公开(公告)号：AU5592094A

公开(公告)日：1995-05-23

申请号：AU5592094

申请日：1993-11-05

Applicant: BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY THE ,  SCICLONE PHARMACEUTICALS INC

Inventor： CHRETIEN PAUL B ,  MUTCHNICK MILTON G

IPC: A61K38/00 ,  A61K38/22 ,  A61P1/16 ,  A61P31/12 ,  A61K37/00

Abstract: A method and composition for treating a Hepatitis B patient having hepatic decompensation utilizes Hepatitis B virus-reducing amounts of T alpha 1, administered to a patient having decompensated liver disease so as to render the patient seronegative for Hepatitis B virus DNA.

公开(公告)号：AU6275994A

公开(公告)日：1994-09-26

申请号：AU6275994

申请日：1994-03-03

Applicant: BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY THE ,  SCICLONE PHARMACEUTICALS INC

Inventor： CHRETIEN PAUL B ,  MUTCHNICK MILTON

IPC: A61K38/00 ,  A61K38/22 ,  A61P31/12 ,  A61K37/24

Abstract: A method of treating Hepatitis C by administering an immune system-potentiating dose of at least one Thymosin or system-potentiating Thymosin fragment to a mammal infected with Hepatitis C virus, which Hepatitis C infection in the mammal is non-responsive to treatment with interferon alone.

公开(公告)号：AU2644792A

公开(公告)日：1993-04-27

申请号：AU2644792

申请日：1992-09-08

Applicant: BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY THE ,  SCICLONE PHARMACEUTICALS INC ,  UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY

Inventor： MILTON MUTCHNICK ,  PAUL CHRETIAN

IPC: A61K38/55 ,  A61K35/26 ,  A61K38/16 ,  A61K38/21 ,  A61K38/22 ,  A61P1/16 ,  A61P31/12 ,  A61P31/14 ,  A61P37/00

Abstract: Method comprises administering immune system-potentiating dose of at least one thymosin or an immune system-potentiating thymosin fragment. The thymosin is pref. Thymosin Fraction Five or Thymosin alpha-1.

公开(公告)号：DE352713T1

公开(公告)日：1990-07-26

申请号：DE89113627

申请日：1989-07-24

Applicant: THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY, DETROIT, MICH., US

Inventor： SCHAAP, ARTHUR PAUL, DETROIT MICHIGAN 48207, US

IPC: G01N33/532 ,  C07C37/00 ,  C07C37/62 ,  C07C39/38 ,  C07C51/15 ,  C07D207/46 ,  C07D311/82 ,  C07D311/86 ,  C07D311/90 ,  C07D321/00 ,  C07D405/12 ,  C07D407/12 ,  C07D417/12 ,  C07D493/10 ,  C07D495/04 ,  C07F7/18 ,  C07F9/12 ,  C07F9/655 ,  C07F9/6561 ,  C07H15/203 ,  C09K11/06 ,  C09K11/07 ,  C12Q1/34 ,  C12Q1/42 ,  C12Q1/44 ,  C12Q1/46 ,  C12Q1/58 ,  C12Q1/68 ,  G01N21/76 ,  G01N33/533 ,  G01N33/58

Abstract: A 1,2-dioxetane of the formulaand an alkene of the formulaare described. The 1,2-dioxetane is useful in immunoassays and in DNA probes used for various purposes.

公开(公告)号：DE221382T1

公开(公告)日：1987-10-15

申请号：DE86113897

申请日：1986-10-07

Applicant: THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY, DETROIT, MICH., US

Inventor： HONN, KENNETH V., GROSSE POINTE WOODS, MICHIGAN 48236, US ,  TAYLOR, JOHN D., DETROIT, MICHIGAN 48207, US ,  ONODA, JAMES M., NO. 203, ROYAL OAK, MICHIGAN 48067, US

IPC: A61K31/455 ,  A61K31/275 ,  A61K31/28 ,  A61K31/282 ,  A61K31/44 ,  A61K31/55 ,  A61K33/24 ,  A61P35/00 ,  C07D211/90

Abstract: The invention relates to compositions for the treatment of malignant tumors in a mammal which comprise: (a) a calcium channel blocker compound of the dihydropyridine class selected from the group consisting of wherein R1 and R2 are methyl groups, R3 and R4 are alkyl or alkyloxyalkylene groups containing l to 8 carbon atoms and R5 and R6 are hydrogen or one or two electron withdrawing substituents; and (b) a platinum coordination compound which has antitumor properties in humans wherein the weight ratio of the calcium channel blocker compound to the platinum coordination compound is between l and l000 and l0 to l. Furthermore, the invention relates to a method for the treatment of malignant tumors in vitro by administering the afore-mentioned compositions.

公开(公告)号：EP1165560A1

公开(公告)日：2002-01-02

申请号：EP00913872.8

申请日：2000-03-10

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY

Inventor： ZEMLICKA, Jiri ,  QIU, Yao-Ling ,  DRACH, John, C. ,  PTAK, Roger, G.

IPC: C07D473/16 ,  C07D473/18 ,  A61K31/52 ,  A61K31/522

CPC classification number: C07D239/47 ,  C07D239/54 ,  C07D473/00 ,  C07D473/16 ,  C07D473/18 ,  C07D473/34 ,  C07F9/65061 ,  C07F9/65616

Abstract: Compounds which are active against viruses have Formulas (1, 2, 3 and 4) wherein B is a purine or pyrimidine heterocyclic ring and is preferably selected from the group consisting of 6-aminopurine (adenine), 2,6-diaminopurine, 2-amino-6-azidopurine, 2-amino-6-cyclopropylaminopurine, 6-hydroxypurine (hypoxanthine), 2-amino-6-halo substituted purines, 2-amino-6-alkoxy substituted purines, 2-amino-6-hydroxypurine (guanine), 3-deazapurines, 7-deaza-purines, 8-azapurines, cytosine, 5-halo substituted cytosines, 5-alkyl substituted cytosines, thymine, uracil and 6-azapyrimidines; X is O; and, R1 and R2 are alkyl or aryl groups. The compounds of the present invention also include the R- and S-enantiomers of the above compounds. The R1X and/or R2X can also be amino acid residues with X as NH.

Abstract translation: 对病毒具有活性的化合物具有式（1,2,3和4），其中B是嘌呤或嘧啶杂环并且优选选自6-氨基嘌呤（腺嘌呤），2,6-二氨基嘌呤，2-氨基嘌呤， 氨基-6-叠氮基嘌呤，2-氨基-6-环丙基氨基嘌呤，6-羟基嘌呤（次黄嘌呤），2-氨基-6-卤代嘌呤，2-氨基-6-烷氧基取代的嘌呤，2-氨基-6-羟基嘌呤（鸟嘌呤 ），3-脱氮嘌呤，7-脱氮嘌呤，8-氮杂嘌呤，胞嘧啶，5-卤代取代的胞嘧啶，5-烷基取代的胞嘧啶，胸腺嘧啶，尿嘧啶和6-氮杂嘧啶; X是O; 并且，R1和R2是烷基或芳基。 本发明的化合物还包括上述化合物的R-和S-对映体。 R1X和/或R2X也可以是X为NH的氨基酸残基。

公开(公告)号：EP0603305B1

公开(公告)日：1997-05-14

申请号：EP92919977.6

申请日：1992-09-08

Applicant: ALPHA 1 BIOMEDICALS, INC. ,  THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY ,  THE UNITED STATES OF AMERICA as represented by the Secretary of the Army

Inventor： MUTCHNICK, Milton ,  CHRETIAN, Paul ,  SHERMAN, Kenneth E.

IPC: A61K38/16

CPC classification number: A61K38/2292 ,  Y10S514/885 ,  Y10S514/894

Abstract: Compositions and methods of use for treating hepatitis C virus-infected mammals are disclosed. The compositions include one or more thymosins alone or in combination with one or more interferons. Methods of treatment include use of thymosins alone, or together, or sequentially with interferon.

公开(公告)号：EP0757052A1

公开(公告)日：1997-02-05

申请号：EP96112386.6

申请日：1996-07-31

Applicant: BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY ,  LUMIGEN, INC.

Inventor： Akhavan-Tafti, Hashem ,  De Silva, Renuka ,  Schaap, Paul A.

IPC: C07F9/655 ,  G01N33/533 ,  C07D321/00 ,  C07F9/12 ,  C07C69/708

CPC classification number: G01N33/582 ,  C07C69/00 ,  C07C2603/00 ,  C07D321/00 ,  C07F9/12 ,  C07F9/65512 ,  G01N33/5308 ,  G01N33/54326

Abstract: Stable, enzymatically triggered chemiluminescent 1,2-dioxetanes with improved water solubility are provided. Dioxetanes further substituted with two or more water-solubilizing groups disposed on the dioxetane structure provide superior performance by eliminating the problem of reagent carryover when used in assays performed on capsule chemistry analytical systems. Compositions comprising a dioxetane with two or more water-solubilizing groups, a non-polymeric cationic surfactant enhancer and optionally a fluorescer, for providing enhanced chemiluminescence are also provided.

公开(公告)号：EP0254051B1

公开(公告)日：1994-08-31

申请号：EP87108978.5

申请日：1987-06-23

Applicant: THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY

Inventor： Schaap, Arthur P.

IPC: C07D321/00 ,  C07D493/10 ,  C07F7/18 ,  C07F9/12 ,  C09K11/00

CPC classification number: C07D405/12 ,  C07C37/00 ,  C07C37/055 ,  C07C37/62 ,  C07C51/15 ,  C07C2603/18 ,  C07C2603/74 ,  C07D207/46 ,  C07D311/82 ,  C07D321/00 ,  C07D407/10 ,  C07D407/12 ,  C07D417/12 ,  C07D493/10 ,  C07D495/04 ,  C07F7/1852 ,  C07F7/1856 ,  C07F9/6541 ,  C07F9/65512 ,  C07F9/65522 ,  C07F9/65586 ,  C07F9/6561 ,  C07H15/203 ,  C07C65/11 ,  C07C39/38 ,  C07C39/23

公开(公告)号：EP1325922B1

公开(公告)日：2005-08-03

申请号：EP03005154.4

申请日：1995-11-03

Applicant: Indiana University Research and Technology Corporation ,  PURDUE RESEARCH FOUNDATION ,  THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY

Inventor： Grieco, Paul A ,  Morre, D. James ,  Corbett, Thomas H. ,  Valeriote, Frederick A.

IPC: A61K31/35 ,  A61K31/365 ,  A01N43/16 ,  C07D493/10

CPC classification number: C07D493/10 ,  A01N43/90 ,  A01N65/08 ,  A61K31/366