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    POLYMER PROBE DOPED WITH CONDUCTIVE MATERIAL FOR MASS SPECTROMETRY
    22.
    发明申请
    POLYMER PROBE DOPED WITH CONDUCTIVE MATERIAL FOR MASS SPECTROMETRY 审中-公开

    公开(公告)号：WO2007061643A3

    公开(公告)日：2007-05-31

    申请号：PCT/US2006/043695

    申请日：2006-11-09

    Applicant: BIO-RAD LABORATORIES, INC. ,  BOSCHETTI, Egisto ,  LOMAS, Lee, O.

    Inventor： BOSCHETTI, Egisto ,  LOMAS, Lee, O.

    IPC: H01J49/40

    Abstract: A mass spectrometer probe is formed of a nonconductive polymer that is doped with conductive material. The probe may be used as, or as part of, a repeller plate in a parallel laser ion desorption/ionization time-of-flight mass spectrometer. Transparent locations on the probe enable a sample placed thereon to be visualized before or during mass spectrometry. The conductive nature of the probe maintains the consistency of the electromagnetic field applied to the sample. The probe also displays low outgassing and high mechanical and chemical stability, thereby enabling it to be used repetitively.

    POLYMER PROBE DOPED WITH CONDUCTIVE MATERIAL FOR MASS SPECTROMETRY
    23.
    发明申请
    POLYMER PROBE DOPED WITH CONDUCTIVE MATERIAL FOR MASS SPECTROMETRY 审中-公开
    聚合物探针与导电材料进行质谱分析

    公开(公告)号：WO2007061643A2

    公开(公告)日：2007-05-31

    申请号：PCT/US2006043695

    申请日：2006-11-09

    Applicant: BIO RAD LABORATORIES ,  BOSCHETTI EGISTO ,  LOMAS LEE O

    Inventor： BOSCHETTI EGISTO ,  LOMAS LEE O

    IPC: B01D59/44

    CPC classification number: H01J49/0418

    Abstract: A mass spectrometer probe is formed of a nonconductive polymer that is doped with conductive material. The probe may be used as, or as part of, a repeller plate in a parallel laser ion desorption/ionization time-of-flight mass spectrometer. Transparent locations on the probe enable a sample placed thereon to be visualized before or during mass spectrometry. The conductive nature of the probe maintains the consistency of the electromagnetic field applied to the sample. The probe also displays low outgassing and high mechanical and chemical stability, thereby enabling it to be used repetitively.

    Abstract translation: 质谱仪探针由掺杂有导电材料的非导电聚合物形成。 探针可以用作平行激光离子解吸/电离飞行时间质谱仪中的或作为排斥板的一部分。 在探针之前或期间，探针上的透明位置使其上放置的样品可视化。 探头的导电性质保持了施加到样品的电磁场的一致性。 该探头还显示出低的除气和高的机械和化学稳定性，从而使其能够重复使用。

    FLUIDICS DEVICE
    24.
    发明申请
    FLUIDICS DEVICE 审中-公开
    流体装置

    公开(公告)号：WO2006127056A3

    公开(公告)日：2007-01-18

    申请号：PCT/US2006001687

    申请日：2006-01-19

    Applicant: CIPHERGEN BIOSYSTEMS INC ,  LOMAS LEE ,  DING JIAN ,  BOSCHETTI EGISTO

    Inventor： LOMAS LEE ,  DING JIAN ,  BOSCHETTI EGISTO

    IPC: B01D15/08

    CPC classification number: G01N30/461 ,  B01D15/325 ,  B01D15/362 ,  B01D15/363 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/563 ,  B01L2200/026 ,  B01L2200/028 ,  B01L2300/0681 ,  B01L2300/0829 ,  B01L2300/087 ,  B01L2400/0487 ,  C07K1/34 ,  G01N27/44704 ,  G01N27/44795 ,  G01N30/466 ,  G01N30/468 ,  Y10T137/2224 ,  Y10T137/794 ,  Y10T137/86187 ,  Y10T436/255

    Abstract: The present invention contemplates various devices that are configured to separate a sample, which contains more than one unique species, into any desired number of sub-samples by passing the sample across a like number of separation media configured for a first separation protocol. Each of the sub-samples may be further separated by an additional separation protocol, thereby creating a plurality of mini-samples, each of which may be further separated and/or analyzed. The invention also contemplates using a simple method of using conduits to form a fluid path that passes through a plurality of separation media, each of which media is configured to isolate a particular sub-sample. After various sub-samples of the sample are isolated by the various separation media, the conduits may be removed, thereby enabling each of the isolated sub-samples to be further separated and/or analyzed independent of any other sub-sample.

    Abstract translation: 本发明考虑了通过将样品穿过配置用于第一分离方案的相似数量的分离介质，将被配置成将含有多于一种独特物种的样品分离成任何所需数量的子样品的各种装置。 每个子样品可以通过另外的分离方案进一步分离，从而产生多个微型样品，每个小样品可进一步分离和/或分析。 本发明还考虑使用简单的方法来使用导管来形成通过多个分离介质的流体路径，其中每个介质被配置为隔离特定的子样品。 在通过各种分离介质分离样品的各种亚样品之后，可以去除导管，从而使每个分离的子样品能够独立于任何其它亚样品进一步分离和/或分析。

    PHOTOCROSSLINKED HYDROGEL SURFACE COATINGS
    26.
    发明申请
    PHOTOCROSSLINKED HYDROGEL SURFACE COATINGS 审中-公开
    光交联水凝胶表面涂料

    公开(公告)号：WO2004076511A3

    公开(公告)日：2004-12-16

    申请号：PCT/US2004004847

    申请日：2004-02-20

    Applicant: CIPHERGEN BIOSYSTEMS INC ,  HUANG WENXI ,  AGROSKIN YURY ,  BOSCHETTI EGISTO

    Inventor： HUANG WENXI ,  AGROSKIN YURY ,  BOSCHETTI EGISTO

    IPC: A61L27/00 ,  C08F290/00 ,  C08G20060101 ,  C08J7/16 ,  G01N33/543

    CPC classification number: H01J49/0418 ,  A61L27/52

    Abstract: A hydrogel layer is applied to a substrate advantageously when the layer is formed in situ, using a polymeric or copolymeric precursor that includes, respectively, monomer subunits that have a photocrosslinkable functionality and monomer subunits that have a chemically selective functionality for binding a biomolecular analyte, such as a protein. A hydrogel-coated substrate thus obtained is particularly useful as a probe for mass spectroscopic analysis, including SELDI analysis. Hydrogel particles also can be used for SELDI analysis.

    Abstract translation: 使用聚合物或共聚物前体分别形成具有光可交联官能团的单体亚单位和具有化学选择性功能性用于结合生物分子分析物的单体亚单位，当层原位形成时，将水凝胶层有利地施加到基底上， 如蛋白质。 由此获得的水凝胶涂覆的基底特别可用作用于质谱分析的探针，包括SELDI分析。 水凝胶颗粒也可用于SELDI分析。

    METHOD FOR PURIFYING PROTEINS
    30.
    发明申请
    METHOD FOR PURIFYING PROTEINS 审中-公开
    净化蛋白质的方法

    公开(公告)号：WO2006102547A3

    公开(公告)日：2009-04-16

    申请号：PCT/US2006010656

    申请日：2006-03-22

    Applicant: BIO RAD LABORATORIES ,  BOSCHETTI EGISTO ,  LOMAS LEE

    Inventor： BOSCHETTI EGISTO ,  LOMAS LEE

    IPC: C12P21/06 ,  C07K1/08

    CPC classification number: C07K1/047 ,  C07K1/22

    Abstract: The present invention provides methods and kits for purifying a target protein group. The method comprises the steps of contacting a sample comprising at least 95% of the target protein group and at most 5% of contaminating proteins with a library of binding moieties having different binding moieties, binding the contaminating proteins and a minority of the target protein group to the library of binding moieties, separating the unbound target protein group from the proteins bound to the library of binding moieties and collecting the unbound target protein. The collected target protein is more pure than the target protein group in the sample.

    Abstract translation: 本发明提供了用于纯化靶蛋白质组的方法和试剂盒。 该方法包括以下步骤：将包含至少95％的目标蛋白质组和至多5％的污染蛋白质的样品与具有不同结合部分的结合部分的文库结合，将污染性蛋白质和少量靶蛋白质组 到结合部分的文库，将未结合的靶蛋白基团与结合到结合部分文库的蛋白质分离并收集未结合的靶蛋白质。 收集的目标蛋白质比样品中的目标蛋白质组更为纯净。

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