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    Disposable sterile fluid transfer device
    21.
    发明专利
    Disposable sterile fluid transfer device 有权
    可替代的无效流体传输装置

    公开(公告)号：JP2013234761A

    公开(公告)日：2013-11-21

    申请号：JP2013161276

    申请日：2013-08-02

    Applicant: Emd Millipore Corp ,  イー・エム・デイー・ミリポア・コーポレイシヨン

    Inventor： PROULX STEPHEN ,  ALMASIAN JOSEPH ,  RENGANATH NAREN ,  TINGLEY STEPHEN ,  MORRISSEY MARTIN

    IPC: B67D99/00 ,  F16K3/24 ,  A61M39/10 ,  A61M39/16 ,  A61M39/18 ,  A61M39/22 ,  F16K3/26 ,  F16K15/18 ,  F16K17/40 ,  F16K31/524 ,  F16K41/04 ,  F16L37/107

    CPC classification number: F16K5/00 ,  A61M39/10 ,  A61M39/16 ,  A61M39/18 ,  A61M39/22 ,  A61M2039/1027 ,  A61M2039/222 ,  F16K3/265 ,  F16K13/04 ,  F16K15/18 ,  F16L37/107

    Abstract: PROBLEM TO BE SOLVED: To provide a connector of a system in which a connection part is subjected to steam sterilization, the connector being disposable after used.SOLUTION: The present invention relates to a sterile transfer device. The device is comprised of a body having a bore formed through at least a portion of its interior. It is preferable that the bore is a center hole formed in the whole length of the body. A plunger is contained inside of the hole. The body has a first and a second end. The first end contains a surface designed to be attached to an upstream component. The second end is connected to a downstream component such as a filter, a pipeline, a sample bag and the like. The plunger has corresponding first and second ends. The first end of the plunger when it is in a closed position is in alignment with the surface of the body, which collectively forms a steamable surface and a sterile barrier against the environment to the rest of the interior of the body, the plunger and downstream components.

    Abstract translation: 要解决的问题：为了提供连接部件进行蒸汽灭菌的系统的连接器，连接器在使用后是一次性的。解决方案：本发明涉及无菌转移装置。 该装置包括具有通过其内部的至少一部分形成的孔的主体。 优选地，孔是形成在主体的整个长度上的中心孔。 孔内装有柱塞。 身体有第一和第二端。 第一端包含设计成连接到上游部件的表面。 第二端连接到诸如过滤器，管道，样品袋等的下游部件。 柱塞具有相应的第一和第二端。 当柱塞处于关闭位置时，柱塞的第一端与主体的表面对准，这些表面共同形成可蒸发的表面和抵抗环境的无菌屏障抵抗主体内部的其余部分，柱塞和下游 组件。

    Filter with memory, communication device and pressure sensor
    23.
    发明专利
    Filter with memory, communication device and pressure sensor 审中-公开
    带存储器的过滤器，通信设备和压力传感器

    公开(公告)号：JP2012101226A

    公开(公告)日：2012-05-31

    申请号：JP2012014179

    申请日：2012-01-26

    Applicant: Emd Millipore Corp ,  イーエムディー ミリポア コーポレイション

    Inventor： DILEO ANTHONY ,  HUBBARD JOHN DANA

    IPC: B01D24/00 ,  B01D29/00 ,  B01D46/42

    CPC classification number: B01D35/143 ,  B01D61/147 ,  B01D61/22 ,  B01D65/102 ,  B01D65/104 ,  B01D2201/291 ,  B01D2201/52 ,  B01D2201/56 ,  B01D2311/14 ,  B01D2313/44

    Abstract: PROBLEM TO BE SOLVED: To provide a method for accurately measuring the pressure and/or flow of a filter element at various points within a filter housing that solves disadvantages of the conventional system and method.SOLUTION: A pressure sensor 30 is installed in the filter element 10 and a wireless transmitter 40 is also located near the pressure sensor 30 or integrated with the pressure sensor. The wireless transmitter 40 can be encapsulated in a single integrated component together with the pressure sensor 30. Alternatively, the transmitter 40 and the sensor 30 can be separated, and in communication with each other via an electrical signal or the like. A wireless receiver 60 located outside the filter housing 20 is used to communicate with the wireless transmitter and an RFID reader or base station is used as the wireless receiver. The wireless transmitter 40 such as the RFID reader tag can be coupled with the pressure sensor 30.

    Abstract translation: 要解决的问题：提供一种用于在过滤器壳体内的各个点处精确地测量过滤元件的压力和/或流动的方法，其解决了常规系统和方法的缺点。 解决方案：压力传感器30安装在过滤元件10中，无线发射器40也位于压力传感器30附近或与压力传感器集成。 无线发射机40可以与压力传感器30一起封装在单个集成部件中。或者，发射机40和传感器30可以被分离，并且经由电信号等彼此通信。 位于过滤器壳体20外部的无线接收器60用于与无线发射器进行通信，RFID读取器或基站用作无线接收器。 诸如RFID读取器标签之类的无线发射器40可与压力传感器30耦合。版权所有：（C）2012，JPO＆INPIT

    ASEPTIC FILTER VENT VALVE AND PORT FOR INTEGRITY TESTING
    24.
    发明申请
    ASEPTIC FILTER VENT VALVE AND PORT FOR INTEGRITY TESTING 审中-公开
    ASEPTIC过滤阀和完整性测试端口

    公开(公告)号：WO2016109230A2

    公开(公告)日：2016-07-07

    申请号：PCT/US2015066348

    申请日：2015-12-17

    Applicant: EMD MILLIPORE CORP

    Inventor： HUNT STEPHEN G ,  LANDRY NICHOLAS ,  SZYK MARTIN

    IPC: G01N11/10

    CPC classification number: B01D65/022 ,  B01D65/104 ,  B01D2273/18 ,  B01D2313/58

    Abstract: The present disclosure relates to a filter capsule that supports direct integrity testing of an internal filter element. The filter capsule includes a filter housing having an inlet port, an outlet port, a passage running longitudinally between the inlet port and outlet port and holding a filter element, and an aseptic vent assembly. The filter housing also includes an integrity test assembly that can be used as a direct connection for integrity testing hardware, as opposed to upstream of the filter capsule. In one embodiment, the integrity test assembly comprises a body having a bore formed through its interior and a movable plunger within the bore. The plunger includes a handle to move the plunger between a closed position and an open position. Various seals between the plunger and the bore form a fluid tight seal between various portions of the plunger and the bore.

    Abstract translation: 本公开涉及一种支持内部过滤元件的直接完整性测试的过滤器囊。 过滤器囊包括过滤器壳体，其具有入口端口，出口端口，在入口端口和出口端口之间纵向延伸并且保持过滤器元件的通道和无菌通气口组件。 过滤器壳体还包括完整性测试组件，其可以用作完整性测试硬件的直接连接，而不是过滤器胶囊的上游。 在一个实施例中，完整性测试组件包括具有通过其内部形成的孔的主体和孔内的活动柱塞。 柱塞包括用于在关闭位置和打开位置之间移动柱塞的手柄。 柱塞和孔之间的各种密封件在柱塞和孔的各个部分之间形成流体密封。

    METHOD AND APPARATUS FOR FILTERING A LIQUID SAMPLE
    26.
    发明申请
    METHOD AND APPARATUS FOR FILTERING A LIQUID SAMPLE 审中-公开
    用于过滤液体样品的方法和装置

    公开(公告)号：WO2013106081A3

    公开(公告)日：2013-10-10

    申请号：PCT/US2012041568

    申请日：2012-06-08

    Applicant: EMD MILLIPORE CORP ,  OLIVIER STEPHANE ,  METZ DIDIER

    Inventor： OLIVIER STEPHANE ,  METZ DIDIER

    IPC: G01N1/28 ,  B01D29/01 ,  G01N35/10

    CPC classification number: B01D27/04 ,  G01N1/4077 ,  G01N2001/4088

    Abstract: The invention relates to the filtering of liquid samples, preferably in a laboratory environment, for example for collecting micro organisms from the liquid sample for subsequent testing. The invention provides a method for filtering a liquid sample which comprises providing a blank of a deformable sheet material and a filtration medium, deforming the blank to form a funnel extending above and about the filtration medium, introducing the liquid sample to be filtered into the so formed funnel, and filtering the liquid sample from the funnel through the filtration medium, for example to a downstream receptacle. The method is accordingly based on the concept that the funnel is not or at least not completely preformed but provided in a form of a blank of a deformable material sheet which is deformed so as to form the funnel at the point and time of use during filtration.

    Abstract translation: 本发明涉及液体样品的过滤，优选在实验室环境中，例如用于从液体样品中收集微生物用于随后的测试。 本发明提供了一种用于过滤液体样品的方法，该方法包括提供可变形片材料和过滤介质的坯件，使坯料变形以形成在过滤介质上方和周围延伸的漏斗，将待过滤的液体样品引入 并且将来自漏斗的液体样品通过过滤介质过滤，例如到下游容器。 因此，该方法基于以下概念：漏斗不是或至少不完全预成型，而是以可变形材料片的坯料的形式提供，该可变形材料片在过滤期间在使用的时间点变形以形成漏斗 。

    NANOFIBER CONTAINING COMPOSITE STRUCTURES
    27.
    发明申请
    NANOFIBER CONTAINING COMPOSITE STRUCTURES 审中-公开
    含有纳米纤维的复合结构

    公开(公告)号：WO2012135679A3

    公开(公告)日：2013-03-14

    申请号：PCT/US2012031549

    申请日：2012-03-30

    Applicant: EMD MILLIPORE CORP ,  KAS ONUR Y ,  KOZLOV MIKHAL ,  TKACIK GABRIEL ,  NHIEM DAVID ,  LEON SHERRY ASHBY

    Inventor： KAS ONUR Y ,  KOZLOV MIKHAL ,  TKACIK GABRIEL ,  NHIEM DAVID ,  LEON SHERRY ASHBY

    IPC: B01D69/12 ,  B01D69/00 ,  B01D69/10 ,  B01D71/06 ,  D01D5/00

    CPC classification number: B01D69/12 ,  B01D71/56 ,  B01D2323/39 ,  B01D2325/02 ,  D01D5/0084

    Abstract: A composite liquid filtration platform including a composite filtration medium featuring an electrospun polymeric nanofiber layer collected on a porous membrane. When in use, the porous membrane acts as a prefilter used upstream from the polymeric nanofiber layer to remove particles from a liquid stream flowing through the composite filtration structure. The nanofiber layer, positioned downstream from the porous membrane, is used as the retentive layer for critical filtration to provide biosafety assurance, and is responsible for capturing microorganisms like bacteria, mycoplasma or viruses. The composite liquid filtration platform provided herein exhibits permeability advantages over conventional porous membranes or nanofiber mats spun on coarse non-wovens.

    Abstract translation: 一种复合液体过滤平台，其包括复合过滤介质，其特征在于在多孔膜上收集的电纺聚合物纳米纤维层。 当使用时，多孔膜用作在聚合物纳米纤维层上游使用的预过滤器，以从流过复合过滤结构的液体流中除去颗粒。 位于多孔膜下游的纳米纤维层用作临界过滤的保留层，以提供生物安全保证，并负责捕获细菌，支原体或病毒等微生物。 本文提供的复合液体过滤平台相对于在粗糙无纺布上纺出的常规多孔膜或纳米纤维垫表现出渗透性优点。

    TUBING AND CONNECTOR AND METHOD MAKING THE SAME
    28.
    发明申请
    TUBING AND CONNECTOR AND METHOD MAKING THE SAME 审中-公开
    管和连接器及其制造方法

    公开(公告)号：WO2012150991A2

    公开(公告)日：2012-11-08

    申请号：PCT/US2012026858

    申请日：2012-02-28

    Applicant: EMD MILLIPORE CORP ,  MORRISSEY MARTIN ,  HARTNETT JEFF

    Inventor： MORRISSEY MARTIN ,  HARTNETT JEFF

    IPC: F16L47/02 ,  F16L47/26

    CPC classification number: B29C45/14467 ,  A61M39/12 ,  A61M2039/1083 ,  A61M2039/1088 ,  B29C45/14598 ,  B29L2031/24 ,  F16L33/34 ,  F16L47/32

    Abstract: The present invention is a device for fluid movement and method of making the same. The device has a core element comprised of a preformed barbed fitting having two or more barbed extensions. Each extension has a central bore connected to the central bores of the other extensions so as to provide fluid communications between them. A tube having a central bore is fitted over the barb of each extension. A molded housing is formed over the fitting and tubes to form the device.

    Abstract translation: 本发明是一种流体移动装置及其制造方法。 该装置具有由具有两个或更多个有倒钩的延伸部的预成型的倒钩配件构成的芯部元件。 每个延伸部具有连接到另一个延伸部的中心孔的中心孔，以便在它们之间提供流体连通。 具有中心孔的管装配在每个延伸部的倒钩上。 模制的壳体形成在配件和管上以形成装置。

    METHODS OF PRODUCING HIGH TITER, HIGH PURITY VIRUS STOCKS AND METHODS OF USE THEREOF
    30.
    发明申请
    METHODS OF PRODUCING HIGH TITER, HIGH PURITY VIRUS STOCKS AND METHODS OF USE THEREOF 审中-公开
    生产高价，高利润病毒库的方法及其使用方法

    公开(公告)号：WO2011130119A3

    公开(公告)日：2012-03-29

    申请号：PCT/US2011031747

    申请日：2011-04-08

    Applicant: EMD MILLIPORE CORP ,  ASHER DAMON R ,  KATZ AMANDA B ,  KHAN NAVID Z ,  MEHTA USHMA

    Inventor： ASHER DAMON R ,  KATZ AMANDA B ,  KHAN NAVID Z ,  MEHTA USHMA

    IPC: C12N7/02 ,  C12Q1/70

    CPC classification number: C12N7/00 ,  C12N2750/14351

    Abstract: The purity and titer of virus stocks used for virus clearance studies have a significant influence on study outcome, and impact how well the scale-down model represents the production-scale process. Impurities in virus stocks are particularly important in the testing of small virus retentive filters because these impurities may cause a filter to foul prematurely, leading to underestimation of the true throughput capability of the filter and consequent inappropriate sizing of the production scale unit. In addition, impurities can also affect the levels of virus clearance observed by altering the fouling mechanisms and subsequent fluid passage through the virus filter. Described herein are methods for making, producing and using high purity virus stocks having high titer.

    Abstract translation: 用于病毒清除研究的病毒库的纯度和滴度对研究结果有重要影响，并影响缩小模型代表生产规模过程的程度。 病毒库中的杂质在小型病毒保持性过滤器的检测中特别重要，因为这些杂质可能导致过滤器过早的过度污染，从而低估了过滤器的真实通过能力，从而导致了生产规模单元的不当尺寸化。 此外，杂质还可以通过改变结垢机制和随后的流体通过病毒过滤器而影响病毒清除的水平。 本文描述了制备，生产和使用具有高效价的高纯度病毒原种的方法。

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