公开(公告)号：JP2006232862A

公开(公告)日：2006-09-07

申请号：JP2006162539

申请日：2006-06-12

Applicant: Board Of Governors Of Wayne State Univ ,  Sciclone Pharmaceuticals Inc ,  ザ・ボード・オブ・ガバナーズ・オブ・ウェイン・ステイト・ユニバーシティThe Board of Governors of Wayne State University ,  サイクローン・ファーマシューティカルズ・インコーポレイテッドSciClone Pharmaceuticals,Inc.

Inventor： CHRETIEN PAUL B ,  MUTCHNICK MILTON G

IPC: A61K38/22 ,  A61K9/08 ,  A61P1/16 ,  A61P31/20

Abstract: PROBLEM TO BE SOLVED: To provide a medicinal composition for suiting a patient of decompensation hepatic failure to liver transplantation by treating the patient.
SOLUTION: The medicinal composition for suiting the patient of hepatitis B suffering from the decompensation hepatic failure and requiring the liver transplantation to the liver transplantation contains Tα
1 of a reduced amount of hepatitis B virus. At least two doses of the dose units of Tα
1 are administered per day to the patient of the hepatitis B suffering from the decompensation hepatic failure to make the serological reaction of the patient negative as the hepatitis B virus DNA, and the dose unit of Tα
1 is at least about 1.6 mg.
COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 待解决的问题：通过治疗患者，提供一种用于服用肝移植失代偿性肝衰竭患者的药物组合物。 解决方案：适用乙型肝炎失代偿肝脏肝移植肝移植患者的药物组合物含有减少乙型肝炎病毒的Tα 1 。 至少两剂量的Tα<1μg/天的剂量单位每日给予患有肝功能衰竭的乙型肝炎患者，以使患者的血清学反应为乙型肝炎病毒DNA阴性 ，并且Tα<1S 的剂量单位为至少约1.6mg。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：AU8960598A

公开(公告)日：1999-02-11

申请号：AU8960598

申请日：1998-10-29

Applicant: BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY THE ,  LUMIGEN INC

Inventor： AKHAVAN-TAFTI HASHEM ,  DESILVA RENUKA ,  SCHAAP A PAUL

IPC: C07D321/00 ,  F21K2/06

公开(公告)号：AU6081796A

公开(公告)日：1997-02-06

申请号：AU6081796

申请日：1996-07-30

Applicant: BAYER CORP ,  BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY THE

Inventor： ADOLFSEN ROBERT H ,  AKHAVAN-TAFTI HASHEM ,  DE SILVA RENUKA ,  SCHAAP PAUL A

IPC: G01N21/78 ,  C07D321/00 ,  C07F9/54 ,  C09K11/06 ,  C09K11/07 ,  C12Q1/42 ,  G01N33/53 ,  G01N33/58 ,  G01N21/76 ,  G01N33/533

Abstract: Improved assay methods utilizing stable, enzymatically triggered chemiluminescent 1,2-dioxetanes with improved water solubility are provided. Assays are performed by a capsule chemistry analytical assay method wherein fluid capsules comprising discrete aqueous segments containing either a chemiluminescent dioxetane reagent or an activating agent separated by an oil-based isolating fluid are flowed through a conduit, and subsequently reacted to produce light. The improvement comprises using a dioxetane substituted with two or more water-solubilizing groups disposed on the dioxetane structure to provide the chemiluminescence. Compositions comprising such a dioxetane, a non-polymeric surfactant enhancer and optionally a fluorescer, provide enhanced chemiluminescence and eliminate the problem of reagent carryover when used in assays performed on capsule chemistry analytical systems.

公开(公告)号：AU3677097A

公开(公告)日：1998-01-22

申请号：AU3677097

申请日：1997-09-02

Applicant: BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY THE ,  LUMIGEN INC

IPC: C07D321/00 ,  C09K11/07

公开(公告)号：ES2038092T1

公开(公告)日：1993-07-16

申请号：ES91113601

申请日：1991-08-13

Applicant: THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY

Inventor： SCHAAP, ARTHUR PAUL ,  ROMANO, LOUISE J. ,  GOUDAR, JAIDEV S.

IPC: C07D207/404 ,  C07D207/46 ,  C07D321/00 ,  C07D405/12 ,  C07D407/12 ,  C07D495/04 ,  C07F7/18 ,  C09K11/07 ,  G01N33/533 ,  C07D311/82 ,  C07C217/10 ,  C07C59/66

Abstract: Dioxetanes which couple with organic and biological molecules of the formula: wherein X is a leaving group which is removed by an activating agent to produce light, wherein A is a coupling substituent, Ar is a substituent selected from the group consisting of phenyl and naphthyl to provide a label are described. R1 is an optional linker substituent and can have between 1 and 30 carbon atoms with some of the carbon atoms being oxygen, sulfur, nitrogen or phosphorus. Ar as phenyl is preferred. The dioxetane coupled molecules are useful in assays of all types where luminescence can be used as an indicator.

公开(公告)号：DE254051T1

公开(公告)日：1988-08-11

申请号：DE87108978

申请日：1987-06-23

Applicant: THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY, DETROIT, MICH., US

Inventor： SCHAAP, ARTHUR P., DETROIT MICHIGAN 48207, US

IPC: G01N21/78 ,  C07C37/00 ,  C07C37/62 ,  C07C39/19 ,  C07C39/23 ,  C07C39/38 ,  C07C43/178 ,  C07C51/15 ,  C07C69/14 ,  C07C69/24 ,  C07C69/76 ,  C07C305/04 ,  C07D207/46 ,  C07D311/82 ,  C07D311/86 ,  C07D321/00 ,  C07D405/12 ,  C07D407/10 ,  C07D407/12 ,  C07D417/12 ,  C07D493/10 ,  C07D495/04 ,  C07F7/18 ,  C07F9/12 ,  C07F9/6541 ,  C07F9/655 ,  C07F9/6558 ,  C07F9/6561 ,  C07H15/203 ,  C09K11/07 ,  C09K11/00

Abstract: An alkene compound of the formula wherein R1 is selected from an alkyl, alkoxy, aryloxy, and aryl group or R1 and R2 together form a condensed polycyclic aryl group bonded to the carbon atom through a spiro linkage, R2 is an aryl group and is substituted with an X-oxy group wherein X is a group removable by an activating agent selected from bases, enzymes and electron donors, and R3 and R4 are combined together to form a polycyclic carbon containing organic group which is spirofused to the carbon atom.

公开(公告)号：DE123850T1

公开(公告)日：1985-02-14

申请号：DE84102861

申请日：1984-03-15

Applicant: THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY, DETROIT, MICH., US

Inventor： TAYLOR, JOHN D., DETROIT MICHIGAN 48207, US ,  HONN, KENNETH V., MICHIGAN 48236, US

IPC: A61K31/135 ,  A61K31/275 ,  A61K31/44 ,  A61K31/455 ,  A61K31/495 ,  A61K31/55 ,  A61P35/00 ,  C07D211/90 ,  A61K31/445

公开(公告)号：ES2040682T1

公开(公告)日：1993-11-01

申请号：ES89123690

申请日：1989-12-21

Applicant: THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY

Inventor： SCHAAP, ARTHUR PAUL ,  AKHAVEN-TAFTI, HASHEM

IPC: G01N21/78 ,  C07C37/00 ,  C07C37/62 ,  C07C39/19 ,  C07C39/38 ,  C07C43/178 ,  C07C51/15 ,  C07C69/14 ,  C07C69/24 ,  C07C69/76 ,  C07C305/04 ,  C07D207/46 ,  C07D277/68 ,  C07D311/80 ,  C07D311/82 ,  C07D311/86 ,  C07D321/00 ,  C07D405/12 ,  C07D407/10 ,  C07D407/12 ,  C07D417/12 ,  C07D493/10 ,  C07D495/04 ,  C07F7/18 ,  C07F9/12 ,  C07F9/6541 ,  C07F9/655 ,  C07F9/6558 ,  C07F9/6561 ,  C07H15/203 ,  C07H15/26 ,  C09K11/07 ,  C12Q1/44 ,  G01N31/22 ,  C07D277/64

Abstract: Triggerable dioxetanes with a fluorescent molecule containing group bonded or tethered in the dioxetane so as to produce fluorescence from the group are described. The compounds are useful in immunoassays and in probes using enzymes or other chemicals for triggering the dioxetanes to produce light from the fluorescent molecule in the group as a signal.

公开(公告)号：AU640514B2

公开(公告)日：1993-08-26

申请号：AU8279391

申请日：1991-08-28

Applicant: BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY

Inventor： ARTHUR PAUL SCHAAP ,  LOUIS J. ROMANO ,  JAIDEV S. GOUDAR

IPC: C07D207/404 ,  C07D207/46 ,  C07D321/00 ,  C07D405/12 ,  C07D407/12 ,  C07D495/04 ,  C07F7/18 ,  C09K11/07 ,  G01N33/533

Abstract: Dioxetanes which couple with organic and biological molecules of the formula: wherein X is a leaving group which is removed by an activating agent to produce light, wherein A is a coupling substituent, Ar is a substituent selected from the group consisting of phenyl and naphthyl to provide a label are described. R1 is an optional linker substituent and can have between 1 and 30 carbon atoms with some of the carbon atoms being oxygen, sulfur, nitrogen or phosphorus. Ar as phenyl is preferred. The dioxetane coupled molecules are useful in assays of all types where luminescence can be used as an indicator.

公开(公告)号：DE518387T1

公开(公告)日：1993-04-29

申请号：DE92114339

申请日：1989-07-24

Applicant: THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY, DETROIT, MICH., US

Inventor： SCHAAP, ARTHUR PAUL, DETROIT, MICHIGAN 48207, US

IPC: G01N33/532 ,  C07C37/00 ,  C07C37/62 ,  C07C39/38 ,  C07C51/15 ,  C07D207/46 ,  C07D311/82 ,  C07D311/86 ,  C07D311/90 ,  C07D321/00 ,  C07D405/12 ,  C07D407/12 ,  C07D417/12 ,  C07D493/10 ,  C07D495/04 ,  C07F7/18 ,  C07F9/12 ,  C07F9/655 ,  C07F9/6561 ,  C07H15/203 ,  C09K11/06 ,  C09K11/07 ,  C12Q1/34 ,  C12Q1/42 ,  C12Q1/44 ,  C12Q1/46 ,  C12Q1/58 ,  C12Q1/68 ,  G01N21/76 ,  G01N33/533 ,  G01N33/58

Abstract: A 1,2-dioxetane of the formulaand an alkene of the formulaare described. The 1,2-dioxetane is useful in immunoassays and in DNA probes used for various purposes.