公开(公告)号：WO2007047921A3

公开(公告)日：2007-05-24

申请号：PCT/US2006041034

申请日：2006-10-19

Applicant: ADA FOUNDATION ,  CHOW LAURENCE C ,  TAKAGI SHOZO

Inventor： CHOW LAURENCE C ,  TAKAGI SHOZO

IPC: A61K33/42 ,  A61K31/19

CPC classification number: A61K33/42 ,  A61K45/06 ,  A61L24/02 ,  A61L27/12 ,  A61L27/46 ,  A61L27/50 ,  A61L27/58 ,  A61K2300/00 ,  C08L89/00

Abstract: Disclosed are dual-phase cement precursor systems and related methods and kits. The cement precursor systems are composed of a first and second discrete phases, at least one of which is aqueous. When combined, the cement precursor phases form a cement that is suitable as a bone graft material for bone repair procedures. In preferred embodiments, the materials are highly biocompatible, osteoinductive, and bioresorbable. A number of different but not mutually exclusive cement chemistries may be employed in the cement precursor systems. For instance, hydrogel-forming polymer cements, carboxyl/calcium cements, or calcium phosphate cements may be employed.

Abstract translation: 公开了双相水泥前体体系及相关方法和试剂盒。 水泥前体体系由第一和第二离散相组成，其中至少一个是水性的。 当组合时，水泥前体相形成适合作为骨修复程序的骨移植材料的水泥。 在优选的实施方案中，所述材料是高生物相容性的，骨诱导性的和生物可再吸收的。 在水泥前体体系中可以使用许多不同但不相互排斥的水泥化学物质。 例如，可以使用水凝胶形成聚合物水泥，羧基/钙水泥或磷酸钙水泥。

公开(公告)号：WO2006130167A1

公开(公告)日：2006-12-07

申请号：PCT/US2005/033406

申请日：2005-09-16

Applicant: ADA FOUNDATION ,  CHOW, Laurence, C. ,  SUN, Limin

Inventor： CHOW, Laurence, C. ,  SUN, Limin

IPC: C01B25/16

CPC classification number: C01F11/22 ,  C01B25/322 ,  C01B25/455 ,  C01B33/24

Abstract: Nano-particles of calcium and phosphorous compounds are made in a highly pure generally amorphous state by spray drying a weak acid solution of said compound and evaporating the liquid from the atomized spray in a heated column followed by collection of the precipitated particles. Hydroxyapatite (HA) particles formed by such apparatus and methods are examples of particle manufacture useful in bone and dental therapies. Dual nozzle spraying techniques are utilized for generally insoluble compounds.

Abstract translation: 钙和磷化合物的纳米颗粒通过喷雾干燥所述化合物的弱酸溶液并在加热的柱子中蒸发来自雾化喷雾的液体然后收集沉淀的颗粒而以高纯度的通常非晶态制备。 通过这种装置和方法形成的羟基磷灰石（HA）颗粒是用于骨和牙科治疗的颗粒制造的实例。 双喷嘴喷涂技术用于一般不溶性的化合物。

公开(公告)号：WO2006127989A1

公开(公告)日：2006-11-30

申请号：PCT/US2006/020409

申请日：2006-05-25

Applicant: ADA FOUNDATION ,  XU, Huakun ,  SUN, Limin ,  TAKAGI, Shozo ,  CHOW, Lawrence, C.

Inventor： XU, Huakun ,  SUN, Limin ,  TAKAGI, Shozo ,  CHOW, Lawrence, C.

IPC: A61K6/08 ,  A61L27/14 ,  C08K3/04 ,  C08K3/34 ,  C08K3/32 ,  C08K3/40

CPC classification number: A61L27/54 ,  A61L27/44 ,  A61L2300/112 ,  A61L2300/624 ,  A61L2400/12

Abstract: Combining nanosized particles of a source of desired dental restorative, repair or therapeutic materials with strengthening agents in various generally nanosized form such as whiskers, fibers, particles and the like in a resin matrix provides a highly strain resistant composite which more effectively releases the therapeutic agents. The utilization of nano sized particles of the therapeutic agent in the combination enables observation of significantly improved therapeutic results.

Abstract translation: 将所需牙科修复剂，修复或治疗材料源的纳米尺寸颗粒与各种通常纳米尺寸形式的增强剂（例如晶须，纤维，颗粒等）在树脂基质中组合提供了高度耐应变的复合材料，其更有效地释放治疗剂 。 联合使用治疗剂的纳米尺寸颗粒可以观察到明显改善的治疗结果。

公开(公告)号：AU2011272740A1

公开(公告)日：2013-02-07

申请号：AU2011272740

申请日：2011-07-01

Applicant: ADA FOUNDATION

Inventor： CHOW LAURENCE C ,  TAKAGI SHOZO

IPC: C09K3/00

Abstract: This study reports in vitro and in vivo properties of fluorapatite (FA)-forming calcium phosphate cements (CPCs). Experimental cements contained from (0 to 3.1) mass % of F, corresponding to presence of FA at levels of approximately (0 to 87) mass %. The crystallinity of the apatitic cement product increased greatly with the FA content. When implanted subcutaneously in rats, the in vivo resorption rate decreased significantly with increasing FA content. The cement with the highest FA content was not resorbed in soft tissue, making it biocompatible and bioinert CPC. These bioinert CPCs are candidates for use in useful applications where slow or no resorption of the implant is required to achieve the desired clinical outcome.

公开(公告)号：DE69740186D1

公开(公告)日：2011-06-16

申请号：DE69740186

申请日：1997-08-19

Applicant: ADA FOUNDATION

Inventor： CHOW LAURENCE C ,  TAKAGI SHOZO ,  VOGEL GERALD L

IPC: A61K47/00 ,  A23G3/00 ,  A23G3/34 ,  A23G3/36 ,  A23G4/00 ,  A23G4/06 ,  A61K8/00 ,  A61K8/19 ,  A61K8/20 ,  A61K8/24 ,  A61K8/36 ,  A61K8/362 ,  A61K8/365 ,  A61K9/68 ,  A61K33/42 ,  A61P19/00 ,  A61Q11/00

公开(公告)号：AU2004315502A1

公开(公告)日：2005-08-18

申请号：AU2004315502

申请日：2004-11-29

Applicant: ADA FOUNDATION

Inventor： TAKAGI SHOZO ,  CHOW LAURENCE C

IPC: A61K6/00 ,  A61K6/838 ,  A61K6/898 ,  A61L24/02 ,  A61L27/12 ,  C04B28/34

Abstract: A bone or dental implant material in the form of a paste includes a mixture of calcium phosphate and/or calcium-containing powders and salt solutions with a cationic component other than calcium and an anionic component that forms strong calcium complexes in the solution, or is insoluble with calcium. The paste is stable, resistant to washout and will form hydroxyapatite and harden relatively rapidly to a cement.

公开(公告)号：WO2018063816A1

公开(公告)日：2018-04-05

申请号：PCT/US2017/051584

申请日：2017-09-14

Applicant: ADA FOUNDATION ,  SUN, Jirun ,  LEE, Young

Inventor： SUN, Jirun ,  LEE, Young

IPC: B33Y10/00 ,  B33Y30/00 ,  B33Y70/00 ,  B29C67/20 ,  B29C67/24 ,  C08J5/12

Abstract: A computer-controiied method for forming a composition-controlled product using 3D printing includes disposing two or more liquid reactant compositions in respective two or more reservoirs; and mixing the two or more liquid reactant compositions, which in turn includes controlling by the computer a mass ratio of the mixed two or more liquid reactant compositions. The computer-controlled method further inciudes scanning, under control of the computer, a mixed liquid reactants nozzle over a substrate; depositing the mixed liquid reactant compositions onto the substrate; and operating, under control of the computer, a light source to polymerize the deposited mixed liquid reactant compositions.

Abstract translation: 计算机控制的使用3D打印形成组合物控制产品的方法包括将两种或更多种液体反应物组合物设置在相应的两个或更多个储存器中; 以及混合两种或更多种液体反应物组合物，其又包括通过计算机控制混合的两种或更多种液体反应物组合物的质量比。 计算机控制的方法还包括在计算机的控制下，在衬底上扫描混合液体反应物喷嘴; 将混合液体反应物组合物沉积到基底上; 并在计算机控制下操作光源以聚合沉积的混合液体反应物组合物。

公开(公告)号：WO2016160299A1

公开(公告)日：2016-10-06

申请号：PCT/US2016/021686

申请日：2016-03-10

Applicant: ADA FOUNDATION

Inventor： SUN, Jirun ,  BOWEN, Rafael Lee

IPC: A61K6/083 ,  C08G61/02

CPC classification number: A61K6/083 ,  A61K6/0835 ,  C08L33/08

Abstract: A composition of matter includes one or more functionalized vinylbenzyl components of the formula covalently connected to one or more R functional components; the one or more R functional groups selected from a group including one or more hydroxyl methyl (-CHOH-) moieties and/or derivatives thereof, one or more ethoxy (-CH2-CH2-O-) moieties and/or derivatives thereof, and one or more benzene (C6H6) and/or derivatives thereof; and ether links that connect the functionalized vinylbenzyl components and the R functional components.

Abstract translation: 物质组合物包括共价连接到一个或多个R官能组分的一种或多种下式的官能化乙烯基苄基组分; 一个或多个选自包括一个或多个羟基甲基（-CHOH-）部分和/或其衍生物，一个或多个乙氧基（-CH 2 -CH 2 -O-）部分和/或其衍生物的基团的R官能团，以及 一种或多种苯（C 6 H 6）和/或其衍生物; 和连接官能化乙烯基苄基组分和R官能组分的醚连接。

公开(公告)号：WO2012094311A2

公开(公告)日：2012-07-12

申请号：PCT/US2012/020070

申请日：2012-01-03

Applicant: ADA FOUNDATION ,  SUN, Jirun ,  WU, Wien-li

Inventor： SUN, Jirun ,  WU, Wien-li

IPC: B82Y30/00

CPC classification number: C08F2/46 ,  A61K6/0023 ,  A61K6/0073 ,  A61K6/083 ,  B01J21/063 ,  B01J35/0013 ,  B01J35/004 ,  B01J35/023 ,  B82Y5/00 ,  B82Y30/00 ,  C01P2004/64 ,  C01P2006/22 ,  C08F2/44 ,  C09C1/3669 ,  Y10T428/2982 ,  C08L33/00

Abstract: A polymeric composition comprising modified-TiO 2 nanoparticles, with or without a solvent, and polymer precursors; wherein the modified-TiO 2 nanoparticles comprise titanium dioxide nanoparticles modified with a short-chain unsaturated compound comprising 2 to 10 carbon atoms. The polymeric composition may be used in dental compositions such as dental adhesives, dental composites, and dental sealants.

Abstract translation: 包含具有或不具有溶剂的改性TiO 2纳米颗粒和聚合物前体的聚合物组合物; 其中所述改性TiO 2纳米颗粒包含用包含2至10个碳原子的短链不饱和化合物改性的二氧化钛纳米颗粒。 该聚合物组合物可用于牙科组合物，例如牙科粘合剂，牙科复合材料和牙科密封剂。

公开(公告)号：WO2007047994A2

公开(公告)日：2007-04-26

申请号：PCT/US2006/041164

申请日：2006-10-19

Applicant: ADA FOUNDATION ,  CHOW, Laurence, C. ,  TAKAGI, Shozo

Inventor： CHOW, Laurence, C. ,  TAKAGI, Shozo

IPC: A61C5/00

CPC classification number: A61C5/50 ,  A61K6/0038 ,  A61K6/0067 ,  A61K6/0606 ,  A61K6/0612 ,  A61K6/0625 ,  A61K6/0643 ,  A61K6/097 ,  C08L31/04 ,  C08L1/284 ,  C08L5/04 ,  C08L29/04 ,  C08L33/08 ,  C08L5/08 ,  C08L5/06

Abstract: Disclosed are endodontic filling materials and methods. A method for filling a dental root canal may include providing a hydrosetting filling material and inserting the hydrosetting filling material into the dental root canal, the material setting in the root canal to form a biocompatible filling. The hydrosetting filling material comprises a hydrogel former and a filler. The hydrogel former is at least one of a reactive organic hydrogel formers, an inorganic hydrogel formers, and a non-reactive organic hydrogel formers, and the filler is at least one of a self-hardening and a non-hardening filler. Plural filling material precursor compositions that collectively contain hydrogel formers and fillers may be provided.

Abstract translation: 公开了牙髓填充材料和方法。 一种用于填充牙根管的方法可以包括提供一种水凝填充材料并且将该水凝填充材料插入到牙根管中，该材料设置在牙根管中以形成生物相容性填充物。 水凝固填充材料包含水凝胶形成剂和填充剂。 水凝胶形成剂是反应性有机水凝胶形成剂，无机水凝胶形成剂和非反应性有机水凝胶形成剂中的至少一种，并且填料是自硬化和非硬化填料中的至少一种。 可以提供共同包含水凝胶形成剂和填充剂的多种填充材料前体组合物。