公开(公告)号：US20080052006A1

公开(公告)日：2008-02-28

申请号：US11749073

申请日：2007-05-15

Applicant: Homer Pien ,  William Karl ,  Derek Puff ,  Peter Li ,  Brian Cunningham

Inventor： Homer Pien ,  William Karl ,  Derek Puff ,  Peter Li ,  Brian Cunningham

IPC: G01N21/63

CPC classification number: G01N21/7743 ,  B01L3/5085 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0224 ,  G01J3/1804 ,  G01J3/42 ,  G01N21/253 ,  G01N21/31 ,  G01N33/54373 ,  G01N2021/3196 ,  G01N2021/7773 ,  G02B5/1809 ,  Y10S436/805

Abstract: Performing high-resolution determination of the relative shift of the spectral properties of a biosensor. The shift in the resonance peak of the biosensor is indicative of the amount of material bound to the surface of the biosensor. A preferred biosensor is a Guided Mode Resonant Filter Biosensor (GMRFB). In one aspect of the invention, curve fitting is used to determine the relative location of the spectrum of the unexposed biosensor with respect to those spectra that are altered (e.g., shifted) by the presence of materials bound to the surface of the biosensor. In an alternative embodiment, the cross correlation function is used to detect spectral peak offsets between a reference spectrum and a spectrum measured from an exposed biosensor. In yet another alternative, maximal likelihood estimation techniques are used to determine the spectral shift or offs.

Abstract translation: 对生物传感器的光谱特性进行相对偏移的高分辨率测定。 生物传感器的共振峰的偏移指示与生物传感器的表面结合的材料的量。 优选的生物传感器是引导模式谐振滤波器生物传感器（GMRFB）。 在本发明的一个方面，使用曲线拟合来确定未暴露的生物传感器的光谱相对于通过存在与生物传感器的表面结合的材料而被改变（例如，偏移）的那些光谱的相对位置。 在替代实施例中，互相关函数用于检测参考光谱和从暴露的生物传感器测量的光谱之间的光谱峰值偏移。 在另一替代方案中，使用最大似然估计技术来确定频谱偏移或偏移。

公开(公告)号：US20070195318A1

公开(公告)日：2007-08-23

申请号：US11703643

申请日：2007-02-08

Applicant: Toshikazu Yamamoto

Inventor： Toshikazu Yamamoto

IPC: G01J3/00 ,  G01D18/00

CPC classification number: G01J3/1804 ,  G01J3/02 ,  G01J3/0297 ,  G01J3/08 ,  G01J3/10 ,  G01J3/28 ,  G01J2003/2873 ,  G01N21/274

Abstract: In a wavelength calibration method, an observed spectrum of a light that has a wavelength band is obtained, wherein the light has at least an attenuated wavelength component that corresponds to at least a predetermined absorption wavelength that is included in the wavelength band. A corrected spectrum is then obtained from the observed spectrum, wherein the corrected spectrum has reduced dependencies upon the full width at half maximum of an emission band of the light and upon an intensity ripple period of the light.

Abstract translation: 在波长校准方法中，获得具有波长带的光的观察光谱，其中光至少具有对应于包括在波长带中的至少预定吸收波长的衰减波长分量。 然后从观察到的光谱获得校正的光谱，其中校正光谱对光的发射带的半峰全宽和光强度波动周期的依赖性降低。

公开(公告)号：US20070177145A1

公开(公告)日：2007-08-02

申请号：US11698047

申请日：2007-01-26

Applicant: Kazushi Ohishi ,  Hiroshi Ohta ,  Yoshinobu Sugihara

Inventor： Kazushi Ohishi ,  Hiroshi Ohta ,  Yoshinobu Sugihara

IPC: G01J3/28

CPC classification number: G01J3/1804 ,  G01J3/02 ,  G01J3/021 ,  G01J2001/4242

Abstract: An optical spectrum analyzer has a deflection section for changing an incidence angle of measured light on a diffraction grating, a plurality of light detection sections for detecting the dispersed measured light and outputting an electric signal responsive to the light strength, and a signal processing section for finding an optical spectrum of the measured light based on the electric signal from the light detection sections. The light detection sections are arranged along the wavelength dispersion direction of the diffraction grating and output electric signals independently of each other.

Abstract translation: 光谱分析仪具有用于改变衍射光栅上的测量光的入射角的偏转部分，用于检测分散的测量光并响应于光强度输出电信号的多个光检测部分，以及用于 基于来自光检测部的电信号，求出测定光的光谱。 光检测部沿着衍射光栅的波长色散方向排列并且彼此独立地输出电信号。

公开(公告)号：US07170600B2

公开(公告)日：2007-01-30

申请号：US10528521

申请日：2003-09-22

Applicant: Junji Nishii ,  Tatsuhiro Nakazawa ,  Shigeo Kittaka ,  Keiji Tsunetomo ,  Kazuaki Oya

Inventor： Junji Nishii ,  Tatsuhiro Nakazawa ,  Shigeo Kittaka ,  Keiji Tsunetomo ,  Kazuaki Oya

IPC: G01J3/18 ,  G02B6/34

CPC classification number: G01J3/1804 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/18 ,  G01J3/24 ,  G02B5/1866 ,  G02B6/29311

Abstract: A spectrometer using a diffraction grating includes a light-incident portion including an incident-side optical waveguide emitting a light beam that includes a plurality of wavelength components and that approximates a Gaussian beam, and a collimating lens that is arranged on an emission side of the incident-side optical waveguide and that converts the light beam approximating a Gaussian beam that is emitted from the incident-side optical waveguide into a substantially collimated light beam; a diffraction grating having grooves on its surface, on which the light beam that has been converted into the substantially collimated light beam by the collimating lens is incident, the diffraction grating spectrally separating the light beam by emitting light beams whose emission direction depends on their wavelength; and a light-emitting portion having a plurality of focusing lenses that respectively condense the light beams that have been spectrally separated by the diffraction grating.

Abstract translation: 使用衍射光栅的光谱仪包括光入射部分，其包括发射包括多个波长分量并且近似高斯光束的光束的入射侧光波导，以及配置在该发射侧的发射侧的准直透镜 并且将从入射侧光波导发射的高斯光束近似的光束转换成基本上准直的光束; 衍射光栅在其表面上具有凹槽，其上已经被准直透镜转换成基本上准直的光束的光束入射，衍射光栅通过发射发射方向取决于其波长的光束而光谱地分离光束 ; 以及具有多个聚焦透镜的发光部分，其分别冷凝由衍射光栅分光的光束。

公开(公告)号：US20060285109A1

公开(公告)日：2006-12-21

申请号：US11156424

申请日：2005-06-20

Applicant: Jefferson Odhner

Inventor： Jefferson Odhner

IPC: G01J3/28

CPC classification number: G01J3/1804 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/06

Abstract: The present invention is directed to method and apparatus for measuring the spectral characteristics of an object from a formed object generated input signal. The method comprises the steps of directing the input signal onto a diffraction grating. Diffracted signals are directed to a resonant mirror assembly for sequentially focusing a select diffracted signal. From that focused select diffracted signal, a spectral characteristic of said object is determined. Each said spectral characteristic is associated with each corresponding focused select diffracted signal and the associated signals are published. The apparatus is an improved spectrometer comprising a fiber cable assembly for receiving an object generated input signal and a diffraction grating. A resonant mirror assembly sequentially focuses a select diffracted signal, a sensor sensing which diffracted signal has been focused from the diffraction grating. An analyzer coupled with the sensor determines a spectral characteristic of the object from said select diffracted signal.

Abstract translation: 本发明涉及从形成对象生成的输入信号测量物体的光谱特性的方法和装置。 该方法包括将输入信号引导到衍射光栅上的步骤。 衍射信号被引导到谐振反射镜组件，用于顺序聚焦选择衍射信号。 从该聚焦选择衍射信号，确定所述对象的光谱特性。 每个所述光谱特性与每个对应的聚焦选择衍射信号相关联，并且相关联的信号被公布。 该装置是一种改进的光谱仪，包括用于接收物体产生的输入信号的光缆组件和衍射光栅。 共振反射镜组件顺序聚焦选择衍射信号，感测从衍射光栅聚焦衍射信号的传感器。 与传感器耦合的分析器根据所述选择衍射信号确定物体的光谱特性。

公开(公告)号：US20060238764A1

公开(公告)日：2006-10-26

申请号：US11302993

申请日：2005-12-13

Applicant: Dean Hafeman ,  Calvin Chow

Inventor： Dean Hafeman ,  Calvin Chow

IPC: G01N21/00 ,  G01J3/427

CPC classification number: G01J3/08 ,  G01J3/1804 ,  G01N21/253 ,  G01N21/31 ,  G01N21/314 ,  G01N21/6452

Abstract: Disclosed are photometric methods and devices for determining optical pathlength of liquid samples containing analytes dissolved or suspended in a solvent. The methods and devices rely on determining a relationship between the light absorption properties of the solvent and the optical pathlength of liquid samples containing the solvent. This relationship is used to establish the optical pathlength for samples containing an unknown concentration of analyte but having similar solvent composition. Further disclosed are methods and devices for determining the concentration of analyte in such samples where both the optical pathlength and the concentration of analyte are unknown. The methods and devices rely on separately determining, at different wavelengths of light, light absorption by the solvent and light absorption by the analyte. Light absorption by the analyte, together with the optical pathlength so determined, is used to calculate the concentration of the analyte. Devices for carrying out the methods particularly advantageously include vertical-beam photometers containing samples disposed within the wells of multi-assay plates, wherein the photometer is able to monitor light absorption of each sample at multiple wavelengths, including in the visible or UV-visible region of the spectrum, as well as in the near-infrared region of the electromagnetic spectrum. Novel photometer devices are described which automatically determine the concentration of analytes in such multi-assay plates directly without employing a standard curve.

公开(公告)号：US07099086B2

公开(公告)日：2006-08-29

申请号：US10257198

申请日：2000-12-05

Applicant: Mikhail A. Gutin

Inventor： Mikhail A. Gutin

IPC: G02B5/18

CPC classification number: G02B6/2931 ,  G01J3/02 ,  G01J3/0235 ,  G01J3/0256 ,  G01J3/1804 ,  G02B5/1828 ,  G02B6/29313 ,  G02B6/29314 ,  G02B6/2938 ,  G02B6/29395 ,  G02B26/0808

Abstract: An improvement in a wavelength division multiplexer and/or a dense wavelength division multiplexer (WDM/DWDM) is achieved by incorporating an electronically reconfigurable diffraction grating (108). The introduction of the electronically reconfigurable diffraction grating (108), which is typically fabricated using MEMS (microelectromechanical systems) technology, improves the compact design, durability, and dynamic functionality of the WDM/DWDM system.

Abstract translation: 波分多路复用器和/或密集波分复用器（WDM / DWDM）的改进通过并入电子可重构衍射光栅（108）来实现。 通常使用MEMS（微机电系统）技术制造的电子可重构衍射光栅（108）的引入改善了WDM / DWDM系统的紧凑设计，耐用性和动态功能。

公开(公告)号：US07002680B2

公开(公告)日：2006-02-21

申请号：US10641387

申请日：2003-08-13

Applicant: Yasuhisa Kaneko

Inventor： Yasuhisa Kaneko

IPC: G01J11/00 ,  G01J3/30

CPC classification number: H04J14/02 ,  G01J3/1804 ,  G01J2003/1866

Abstract: A method and apparatus for measuring characteristics of a single-wavelength optical signal constituting part of a wavelength division multiplexed (WDM) optical signal is provided. The WDM optical signal is adjustably diffracted to select the single-wavelength optical signal. An optical-to-electrical conversion is performed. An electrical sampling signal representing the selected single-wavelength optical signal is generated by one of (a) optically sampling the selected single-wavelength optical signal to generate an optical sampling signal on which the optical-to-electrical conversion is performed, and (b) electrically sampling an electrical signal generated by performing the optical-to-electrical conversion on the selected single-wavelength optical signal.

Abstract translation: 提供了一种用于测量构成波分复用（WDM）光信号的一部分的单波长光信号的特性的方法和装置。 WDM光信号被可调谐地衍射以选择单波长光信号。 进行光电转换。 代表选择的单波长光信号的电采样信号由以下之一产生：（a）对所选择的单波长光信号进行光学采样以产生执行光电转换的光采样信号，（b ）对所选择的单波长光信号执行光电转换而产生的电信号进行电采样。

公开(公告)号：US20060023212A1

公开(公告)日：2006-02-02

申请号：US10528521

申请日：2003-09-22

Applicant: Junji Nishii ,  Tatsuhiro Nakazawa ,  Shigeo Kittaka ,  Keiji Tsunetomo ,  Kazuaki Oya

Inventor： Junji Nishii ,  Tatsuhiro Nakazawa ,  Shigeo Kittaka ,  Keiji Tsunetomo ,  Kazuaki Oya

IPC: G01J3/28

CPC classification number: G01J3/1804 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/18 ,  G01J3/24 ,  G02B5/1866 ,  G02B6/29311

Abstract: A spectrometer using a diffraction grating includes a light-incident portion including an incident-side optical waveguide emitting a light beam that includes a plurality of wavelength components and that approximates a Gaussian beam, and a collimating lens that is arranged on an emission side of the incident-side optical waveguide and that converts the light beam approximating a Gaussian beam that is emitted from the incident-side optical waveguide into a substantially collimated light beam; a diffraction grating having grooves on its surface, on which the light beam that has been converted into the substantially collimated light beam by the collimating lens is incident, the diffraction grating spectrally separating the light beam by emitting light beams whose emission direction depends on their wavelength; and a light-emitting portion having a plurality of focusing lenses that respectively condense the light beams that have been spectrally separated by the diffraction grating.

Abstract translation: 使用衍射光栅的光谱仪包括光入射部分，其包括发射包括多个波长分量并且近似高斯光束的光束的入射侧光波导，以及布置在所述发射侧的准直透镜 并且将从入射侧光波导发射的高斯光束近似的光束转换成基本上准直的光束; 衍射光栅在其表面上具有凹槽，其上已经被准直透镜转换成基本上准直的光束的光束入射，衍射光栅通过发射发射方向取决于其波长的光束而光谱地分离光束 ; 以及具有多个聚焦透镜的发光部分，其分别冷凝由衍射光栅分光的光束。

公开(公告)号：US06839136B2

公开(公告)日：2005-01-04

申请号：US10011236

申请日：2001-10-19

Applicant: Thomas L. Mikes

Inventor： Thomas L. Mikes

IPC: G01J3/02 ,  G01J3/18 ,  G01J3/28 ,  G02B6/34

CPC classification number: G01J3/1838 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/1804 ,  G01J3/28 ,  G01J2003/2866 ,  G02B6/2931 ,  G02B6/29314 ,  G02B6/29395 ,  G02B6/29398

Abstract: A spectrum analyzer providing an integrated calibration function and for providing that calibration function automatically. The injection of light to be analyzed through a central aperture of a scanning grating onto a focusing reflector provides in combination four traversals of the space therebetween. The spectrometer thus is used to separate wavelength information spacially and receive it back at the same or adjacent aperture(s) to be analyzed by a processing system to establish the spectra for the incident light. The light is typically injected from and received back into optical fibers or other light carrying elements. Calibration light is also applied through the same or adjacent apertures in the grating from a known source and spectra such as Argon to use as a calibration reference by detecting the known spectra peaks and correlating it to grating scan angle. The same structure is also used as a telecommunications channel router by injecting light of multi-channel and thus broadband spectral content into the spectrometer through the central aperture(s) and angling the grating so that a selected channel or channels are reflected back after four passages of the spectral separator to output one or more optical fibers or other guides.

Abstract translation: 频谱分析仪提供集成校准功能，并自动提供校准功能。 通过扫描光栅的中心孔将待分析的光注入到聚焦反射器上，四者之间的空间组合四次。 因此，光谱仪用于空间分离波长信息并在相同或相邻孔径处接收，以便由处理系统分析以建立入射光的光谱。 光通常从光纤或其他轻载元件注入并接收回。 校准光也通过来自已知源和光谱（例如氩）的光栅中的相同或相邻孔径施加，以通过检测已知光谱峰值并将其与光栅扫描角度相关联来用作校准参考。 同样的结构也被用作通信信道路由器，它通过中心孔和多个通道将光通道注入光谱仪，从而使光纤通过四通道反射回所选择的通道 的光谱分离器以输出一个或多个光纤或其它引导件。