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公开(公告)号:WO1995000824A1
公开(公告)日:1995-01-05
申请号:PCT/SE1994000575
申请日:1994-06-14
Applicant: SPECTRAPHOS AB , SVANBERG, Sune
Inventor: SPECTRAPHOS AB
IPC: G01J03/44
CPC classification number: G01N21/6456 , G01N2021/1776 , G01N2021/6417
Abstract: The purpose of the invention is to enhance differences between differently fluorescing parts of the object under investigation by pointwise forming functions of the intensities in the different wavelength bands. Since the imaging of the different wavelength bands is truly simultaneous, false results due to that images in different wavelength bands are detected at different times will be avoided. The present invention is to utilize deviating prisms to achieve the multiple images. Such prisms makes it possible to use commercially available camera optics for the image production which gives the advantages: faster, less bulky, easy to find commercially and cheaper. A telescope is best suited for imaging distant objects, the prism solution produces good images also of close objects which is of importance when used in the medical field.
Abstract translation: 本发明的目的是通过在不同波长带中的强度的点形成功能来增强被研究对象的不同荧光部分之间的差异。 由于不同波长带的成像是真正的同时进行的,因此可以避免在不同时间检测出不同波段的图像的错误结果。 本发明是利用偏光棱镜来实现多个图像。 这样的棱镜使得可以使用市售的相机光学器件用于图像生产,其具有以下优点:更快,更小体积,容易找到商业和便宜的优点。 望远镜最适用于远距离物体的成像,棱镜解决方案也能产生良好的图像,也可用于医疗领域。
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公开(公告)号:WO1994024529A1
公开(公告)日:1994-10-27
申请号:PCT/SE1994000352
申请日:1994-04-20
Applicant: SPECTRAPHOS AB , SVANBERG, Sune , MONTAN, Sune
Inventor: SPECTRAPHOS AB
IPC: G01J03/44
CPC classification number: G01N21/6456 , G01N2021/1772 , G01N2021/6421 , G01N2021/6471
Abstract: The present invention is a fluorescence imaging system comprising a light source (1) for irradiating an object (2), an optical filter (3) for separating fluorescence radiation emitted by said object and detector means (5) to generate a respective signal for each image point and a recording and computing unit for the recording of said fluorescence radiation in a plurality of wavelength bands and executing a mathematical and/or logic operation on signals on the same image point corresponding to one and the same point on the object, therewith to obtain an expression for a weighted signal value and to produce an image of the object from the weighted signal values for the different points of the object; said optical filter being tunable to an arbitrary wavelength passband within a large wavelength range. The optical filter is an electronically tunable interference filter.
Abstract translation: 本发明是一种荧光成像系统,包括用于照射物体的光源(1),用于分离由所述物体发射的荧光辐射的光学滤光器(3)和检测器装置(5),以产生每个信号 图像点和用于记录多个波长带中的所述荧光辐射的记录和计算单元,并对与对象上的同一点对应的相同图像点上的信号执行数学和/或逻辑运算,由此, 获得加权信号值的表达式,并从对象的不同点的加权信号值产生对象的图像; 所述滤光器可调谐到大波长范围内的任意波长通带。 光滤波器是电子可调谐干涉滤波器。
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公开(公告)号:DE69015916D1
公开(公告)日:1995-02-23
申请号:DE69015916
申请日:1990-02-21
Applicant: SPECTRAPHOS AB
Inventor: ANDERSSON-ENGELS STEFAN , JOHANSSON JONAS , STENRAM UNNE , SVANBERG KATARINA , SVANBERG SUNE
IPC: A61B1/00 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1495 , A61B10/00 , G01N21/31 , G01N21/64
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公开(公告)号:AU5065485A
公开(公告)日:1986-05-15
申请号:AU5065485
申请日:1985-10-22
Applicant: SPECTRAPHOS AB
Inventor: SUNE SVANBERG , SUNE MONTAN
Abstract: PCT No. PCT/SE85/00408 Sec. 371 Date Jun. 23, 1986 Sec. 102(e) Date Jun. 23, 1986 PCT Filed Oct. 22, 1985 PCT Pub. No. WO86/02730 PCT Pub. Date May 9, 1986.A fluorescence imaging system. A light source irradiates an object to be viewed. The irradiated object is imaged through a beam-splitting system to form individual displaced images of the object. The displaced images are further filtered in a filter having a frequency passband different from the other filters. The filtered images are imaged on a detector. The same image point of each image is detected and converted into an electrical signal. A circuit means is provided to receive the signals of each common image point, and weight the same. The weighted signal represents an image point pixel. The weighted pixels are displayed as an image of the object having improved contrast.
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公开(公告)号:CA2027561C
公开(公告)日:2001-02-20
申请号:CA2027561
申请日:1990-02-21
Applicant: SPECTRAPHOS AB
Inventor: ANDERSSON-ENGELS STEFAN , JOHANSSON JONAS , SVANBERG SUNE , STENRAM UNNE , SVANBERG KATARINA
IPC: A61B1/00 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1495 , A61B10/00 , G01N21/31 , G01N21/64 , A61B6/00
Abstract: A sample (1) is irradiated by a pulse from a laser (2), creating fluorescence radiation, which is brought, in imaging relation or otherwise, to a detector (6) sensing from the same sample (1) in a plurality of spectral intervals (6A-6D), for obtaining intensity values. The radiation may be sensed in imaging relation, creating a multiplicity of said pluralities. The spectral intervals may be wavelength defined by passband filters (5A-5D) or time interval defined time spectral intervals controlled by a computer (7), which makes a numerical evaluation comprising a division. The tissue character may then be evaluated from the evaluation.
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公开(公告)号:ES2067021T3
公开(公告)日:1995-03-16
申请号:ES90903982
申请日:1990-02-21
Applicant: SPECTRAPHOS AB
Inventor: ANDERSSON-ENGELS STEFAN , JOHANSSON JONAS , STENRAM UNNE , SVANBERG KATARINA , SVANBERG SUNE
IPC: A61B1/00 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1495 , A61B10/00 , G01N21/31 , G01N21/64
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公开(公告)号:DE69015916T2
公开(公告)日:1995-08-10
申请号:DE69015916
申请日:1990-02-21
Applicant: SPECTRAPHOS AB
Inventor: ANDERSSON-ENGELS STEFAN , JOHANSSON JONAS , STENRAM UNNE , SVANBERG KATARINA , SVANBERG SUNE
IPC: A61B1/00 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1495 , A61B10/00 , G01N21/31 , G01N21/64
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公开(公告)号:AU638978B2
公开(公告)日:1993-07-15
申请号:AU5193790
申请日:1990-02-21
Applicant: SPECTRAPHOS AB
Inventor: STEFAN ANDERSSON-ENGELS , JONAS JOHANSSON , UNNE STENRAM , KATARINA SVANBERG , SUNE SVANBERG
IPC: A61B1/00 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1495 , A61B10/00 , G01N21/31 , G01N21/64
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公开(公告)号:DE3584367D1
公开(公告)日:1991-11-14
申请号:DE3584367
申请日:1985-10-22
Applicant: SPECTRAPHOS AB
Inventor: SVANBERG SUNE , MONTAN SUNE
Abstract: PCT No. PCT/SE85/00408 Sec. 371 Date Jun. 23, 1986 Sec. 102(e) Date Jun. 23, 1986 PCT Filed Oct. 22, 1985 PCT Pub. No. WO86/02730 PCT Pub. Date May 9, 1986.A fluorescence imaging system. A light source irradiates an object to be viewed. The irradiated object is imaged through a beam-splitting system to form individual displaced images of the object. The displaced images are further filtered in a filter having a frequency passband different from the other filters. The filtered images are imaged on a detector. The same image point of each image is detected and converted into an electrical signal. A circuit means is provided to receive the signals of each common image point, and weight the same. The weighted signal represents an image point pixel. The weighted pixels are displayed as an image of the object having improved contrast.
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公开(公告)号:CA2027561A1
公开(公告)日:1990-08-23
申请号:CA2027561
申请日:1990-02-21
Applicant: SPECTRAPHOS AB
Inventor: ANDERSSON-ENGELS STEFAN , JOHANSSON JONAS , STENRAM UNNE , SVANBERG KATARINA , SVANBERG SUNE
IPC: A61B1/00 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1495 , A61B10/00 , G01N21/31 , G01N21/64
Abstract: A sample (1) is irradiated by a pulse from a laser (2), creating fluorescenc e radiation, which is brought, in imaging relation or otherwise, to a detector (6) sensing from the same sample (1) in a plurality of spectral intervals (6A-6D), for obtaining intensity values. The radiation may be sensed in imaging relation, creating a multiplicity of said pluralities. The spectral intervals may be wavelength defined by passband filters (5A-5D) or time interval defined time spectral intervals controlled by a computer (7), which makes a numerical evaluation comprising a division. The tissue charact er may then be evaluated from the evaluation.
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