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    COMPOSITIONS AND METHODS FOR TREATING RESPIRATORY DISORDERS
    23.
    发明专利
    COMPOSITIONS AND METHODS FOR TREATING RESPIRATORY DISORDERS 未知

    公开(公告)号：CA2644613A1

    公开(公告)日：2007-09-13

    申请号：CA2644613

    申请日：2007-03-07

    Applicant: ENDACEA INC

    Inventor： PARTRIDGE JOHN J ,  WILSON CONSTANCE N

    IPC: C07D473/04 ,  A61K31/52 ,  A61P11/00

    Abstract: Methods and compositions for treating and preventing respiratory disorders are provided. The methods of the invention comprise administering to a subject a therapeutically effective amount of a pharmaceutically acceptable salt of an A 1 adenosine receptor antagonist, particularly 1-hydroxy-2-naphthoic acid salts or 3-hydroxy-2-naphthoic acid salts, more particularly a 1-hydroxy-2-naphthoic acid salt of 3-[2-(4-aminophenyl)ethyl]-8-benzyl-7-{2-[ethyl-(2-hydroxyethyl)amino]ethyl}-1-propyl-3,7-dihydropurine-2,6-dione (i.e., an L-97-1 xinafoic acid salt). Hydrates of the A 1 adenosine receptor antagonist salts described herein are further provided. The invention further encompasses pharmaceutical compositions comprising a pharmaceutically acceptable salt of an A 1 adenosine receptor antagonist in a pharmaceutically acceptable carrier. The compositions of the invention find use in methods for treating and preventing respiratory disorders.

    A1 ADENOSINE RECEPTOR ANTAGONISTS
    24.
    发明专利
    A1 ADENOSINE RECEPTOR ANTAGONISTS 未知

    公开(公告)号：CA2528367A1

    公开(公告)日：2004-12-23

    申请号：CA2528367

    申请日：2004-06-07

    Applicant: ENDACEA INC

    Inventor： WILSON CONSTANCE N ,  PARTRIDGE JOHN J

    IPC: C07D473/06 ,  A61K20060101 ,  A61K31/522 ,  A61P3/04 ,  A61P3/10 ,  A61P9/04 ,  A61P11/06 ,  A61P13/12 ,  A61P25/16 ,  A61P25/24 ,  A61P25/28 ,  A61P29/00 ,  A61P37/08

    Abstract: This invention relates to compounds of formula (I): wherein R1 is a branched or straight chain C1-C8 alkyl; R2 is of the formula (II), wherein n is an integer ranging from 1 to 8; R5 is H or (CH2)pCH3, and R6 is H or (CH2)mOH, wherein p is an integer ranging from 1 to 7 and m is an integer ranging from 1 to 8; R3 is of the formula (III), wherein q is an integer ranging from 1 to 8; and R7 is selected from the group consisting of H, OH, NH2, (CH2)tOH, and R9COOH; wherein R9 is a straight or branched chain alkylene or alkenylene group having 1 to 8 carbon atoms, and t is an integer ranging from 1 to 8; R 4 is of the formula (IV), wherein r is an integer ranging from 1 to 8 and R8 i s selected from the group consisting of H, OH, (CH2)fNH2, (CH2)sOH, and R10COO H; wherein f is 0 or f and s are independently integers ranging from 1 to 8; an d, R10 is a C1-C8 straight or branched chain alkylene or alkenylene; and; salts , solvates, and hydrates thereof. The present invention further provides metho ds of preparing the compounds of formula (I) and their use as therapeutic agent s and diagnostic agents.

    METHODS OF USE AND KIT FOR MEASUREMENT OF LIPOPOLYSACCHARIDE WITH A TIME RESOLVED FLUORESCENCE BASED ASSAY
    28.
    发明申请
    METHODS OF USE AND KIT FOR MEASUREMENT OF LIPOPOLYSACCHARIDE WITH A TIME RESOLVED FLUORESCENCE BASED ASSAY 审中-公开
    用时间分辨荧光测定法测定脂多糖的使用方法和试剂盒

    公开(公告)号：WO2012037361A3

    公开(公告)日：2012-05-18

    申请号：PCT/US2011051779

    申请日：2011-09-15

    Applicant: ENDACEA INC ,  WILSON CONSTANCE NEELY

    Inventor： WILSON CONSTANCE NEELY

    IPC: G01N33/68 ,  G01N33/52 ,  G01N33/533 ,  G01N33/92

    CPC classification number: G01N33/92 ,  G01N33/56911 ,  G01N33/582 ,  G01N33/68

    Abstract: The present invention relates to the methods of use for measurement of lipopolysaccharide (LPS) and methods of use for diagnosis of sepsis and LPS-related conditions. Specifically the present invention relates to a time resolved fluorescence (TRF) based assay for the measurement of LPS and methods of use for the measurement of LPS to diagnose sepsis, Gram-negative bacterial infections, and LPS-related conditions.

    Abstract translation: 本发明涉及用于测量脂多糖（LPS）的方法和用于诊断败血症和LPS相关病症的方法。 具体而言，本发明涉及用于测量LPS的基于时间分辨荧光（TRF）的测定法和用于测量LPS以诊断脓毒症，革兰氏阴性细菌感染和LPS相关病症的方法。

    A1 ADENOSINE RECEPTOR ANTAGONISTS
    30.
    发明申请
    A1 ADENOSINE RECEPTOR ANTAGONISTS 审中-公开

    公开(公告)号：WO2009086077A3

    公开(公告)日：2009-07-09

    申请号：PCT/US2008/087638

    申请日：2008-12-19

    Applicant: ENDACEA, INC.

    Inventor： WILSON, Constance, N.

    IPC: C07D473/14 ,  C07D473/02

    Abstract: This invention relates to compounds of formula (I), Wherein R 1 - R 4 are defined in the Specification, their uses in the practice of medicine, their medicinal formulations, their use in medical diagnosis, and their preparation.

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