公开(公告)号：WO2013036775A1

公开(公告)日：2013-03-14

申请号：PCT/US2012/054176

申请日：2012-09-07

Applicant: AXXIA PHARMACEUTICALS, LLC ,  HOLL, Richard, J. ,  HARTMAN, Katherine ,  GROSSMAN, Stuart, A. ,  POLLOCK, Wayne, C.

Inventor： HOLL, Richard, J. ,  HARTMAN, Katherine ,  GROSSMAN, Stuart, A. ,  POLLOCK, Wayne, C.

IPC: A61K9/00 ,  A61K31/485 ,  A61K47/34

CPC classification number: A61K9/0002 ,  A61K9/0024 ,  A61K31/485 ,  A61K47/34

Abstract: Implants for delivery of therapeutic agents such as opioids, and the manufacture and uses of such implants are provided. In particular, subcutaneous drug delivery systems having a biocompatible thermoplastic elastomeric polymer matrix, a therapeutic agent embedded homogeneously in said matrix, and a biocompatible drug impermeable cross-linked silicone polymer coating said matrix and methods of making the same are provided.

Abstract translation: 提供用于递送治疗剂如阿片样物质的植入物，以及这种植入物的制造和用途。 特别地，提供了具有生物相容性热塑性弹性体聚合物基质，均匀地嵌入所述基质中的治疗剂和涂覆所述基质的生物相容性药物不可渗透交联的硅氧烷聚合物的皮下药物递送系统及其制备方法。

公开(公告)号：WO2013010189A3

公开(公告)日：2013-01-17

申请号：PCT/US2012/046979

申请日：2012-07-16

Applicant: SIRIUS XM RADIO INC. ,  COX, Stuart, A. ,  MARKO, Paul ,  WADIN, Craig

Inventor： COX, Stuart, A. ,  MARKO, Paul ,  WADIN, Craig

IPC: H04N21/2381 ,  H04N21/233 ,  H04N21/60

Abstract: Systems and methods are presented to facilitate caching of programming from broadcast and/or content streaming services to a user device for local playback. In addition, metadata can be provided to guide the user in selecting, caching, or playing the cachable content. In some exemplary embodiments, a receiver or other user device can automatically select the programming to be cached based on a user's historical topic interest and listening history. In some exemplary embodiments, the metadata can also include DRM information that can limit the ability of a user to playback the content, so as to comply, if necessary, with operative legal requirements related to usage of the content.

公开(公告)号：WO2012166523A1

公开(公告)日：2012-12-06

申请号：PCT/US2012/039366

申请日：2012-05-24

Applicant: JOULE UNLIMITED TECHNOLOGIES, INC. ,  TUTTMAN, Max, B. ,  JACOBSON, Stuart, A. ,  PONZEL, Rainer ,  LONGAN, John, E.

Inventor： TUTTMAN, Max, B. ,  JACOBSON, Stuart, A. ,  PONZEL, Rainer ,  LONGAN, John, E.

IPC: C12M1/00

CPC classification number: C12M21/02 ,  C12M23/14 ,  C12M23/22 ,  C12M23/44 ,  C12M23/48 ,  C12M27/00 ,  C12M31/00

Abstract: The present invention provides a bioreactor having a reactor chamber and one or more support chambers. The reactor chamber can have one or more flexible walls for enclosing microorganisms and culture medium. The reactor chamber provides an enclosure for microorganism and culture medium. The support chamber can also have one or more flexible walls. When inflated to a predetermined amount, the support chamber causes the microorganisms and culture medium to distribute to a substantially even depth across the reactor chamber.

Abstract translation: 本发明提供一种具有反应室和一个或多个支撑室的生物反应器。 反应器室可以具有一个或多个用于封闭微生物和培养基的柔性壁。 反应器室提供微生物和培养基的外壳。 支撑室也可以具有一个或多个柔性壁。 当充气到预定量时，支撑室使得微生物和培养基在整个反应室中分布到基本均匀的深度。

公开(公告)号：WO2012054939A3

公开(公告)日：2012-04-26

申请号：PCT/US2011/057554

申请日：2011-10-24

Applicant: AGILEX FLAVOR & FRAGRANCES ,  VLAD, Florin-Joseph ,  ZLOTNIK, Stuart, A. ,  HINDEN-KUHLES, Natalie

Inventor： VLAD, Florin-Joseph ,  ZLOTNIK, Stuart, A. ,  HINDEN-KUHLES, Natalie

IPC: A61L9/01 ,  A61L9/12 ,  A61L101/32

Abstract: Air freshener compositions, devices, and methods are disclosed.

公开(公告)号：WO2011153008A3

公开(公告)日：2011-12-08

申请号：PCT/US2011/037426

申请日：2011-05-20

Applicant: BUCYRUS MINING EQUIPMENT, INC. ,  CONNELL, Stuart, A.

Inventor： CONNELL, Stuart, A.

IPC: E21B17/10

Abstract: A drill system for use with a drill rod includes a support member, and a drill assembly movably associated with the support member and configured to be connected to the drill rod. The system further includes a centralizing device movably associated with the support member and configured to receive the drill rod. The centralizing device includes a movable jaw and a latch arm connected to the jaw and configured to move the jaw between an open position and a closed position for retaining the drill rod. Furthermore, the latch arm has a locking feature configured to hold the latch arm in a locked position to thereby hold the jaw in the closed position.

公开(公告)号：WO2011143356A1

公开(公告)日：2011-11-17

申请号：PCT/US2011/036137

申请日：2011-05-11

Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION ,  WOLF, Stuart A. ,  LU, Jiwei ,  STAN, Mircea R.

Inventor： WOLF, Stuart A. ,  LU, Jiwei ,  STAN, Mircea R.

IPC: G11C11/22

CPC classification number: G11C11/14 ,  G11C11/161 ,  G11C11/1675 ,  Y10T29/49069

Abstract: The present invention proposes an electronic memory device comprising a memory line including a memory domain. The memory line may contain a number of memory domains and a number of fixed domains, wherein each memory domain stores a single binary bit value. A multiferroic element may be disposed proximate to each memory domain allowing the magnetization of the memory domain to be changed using a spin torque current, and ensuring the stability of the magnetization of the domain when it is not being written. The domain boundary between the memory domain and one of its adjacent fixed domains may thereby be moved. An antiferromagnetic element may be disposed proximate to each fixed domain to ensure the stability of the magnetization of these. The value of each memory domain may be read by applying a voltage to a magnetic tunnel junction comprising the memory domain and measuring the current flowing through it.

Abstract translation: 本发明提出了一种包括存储器线的电子存储器件，该存储器线包括存储器域。 存储器线可以包含多个存储器域和多个固定域，其中每个存储器域存储单个二进制位值。 可以将多层元件设置在每个存储器域附近，从而允许使用自旋转矩电流来改变存储器域的磁化，并且当未写入时确保该域的磁化的稳定性。 因此，可以移动存储器域与其一个相邻固定域之间的域边界。 反铁磁元件可以设置在每个固定结构域附近，以确保这些磁化的稳定性。 可以通过将电压施加到包括存储器域的磁性隧道结并测量流过它的电流来读取每个存储器域的值。

公开(公告)号：WO2011085213A2

公开(公告)日：2011-07-14

申请号：PCT/US2011/020536

申请日：2011-01-07

Applicant: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE ,  LIPTON, Stuart, A.

Inventor： LIPTON, Stuart, A.

IPC: G01N33/53

CPC classification number: G01N33/53

Abstract: Disclosed are methods and compositions for identifying, producing, and using pathologically-activated targeting compounds. Pathologically- activated compounds are compound that only have an effect, or have a disproportionate effect, on a target molecule when a pathological condition exists.

Abstract translation: 公开了鉴定，生产和使用病理活化的靶向化合​​物的方法和组合物。 病理活性化合物是当病理状态存在时仅对靶分子具有作用或具有不成比例效应的化合物。

公开(公告)号：WO2011017171A1

公开(公告)日：2011-02-10

申请号：PCT/US2010/043573

申请日：2010-07-28

Applicant: JOULE UNLIMITED, INC. ,  MORGAN, Frederick, W. ,  JACOBSON, Stuart, A. ,  VAN WALSEM, Johan

Inventor： MORGAN, Frederick, W. ,  JACOBSON, Stuart, A. ,  VAN WALSEM, Johan

IPC: C12M1/00

CPC classification number: C12M41/18 ,  C12M21/02 ,  C12M23/04 ,  C12M23/26 ,  C12M37/00

Abstract: The present invention provides photobioreactors, solar energy gathering systems, and methods for thermal control of a culture medium containing a prototrophic organism in a photobioreactor, that allow temperature control in a cost effective manner, reducing the energy required for temperature control of a culture medium containing phototrophic microorganisms in a photobioreactor.

Abstract translation: 本发明提供了光生物反应器，太阳能收集系统和用于热光控制含有光生物反应器中的原养生体的培养基的方法，其以成本有效的方式进行温度控制，降低了温度控制所需的能量，所述培养基含有 光生物反应器中的光养微生物。

公开(公告)号：WO2011014960A1

公开(公告)日：2011-02-10

申请号：PCT/CA2010/001217

申请日：2010-08-05

Applicant: 7267207 CANADA LIMITED CORPORATION ,  LOWTHER, Stuart A. ,  PLANTE, Real ,  PILON, Bradley H. ,  TARNOPOLSKY, Mark A.

Inventor： LOWTHER, Stuart A. ,  PLANTE, Real ,  PILON, Bradley H. ,  TARNOPOLSKY, Mark A.

IPC: A61K9/00 ,  A23G3/36 ,  A23L1/05 ,  A23P1/10 ,  A61K31/137 ,  A61K31/138 ,  A61K31/167 ,  A61K31/192 ,  A61K31/4545 ,  A61K31/495 ,  A61K47/10 ,  A61K47/26 ,  A61K47/36 ,  A61K47/42

CPC classification number: A61K9/0058 ,  A23G3/0004 ,  A23G3/001 ,  A23G3/0053 ,  A23G4/10 ,  A23G4/126 ,  A23L29/20 ,  A23L29/30 ,  A23L29/37 ,  A61K9/0056 ,  A61K31/137 ,  A61K31/138 ,  A61K31/167 ,  A61K31/192 ,  A61K31/4545 ,  A61K31/495

Abstract: Disclosed herein is a process producing a therapeutic comestible gummie product, the process comprises providing a sugar and/or sugar alcohol, water and heating to at least 80°C to produce a first mixture. A gelling agent and water is also provided and heat to at least 80°C to produce a second mixture. Combining the first and second mixtures to produce a slurry. The slurry is heated to at least 112°C to produce a gummie base. The gummie base is cooled to an optimal temperature of below 90°C for the addition of an active drug and the active drug is substantially uniformly mixed with the gummie base. In some embodiments the active is drug is mixed with an ingestible oil and added to the cooling slurry. The gummie base and active drug mixture is then poured into molding trays and allowed to cure. Also disclosed herein by way the process of the present disclosure is therapeutic comestible gummie product. Furthermore, the present disclosure comprises a therapeutic comestible gummie product comprising ibuprofen and/or other active drug(s).

Abstract translation: 本文公开了一种生产治疗性食用口香糖产品的方法，该方法包括提供糖和/或糖醇，水并加热至至少80℃以产生第一混合物。 还提供胶凝剂和水，并加热至至少80℃以产生第二混合物。 组合第一和第二混合物以产生浆料。 将浆料加热至至少112℃以产生胶基。 将牙胶基底冷却至低于90℃的最佳温度以加入活性药物，并且活性药物与牙胶基质基本上均匀混合。 在一些实施方案中，将活性物质与可摄入的油混合并加入到冷却浆液中。 然后将胶基和活性药物混合物倒入模制托盘中并使其固化。 本文还通过本文公开的方法公开了治疗性食用口香糖产品。 此外，本公开内容包括包含布洛芬和/或其它活性药物的治疗性食用口香糖产品。

公开(公告)号：WO2010120389A8

公开(公告)日：2010-10-21

申请号：PCT/US2010/001166

申请日：2010-04-19

Applicant: AXXIA PHARMACEUTICALS, LLC ,  POLLOCK, Wayne, C. ,  GROSSMAN, Stuart A. ,  OWENS, Albert, H. Jr.

Inventor： POLLOCK, Wayne, C. ,  GROSSMAN, Stuart A. ,  OWENS, Albert, H. Jr.

IPC: A61K47/34 ,  A61K9/00 ,  A61K31/485 ,  B29C47/06

Abstract: The subject invention relates to implants for delivery of therapeutic agents such as opioids, and the manufacture and uses of such implants.