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公开(公告)号：US10117878B2
公开(公告)日：2018-11-06
申请号：US13673696
申请日：2012-11-09
Applicant: Board of Regents, University of Texas System
Inventor： David J. Mangelsdorf , Richard J. Auchus , Daniel L. Motola , Carolyn L. Cummins , Kamalesh K. Sharma
IPC: C07J9/00 , A61K31/575
Abstract: An effective anti-nematode methodology entails contacting nematodes with a biologically effective amount of at least one compound according to formula I: where Q, Q′, R1, R2, and n are defined herein, or with a stereoisomer, solvate, or pharmaceutically acceptable salt of such compound.
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公开(公告)号：US20130137667A1
公开(公告)日：2013-05-30
申请号：US13673696
申请日：2012-11-09
Applicant: Board of Regents, University of Texas System
Inventor： DAVID J. MANGELSDORF , Richard J. Auchus , Daniel L. Motola , Carolyn L. Cummins , Kamalesh K. Sharma
IPC: A61K31/575
CPC classification number: A61K31/575 , C07J9/00 , C07J9/005 , Y02P20/582
Abstract: An effective anti-nematode methodology entails contacting nematodes with a biologically effective amount of at least one compound according to formula I: where Q, Q′, R1, R2, and n are defined herein, or with a stereoisomer, solvate, or pharmaceutically acceptable salt of such compound.
Abstract translation: 有效的抗线虫方法需要使线虫与生物有效量的至少一种根据式I的化合物接触：其中Q，Q'，R 1，R 2和n在本文中定义，或与立体异构体，溶剂化物或药学上可接受的 这种化合物的盐。
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公开(公告)号：US20040258556A1
公开(公告)日：2004-12-23
申请号：US10678655
申请日：2003-10-02
Inventor： Choong-Un Kim , Jae-Yong Park , Rajendra R. Kabade , Ted Carper , Steven Dunford , Viswanadham Puligandla
IPC: C22C013/00
CPC classification number: C22C13/00 , B23K35/007 , B23K35/262 , B23K2103/12 , H05K3/3463
Abstract: According to one aspect of the invention, a modified SnnullAgnullCu, lead-free solder alloy is disclosed. The alloy comprises an additive element selected from the group consisting of Au, Ni, Pd, Fe, Co, Zn, Cr and combinations thereof, present in the alloy in an amount effect to form an intermetallic interface between the alloy a substrate, the intermetallic interface having a composite structure without scallop formation and including Sn islands.
Abstract translation: 根据本发明的一个方面，公开了一种改性Sn-Ag-Cu，无铅焊料合金。 该合金包括选自Au，Ni，Pd，Fe，Co，Zn，Cr及其组合的添加元素，其合金中存在的量用于在基体，金属间化合物之间形成金属间界面 界面具有没有扇贝形成并且包括Sn岛的复合结构。
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公开(公告)号：US20040229355A1
公开(公告)日：2004-11-18
申请号：US10437627
申请日：2003-05-14
Applicant: Board of Regents University of Texas System
Inventor： Ming Chen , Iwona Stroynowski
IPC: C12N005/08 , C12N005/02
CPC classification number: C12N5/067 , C12N2500/25 , C12N2500/38 , C12N2501/11 , C12N2501/39
Abstract: A culture medium, which is capable of sustaining long-term cultures of hepatocytes and liver cells. In this medium, mammalian primary hepatocytes retain highly replicative capacity and hepatic gene expression activity. The liver cells from genetically defined sources may be reproducibly immortalized without the delivery of foreign genes, such as viral oncogenes. The immortalized hepatocytes are non-tumorigenic, making them suitable for clinical and therapeutic purposes.
Abstract translation: 一种能够维持肝细胞和肝细胞长期培养的培养基。 在该培养基中，哺乳动物原代肝细胞具有高度复制能力和肝基因表达活性。 来自遗传定义的来源的肝细胞可以可再现地永生化，而不会输送外源基因，如病毒癌基因。 永生化肝细胞是非致瘤性的，使其适合临床和治疗目的。
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公开(公告)号：US20230167154A1
公开(公告)日：2023-06-01
申请号：US17582368
申请日：2022-01-24
Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. , INTEZYNE TECHNOLOGIES INC. , ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM
Inventor： ROBERT J. GILLIES , DAVID L. MORSE , NATALIE M. BARKEY , KEVIN N. SILL , JOSEF VAGNER , NARGES K. TAFRESHI , JONATHAN L. SESSLER , CHRISTIAN PREIHS , VICTOR J. HRUBY
IPC: C07K5/117 , A61K49/10 , C07K14/72 , A61K47/64 , A61K47/69 , C07K14/68 , A61K49/00 , A61K49/18 , C07K7/08
CPC classification number: C07K5/1024 , A61K49/101 , C07K14/723 , A61K47/64 , A61K47/6907 , C07K14/68 , A61K49/0056 , A61K49/1809 , C07K7/08 , A61K38/34
Abstract: The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.
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Patent Agency Ranking
公开(公告)号：US20210016266A1
公开(公告)日：2021-01-21
申请号：US17022304
申请日：2020-09-16
Inventor： Purnendu K. DASGUPTA , Weixiong HUANG , Christopher A. POHL
IPC: B01J39/26 , G01N30/60 , B01J20/32 , B01J20/286 , B01D15/36 , B01D15/20 , B01D15/22 , B01J41/20 , B01J47/02
Abstract: Open tubular capillary columns for liquid and ion chromatography, based upon an ionically impermeable polyolefin capillary having a bore with a sulfonate-group- or amine-group-functionalized internal surface. The capillary columns may include a coating of ion exchanging nanoparticles electrostatically bound to the functionalized internal surface. The capillary columns may be made by exposing the interior surface to a sulfonating reagent comprising chlorosulfonic acid (CISO3H), preferably from 85 wt % to 95 wt % chlorosulfonic acid at a process temperature of 20 to 25° C. The interior surface may be subsequently exposed to an asymmetrical diamine to form a sulfonic mid-linkage to the diamine, i.e., to form a sulfonamide-linked, amine-group-functionalized internal surface. The coating may be provided by subsequently exposing the interior surface to an aqueous suspension of ion exchanging nanoparticles to electrostatically bond the ion exchanging nanoparticles to the functionalized internal surface.
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公开(公告)号：US20200002376A1
公开(公告)日：2020-01-02
申请号：US16450382
申请日：2019-06-24
Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. , INTEZYNE TECHNOLOGIES INC. , ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM
Inventor： ROBERT J. GILLIES , DAVID L. MORSE , NATALIE M. BARKEY , KEVIN N. SILL , JOSEF VAGNER , NARGES K. TAFRESHI , JONATHAN L. SESSLER , CHRISTIAN PREIHS , VICTOR J. HRUBY
IPC: C07K5/117 , A61K49/10 , C07K14/72 , A61K47/64 , A61K47/69 , C07K14/68 , A61K49/00 , A61K49/18 , C07K7/08
Abstract: The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.
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公开(公告)号：US20190286820A1
公开(公告)日：2019-09-19
申请号：US15922747
申请日：2018-03-15
Inventor： Ho Sang YOON , Young IL JUNG , Mi Young LEE , Wonjun LEE , Nidhin ALEXANDER
Abstract: An apparatus and method for detecting a container rootkit are provided. The apparatus for detecting a container rootkit according to one example embodiment of the present disclosure includes a detection target acquirer configured to acquire, as a detection target, a copy of a kernel module program configured to be executed on a host computer system, wherein the host computer system is configured to run one or more containers; and a rootkit detector configured to detect whether a rootkit is present in the detection target based on whether the detection target contains program code for modifying operation of a pre-defined kernel function.
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公开(公告)号：US09481692B2
公开(公告)日：2016-11-01
申请号：US14645591
申请日：2015-03-12
Applicant: Board of Regents, University of Texas System
Inventor： Philip Jones , Maria Emilia DiFrancesco , Alessia Petrocchi , Christopher L. Carroll , Joe Marszalek , Barbara Czako , Ryan Johnson , Jay Theroff
IPC: C07D413/14 , A61K31/454 , C07D513/04 , C07D413/04 , C07D417/14 , C07D417/04 , A61K45/06 , A61K31/496 , C07D471/04 , A61K31/4245 , A61K31/437 , A61K31/4439 , A61K31/4545 , A61K31/519 , A61K31/5377 , A61K31/541 , C07D405/14
CPC classification number: C07D495/04 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D513/04
Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of HIF pathway activity for the treatment or prevention of cancer and other hypoxia-mediated diseases.
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30.发明申请公开(公告)号：US20150239876A1
公开(公告)日：2015-08-27
申请号：US14631454
申请日：2015-02-25
Applicant: Board of Regents, University of Texas System
Inventor： Philip Jones , Maria Emilia Di Francesco , Timothy McAfoos
IPC: C07D413/14
CPC classification number: A61K31/454 , A61K31/4245 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D413/14
Abstract: The present disclosure relates to salts of heterocyclic compounds and methods that inhibit HIF pathway activity. The compounds are designed to treat or prevent cancer and other hypoxia-mediated diseases.
Abstract translation: 本公开涉及杂环化合物的盐和抑制HIF通路活性的方法。 该化合物被设计用于治疗或预防癌症和其他缺氧介导的疾病。
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