公开(公告)号：WO2006034473A2

公开(公告)日：2006-03-30

申请号：PCT/US2005/034243

申请日：2005-09-23

Applicant: REDDY US THERAPEUTICS, INC. ,  KALLEDA, Srinivas ,  PADAKANTI, Srinivas ,  KUMAR SWAMY, Nalivela ,  YELESWARAPU, Koteswar, Rao ,  ALEXANDER, Christopher, W. ,  KHANNA, Ish, Kumar ,  IQBAL, Javed ,  PILLARISETTI, Sivaram ,  PAL, Manojit ,  BARANGE, Deepak

Inventor： KALLEDA, Srinivas ,  PADAKANTI, Srinivas ,  KUMAR SWAMY, Nalivela ,  YELESWARAPU, Koteswar, Rao ,  ALEXANDER, Christopher, W. ,  KHANNA, Ish, Kumar ,  IQBAL, Javed ,  PILLARISETTI, Sivaram ,  PAL, Manojit ,  BARANGE, Deepak

IPC: A61K31/541 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/4545 ,  A61K31/4439 ,  A61K31/44 ,  C07D417/02 ,  C07D403/02 ,  C07D413/02 ,  C07D401/02

CPC classification number: C07D405/14 ,  C07D239/30 ,  C07D239/40 ,  C07D239/42 ,  C07D239/46 ,  C07D239/47 ,  C07D239/48 ,  C07D239/50 ,  C07D239/54 ,  C07D401/04 ,  C07D403/12 ,  C07D405/12

Abstract: The present invention provides new heterocyclic compounds, particularly substituted pyrimidines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.

Abstract translation: 本发明提供了新的杂环化合物，特别是取代的嘧啶，制备和使用这些杂环化合物的方法和组合物，以及治疗多种疾病和疾病状态的方法，包括动脉粥样硬化，关节炎，再狭窄， 糖尿病性肾病或血脂异常，或由基底膜蛋白低表达介导的疾病状态。

公开(公告)号：WO2004106329A3

公开(公告)日：2004-12-09

申请号：PCT/IB2004/001811

申请日：2004-06-03

Applicant: DR. REDDY'S LABORATORIES LTD. ,  MOHAMED, Takhi ,  DAS, Jagattaran ,  NATESAN, Selvakumar ,  TREHAN, Sanjay ,  IQBAL, Javed ,  MAGADI, Sitaram, Kumar

Inventor： MOHAMED, Takhi ,  DAS, Jagattaran ,  NATESAN, Selvakumar ,  TREHAN, Sanjay ,  IQBAL, Javed ,  MAGADI, Sitaram, Kumar

IPC: C07D405/14

Abstract: The present invention provides novel triazole compounds of formula (I), their pharmaceutically acceptable salts and their pharmaceutical compositions, where all symbols are as defined in the specification

公开(公告)号：WO2003053974A1

公开(公告)日：2003-07-03

申请号：PCT/IB2002/005442

申请日：2002-12-17

Applicant: DR. REDDY'S LABORATORIES LTD. ,  DAS, Saibal, Kumar ,  BHUNIYA, Debnath ,  MADHAVAN, Gurram, Ranga ,  IQBAL, Javed ,  CHAKRABARTI, Ranjan

Inventor： DAS, Saibal, Kumar ,  BHUNIYA, Debnath ,  MADHAVAN, Gurram, Ranga ,  IQBAL, Javed ,  CHAKRABARTI, Ranjan

IPC: C07D487/04

CPC classification number: C07D487/04 ,  C07C69/734 ,  C07C229/18 ,  C07C229/34 ,  C07C233/47 ,  C07C323/52

Abstract: The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel alkyl carboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.

Abstract translation: 本发明涉及新型抗糖尿病，降血脂症，抗肥胖症和低胆固醇血症化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和含有它们的药学上可接受的组合物。 更具体地，本发明涉及通式（I）的新型烷基羧酸，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和药学上可接受的组合物，其含有 他们。

公开(公告)号：WO2003006022A1

公开(公告)日：2003-01-23

申请号：PCT/US2002/021096

申请日：2002-07-08

Applicant: DR. REDDY'S LABORATORIES LTD. ,  CORD, Janet, I. ,  GURRAM, Ranga, Madhavan ,  IQBAL, Javed ,  CHAKRABARTI, Ranjan ,  RAMANUJAM, Rajagopalan

Inventor： GURRAM, Ranga, Madhavan ,  IQBAL, Javed ,  CHAKRABARTI, Ranjan ,  RAMANUJAM, Rajagopalan

IPC: A61K31/47

CPC classification number: C07D405/06 ,  A61K31/47 ,  C07D215/06

Abstract: The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel β-aryl-α-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.

Abstract translation: 本发明涉及新型抗糖尿病，降血脂症，抗肥胖症和低胆固醇血症化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和含有它们的药学上可接受的组合物。 更具体地说，本发明涉及通式（I）的新型β-芳基-α-氧基取代的烷基羧酸，其衍生物，它们的类似物，它们的互变异构形式，它们的立体异构体，它们的多晶型物，它们的药学上可接受的盐，它们的药学上可接受的 溶剂合物和含有它们的药学上可接受的组合物。

公开(公告)号：WO2006034474A3

公开(公告)日：2007-05-18

申请号：PCT/US2005034244

申请日：2005-09-23

Applicant: REDDY US THERAPEUTICS INC ,  ALEXANDER CHRISTOPHER W ,  KHANNA ISH KUMAR ,  IQBAL JAVED ,  PILLARISETTI SIVARAM ,  MAITRA SANTANU ,  ROBERTS GAYLA W ,  SAGI LAVANYA ,  PAL MANOJIT ,  KRISHNA CHINTAKUNTA VAMSEE ,  SREENU JENNEPALLI

Inventor： ALEXANDER CHRISTOPHER W ,  KHANNA ISH KUMAR ,  IQBAL JAVED ,  PILLARISETTI SIVARAM ,  MAITRA SANTANU ,  ROBERTS GAYLA W ,  SAGI LAVANYA ,  PAL MANOJIT ,  KRISHNA CHINTAKUNTA VAMSEE ,  SREENU JENNEPALLI

IPC: C07D213/02 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4433 ,  C07D401/02 ,  C07D419/02

CPC classification number: C07D405/14 ,  C07D239/30 ,  C07D239/40 ,  C07D239/42 ,  C07D239/46 ,  C07D239/47 ,  C07D239/48 ,  C07D239/50 ,  C07D239/54 ,  C07D401/04 ,  C07D403/12 ,  C07D405/12

Abstract: The present invention provides new heterocyclic compounds, particularly substituted pyridines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.

Abstract translation: 本发明提供新的杂环化合物，特别是取代的吡啶，制备和使用这些杂环化合物的方法和组合物，以及用于治疗各种疾病和疾病状态的方法，包括动脉粥样硬化，关节炎，再狭窄，糖尿病性肾病或血脂异常或疾病 由Perlecan低表达介导的状态。

公开(公告)号：WO2007005785A1

公开(公告)日：2007-01-11

申请号：PCT/US2006/025898

申请日：2006-06-30

Applicant: DR. REDDY'S LABORATORIES LTD. ,  DR. REDDY'S LABORATORIES, INC. ,  POTLURI, Vijay Kumar ,  DAS, Saibal Kumar ,  SASMAL, Pradip Kumar ,  IQBAL, Javed ,  MISRA, Parimal ,  CHAKRABARTI, Ranjan ,  TALWAR, Rashmi

Inventor： POTLURI, Vijay Kumar ,  DAS, Saibal Kumar ,  SASMAL, Pradip Kumar ,  IQBAL, Javed ,  MISRA, Parimal ,  CHAKRABARTI, Ranjan ,  TALWAR, Rashmi

IPC: C07D277/14 ,  C07D265/32 ,  A61K31/426 ,  A61K31/5377

CPC classification number: C07D277/42

Abstract: The present application provides novel thiazole derivatives that are useful as activators of Adenosine 5'-Monophosphate-Activated Protein Kinase and pharmaceutical compositions containing such compounds.

Abstract translation: 本申请提供了可用作腺苷5'-一磷酸 - 活化蛋白激酶的活化剂的新型噻唑衍生物和含有这些化合物的药物组合物。

公开(公告)号：WO2006073610A3

公开(公告)日：2007-01-04

申请号：PCT/US2005042736

申请日：2005-11-23

Applicant: REDDY US THERAPEUTICS INC ,  PAL MANOJIT ,  RAO YELESWARAPU KOTESWAR ,  KHANNA ISH KUMAR ,  SWAMY NALIVELA KUMARA ,  SUBRAMANIAN VENKATARAMAN ,  BATCHU VENKATESWARA RAO ,  IQBAL JAVED ,  PILLARISETTI SIVARAM

Inventor： PAL MANOJIT ,  RAO YELESWARAPU KOTESWAR ,  KHANNA ISH KUMAR ,  SWAMY NALIVELA KUMARA ,  SUBRAMANIAN VENKATARAMAN ,  BATCHU VENKATESWARA RAO ,  IQBAL JAVED ,  PILLARISETTI SIVARAM

IPC: C07D487/04 ,  A61K31/221 ,  A61K31/415 ,  A61K31/437 ,  A61K31/519 ,  A61K31/5365 ,  C07D205/02 ,  C07D231/04 ,  C07D231/10 ,  C07D471/04

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: The present invention provides, among other things, new bicyclo heterocyclic compounds, compositions comprising these heterocyclic compounds, methods of making the heterocyclic compounds, and methods of using these heterocyclic compounds for treating a variety of conditions and disease states associated with, for example, cellular proliferation, inflammation, glycosidase expression, or the low expression of Perlecan.

Abstract translation: 本发明尤其提供了新的双环杂环化合物，包含这些杂环化合物的组合物，制备杂环化合物的方法，以及使用这些杂环化合物治疗与例如细胞相关的多种病症和疾病状态的方法 增殖，炎症，糖苷酶表达或Perlecan的低表达。

公开(公告)号：WO2006042245A1

公开(公告)日：2006-04-20

申请号：PCT/US2005/036474

申请日：2005-10-11

Applicant: DR. REDDY'S LABORATORIES LTD. ,  DR. REDDY'S LABORATORIES, INC. ,  MADHAVAN, Gurram Ranga ,  IQBAL, Javed ,  BHUNIYA, Debnath ,  DAS, Saibal Kumar ,  SHARMA, Sudhir Kumar ,  CHAKRABARTI, Ranjan

Inventor： MADHAVAN, Gurram Ranga ,  IQBAL, Javed ,  BHUNIYA, Debnath ,  DAS, Saibal Kumar ,  SHARMA, Sudhir Kumar ,  CHAKRABARTI, Ranjan

IPC: C07D261/08

CPC classification number: C07D275/02 ,  C07D261/08 ,  C07D413/12

Abstract: The present invention relates to novel isoxazole compounds of formula (I) having (PPAR) agonist activity, pharmaceutical compositions containing such compounds and methods for their use.

Abstract translation: 本发明涉及具有（PPAR）激动剂活性的式（I）的异恶唑化合物，含有这些化合物的药物组合物及其用途。

公开(公告)号：WO2005082892A3

公开(公告)日：2006-03-23

申请号：PCT/IB2005000343

申请日：2005-02-11

Applicant: REDDYS LAB LTD DR ,  DAS JAGATTARAN ,  TAKHI MOHAMED ,  NATESAN SELVAKUMAR ,  TREHAN SANJAY ,  IQBAL JAVED ,  MAGADI SITARAM KUMAR ,  KANDEPU SREENIVAS

Inventor： DAS JAGATTARAN ,  TAKHI MOHAMED ,  NATESAN SELVAKUMAR ,  TREHAN SANJAY ,  IQBAL JAVED ,  MAGADI SITARAM KUMAR ,  KANDEPU SREENIVAS

IPC: C07D249/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/00 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12

CPC classification number: C07D403/06 ,  C07D249/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12

Abstract: The present invention relates to novel triazole compounds of formula (I), where all symbols are as defined in the detailed description; their pharmaceutically acceptable salts their stereosiomers thereof, their prodrugs, their rotamers, their pharmaceutical compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds.

Abstract translation: 本发明涉及新的式（I）三唑化合物，其中所有符号如详细描述中所定义; 其药学上可接受的盐，它们的立体异构体，它们的前药，它们的旋转异构体，它们含有它们的药物组合物。 本发明还涉及制备上述新化合物的方法。

公开(公告)号：WO2012146980A2

公开(公告)日：2012-11-01

申请号：PCT/IB2012/000922

申请日：2012-04-27

Applicant: DR. REDDY'S LABORATORIES LTD. ,  KATKAM, Srinivas ,  SAGYAM, Rajeswar, Reddy ,  MORTHALA, Raghavendar, Rao ,  IRENI, Babu ,  VINIGARI, Krishna ,  RAMDOSS, Suresh, Kumar ,  RANGINENI, Srinivasulu ,  TUMMALA, Arjunkumar ,  IQBAL, Javed ,  ORUGANTI, Srinivas ,  KANDAGATLA, Bhaskar

Inventor： KATKAM, Srinivas ,  SAGYAM, Rajeswar, Reddy ,  MORTHALA, Raghavendar, Rao ,  IRENI, Babu ,  VINIGARI, Krishna ,  RAMDOSS, Suresh, Kumar ,  RANGINENI, Srinivasulu ,  TUMMALA, Arjunkumar ,  IQBAL, Javed ,  ORUGANTI, Srinivas ,  KANDAGATLA, Bhaskar

CPC classification number: C07C205/45 ,  C07C201/10 ,  C07C201/12 ,  C07C213/00 ,  C07C213/02 ,  C07C213/10 ,  C07C215/28 ,  C07C205/04

Abstract: The present application provide processes for the preparation of fingolimod and its pharmaceutically acceptable salts, process for the purification of fingolimod hydrochloride and process for the preparation of amorphous fingolimod hydrochloride.

Abstract translation: 本申请提供了用于制备芬戈莫德及其药学上可接受的盐的方法，用于纯化芬戈莫德盐酸盐的方法以及用于制备无定形盐酸芬戈莫德的方法。