公开(公告)号：CA2533926C

公开(公告)日：2013-10-15

申请号：CA2533926

申请日：2004-07-30

Applicant: ENDACEA INC

Inventor： WILSON CONSTANCE NEELY ,  BORRON PAUL

IPC: A61K39/00 ,  A01N43/04 ,  A01N43/42 ,  A61K31/70 ,  A61K39/385 ,  A61K39/39 ,  A61K39/40 ,  A61K39/42 ,  A61K39/44 ,  A61K45/00 ,  A61K47/00 ,  C07H19/04 ,  C07H19/20 ,  C12N20060101 ,  C12N5/0784

Abstract: The present invention relates to methods of producing an antigenic response in which an antigen is contacted to an antigen-presenting cell, wherein the improvement comprises contacting the antigen-presenting cell with an A1 adenosine receptor activating agent in an amount sufficient to increase the antigenic response of the antigen-presenting cell to the antigen. The present invention further provides methods, compositions, combination therapies, imaging techniques, and diagnostic kits that may improve the diagnosis, prognosis, and/or survival of cancer patients, pathogen-infected patients, and infectious or non-infectious immune-deficient patients.

公开(公告)号：CA2533926A1

公开(公告)日：2005-03-24

申请号：CA2533926

申请日：2004-07-30

Applicant: ENDACEA INC

Inventor： BORRON PAUL ,  WILSON CONSTANCE NEELY

IPC: A61K39/00 ,  A01N43/04 ,  A01N43/42 ,  A61K31/70 ,  A61K39/385 ,  A61K39/39 ,  A61K39/40 ,  A61K39/42 ,  A61K39/44 ,  A61K45/00 ,  A61K47/00 ,  C07H19/04 ,  C07H19/20 ,  C12N20060101 ,  C12N5/0784

Abstract: The present invention relates to methods of producing an antigenic response in which an antigen is contacted to an antigen-presenting cell, wherein the improvement comprises contacting the antigen-presenting cell with an A1 adenosine receptor activating agent in an amount sufficient to increase the antigenic response of the antigen-presenting cell to the antigen. The presen t invention further provides methods, compositions, combination therapies, imaging techniques, and diagnostic kits that may improve the diagnosis, prognosis, and/or survival of cancer patients, pathogen-infected patients, a nd infectious or non-infectious immune-deficient patients.

公开(公告)号：CA2810725A1

公开(公告)日：2012-03-22

申请号：CA2810725

申请日：2011-09-15

Applicant: ENDACEA INC

Inventor： WILSON CONSTANCE NEELY

IPC: G01N33/68 ,  G01N33/52 ,  G01N33/533 ,  G01N33/92

Abstract: The present invention relates to the methods of use for measurement of lipopolysaccharide (LPS) and methods of use for diagnosis of sepsis and LPS-related conditions. Specifically the present invention relates to a time resolved fluorescence (TRF) based assay for the measurement of LPS and methods of use for the measurement of LPS to diagnose sepsis, Gram-negative bacterial infections, and LPS-related conditions.

公开(公告)号：CA2444487A1

公开(公告)日：2002-11-28

申请号：CA2444487

申请日：2002-05-17

Applicant: ENDACEA INC

Inventor： WILSON CONSTANCE NEELY

IPC: A61K31/52 ,  A61K31/522 ,  A61K39/395 ,  A61K45/06 ,  A61P31/18 ,  A61P37/02 ,  C07K16/28

Abstract: A1 adenosine receptor antagonists and P2X receptor antagonists are useful in the treatments of disorders of the immune system, which include HIV infectio n, AIDS, and adenosine deaminase deficiency-dependent severe immunodeficiency disease (ADA SCID).

公开(公告)号：AU2003268839A1

公开(公告)日：2004-01-22

申请号：AU2003268839

申请日：2003-12-15

Applicant: ENDACEA INC

Inventor： WILSON CONSTANCE NEELY

IPC: A61K39/395

公开(公告)号：CA2441801A1

公开(公告)日：2002-11-28

申请号：CA2441801

申请日：2002-05-23

Applicant: ENDACEA INC

Inventor： WILSON CONSTANCE NEELY

IPC: A61K9/127 ,  A61K45/00 ,  A61K45/06 ,  A61K47/26 ,  A61K47/48 ,  A61P1/04 ,  A61P1/12 ,  A61P1/16 ,  A61P3/10 ,  A61P7/10 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P11/06 ,  A61P11/08 ,  A61P13/02 ,  A61P13/12 ,  A61P25/04 ,  A61P25/08 ,  A61P25/20 ,  A61P25/28 ,  A61P27/06 ,  A61P29/00 ,  A61P31/04 ,  A61P31/18 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07K14/705 ,  G01N33/566 ,  A61K47/44 ,  A61K31/739 ,  A61K38/17 ,  A61K39/395 ,  G01N33/567

Abstract: Glycolipids are useful for enhancing the affinity of A1 adenosine receptor ligands for the A1 adenosine receptor. Glycolipids are accordingly useful in diagnostic and therapeutic methods that require the delivery or administrati on of A1 adenosine ligands.

公开(公告)号：WO2012037361A3

公开(公告)日：2012-05-18

申请号：PCT/US2011051779

申请日：2011-09-15

Applicant: ENDACEA INC ,  WILSON CONSTANCE NEELY

Inventor： WILSON CONSTANCE NEELY

IPC: G01N33/68 ,  G01N33/52 ,  G01N33/533 ,  G01N33/92

CPC classification number: G01N33/92 ,  G01N33/56911 ,  G01N33/582 ,  G01N33/68

Abstract: The present invention relates to the methods of use for measurement of lipopolysaccharide (LPS) and methods of use for diagnosis of sepsis and LPS-related conditions. Specifically the present invention relates to a time resolved fluorescence (TRF) based assay for the measurement of LPS and methods of use for the measurement of LPS to diagnose sepsis, Gram-negative bacterial infections, and LPS-related conditions.

Abstract translation: 本发明涉及用于测量脂多糖（LPS）的方法和用于诊断败血症和LPS相关病症的方法。 具体而言，本发明涉及用于测量LPS的基于时间分辨荧光（TRF）的测定法和用于测量LPS以诊断脓毒症，革兰氏阴性细菌感染和LPS相关病症的方法。

公开(公告)号：EP1390068A4

公开(公告)日：2006-04-05

申请号：EP02736991

申请日：2002-05-17

Applicant: ENDACEA INC

Inventor： WILSON CONSTANCE NEELY

IPC: A61K31/52 ,  A61K31/522 ,  A61K39/395 ,  A61K45/06 ,  A61P31/18 ,  A61P37/02 ,  C07K16/28

CPC classification number: C07K16/28 ,  A61K31/52 ,  A61K45/06 ,  A61K2039/505 ,  A61K2300/00

公开(公告)号：EP2616817A4

公开(公告)日：2014-04-09

申请号：EP11825945

申请日：2011-09-15

Applicant: ENDACEA INC

Inventor： WILSON CONSTANCE NEELY

IPC: G01N33/68 ,  G01N33/52 ,  G01N33/533 ,  G01N33/569 ,  G01N33/58 ,  G01N33/92

CPC classification number: G01N33/92 ,  G01N33/56911 ,  G01N33/582 ,  G01N33/68

公开(公告)号：EP1390740A4

公开(公告)日：2007-04-04

申请号：EP02739334

申请日：2002-05-23

Applicant: ENDACEA INC

Inventor： WILSON CONSTANCE NEELY

IPC: A61K9/127 ,  A61K45/00 ,  A61K45/06 ,  A61K47/26 ,  A61K47/48 ,  A61P1/04 ,  A61P1/12 ,  A61P1/16 ,  A61P3/10 ,  A61P7/10 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P11/06 ,  A61P11/08 ,  A61P13/02 ,  A61P13/12 ,  A61P25/04 ,  A61P25/08 ,  A61P25/20 ,  A61P25/28 ,  A61P27/06 ,  A61P29/00 ,  A61P31/04 ,  A61P31/18 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07K14/705 ,  G01N33/566 ,  G01N31/00 ,  C07H17/00

CPC classification number: G01N33/566 ,  A61K45/06