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公开(公告)号：DE69214942D1
公开(公告)日：1996-12-05
申请号：DE69214942
申请日：1992-03-12
Applicant: DADE CHEMISTRY SYSTEMS INC
Inventor： OBZANSKY DAVID , SIMONS DONALD , TSENG SUSAN
IPC: G01N33/53 , G01N33/543
Abstract: Immunoassays and DNA probe assays utilizing a non-immune, reversible binding displacement system are provided. In the assay, a releasable ligand, a binding partner for the releasable ligand, an analyte of interest, an analytically detectable (reporter) group, and at least one binding partner for the analyte, are first attached to an insoluble phase so as to form reporter-labeled complex bound to an insoluble phase, followed by the addition of a displacer ligand which displaces the releasable ligand along with some portion of the reporter-labeled complex, so that the released reporter is analytically detectable in a free liquid medium and can be related to the concentration of analyte in the sample.
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公开(公告)号：IE904383A1
公开(公告)日：1991-06-19
申请号：IE438390
申请日：1990-12-05
Applicant: DADE CHEMISTRY SYSTEMS INC
Inventor： LUNG KAKI RICK , FOK JOHN SHIU-KANG , CHANIN ALEX JOSEPH
Abstract: This invention relates to a method of determining the accuracy of a liquid dispenser. More particularly, this invention relates to a method of use of robotic equipment in the processing of microliter-plate based assays. The method permits the diagnostic instruments using absorbance type measurements and laboratory robots in the analysis of samples to verify the accuracy of the dispensing portion of the robot by comparing the absorbance due to a dispensed volume of reagent with that due to a known volume of the same reagent. This method finds particular use in the diagnostic instruments analyzing samples which contain viruses (or antibody to the virus) of infectious diseases. Typical of such infectious diseases are the human immunodeficiency virus Type -1(HIV-1).
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公开(公告)号：AT145075T
公开(公告)日：1996-11-15
申请号：AT89115957
申请日：1989-08-30
Applicant: DADE CHEMISTRY SYSTEMS INC
Inventor： HUBNER ROMEO JOSE
IPC: G01N27/447 , C12M1/34 , C12Q1/68 , C12Q1/683 , C12Q3/00 , G06F17/30 , G06F19/28 , G06Q50/00 , G06T1/00 , H04N7/18 , G01N27/26 , G06K9/62
Abstract: A method is described for establishing a hierarchial library of spectra representing the point-by-point characteristics of known samples. Vectors representing each spectrum are classified according to their similarity and dissimilarity. Vectors representing unknown samples are compared to known groups of vectors according to similarity until a near match is found.
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公开(公告)号：CA2088260A1
公开(公告)日：1992-02-08
申请号：CA2088260
申请日：1991-08-01
Applicant: DU PONT , DADE CHEMISTRY SYSTEMS INC
Inventor： HOCHBERG ALAN M
IPC: C12Q1/68
Abstract: 2088260 9202635 PCTABS00010 A method is disclosed for determining the sequence of DNA bases by using two electrophoretic lanes for each DNA sample to be sequenced. Each lane incorporates two dyes.
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公开(公告)号：DE69515565T2
公开(公告)日：2000-11-02
申请号：DE69515565
申请日：1995-07-11
Applicant: DADE CHEMISTRY SYSTEMS INC
Inventor： ELY KEITH ALDAN , BERNSTINE ROBERT ERIC , EVERS TIMOTHY PATRICK
Abstract: BACKGROUND OF THE INVENTION An analysis instrument includes a container support (12), a carrier (24) having a plurality of liquid receiving wells (24W), a gross probe (40) movable along a locus of action (42) and a fine probe (50), the fine probe (50) being movable along a locus of action (52). In addition, various analysis, treatment and/or handling devices are also disposed at predetermined operating positions arranged along the loci of action (42, 52). Both the gross probe 40 and the fine probe 50 are each independently movable along their respective loci of action 42, 52 among one or more various extracting position(s) and one or more various dispensing position(s) to which either the support (12) and/or the carrier (24) may be moved, and/or among various operating position(s).
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Patent Agency Ranking
公开(公告)号：DE69319693T2
公开(公告)日：1998-12-10
申请号：DE69319693
申请日：1993-09-09
Applicant: DADE CHEMISTRY SYSTEMS INC
Inventor： LOYD JOSEPH , SEARCH BARBARA A
IPC: C12N9/12 , C12N9/96 , C12Q1/50 , G01N33/573
Abstract: A formulation for stabilizing enzymatic activity and immunoreactivity of creatine kinase and creatine kinase isoenzymes comprising animal serum, creatine kinase and/or creatine kinase isoenzymes, an effective amount of a buffer having a pKa in the range of 6.2-7.6 to maintain pH of the formulation at 6.7+/-0.1, an effective amount of a non-thiol antioxidant to prevent oxidation of creatine kinase or creatine kinase isoenzyme thiol groups, an effective amount of a non-reducing polyol to stabilize immunoreactivity of creatine kinase or creatine kinase isoenzymes, and an effective amount of an antimicrobial to prevent microbial growth is provided.
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公开(公告)号：DE69316281T2
公开(公告)日：1998-07-30
申请号：DE69316281
申请日：1993-07-02
Applicant: DADE CHEMISTRY SYSTEMS INC
Inventor： PACE SALVATORE J , HAMERSLAG JAMES DAVID
IPC: G01N27/28 , G01N27/27 , G01N27/403 , G01N27/416
Abstract: A readily disposable ion selective electrode assembly, free of onboard reagents, for use in analyzers has a reference element and plural sensor elements linearly positioned in parallel on a substrate. An elastomeric flow channel member containing two parallel grooves creates flow channels on the substrate above the elements. The substrate holds the elastomer in compression and is retained by snaps injection molded into a housing. Electrical contacts and leakfree fluidic connections are provided by spring loaded connectors through the housing. Reference and sample fluids are drawn through the respective flow channels and come together to form a liquid junction downstream from the sensor elements. Bubbles, that might otherwise cause erroneous results, are detected.
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公开(公告)号：ES2104652T3
公开(公告)日：1997-10-16
申请号：ES91121232
申请日：1991-12-11
Applicant: DADE CHEMISTRY SYSTEMS INC
Inventor： WANG CHI-CHI , SALYERS MARSHALL L , MCKEEVER ROBERT THOMAS
Abstract: An automatic chemistry system having a wheel for mounting reaction vessels is provided with a programmable permanent magnet which is selectively positioned adjacent a reaction vessel to separate magnetizable particles in the vessel from the vessels liquid contents. This facilitates performing heterogeneous immunoassays.
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公开(公告)号：AT154136T
公开(公告)日：1997-06-15
申请号：AT91121232
申请日：1991-12-11
Applicant: DADE CHEMISTRY SYSTEMS INC
Inventor： WANG CHI-CHI , SALYERS MARSHALL L , MCKEEVER ROBERT THOMAS
Abstract: An automatic chemistry system having a wheel for mounting reaction vessels is provided with a programmable permanent magnet which is selectively positioned adjacent a reaction vessel to separate magnetizable particles in the vessel from the vessels liquid contents. This facilitates performing heterogeneous immunoassays.
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公开(公告)号：DE69515565D1
公开(公告)日：2000-04-20
申请号：DE69515565
申请日：1995-07-11
Applicant: DADE CHEMISTRY SYSTEMS INC
Inventor： ELY KEITH ALDAN , BERNSTINE ROBERT ERIC , EVERS TIMOTHY PATRICK
Abstract: BACKGROUND OF THE INVENTION An analysis instrument includes a container support (12), a carrier (24) having a plurality of liquid receiving wells (24W), a gross probe (40) movable along a locus of action (42) and a fine probe (50), the fine probe (50) being movable along a locus of action (52). In addition, various analysis, treatment and/or handling devices are also disposed at predetermined operating positions arranged along the loci of action (42, 52). Both the gross probe 40 and the fine probe 50 are each independently movable along their respective loci of action 42, 52 among one or more various extracting position(s) and one or more various dispensing position(s) to which either the support (12) and/or the carrier (24) may be moved, and/or among various operating position(s).
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