公开(公告)号：US20180280690A1

公开(公告)日：2018-10-04

申请号：US15525277

申请日：2015-03-31

Applicant: Seoul National University R&DB Foundation ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Dae-Hyeong KIM ,  Taeghwan HYEON ,  Hye Jin HWANG ,  Jinkyung PARK ,  Suji CHOI

IPC: A61N1/05 ,  A61L31/02 ,  A61L31/14 ,  A61L31/04 ,  B29C39/10

Abstract: The present invention relates to a mesh electrode for cardiac resynchronization therapy, and a manufacturing method therefor. More specifically, the present invention relates to: a mesh electrode for cardiac resynchronization therapy, formed from a wire composed of a first biocompatible rubber layer in which silver nanowires are dispersed, and a second biocompatible rubber layer famed so as to be adjacent to the first biocompatible rubber layer; and a manufacturing method therefor.

公开(公告)号：US20180251605A1

公开(公告)日：2018-09-06

申请号：US15760135

申请日：2016-09-12

Applicant: INSTITUTE FOR BASIC SCIENCE ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sukbok CHANG ,  Seewon JOUNG ,  Dongwook KIM ,  Jeung Gon KIM

IPC: C08G77/08

CPC classification number: C08G77/08 ,  C08G77/50 ,  C08G77/52

Abstract: The present invention relates to a silicon polymer production method using a non-transition-metal-catalyst method of hydrosilylation, and more specifically relates to a production method for a silicon polymer using a non-transition-metal-catalyst method of hydrosilylation, wherein an environmentally friendly silicon polymer is produced by using hydrosilylation using a non-transition metal as a catalyst, thereby avoiding the use of platinum, palladium and rhodium or other expensive platinum group catalysts and so achieving outstanding economic viability and making it possible to prevent residues of heavy metals.

公开(公告)号：US20180145342A1

公开(公告)日：2018-05-24

申请号：US15814916

申请日：2017-11-16

Applicant: Seoul National University, R&DB Foundation ,  Institute for Basic Science ,  Kangwon National University, University-Industry Cooperation Foundation

Inventor： Yung-Eun SUNG ,  Yong-Hun CHO ,  Ji Eun PARK ,  Chi-Yeong AHN ,  Sungjun KIM

IPC: H01M8/0234 ,  H01M8/04007 ,  H01M8/2483 ,  H01M8/1018

CPC classification number: H01M8/0234 ,  H01M8/04074 ,  H01M8/1018 ,  H01M8/2483 ,  H01M2008/1095

Abstract: A flow field including graphene foam for a fuel cell. The flow field is made of graphene foam that enhances mass transport and suffers no corrosion under operating conditions of the fuel cell when compared with conventional flow fields. In addition, compressed graphene foam has smaller in-plane pores due to the compression and has more tortuous pathways for flowing reactants, thereby increasing retention time of reactants and accelerating diffusion of reactants into a gas diffusion layer (GDL). Further, large through-plane pores inside the graphene foam transport reactants to entire areas of a catalyst layer, and faster flow velocity compared with the conventional membrane electrode assembly (MEA) is derived from a decreased flow field width due to compression. Therefore, mass transport of reactants and products is enhanced, and performance of the fuel cell is improved at high current density regions.

公开(公告)号：US09851314B2

公开(公告)日：2017-12-26

申请号：US14947538

申请日：2015-11-20

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Hyunwoo Kim ,  Min-Seob Seo

IPC: C07C51/41 ,  G01N24/08 ,  C07C215/50 ,  C07F7/28 ,  C07F5/00 ,  C07F5/06

CPC classification number: G01N24/08 ,  C07B2200/07 ,  C07C215/50 ,  C07C2601/14 ,  C07F5/003 ,  C07F5/069 ,  C07F7/28

Abstract: Provided are novel ligand, a chiral metal complex including the same, and a use of the chiral metal complex for analyzing the chirality of a charged compound by 1H NMR spectroscopy. The chiral metal complex of the present invention may be used as the chiral solvating agent to conveniently analyze the optical purity of charged compounds such as various amine derivatives, carboxylic acid derivatives, cyanohydrin derivatives and charged metal complexes by 1H NMR spectroscopy.

公开(公告)号：US20170314016A1

公开(公告)日：2017-11-02

申请号：US15347871

申请日：2016-11-10

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Jin-Soo KIM ,  So Jung KIM

IPC: C12N15/11 ,  A61K48/00 ,  C12N9/22 ,  C12P19/34 ,  C12N15/10 ,  C12N2310/20

CPC classification number: C12N15/11 ,  A61K48/005 ,  C12N9/22 ,  C12N15/1024 ,  C12N15/111 ,  C12N15/63 ,  C12N2310/20 ,  C12N2310/31 ,  C12N2320/32 ,  C12N2320/53 ,  C12N2330/30 ,  C12P19/34

Abstract: Provided are a composition for ribonucleoprotein delivery, comprising a guide RNA free of 5′-terminal phosphates, and a method for ribonucleoprotein delivery, using the same.

公开(公告)号：US09745329B1

公开(公告)日：2017-08-29

申请号：US14891096

申请日：2015-01-29

Applicant: INSTITUTE FOR BASIC SCIENCE ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sukbok Chang ,  Sehoon Park ,  Narasimhulu Gandhamsetty ,  Seewon Joung ,  Sung-Woo Park

IPC: C07F7/08

CPC classification number: C07F7/0896 ,  B01J31/14 ,  C07F7/0829 ,  C07F7/0836 ,  C07F7/0874

Abstract: Provided is a method of preparing a silylative-reduced N-heterocyclic compound by reducing an N-heteraromatic compound including a sp2 hybridized nitrogen atom while simultaneously introducing a silyl group into a beta-position with respect to a nitrogen atom of the N-heteroaromatic compound, using a silane compound, in the presence of an organoboron catalyst.

公开(公告)号：US20160375000A1

公开(公告)日：2016-12-29

申请号：US14966706

申请日：2015-12-11

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Eun-Joon KIM ,  Su-Yeon CHOI ,  Wook-Suk CHUNG ,  Eun-Ee LEE ,  Ha-Ram PARK

IPC: A61K31/44 ,  A61K31/13

CPC classification number: A61K31/44 ,  A61K31/13 ,  A61K31/439 ,  A61K31/662

Abstract: The present invention relates to a pharmaceutical composition for improving a sociability behavior in a patient having a mental disease with an enhanced NMDAR function.

Abstract translation: 本发明涉及用于改善具有增强的NMDAR功能的精神疾病患者的社交行为的药物组合物。

公开(公告)号：US09514549B2

公开(公告)日：2016-12-06

申请号：US14748935

申请日：2015-06-24

Applicant: Institute for Basic Science

Inventor： Sung Whan Kim ,  Ki Wan Jeon ,  Chi Young Ahn

IPC: G06K9/00 ,  G06T11/00 ,  A61B6/03 ,  A61B6/00 ,  G06T7/00 ,  G06T5/00

CPC classification number: G06T11/003 ,  A61B6/032 ,  A61B6/5205 ,  A61B6/5258 ,  A61B6/5264 ,  G06T5/001 ,  G06T7/0012 ,  G06T11/005 ,  G06T2207/10081 ,  G06T2207/30004 ,  G06T2210/41 ,  G06T2211/421

Abstract: A method for reducing metal artifacts in computed tomography (CT) is disclosed. The method for reducing metal artifacts in CT includes: obtaining a sinogram reduced in size from an original sinogram; setting up a linear algebraic equation according to remaining data excluding data damaged by a metal based on the obtained sinogram; restoring a low-resolution image based on the set up linear algebraic equation; calculating a sinogram from the restored low-resolution image; restoring a sinogram by disposing the calculated sinogram data in the original sinogram and by utilizing the calculated sinogram data as pre-information; and restoring a final CT image from the restored sinogram. Through introduction of a novel metal artifact reduction (MAR) technique referred to as an algebraic correction technique (ACT) using an intermediate image of an attenuation coefficient of an outside of a metal area, an image closest to an original image can be obtained by minimizing metal artifacts in CT.

Abstract translation: 公开了一种在计算机断层摄影（CT）中减少金属伪影的方法。 降低CT中金属伪影的方法包括：从原始正弦图获得尺寸减小的正弦图; 根据剩余的数据建立线性代数方程，不包括基于获得的正弦图的金属损坏的数据; 基于建立的线性代数方程恢复低分辨率图像; 从恢复的低分辨率图像中计算正弦图; 通过将计算的正弦图数据放置在原始正弦图中并通过利用计算的正弦图数据作为预信息来恢复正弦图; 并从恢复的正弦图恢复最终CT图像。 通过引入使用金属区域的外部的衰减系数的中间图像被称为代数校正技术（ACT）的新颖的金属伪影减少（MAR）技术，可以通过最小化最小化原始图像的图像来获得最接近原始图像的图像 CT中的金属文物。

公开(公告)号：US09354187B2

公开(公告)日：2016-05-31

申请号：US14538150

申请日：2014-11-11

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Ki Wan Jeon ,  Chi Young Ahn ,  Sung Whan Kim

IPC: G06K9/00 ,  G01N23/04 ,  G06T11/00

CPC classification number: G01N23/046 ,  G06T11/003 ,  G06T11/005 ,  G06T2211/408

Abstract: An apparatus and method for computed tomography image processing is provided. The apparatus includes: an X-ray detection unit that detects an X-ray beam having passed through a subject and outputs an energy value thereof; a line integral calculation unit that calculates line integral values of attenuation coefficients representing attenuation of the energy value of the X-ray beam having passed through the subject and been detected, based on the energy value; an image processing unit that reconstructs a tomogram based on the line integral values; and an image output unit that outputs the tomogram. The apparatus and method for computed tomography image processing can calculate line integral values of attenuation coefficients constituting an integrand of an X-ray projection function using the mean value theorem for integrals in order to restore an image of a subject from an X-ray beam detected in computed tomography image processing.

Abstract translation: 提供了一种用于计算机断层摄影图像处理的装置和方法。 该装置包括：X射线检测单元，其检测通过被检体的X射线束，并输出其能量值; 线积分计算单元，其基于能量值计算表示已经通过被检体并被检测的X射线束的能量值的衰减的衰减系数的线积分值; 图像处理单元，其基于线积分值重建断层图像; 以及输出断层图像的图像输出单元。 计算机断层图像处理的装置和方法可以使用积分的平均值定理来计算构成X射线投影函数的被积函数的衰减系数的线积分值，以便从检测到的X射线束恢复被摄体的图像 在计算机断层摄影图像处理中。

公开(公告)号：US20150366531A1

公开(公告)日：2015-12-24

申请号：US14741178

申请日：2015-06-16

Applicant: Institute for Basic Science

Inventor： Chi Young Ahn ,  Ki Wan Jeon ,  Jung II Choi

IPC: A61B8/06 ,  A61B8/08 ,  A61B8/14

CPC classification number: A61B8/06 ,  A61B8/0883 ,  A61B8/0891 ,  A61B8/14 ,  A61B8/488 ,  A61B8/5207 ,  A61B8/5223 ,  A61B8/5246

Abstract: Disclosed is an ultrasonic diagnostic apparatus. The ultrasonic diagnostic apparatus includes: an ultrasonic sensor transmitting ultrasonic waves and sensing echo signals thereof; a signal processor processing the signals sensed by the ultrasonic sensor; a B-mode image generation unit generating a brightness mode (B-mode) image in a 2D plane based on the signal processing results by the signal processor and extracting left ventricle boundary data from the generated B-mode image; a C-mode image generation unit generating Doppler data for generation of a C-mode image based on the signal processing results by the signal processor; and a blood flow velocity vector calculation unit calculating a blood flow velocity vector in a 2D image plane based on a simultaneous equation composed of a relation equation between the extracted left ventricle boundary data, the Doppler data and the blood flow velocity vector, and a 2D Navier-Stokes equation obtained from image data generated through signal processing by the signal processor, wherein the Navier-Stokes equation further uses, as a variable, a mass source term representing distribution of source and sink of mass with respect to the 2D image plane.

Abstract translation: 公开了一种超声波诊断装置。 超声波诊断装置包括：超声波传感器，其发送超声波并感测其回波信号; 信号处理器处理由超声波传感器感测的信号; B模式图像生成单元，基于信号处理器的信号处理结果生成2D平面中的亮度模式（B模式）图像，并从所生成的B模式图像中提取左心室边界数据; C模式图像生成单元，基于信号处理器的信号处理结果生成用于生成C模式图像的多普勒数据; 以及血流速度矢量计算单元，其基于由提取的左心室边界数据，多普勒数据和血流速度矢量之间的关系式组成的联立方程，2D图像平面中的血流速度矢量和2D 从通过信号处理器的信号处理产生的图像数据获得的Navier-Stokes方程，其中Navier-Stokes方程进一步使用表示相对于2D图像平面的质量的源和沉的分布的质量源项作为变量。