公开(公告)号：EP2211154A1

公开(公告)日：2010-07-28

申请号：EP09151155.0

申请日：2009-01-22

Applicant: CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Développement

Inventor： Tormen, Maurizio ,  Ross, Stanley ,  Lockhart, Robert

IPC: G01J3/02 ,  G01J3/18 ,  G01J3/32 ,  G02B5/18

CPC classification number: G01J3/1804 ,  G01J3/02 ,  G01J3/0237 ,  G01J3/32 ,  G02B5/1828

Abstract: The present invention discloses a monochromator comprising:
- an entrance aperture,
- a collimator, intended to produce, from a light source, a collimated input light (5),
- a grating comprising a plurality of non-overlapping parallel reflective flat surfaces (4a) juxtaposed along an axis x, and spaced in the direction of the normal to the flat surfaces (4a) by a distance d 1 , the distance d 1 being the same for the whole grating and being tunable and the grating being arranged to diffract the collimated input light (5), and
- an exit aperture.
The collimator is arranged in order the collimated input light (5) to be parallel to a plan P, the plan P being perpendicular to axis x. The collimator is also arranged in order that the angle α between the collimated input light (5) and the normal to the reflective flat surfaces (4a) is different from 0°.

公开(公告)号：EP1723398B1

公开(公告)日：2010-03-03

申请号：EP05737002.5

申请日：2005-03-04

Applicant: Meffre, Wilfrid

Inventor： Meffre, Wilfrid

IPC: G01J3/50 ,  G06K7/10 ,  B41F33/00

CPC classification number: G01J3/50 ,  G01J3/0237

公开(公告)号：EP2116828A1

公开(公告)日：2009-11-11

申请号：EP08765364.8

申请日：2008-06-10

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： SHIBAYAMA, Katsumi ,  YOKINO, Takafumi ,  SUZUKI, Tomofumi ,  TEICHMANN, Helmut ,  HILLER, Dietmar ,  STARKER, Ulrich

IPC: G01J3/02

CPC classification number: G01J3/18 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0237 ,  G01J3/0259 ,  G01J3/0291

Abstract: Alignment marks 12a, 12b, 12c, and 12d are formed on the flat plane 11a of the peripheral edge portion 11 formed integrally with the diffracting layer 8, and when the lens portion 7 is mounted onto the substrate 2, these alignment marks 12a, 12b, 12c and 12d are positioned to the substrate 2, thereby making exact alignment of the diffracting layer 8 with respect to the light detecting portion 4a of the light detecting element 4, for example, not by depending on a difference in curvature radius of the lens portion 7. In particular, the alignment marks 12a, 12b, 12c and 12d are formed on the flat plane 11a, thereby image recognition is given to exactly detect positions of the alignment marks 12a, 12b, 12c and 12d, thus making it possible to make exact alignment.

Abstract translation: 这些对准标记12a，12b，12c和12d形成在与衍射层8一体形成的周边边缘部分11的平面11a上，并且当透镜部分7安装到基底2上时，这些对准标记12a，12b ，12c和12d定位在基板2上，由此例如不依赖于透镜的曲率半径的差异而使衍射层8相对于光检测元件4的光检测部分4a精确对准 特别是，在平面11a上形成对准标记12a，12b，12c和12d，从而图像识别被准确地检测到对准标记12a，12b，12c和12d的位置，从而使得有可能 精确对齐。

公开(公告)号：EP1428014A4

公开(公告)日：2009-08-12

申请号：EP02768427

申请日：2002-08-06

Applicant: BECTON DICKINSON CO

Inventor： OOSTMAN CLIFFORD A JR ,  BLASENHEIM BARRY J

IPC: G01N21/64 ,  G01J3/36

CPC classification number: G01J3/4406 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0237 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/36 ,  G01N21/6428 ,  G01N21/645 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6463 ,  G01N2021/6484

Abstract: An optical instrument using a plurality of lasers (85, 87, 89, 91) of different colors with parallel, closely spaced beams (95, 97, 99, 101) to stimulate scattering and fluorescence from fluorescent biological particulate matter, including cells and large molecules. A large numerical aperture objective lens (111) collects fluorescent light (133, 135, 137, 139) while maintaining spatial separation of light stimulated by the different sources. The collected light is imaged into a plurality of fibers (123, 125, 127, 129) , one fiber associated with each optical source (95, 97, 99, 101) , which conducts light to a plurality of arrays of detectors (124, 126, 128, 130, 301, 303, 305) , with each array associated with light from one of the fibers (123, 125, 127, 129) and one of the lasers (95, 97, 99, 101) .A detector array (301, 303, 305) has up to ten detectors (160, 170, 180, 159, 169, 179, 189) arranged to separate and measure colors within relatively narrow bands by decimation of light arriving in a fiber (123) .A large number of detectors is mounted in a compact polygonal arrangement by using reflective transfer legs from multiple beam splitters (151, 161, 171, 181, 191, 201) where the transfer legs arise from a polygonal arrangement of beam splitters.

公开(公告)号：EP1950541A3

公开(公告)日：2009-05-06

申请号：EP08075196.9

申请日：2004-01-20

Applicant: PerkinElmer Ltd.

Inventor： Hoult, Robert Alan ,  Evetts, Paul Alexander

IPC: G01J3/44

CPC classification number: G01N21/55 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0237 ,  G01J3/0291 ,  G01J3/42

Abstract: An accessory for a spectrometer for carrying out measurements of specular reflectance of a sample. The accessory is designed so that all components can be located in a housing and the sample can be located horizontally on a top-plate of the housing with the components disposed below the plane of that plate. The radiation can be arranged to be incident at a number of different angles on the sample and it can also be arranged that the radiation is directed to the detector without being incident on the sample.

公开(公告)号：EP2042853A1

公开(公告)日：2009-04-01

申请号：EP07790672.5

申请日：2007-07-12

Applicant: Toyo Boseki Kabushiki Kaisha

Inventor： OKUDA, Yohei, c/o TOYO BOSEKI KABUSHIKI KAISHA ,  YONEDA, Keizo, c/o TOYO BOSEKI KABUSHIKI KAISHA

IPC: G01N21/17 ,  G01N21/27 ,  G01N33/48 ,  G02B7/28

CPC classification number: G01N1/312 ,  G01J3/0237 ,  G01J3/46 ,  G01J3/463 ,  G01N15/1456 ,  G01N15/1463 ,  G01N33/493 ,  G01N2015/1452 ,  G02B7/28 ,  G02B21/006 ,  G02B21/365

Abstract: This invention provides an analyzer for judging whether or not a tangible component is present in a sample in a preparation, and analyzing, if a tangible component is present, the tangible component with efficiency and high accuracy. For this purpose, an analyzer (100) of the present invention analyzes a tangible component in a sample (23) held by a preparation (20). The analyzer (100) checks whether or not a tangible component is present in the sample (23) by extensively observing an area in a certain visual field in which area the tangible component is assumed to be present. If the tangible component is judged to be present, the analyzer (100) analyzes the tangible component. Then, another visual field is selected, and another analysis is started therein so as to analyze only in the vicinity of the area where the tangible component was judged to be present. The analyzer (100) can determine whether or not a tangible component is present, and can analyze the tangible component with efficiency and high accuracy.

Abstract translation: 本发明提供了一种用于判断制剂中的样品中有形成分是否存在的分析装置，并且如果存在有形成分，则以有效且高精度分析有形成分。 为此，本发明的分析仪（100）分析由制剂（20）保持的样品（23）中的有形成分。 分析器（100）通过广泛地观察假设存在有形分量的某个视野中的区域来检查样本（23）中有形成分是否存在。 如果有形成分被判定为存在，则分析器（100）分析有形分量。 然后，选择另一个视野，并开始另一个视野，以便仅在判定出有形成分的区域附近进行分析。 分析器（100）可以确定是否存在有形分量，并且可以高效率和高精度地分析有形分量。

公开(公告)号：EP1754032B1

公开(公告)日：2008-05-07

申请号：EP05766803.0

申请日：2005-06-02

Applicant: Gesellschaft zur Förderung angewandter Optik, Optoelektronik, Quantenelektronik und Spektroskopie e.V. ,  Gesellschaft zur Förderung der Analytischen Wissenschaft e.V.

Inventor： BECKER-ROSS, Helmut ,  FLOREK, Stefan ,  WESEMANN, Günter ,  OKRUSS, Michael

IPC: G01J3/18

CPC classification number: G01J3/1809 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0232 ,  G01J3/0237 ,  G01J3/0286 ,  G01J3/0294 ,  G01J3/08 ,  G01J3/12 ,  G01J3/2803

Abstract: The invention relates to a spectrometer arrangement (10) comprising a spectrometer (14) for producing a spectrum of a first wavelength range of radiation from a radiation source on a detector (42). Said arrangement also comprises: an Echelle grating (36) for the spectral decomposition of the radiation penetrating the spectrometer arrangement (10) in a main dispersion direction (46); a dispersing element (34) for separating the degrees by means of spectral decomposition of the radiation in a transversal dispersion direction (48) which forms an angle with the main dispersion direction of the Echelle grating (36), in such a way that a two-dimensional spectrum (50) can be produced with a plurality of separated degrees (52); an imaging optical element (24, 38) for imaging the radiation penetrating through an inlet gap (20) into the spectrometer arrangement (10), in an image plane (40); and a surface detector (42) comprising a two-dimensional arrangement of a plurality of detector elements in the image plane (40). The inventive arrangement is characterised in that another spectrometer (12) comprising at least one other dispersing element (64) and another imaging optical element (60, 66) is provided in order to produce a spectrum (68) of a second wavelength range of radiation, which is different from the first wavelength range, from a radiation source on the same detector (42). The spectra can be spatially or temporally separated on the detector.

公开(公告)号：EP1761816A1

公开(公告)日：2007-03-14

申请号：EP05745517.2

申请日：2005-06-07

Applicant: Koninklijke Philips Electronics N.V.

Inventor： VAN BEEK, Michael Cornelis ,  LUCASSEN, Gerald ,  VAN DER VOORT, Marjolein ,  RENSEN, Wouter Harry Jacinth ,  DE VRIES, Durk Jolmer

IPC: G02B21/24

CPC classification number: G02B21/247 ,  G01J3/02 ,  G01J3/0237 ,  G01J3/44 ,  G01N21/645 ,  G01N21/65 ,  G01N2021/6463 ,  G01N2021/653 ,  G01N2021/655

Abstract: The present invention provides an autofocus mechanism for a spectroscopic system (400) that is adapted to determine a property of a volume of interest. The volume of interest has an optical property that varies with time. The invention provides measurement means that are adapted to measure the fluctuations of the optical property of the volume of interest for determining the position (428) of the volume of interest. The spectroscopic system being further adapted to focus an excitation beam (418) into the determined volume of interest and for collecting return radiation (420) emanating from the volume of interest for spectroscopic analysis. Preferably, inelastically scattered radiation of an excitation beam (428) is separated from elastically scattered radiation for spectroscopic analysis. The elastically scattered radiation of the excitation beam is in turn exploited in order to measure the fluctuations of the optical property of the volume of interest. Making use of a control loop allows for maximization of the amplitude and/or intensity of the fluctuation inherently specifying the position of a volume of interest e.g. the center of a capillary vessel (450).

公开(公告)号：EP0199767B1

公开(公告)日：1991-10-09

申请号：EP85905342.3

申请日：1985-10-22

Applicant: SPECTRAPHOS AB

Inventor： SVANBERG, Sune ,  MONTAN, Sune

IPC: G01N21/64 ,  G02B27/14

CPC classification number: G01N21/6456 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0237 ,  G01J3/36 ,  G01J2003/1239 ,  G01N2021/6421

Abstract: A fluorescence imaging system includes a light source, preferably a pulsated laser (1), which irradiates an object, optionally via further optical components (2, 3, 5), so as to induce fluorescence radiation in the object. This radiation images the object on a detector plane (11). In accordance with the invention there is provided a beam-splitting system (6), such that the fluorescent object is reproduced in the form of at least three, and preferably four separate and mutually adjacent images. A selected filter is placed in each of the paths of these partial light beams. The detector plane has a plurality of image-point detectors each of which produces a respective electric signal, so that there is obtained for each image point at least three, and preferably four intensity signals recorded for a respective frequency band determined by respective filters. These signals are processed mathematically to provide a weighted signal value, which may be dimensionless. These weighted image-point values are reproduced, for example on a video-monitor (13), which makes possible fluorescence reproduction rich in contrast and free from disturbances with respect to spectral signatures. One example of the use to which the invention can be put is the detection of cancer cells to which a fluorescence signature has been imparted with the aid of HPD.

公开(公告)号：EP0425882A1

公开(公告)日：1991-05-08

申请号：EP90119771.5

申请日：1990-10-15

Applicant: HORIBA, LTD.

Inventor： Ukon, Juichiro

IPC: G01N21/55 ,  G02B21/00 ,  G02B21/04

CPC classification number: G01J3/02 ,  G01J3/0237 ,  G01J3/0289 ,  G01N21/552 ,  G02B19/0023 ,  G02B19/0047 ,  G02B19/009 ,  G02B21/0004

Abstract: An infrared microscopic spectrometer is composed of a collecting element por­tion (A), a focusing-into-an image portion (B) and of a transferring mechanism (14) for shifting one of said portions (A, B) toward each other in a direction meeting at right angels with an optical axis. The collecting element portion (A) contains a light source (1) and a condenser mirror (2) whereas the focusing-into-an image ele­ment portion (B) contains an object mirror (4) and a spectrometrical measure­ment system (5). An ATR crystal is to be positioned between the portions (A) and (B) so as to carry out the ATR analysis.

Abstract translation: 红外显微镜光谱仪由收集元件部分（A），聚焦图像部分（B）和转印机构（14）组成，用于将所述部分（A，B）中的一个朝向彼此移动 方向会议在右天使与光轴。 收集元件部分（A）包含光源（1）和聚光镜（2），而聚焦到图像元件部分（B）中包含物镜（4）和光谱测量系统（5）。 将ATR晶体定位在部分（A）和（B）之间，以进行ATR分析。