCK, Robert ,  HALPERIN, Scott ,  . KOVACS-NOLAN, Jennifer ,  MUTWIRI, George ,  LEE, Song ,  KWEON, Mi-Na ,  KINDRACHUK, Jason ,  ELLIOTT, Melissa

IPC: C07K7/08 ,  A61K39/10 ,  A61K39/155 ,  A61K39/39 ,  A61P31/04 ,  A61P31/12 ,  A61P37/04

CPC classification number: A61K39/39 ,  A61K39/099 ,  A61K39/12 ,  A61K39/155 ,  A61K45/06 ,  A61K47/30 ,  A61K2039/55516 ,  A61K2039/55561 ,  A61K2039/6093 ,  C07K7/08 ,  C12N2760/18534

Abstract: Methods and compositions for enhancing an immune response to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites. The methods and compositions include host defense peptides, polyphosphazenes and immunostimulatory sequences to enhance the immune response to a coadministered antigen.

Abstract translation: 描述了增强对所选抗原的免疫应答的方法和组合物。 该方法可用于治疗和预防微生物感染，例如由细菌，病毒，真菌和寄生虫引起的感染。 方法和组合物包括宿主防御肽，聚磷腈和免疫刺激序列，以增强对共同施用的抗原的免疫应答。

公开(公告)号：WO2021212215A1

公开(公告)日：2021-10-28

申请号：PCT/CA2021/050527

申请日：2021-04-19

Applicant: UNIVERSITY OF SASKATCHEWAN ,  THE UNIVERSITY OF BRITISH COLUMBIA

Inventor： FACCIUOLO, Antonio ,  GRIEBEL, Philip ,  GERDTS, Volker ,  POTTER, Andrew ,  RAWLYK, Neil ,  CHEN, Jeffrey ,  PASTURAL, Elodie ,  BAINS, Manjeet ,  TRIMBLE, Michael ,  LEE, Amy ,  HANCOCK, Robert

IPC: A61K39/04 ,  A61P31/04 ,  A61P31/06 ,  A61P37/04 ,  G01N33/564

Abstract: Mycobacterial antigens, such as MAP and M. bovis antigens, are described. The antigens can be used in subunit compositions to elicit immune responses in order to prevent and/or control mycobacterial infections, as well as in diagnostics in order to detect mammals infected with mycobacteria.

公开(公告)号：WO2017088060A1

公开(公告)日：2017-06-01

申请号：PCT/CA2016/051381

申请日：2016-11-24

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： GERDTS, Volker ,  ALLAN, Brenda ,  VAN DEN HURK, Jan ,  ZHOU, Yan ,  ZAKHARTCHOUK, Alexander ,  TIKOO, Suresh ,  POTTER, Andrew

IPC: C07K14/165 ,  A61K39/215 ,  A61K39/42 ,  A61P31/14 ,  C07K16/10 ,  C12N7/00 ,  G01N33/564 ,  G01N33/569 ,  G01N33/577

CPC classification number: C07K16/10 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/575 ,  C12N2770/20022 ,  C12N2770/20034 ,  G01N33/56983 ,  G01N2333/17

Abstract: Immunogens, compositions and methods for treating, preventing and/or diagnosing PEDV infection in pigs are disclosed. The compositions and methods use inactivated or attenuated virus-containing vaccines, or subunit vaccines, including immunogens and mixtures of immunogens derived from PEDV isolates.

Abstract translation: 公开了用于治疗，预防和/或诊断猪PEDV感染的免疫原，组合物和方法。 该组合物和方法使用灭活的或减毒的含病毒的疫苗或亚单位疫苗，包括免疫原和衍生自PEDV分离物的免疫原的混合物。

公开(公告)号：WO2009130612A2

公开(公告)日：2009-10-29

申请号：PCT/IB2009/005890

申请日：2009-04-23

Applicant: UNIVERSITY OF SASKATCHEWAN ,  NAPPER, Scott ,  HEDLIN, Peter ,  GRIEBEL, Philip ,  BABIUK, Lorne ,  CASHMAN, Neil ,  CHAKRABARTTY, Avijit ,  POTTER, Andrew

Inventor： NAPPER, Scott ,  HEDLIN, Peter ,  GRIEBEL, Philip ,  BABIUK, Lorne ,  CASHMAN, Neil ,  CHAKRABARTTY, Avijit ,  POTTER, Andrew

IPC: C07K14/47 ,  A61K39/00 ,  A61K39/385 ,  A61K39/395 ,  C07K16/18 ,  C07K17/00 ,  C07K19/00 ,  C07K7/06 ,  C07K7/08 ,  C12N15/12 ,  G01N33/53 ,  G01N33/564

CPC classification number: C07K14/47 ,  A61K39/0007 ,  A61K2039/6037 ,  C07K7/06 ,  C07K7/08 ,  C07K16/2872 ,  C07K2317/34 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2333/705 ,  G01N2800/2828

Abstract: Prion peptides comprising prion epitopes and fusions thereof, that display enhanced immunogenicity are described. Also described are methods of treating and diagnosing prion disease.

Abstract translation: 描述了包含朊病毒表位和其融合物的朊病毒肽，其显示增强的免疫原性。 还描述了治疗和诊断朊病毒疾病的方法。

公开(公告)号：WO2008025171A1

公开(公告)日：2008-03-06

申请号：PCT/CA2007/001555

申请日：2007-08-31

Applicant: THE UNIVERSITY OF BRITISH COLUMBIA ,  UNIVERSITY OF SASKATCHEWAN AS REPRESENTED BY VACCINE AND INFECTIOUS DISEASE ORGANIZATION ,  FINLAY, Brett, B. ,  COOMBES, Brian ,  LI, Yuling ,  POTTER, Andrew

Inventor： FINLAY, Brett, B. ,  COOMBES, Brian ,  LI, Yuling ,  POTTER, Andrew

IPC: A61K39/112 ,  A61P31/04 ,  A61P37/04 ,  C12N1/20 ,  A61K39/39

CPC classification number: C12N1/20 ,  A61K39/0275 ,  Y02A50/482

Abstract: Vaccine compositions comprising isolated Salmonella spp. cell culture supernatant for the prevention and treatment of Salmonella spp. infection are provided. The culture supernatant is produced under Salmonella pathogenicity island 2 (SPI-2) inducing conditions by incubating Salmonella spp. cells in a low phosphate and low magnesium medium (LPM). Methods for reducing colonization and shedding of Salmonella spp. in a subject by administration of the vaccine compositions are also provided.

Abstract translation: 包含分离的沙门氏菌属的疫苗组合物 用于预防和治疗沙门氏菌的细胞培养上清液。 提供感染。 培养上清液通过培养沙门氏菌（Salmonella spp。）在沙门氏菌致病岛2（SPI-2）诱导条件下产生。 细胞处于低磷酸盐和低镁培养基（LPM）。 减少沙门氏菌定居和脱落的方法 还提供了通过施用疫苗组合物的受试者。

公开(公告)号：EP2279203B1

公开(公告)日：2016-06-15

申请号：EP09735414.6

申请日：2009-04-23

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： NAPPER, Scott ,  HEDLIN, Peter ,  GRIEBEL, Philip ,  BABIUK, Lorne ,  CASHMAN, Neil ,  CHAKRABARTTY, Avijit ,  POTTER, Andrew

IPC: C07K14/47 ,  A61K39/00 ,  A61K39/385 ,  A61K39/395 ,  C07K16/18 ,  C07K17/00 ,  C07K19/00 ,  C07K7/06 ,  C07K7/08 ,  C12N15/12 ,  G01N33/53 ,  G01N33/564

CPC classification number: C07K14/47 ,  A61K39/0007 ,  A61K2039/6037 ,  C07K7/06 ,  C07K7/08 ,  C07K16/2872 ,  C07K2317/34 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2333/705 ,  G01N2800/2828

公开(公告)号：EP2344522A1

公开(公告)日：2011-07-20

申请号：EP09820153.6

申请日：2009-10-15

Applicant: The University of Saskatchewan ,  The University of British Columbia ,  Dalhousie University ,  International Vaccine Institute

Inventor： VAN DRUNEN LITTEL-VAN DEN HURK, Sylvia ,  GERDTS, Volker ,  POTTER, Andrew ,  BABIUK, Lorne ,  HANCOCK, Robert ,  HALPERIN, Scott ,  KOVACS-NOLAN, Jennifer ,  MUTWIRI, George ,  LEE, Song ,  KWEON, Mi-Na ,  KINDRACHUK, Jason ,  ELLIOTT, Melissa

IPC: C07K7/08 ,  A61K39/10 ,  A61K39/155 ,  A61K39/39 ,  A61P31/04 ,  A61P31/12 ,  A61P37/04

CPC classification number: A61K39/39 ,  A61K39/099 ,  A61K39/12 ,  A61K39/155 ,  A61K45/06 ,  A61K47/30 ,  A61K2039/55516 ,  A61K2039/55561 ,  A61K2039/6093 ,  C07K7/08 ,  C12N2760/18534

Abstract: Methods and compositions for enhancing an immune response to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites. The methods and compositions include host defense peptides, polyphosphazenes and immunostimulatory sequences to enhance the immune response to a coadministered antigen.