公开(公告)号：US20060030036A1

公开(公告)日：2006-02-09

申请号：US11136841

申请日：2005-05-24

Applicant: Victor Joseph ,  Amjad Huda ,  Alnoor Shivji ,  Jie Zhou

Inventor： Victor Joseph ,  Amjad Huda ,  Alnoor Shivji ,  Jie Zhou

IPC: C12M1/34

CPC classification number: C12Q1/686 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/52 ,  B01L7/54 ,  B01L2200/0689 ,  B01L2300/044 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/1827 ,  B82Y30/00 ,  C12Q1/6806 ,  C12Q1/6844 ,  G01N21/01 ,  G01N21/0332 ,  G01N21/6408 ,  G01N21/6452 ,  G01N21/76 ,  G01N35/0099 ,  G01N2021/6417 ,  G01N2021/6484 ,  G01N2035/0405 ,  G01N2201/0231 ,  H01L27/1443 ,  H01L31/0203 ,  H01L31/02325 ,  H01L31/024 ,  H01L31/105 ,  H01L31/18 ,  C12Q2565/501

Abstract: The present invention provides miniaturized instruments for conducting chemical reactions where control of the reaction temperature is desired or required. Specifically, this invention provides chips and optical systems for performing and monitoring temperature-dependent chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost amplification of nucleic acids.

Abstract translation: 本发明提供了在需要或需要反应温度的控制下进行化学反应的小型化仪器。 具体地，本发明提供用于执行和监测温度依赖性化学反应的芯片和光学系统。 本发明中体现的装置和方法对于核酸的高通量和低成本扩增特别有用。

公开(公告)号：US6151111A

公开(公告)日：2000-11-21

申请号：US929552

申请日：1997-09-15

Applicant: Mark Wechsler ,  Howard H. Barney ,  Roger A. Kaye ,  David G. Ogle ,  Michael M. Lacy ,  Calvin Y. Chow ,  Kimberly L. Crawford ,  Dean G. Hafeman

Inventor： Mark Wechsler ,  Howard H. Barney ,  Roger A. Kaye ,  David G. Ogle ,  Michael M. Lacy ,  Calvin Y. Chow ,  Kimberly L. Crawford ,  Dean G. Hafeman

IPC: G01N21/33 ,  G01N21/25 ,  G01N21/31 ,  G01N21/59 ,  G01N35/02 ,  G01J3/30

CPC classification number: G01N21/33 ,  G01N21/253 ,  G01N21/31 ,  G01N2201/0231 ,  G01N2201/0446 ,  G01N2201/1222 ,  G01N2201/127 ,  G01N35/028

Abstract: The present invention relates to a photometric device for measuring optical parameters. The invention functions in the ultraviolet light range through use of a monochromator and splits the test light in multiple channels by a rotor assembly, including a mirror.

公开(公告)号：US5223218A

公开(公告)日：1993-06-29

申请号：US179645

申请日：1988-04-08

Applicant: Masayoshi Fukuoka ,  Akira Matsuyuki

Inventor： Masayoshi Fukuoka ,  Akira Matsuyuki

IPC: G01N21/03 ,  G01N21/76

CPC classification number: G01N21/76 ,  G01N2021/0375 ,  G01N2201/0231 ,  G01N2201/0253 ,  G01N2201/0648

Abstract: An instrument for quantitative analysis includes two shutters, one of which prevents light from being introduced into a black box housing a cell holder from the outside through a port in which a cell may be placed in and taken out the black box, and the other of which prevents light from impinging on a photomultiplier tube which is in communication with the black box. The shutters are controlled by a control unit so that one of the shutters opens when the other closes. The instrument also includes detectors which detect whether or not the cell holder and the cell are disposed at predetermined positions, respectively. The detectors output signals to the control unit. The control unit controls an automatic pipetting device to restrict a sample from being introduced into the cell when both the cell holder and the cell are not disposed at the predetermined position.

公开(公告)号：US5157678A

公开(公告)日：1992-10-20

申请号：US725785

申请日：1991-07-03

Applicant: Peter Borden

Inventor： Peter Borden

IPC: G01N15/02 ,  G01N21/53

CPC classification number: G01N21/53 ,  G01N15/0205 ,  G01N2201/0231

Abstract: A housing for a laser based particle monitor comprising a pair of pipes for directing particle flow through a chamber. In one embodiment, elbows are disposed on the piping such that the interior of the chamber cannot be viewed from a point outside the housing.

Abstract translation: 一种用于激光粒子监测器的壳体，包括用于引导颗粒流过腔室的一对管道。 在一个实施例中，弯管被布置在管道上，使得不能从壳体外部的点观察室的内部。

公开(公告)号：US4898462A

公开(公告)日：1990-02-06

申请号：US160302

申请日：1988-02-25

Applicant: Koji Numata ,  Fumio Asakura ,  Yoshiyuki Kago ,  Masaei Nozawa ,  Takahiro Shibakawa ,  Hajime Akado ,  Hideharu Kato

Inventor： Koji Numata ,  Fumio Asakura ,  Yoshiyuki Kago ,  Masaei Nozawa ,  Takahiro Shibakawa ,  Hajime Akado ,  Hideharu Kato

IPC: G01J1/44 ,  G01N21/27 ,  G01N21/85 ,  G01N33/28

CPC classification number: G01N21/27 ,  G01N33/2829 ,  G01N33/2888 ,  G01N21/85 ,  G01N2201/0231 ,  G01N2201/0621 ,  G01N2201/1212

Abstract: A device for detecting a transmissivity of a substance utilizing a transmitted light value, which comprises a light emitting element and a photo detecting element. The light emitting element and the photo detecting element are spaced from each other at a predetermined distance so that a transmitted light value of a substance passing through the space is detected as an amount of light transmitted therethrough. The photo detecting element further comprises a photo oscillator circuit including the photo detecting element as one component thereof and outputs a signal having characteristics selected from a cycle and a frequency corresponding to the transmitted light value, and when the condition of a substance exceeds a predetermined reference level, such information is displayed at a display unit. Further, the device carries out a detecting and discriminating operation when a temperature of a substance is at a level lower than a maximum temperature at which each component of the detecting circuit will not work effectively.The device is also provided with a detecting unit in which the light emitting element and the photo detecting element are kept firmly in contact with each other, with a spacer placed therebetween, by an external force caused by a spring, to make the space provided therebetween constant regardless of any deformation of any component of the device caused by heat or aging.

Abstract translation: 一种用于检测利用透射光值的物质的透射率的装置，其包括发光元件和光检测元件。 发光元件和光电检测元件以预定距离彼此间隔开，以便检测通过该空间的物质的透射光值作为透射的光量。 该光检测元件还包括一个光电振荡器电路，它包括作为其一个分量的光电检测元件，并且输出具有从与透射光值相对应的周期和频率中选择的特性的信号，并且当物质的条件超过预定参考值 这样的信息显示在显示单元上。 此外，当物质的温度处于低于检测电路的每个部件不能有效工作的最高温度的水平时，该装置进行检测和识别操作。 该装置还设置有检测单元，其中发光元件和光检测元件通过由弹簧引起的外力保持牢固地彼此接触，并且间隔件被放置在其间，以使得设置在其间的空间 恒定，不管由热或老化引起的器件的任何部件的任何变形。

公开(公告)号：US4888484A

公开(公告)日：1989-12-19

申请号：US139964

申请日：1987-12-31

Applicant: Robert J. Harvey

Inventor： Robert J. Harvey

IPC: G01J3/42 ,  G01J3/45 ,  G01N21/03 ,  G01N21/05 ,  G01N21/35 ,  G01N21/85 ,  G01N30/74

CPC classification number: G01N21/05 ,  G01N21/3577 ,  G01N21/85 ,  G01N2021/1751 ,  G01N2021/3595 ,  G01N21/0332 ,  G01N21/35 ,  G01N2201/0231 ,  G01N2201/1224

Abstract: An apparatus and method for spectrophotometric analysis of material in a moving process stream wherein the material is directed into an observation chamber within a sample cell and exposed to a radiation beam suitable for spectrophotometric purposes. A radiation source and a radiation detector are contained within a first compartment and a second compartment environmentally isolated from the first compartment and within which the sample cell is contained. Reflectors are positioned within the second compartment for receiving the radiation beam from the first compartment, directing the radiation beam through the sample cell and the material to be analyzed contained therein, and directing the radiation beam back into the second compartment and the radiation detector positioned therein. The second compartment maintains the environment therein within a range acceptable for radiation analysis of the material within the sample cell. Mirrors are positioned within the second compartment for diverting the radiation beam from passage through the material and for determining a reference spectrum within the same environment as the sample cell and directing the diverted beam to the radiation detector.

Abstract translation: 用于对移动工艺流中的材料进行分光光度分析的装置和方法，其中材料被引入样品池内的观察室并暴露于适于分光光度目的的辐射束。 辐射源和放射线检测器包含在第一隔室中，并且第二隔室与第一隔室环境隔离并且其中容纳有样品池。 反射器定位在第二隔室内，用于接收来自第一隔室的辐射束，将辐射束引导通过样品池和待分析的材料容纳在其中，并且将辐射束引导回第二隔室和放置在其中的辐射探测器 。 第二隔室将其中的环境保持在对样品池内的材料的辐射分析可接受的范围内。 反射镜位于第二隔室内，用于将辐射束从通过材料转移，并用于确定与样品池相同的环境内的参考光谱，并将转向的光束引导到辐射探测器。

公开(公告)号：US4643580A

公开(公告)日：1987-02-17

申请号：US678779

申请日：1984-12-06

Applicant: Jurgen Gross ,  Reinhard Dinges

Inventor： Jurgen Gross ,  Reinhard Dinges

IPC: G01N21/59 ,  G01N21/01 ,  G01N21/25 ,  G01N21/51 ,  G01N21/85 ,  G01N21/03

CPC classification number: G01N21/255 ,  G01N21/0303 ,  G01N2021/035 ,  G01N2021/8564 ,  G01N21/51 ,  G01N2201/0231 ,  G01N2201/08

Abstract: A photometer head having a housing for receiving and supporting small test volumes. The housing includes a recess and a plate for substantially covering the recess. A light transmitter and a light receiver having first and second end surfaces are mounted within the housing and project into the recess at locations substantially opposite one another to define a gap between the first and second end surfaces for retaining the small test volumes. A liquid applicator extends through an aperture in the housing to dispense droplets of liquid test volumes into the gap. The light transmitter directs optical energy at the droplets and the light receiver receives the transmitted energy.

Abstract translation: 光度计头部具有用于接收和支撑小测试体积的壳体。 壳体包括用于基本上覆盖凹部的凹部和板。 具有第一和第二端表面的光发射器和光接收器安装在壳体内并且在基本上彼此相对的位置处突出到凹部中，以限定第一和第二端面之间的间隙，用于保持小的测试体积。 液体涂抹器延伸穿过壳体中的孔，以将液体测试体积的液滴分配到间隙中。 光发射器在液滴处引导光能，并且光接收器接收透射的能量。

公开(公告)号：US4632563A

公开(公告)日：1986-12-30

申请号：US619818

申请日：1984-06-12

Applicant: Harry C. Lord, III

Inventor： Harry C. Lord, III

IPC: G01N21/03 ,  G01N21/35

CPC classification number: G01N21/3518 ,  G01N21/031 ,  G01N2201/0231

Abstract: A gas analyzer which utilizes an infrared beam which passes through or has emanated from a gas stream. The analyzer has a plurality of gas cells which contain gas of the type whose concentration is being measured in various concentrations and at various total pressures. A beam of energy is forwarded to the analyzer, and is passed selectively to the various cells. In one embodiment, the cells are mounted where a rotatable deflector can selectively deflect and receive the beam to and from two fixed beam segments so that sequential readings at an infrared detector can provide measurements of concentrations, and calibration. In another embodiment, the cells are selectively moved into the beam path. The beam is formed and forwarded by a Cassegrainean system or by a combination of reflectors including a retro-reflector. An infrared calibration beam which does not pass through the gas stream is utilized for calibration.

Abstract translation: 一种气体分析仪，其利用通过或已经从气流中发出的红外光束。 分析仪具有多个气体单元，其包含其浓度以各种浓度和各种总压力测量的类型的气体。 能量束被转发到分析器，并且被选择性地传送到各种单元。 在一个实施例中，电池被安装在可旋转偏转器可以选择性地偏转和接收来自两个固定光束段的光束的位置，使得红外检测器处的​​顺序读数可以提供浓度和校准的测量。 在另一个实施例中，单元被选择性地移动到光束路径中。 光束由Cassegrainean系统或包括反射器的反射器的组合形成和转发。 不通过气流的红外校准光束用于校准。

公开(公告)号：US3941487A

公开(公告)日：1976-03-02

申请号：US516008

申请日：1974-10-18

Applicant: Robert J. Ehret ,  Donald E. Stephens ,  Douglas H. Durland ,  Thomas D. Sharples

Inventor： Robert J. Ehret ,  Donald E. Stephens ,  Douglas H. Durland ,  Thomas D. Sharples

IPC: G01J3/12 ,  G01N21/03 ,  G01N21/31 ,  G01J3/46 ,  G01N1/10 ,  G01N21/28

CPC classification number: G01N21/314 ,  G01J2003/1213 ,  G01J2003/1226 ,  G01N2021/3166 ,  G01N21/03 ,  G01N2201/0231 ,  G01N2201/069

Abstract: A light beam is passed through a cuvette, through which flows liquid to be analyzed optically for concentration of color reacted amino acids. The emergent beam is directed through a series of dichroic beam separators and pass band filters to produce three beams of substantially three different wavelengths. Photoelectric detectors produce electrical signals corresponding to each of the three wavelengths. Two of the signals are characteristic of the substance to be detected. The third is subtracted from the other two wavelength signals to produce a pair of output signals from which base line noise has been substantially eliminated.

Abstract translation: 将光束通过比色皿，通过该比色液体流动待分析的液体以浓缩着色反应的氨基酸。 出射光束被引导通过一系列二向色光束分离器和通带滤光器以产生三个基本上三个不同波长的光束。 光电探测器产生对应于三个波长中的每一个的电信号。 两个信号是待检测物质的特征。 从其他两个波长信号中减去第三个，以产生基本上消除了基线噪声的一对输出信号。

公开(公告)号：EP3126052A1

公开(公告)日：2017-02-08

申请号：EP15718257.7

申请日：2015-04-07

Applicant: IT-IS International Ltd

Inventor： HOWELL, James Richard ,  WEBSTER, Benjamin Masterman

IPC: B01L7/00 ,  G01N21/25

CPC classification number: B01L7/52 ,  B01L9/06 ,  B01L2300/02 ,  B01L2300/041 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0681 ,  B01L2300/0832 ,  B01L2300/087 ,  B01L2300/123 ,  B01L2300/1805 ,  B01L2300/1822 ,  B01L2300/1827 ,  G01N21/0332 ,  G01N21/272 ,  G01N2201/0231 ,  G01N2201/0846

Abstract: A chemical and/or biochemical apparatus (10) for receiving a plurality of reaction vessels in which chemical and/or biochemical reactions may take place includes a thermal mount (14) having a plurality of wells (26) for receiving the reaction vessels (12), a thermal module (16) having a first side thermally coupled to the thermal mount (14), a first heat sink (18) thermally coupled to a second side of the thermal module, the heat sink (18) having a body and a plurality of thermally conductive fins (32) extending outwards from the body of the first heat sink (18), and a printed circuit board (54) having electronic components for controlling at least the thermal module (16), an excitation light source (62), and a light sensor (52). A first set of light waveguides (60) is provided for delivering excitation light to a reaction vessel, and a second set of light waveguides (38) is provided for receiving light from a reaction vessel and for delivering the light to the light sensor (52). The first heat sink (18) comprises an interior space (5) and the printed circuit board (54), the excitation light source (62), the light sensor (52) and the light waveguides (38, 60) are arranged within the interior space (5).

Abstract translation: 用于接收可能发生化学和/或生物化学反应的多个反应容器的化学和/或生物化学装置（10）包括具有多个用于接收反应容器（12）的多个孔（26）的热装置（14） ），具有热耦合到所述热座（14）的第一侧的热模块（16），热耦合到所述热模块的第二侧的第一散热器（18），所述散热器（18）具有主体和 从第一散热器（18）的主体向外延伸的多个导热翅片（32）以及具有用于至少控制热模块（16）的电子部件的印刷电路板（54），激发光源 62）和光传感器（52）。 提供第一组光波导（60）用于将激发光输送到反应容器，并且第二组光波导（38）被设置用于接收来自反应容器的光并将光传送到光传感器（52 ）。 第一散热器（18）包括内部空间（5）和印刷电路板（54），激发光源（62），光传感器（52）和光波导（38,60）布置在 内部空间（5）。