公开(公告)号：WO2007146224A2

公开(公告)日：2007-12-21

申请号：PCT/US2007/013683

申请日：2007-06-07

Applicant: MERCK & CO., INC. ,  GOTTESDIENER, Keith, M. ,  GREEN, Stuart, A. ,  MACINTYRE, Euan

Inventor： GOTTESDIENER, Keith, M. ,  GREEN, Stuart, A. ,  MACINTYRE, Euan

IPC: A61K31/4015

CPC classification number: A61K31/4015 ,  A61K45/06 ,  A61K2300/00

Abstract: This invention concerns compositions for the treatment of urinary frequency, urinary urgency and urinary incontinence comprising a selected antagonist of the NK-1 receptor or a pharmaceutically acceptable salt thereof and an anti-muscarinic agent or a pharmaceutically acceptable salt thereof. This invention concerns combination therapy for urinary frequency, urinary urgency and urinary incontinence wherein one of the active agents is a selected antagonist of the NK-1 receptor or a pharmaceutically acceptable salt thereof and another is an anti-muscarinic agent or a pharmaceutically acceptable salt thereof.

Abstract translation: 本发明涉及用于治疗尿频，尿急和尿失禁的组合物，其包含选择的NK-1受体拮抗剂或其药学上可接受的盐和抗毒蕈碱剂或其药学上可接受的盐。 本发明涉及尿频，尿急和尿失禁的联合治疗，其中一种活性剂是选择的NK-1受体拮抗剂或其药学上可接受的盐，另一种是抗毒蕈碱剂或其药学上可接受的盐 。

公开(公告)号：WO2006017116A3

公开(公告)日：2007-03-01

申请号：PCT/US2005024084

申请日：2005-07-07

Applicant: CELERITY INC ,  TISON STUART A ,  SUKUMARAN SANDEEP ,  BARKER JAMES

Inventor： TISON STUART A ,  SUKUMARAN SANDEEP ,  BARKER JAMES

IPC: G05D7/06

CPC classification number: G01F25/0038 ,  G01F25/0053 ,  G05D7/0635

Abstract: Systems and methods for flow verification and validation of mass flow controllers are disclosed. A mass flow controller may be commanded to a specified flow and flow measurement commenced. During an interval, gas is accumulated in a first volume and measurements taken within this volume. The various measurements taken during the interval may then be used to calculate the flow rate. The flow rate, in turn, may be used to determine the accuracy of the mass flow controller relative to a setpoint.

Abstract translation: 公开了用于流量验证和质量流量控制器验证的系统和方法。 可以命令质量流量控制器进行指定的流量和流量测量。 在间隔期间，气体积聚在第一个体积中，并在该体积内进行测量。 然后可以使用间隔期间进行的各种测量来计算流量。 流量又可用于确定质量流量控制器相对于设定点的精度。

公开(公告)号：WO2006071714A1

公开(公告)日：2006-07-06

申请号：PCT/US2005/046524

申请日：2005-12-20

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. ,  SHAW, Mark, E. ,  HERRELL, Russ, W. ,  BURKE, Stuart, A.

Inventor： SHAW, Mark, E. ,  HERRELL, Russ, W. ,  BURKE, Stuart, A.

IPC: G06F15/80 ,  G06F15/173

CPC classification number: G06F15/17375 ,  G06F15/8007

Abstract: In an embodiment, a multi-processor computer system includes multiple cells, where a cell may include one or more processors and memory resources. The system may further include a global crossbar network and multiple cell-to-global-crossbar connectors, to connect the multiple cells with the global crossbar network. In an embodiment, the system further includes at least one cell-to-cell connector, to directly connect at least one pair of the multiple cells. In another embodiment, the system further includes one or more local crossbar networks, multiple cell-to-local-crossbar connectors, and local input/output backplanes connected to the one or more local crossbar networks.

Abstract translation: 在一个实施例中，多处理器计算机系统包括多个小区，其中小区可以包括一个或多个处理器和存储器资源。 该系统还可以包括全局交叉网络和多个小区到全局交叉连接器，以将多个小区与全局交叉网络连接。 在一个实施例中，系统还包括至少一个单元到单元连接器，以直接连接至少一对多个单元。 在另一个实施例中，系统还包括一个或多个本地交叉网络，多个小区到本地交叉连接器以及连接到一个或多个本地交叉网络的本地输入/输出背板。

公开(公告)号：WO2006069383A2

公开(公告)日：2006-06-29

申请号：PCT/US2005/047136

申请日：2005-12-22

Applicant: EXAKTIME, INC. ,  PAPPAS, Anthony Henryk ,  PREWETT, Scott K. ,  MILLIGAN, John L. ,  KARTEN, Stuart A. ,  DORAN, Valeria L.

Inventor： PAPPAS, Anthony Henryk ,  PREWETT, Scott K. ,  MILLIGAN, John L. ,  KARTEN, Stuart A. ,  DORAN, Valeria L.

IPC: G04B47/00

CPC classification number: G07C1/10

Abstract: A time attendance system, including a time attendance clock, designed to be used in harsh conditions, such as outdoor job sites. A portable touch button, including a passively readable code, is brought into contact with the time attendance clock so as to create a time attendance record stored in the clock. Visual indicators and audible notification alert the employee of the acceptance of the act. Periodically, the time attendance records are retrieved from the time attendance clock, such as by using a hand-held electronic device which communicates in a wireless manner with the time attendance clock.

Abstract translation: 一个考勤系统，包括一个设计在恶劣条件下使用的考勤时钟，如户外工作现场。 包括被动读取代码的便携式触摸按钮与考勤时钟接触，以便创建存储在时钟中的考勤记录。 视觉指标和听觉通知提醒员工接受该行为。 周期性地，从考勤时钟检索考勤记录，例如通过使用以无线方式与考勤时钟进行通信的手持式电子设备。

公开(公告)号：WO2005110468A3

公开(公告)日：2005-11-24

申请号：PCT/US2005/016248

申请日：2005-05-10

Applicant: THE BURNHAM INSTITUTE ,  LIPTON, Stuart, A. ,  EINHORN, Daniel

Inventor： LIPTON, Stuart, A. ,  EINHORN, Daniel

IPC: C12Q1/00 ,  C12Q1/60 ,  G01N31/00

Abstract: This invention relates to Applicant’s discovery that Metabolic Syndrome, a cluster of disorders stemming from a resistance to insulin, contributes directly to dementia, particularly Alzheimer’s disease. Applicant’s invention includes a screening method to determine susceptibility and diagnosis of dementia based on the risk factors for Metabolic Syndrome. Applicant’s invention further includes methods for the prevention or treatment of dementia and other neurological conditions based on (1) minimizing insulin resistance, thereby preventing excess biosynthesis of insulin; (2) modulating the activity of IDE such that insulin competes less efficiently with β-amyloid protein for the IDE; and (3) blocking the consequences of NMDA receptor activation, such as by minimizing the generation of NO and other harmful free radicals.

公开(公告)号：WO2005048078A3

公开(公告)日：2005-05-26

申请号：PCT/US2004/037722

申请日：2004-11-10

Applicant: GOLD, Stuart, A. ,  DAMER, Bruce, F.

Inventor： GOLD, Stuart, A. ,  DAMER, Bruce, F.

IPC: G06F15/173

Abstract: This invention relates to providing a system for improved methods of promoting, forming and managing Internet-based communities on the Internet through and within standard web pages without requiring the installation of additional software on a user’s computer or on web sites where the system is implemented by using the latest software tools, presentation techniques and Internet communication methods (504). Additionally, this invention provides real time monitoring of user counts (508) to all visitors and web pate owners when a page with the embedded URL is accessed (520). In particular, this invention permits web page visitors to initiate and participate in anonymous and hoc chat sessions initiated from a selected web page (522). Additionally, this invention provides a web-based location which permits Internet users to join and participate in Internet-based communities and the related activities such as messaging other members, participating in member chat sessions and web resource sharing without the need to install software.

公开(公告)号：WO2004064838A1

公开(公告)日：2004-08-05

申请号：PCT/CA2004/000033

申请日：2004-01-19

Applicant: UNIVERSITY HEALTH NETWORK ,  BERGER, Stuart, A. ,  ZHANG, Yicheng

Inventor： BERGER, Stuart, A. ,  ZHANG, Yicheng

IPC: A61K31/4535

CPC classification number: A61K45/06 ,  A61K31/4436 ,  A61K31/4535 ,  A61K31/704 ,  A61K2300/00

Abstract: The invention relates to a pharmaceutical composition comprising i) ketotifen or an analog thereof and ii) a chemotherapeutic drug subject to multi-drug resistance by P-gp, such as doxorubicin or an analog thereof. The pharmaceutical composition is useful for treating cancer. The pharmaceutical composition is also useful for i) preventing or treating multi-drug resistance in a subject or ii) preventing a chemotherapeutic drug subject to multi-drug resistance by P-gp induced cardiac tissue damage in a subject, such as doxorubicin or an analog thereof. The invention relates to a pharmaceutical composition comprising i) ketotifen or an analog thereof and ii) a chemotherapeutic drug subject to multi-drug resistance by P-gp, such as doxorubicin or an analog thereof. The pharmaceutical composition is useful for treating cancer. The pharmaceutical composition is also useful for i) preventing or treating multi-drug resistance in a subject or ii) preventing a chemotherapeutic drug subject to multi-drug resistance by P-gp induced cardiac tissue damage in a subject, such as doxorubicin or an analog thereof.

Abstract translation: 本发明涉及药物组合物，其包含i）酮替芬或其类似物，和ii）受P-gp多药耐药的化疗药物，例如多柔比星或其类似物。 该药物组合物可用于治疗癌症。 药物组合物还可用于i）预防或治疗受试者的多重耐药性，或ii）通过P-gp诱导的受试者的心脏组织损伤（例如多柔比星或类似物）预防受多药耐药性的化疗药物 它们。 本发明涉及药物组合物，其包含i）酮替芬或其类似物，和ii）受P-gp多药耐药的化疗药物，例如多柔比星或其类似物。 该药物组合物可用于治疗癌症。 药物组合物还可用于i）预防或治疗受试者的多重耐药性，或ii）通过P-gp诱导的受试者的心脏组织损伤（例如多柔比星或类似物）预防受多药耐药性的化疗药物 它们。

公开(公告)号：WO2003100356A1

公开(公告)日：2003-12-04

申请号：PCT/US2003/016493

申请日：2003-05-23

Applicant: MYKROLIS CORPORATION ,  TISON, Stuart, A. ,  WU, Guanghua ,  GILL, Tracy ,  LOPEZ, Vincent

Inventor： TISON, Stuart, A. ,  WU, Guanghua ,  GILL, Tracy ,  LOPEZ, Vincent

IPC: G01F1/37

CPC classification number: G01F1/42 ,  G01F1/40

Abstract: A flow restrictor (30) for a mass flow metering device formed of a solid material and slots (32) originating from an outer surface towards inward.

Abstract translation: 一种用于由固体材料形成的质量流量计量装置的限流器（30）和从外表面朝向内部的槽（32）。

公开(公告)号：WO0229134A3

公开(公告)日：2003-11-06

申请号：PCT/US0142427

申请日：2001-10-02

Applicant: UNIV JOHNS HOPKINS ,  SRINIVASAN REGASWAMY ,  SAFFARIAN HASSAN M ,  FOGEL STUART A

Inventor： SRINIVASAN REGASWAMY ,  SAFFARIAN HASSAN M ,  FOGEL STUART A

IPC: C25D9/06 ,  C25D9/10 ,  C25D11/02

CPC classification number: C25D9/10 ,  C25D9/06 ,  C25D11/02

Abstract: A method for inhibiting corrosion, e.g., pitting corrosion, of alloys is provided. Particularly, the method comprises contacting at least a portion of a surface of the alloy with an aqueous solution comprising a salt of one or more rare earth elements selected from the group consisting of yttrium, gadolinium, cerium, europium, terbium, samarium, neodymium, praseodymium, lanthanum, holmium, ytterbium, dysprosium and erbium; and establishing a voltage differential between an anode comprising the alloy and a cathode in the solution at an effective level and for a sufficient period of time wherein a rare earth element oxide-containing coating is formed on the surface of the alloy to inhibit corrosion thereof.

Abstract translation: 提供了一种用于抑制合金腐蚀，例如点腐蚀的方法。 特别地，该方法包括使合金表面的至少一部分与包含一种或多种选自钇，钆，铈，铕，铽，钐，钕， 镨，镧，钬，镱，镝和铒; 并在有效水平下在该溶液中形成包括合金的阳极和阴极之间的电压差，并在合金表面上形成含有稀土元素氧化物的涂层以抑制其腐蚀的充分时间段。

公开(公告)号：WO02102582A3

公开(公告)日：2003-04-10

申请号：PCT/US0218179

申请日：2002-06-10

Applicant: INTERFACE INC ,  BERARD RAYMOND A ,  HENSLER CONNIE D ,  ROMAN JEFFREY J ,  JONES STUART A ,  HALL JERRY C

Inventor： BERARD RAYMOND A ,  HENSLER CONNIE D ,  ROMAN JEFFREY J ,  JONES STUART A ,  HALL JERRY C

IPC: B32B5/02 ,  D06N7/00 ,  E04F15/16 ,  B32B5/08

CPC classification number: B32B5/024 ,  B32B5/02 ,  B32B7/12 ,  B32B27/12 ,  B32B27/18 ,  B32B27/304 ,  B32B27/34 ,  B32B27/36 ,  B32B2250/24 ,  B32B2262/0261 ,  B32B2262/0276 ,  B32B2272/00 ,  B32B2305/022 ,  B32B2327/06 ,  B32B2367/00 ,  B32B2377/00 ,  B32B2471/02 ,  D06N7/0068 ,  D06N7/0073 ,  D06N7/0078 ,  D06N2201/02 ,  D06N2201/0263 ,  D06N2203/048 ,  D06N2203/061 ,  D06N2203/065 ,  D06N2205/04 ,  D06N2205/18 ,  D06N2209/025 ,  D06N2209/067 ,  D06N2209/108 ,  D06N2209/128 ,  D06N2209/1671 ,  D06N2209/1685 ,  Y02P70/649

Abstract: Flooring that utilizes self-stabilizing preshrunk woven face fabric using relatively heavy "carpet weight" nylon, polyester, PTT or other yarns on modern Jacquard computer controlled looms to produce flat-weave fabrics that are bonded to engineered backing structures. Urethane modified bitumen may be used as a backing layer, and an optional latex precoat may be used on the fabric layer, together with an optional antimicrobial in the precoat.

Abstract translation: 在现代提花计算机控制织机上使用相对较重的“地毯重量”尼龙，聚酯，PTT或其他纱线使用自稳定预先编织面料的地板，以生产结合到工程背衬结构的平织织物。 聚氨酯改性沥青可以用作背衬层，并且可选的胶乳预涂层可以与预涂层中任选的抗微生物剂一起在织物层上使用。