公开(公告)号：EP1678157A2

公开(公告)日：2006-07-12

申请号：EP04817481.7

申请日：2004-10-28

Applicant: Reddy US Therapeutics, Inc. ,  Rao, Yeleswarapu Koteswar ,  Pal, Manojit ,  Sharma, Vedula Manohar ,  Venkateswarlu, Akella ,  Pillarisetti, Ram

Inventor： RAO, Yeleswarapu K., Fl. 202 Krishna Arcade ,  PAL, Manojit ,  SHARMA, Vedula Manohar ,  VENKATESWARLU, Akella ,  PILLARISETTI, Ram ,  PADAKANTI, Srinivas ,  RAO, Kalleda, Srinivasa

IPC: C07D311/12 ,  C07D277/34 ,  C07D487/00 ,  A61K31/35 ,  A61K31/497 ,  A61K31/425

CPC classification number: C07D487/04 ,  C07D215/56 ,  C07D239/90 ,  C07D311/30 ,  C07D417/12 ,  C07D417/14

Abstract: Compounds of formula (I), and methods and/or compositions comprising compounds that are effective in modulating inflammatory responses, such as those resulting from AGE and glycated protein accumulation are provided. Methods and/or compositions comprising compounds that are effective in modulating smooth muscle cell proliferation and the diseases or conditions related thereto are also provided.

公开(公告)号：AU2005286593A1

公开(公告)日：2006-03-30

申请号：AU2005286593

申请日：2005-09-23

Applicant: REDDY US THERAPEUTICS INC ,  PAL MANOJIT ,  CHRISTOPHER ALEXANDER ,  ISH KHANNA ,  IQBAL JAVED ,  PILLARISETTI SIVARAM ,  MAITRA SANTANU ,  GAYLA ROBERTS ,  SAGI LAVANYA ,  CHINTAKUNTA KRISHNA ,  SREENU JENNEPALLI

Inventor： SAGI LAVANYA ,  MAITRA SANTANU ,  PILLARISETTI SIVARAM ,  PAL MANOJIT ,  ALEXANDER CHRISTOPHER W ,  IQBAL JAVED ,  KRISHNA CHINTAKUNTA VAMSEE ,  KHANNA ISH KUMAR ,  ROBERTS GAYLA W ,  SREENU JENNEPALLI

IPC: A61K31/541 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  C07D401/02 ,  C07D403/02 ,  C07D413/02 ,  C07D417/02

公开(公告)号：EP1796673A2

公开(公告)日：2007-06-20

申请号：EP05799686.0

申请日：2005-09-23

Applicant: Reddy US Therapeutics, Inc. ,  Kalleda, Srinivas ,  Padakanti, Srinivas ,  Swamy, Nalivela, Kumara ,  Rao, Yeleswarapu Koteswar ,  Alexander, Christopher W. ,  Khanna, Ish Kumar ,  Iqbal, Javed ,  Pillarisetti, Sivaram ,  Pal, Manojit ,  Barange, Deepak

Inventor： PAL, Manojit ,  KALLEDA, Srinivas ,  PADAKANTI, Srivinas ,  KUMAR SWAMY, Nalivela, Plor 191, J.P.N. ,  YELESWARAPU, Koteswar, Rao,Flat 202,Krishna Arcade ,  ALEXANDER, Christopher, W. ,  KHANNA, Ish, Kumar ,  IQBAL, Javed, Flat 101, Sri Krishna Residency ,  PILLARISETTI, Sivaram ,  BARANGE, Deepak, H.No.235, c/o A. Srinivas

IPC: A61K31/506 ,  C07D403/04 ,  C07D239/46

CPC classification number: C07D405/14 ,  C07D239/30 ,  C07D239/40 ,  C07D239/42 ,  C07D239/46 ,  C07D239/47 ,  C07D239/48 ,  C07D239/50 ,  C07D239/54 ,  C07D401/04 ,  C07D403/12 ,  C07D405/12

Abstract: The present invention provides new heterocyclic compounds, particularly substituted pyrimidines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.

公开(公告)号：CA2588627A1

公开(公告)日：2006-07-13

申请号：CA2588627

申请日：2005-11-23

Applicant: SWAMY NALIVELA KUMARA ,  IQBAL JAVED ,  PILLARISETTI SIVARAM ,  RAO YELESWARAPU KOTESWAR ,  PAL MANOJIT ,  SUBRAMANIAN VENKATARAMAN ,  BATCHU VENKATESWARA RAO ,  REDDY US THERAPEUTICS INC ,  KHANNA ISH KUMAR

Inventor： SWAMY NALIVELA KUMARA ,  IQBAL JAVED ,  PILLARISETTI SIVARAM ,  RAO YELESWARAPU KOTESWAR ,  PAL MANOJIT ,  SUBRAMANIAN VENKATARAMAN ,  BATCHU VENKATESWARA RAO ,  KHANNA ISH KUMAR

IPC: C07D487/04 ,  A61K31/221 ,  A61K31/415 ,  A61K31/437 ,  A61K31/519 ,  A61K31/5365 ,  C07D205/02 ,  C07D231/04 ,  C07D231/10 ,  C07D471/04

Abstract: The present invention provides, among other things, new bicyclo heterocyclic compounds, compositions comprising these heterocyclic compounds, methods of making the heterocyclic compounds, and methods of using these heterocyclic compounds for treating a variety of conditions and disease states associated with, for example, cellular proliferation, inflammation, glycosidase expression, or the low expression of Perlecan.

公开(公告)号：AU2004286277A1

公开(公告)日：2005-05-12

申请号：AU2004286277

申请日：2004-10-28

Applicant: REDDY US THERAPEUTICS INC ,  YELESWARAPU RAO ,  PAL MANOJIT ,  VEDULA SHARMA ,  VENKATESWARLU AKELLA ,  PILLARISETTI RAM

Inventor： RAO YELESWARAPU KOTESWAR ,  PILLARISETTI RAM ,  PAL MANOJIT ,  VENKATESWARLU AKELLA ,  SHARMA VEDULA MANOHAR

IPC: C07D311/12 ,  A61K31/35 ,  A61K31/425 ,  A61K31/497 ,  C07D215/56 ,  C07D239/90 ,  C07D277/34 ,  C07D311/30 ,  C07D417/12 ,  C07D417/14 ,  C07D487/00 ,  C07D487/04

Abstract: Compounds of formula (I), and methods and/or compositions comprising compounds that are effective in modulating inflammatory responses, such as those resulting from AGE and glycated protein accumulation are provided. Methods and/or compositions comprising compounds that are effective in modulating smooth muscle cell proliferation and the diseases or conditions related thereto are also provided.

公开(公告)号：AU2005323311A1

公开(公告)日：2006-07-13

申请号：AU2005323311

申请日：2005-11-23

Applicant: BATCHU VENKATESWARA RAO ,  IQBAL JAVED ,  KHANNA ISH KUMAR ,  PAL MANOJIT ,  PILLARISETTI SIVARAM ,  RAO YELESWARAPU KOTESWAR ,  REDDY US THERAPEUTICS INC ,  SUBRAMANIAN VENKATARAMAN ,  SWAMY NALIVELA KUMARA

Inventor： PILLARISETTI SIVARAM ,  RAO YELESWARAPU KOTESWAR ,  BATCHU VENKATESWARA RAO ,  IQBAL JAVED ,  KHANNA ISH KUMAR ,  SWAMY NALIVELA KUMARA ,  SUBRAMANIAN VENKATARAMAN ,  PAL MANOJIT

IPC: C07D487/04 ,  A61K31/221 ,  A61K31/415 ,  A61K31/437 ,  A61K31/519 ,  A61K31/5365 ,  C07D205/02 ,  C07D231/04 ,  C07D231/10 ,  C07D471/04

Abstract: The present invention provides, among other things, new bicyclo heterocyclic compounds, compositions comprising these heterocyclic compounds, methods of making the heterocyclic compounds, and methods of using these heterocyclic compounds for treating a variety of conditions and disease states associated with, for example, cellular proliferation, inflammation, glycosidase expression, or the low expression of Perlecan.

公开(公告)号：AU2005286592A1

公开(公告)日：2006-03-30

申请号：AU2005286592

申请日：2005-09-23

Applicant: REDDY US THERAPEUTICS INC ,  PAL MANOJIT ,  KALLEDA SRINIVAS ,  PADAKANTI SRINIVAS ,  SWAMY NALIVELA KUMAR ,  KOTESWAR YELESWARAPU ,  CHRISTOPHER ALEXANDER ,  ISH KHANNA ,  IQBAL JAVED ,  PILLARISETTI SIVARAM ,  BARANGE DEEPAK

Inventor： BARANGE DEEPAK ,  ALEXANDER CHRISTOPHER W ,  KALLEDA SRINIVAS ,  PAL MANOJIT ,  SWAMY NALIVELA KUMAR ,  YELESWARAPU KOTESWAR RAO ,  PADAKANTI SRINIVAS ,  PILLARISETTI SIVARAM ,  IQBAL JAVED ,  KHANNA ISH KUMAR

IPC: A61K31/506 ,  C07D239/46 ,  C07D403/04

公开(公告)号：EP1814885A4

公开(公告)日：2009-12-16

申请号：EP05857024

申请日：2005-11-23

Applicant: REDDY US THERAPEUTICS INC ,  PAL MANOJIT ,  RAO YELESWARAPU KOTESWAR ,  KHANNA ISH KUMAR ,  SWAMY NALIVELA KUMARA ,  SUBRAMANIAN VENKATARAMAN ,  BATCHU VENKATESWARA RAO ,  IQBAL JAVED ,  PILLARISETTI SIVARAM

Inventor： REDDY US THERAPEUTICS INC ,  PAL MANOJIT ,  RAO YELESWARAPU KOTESWAR ,  KHANNA ISH KUMAR ,  SWAMY NALIVELA KUMARA ,  SUBRAMANIAN VENKATARAMAN ,  BATCHU VENKATESWARA RAO ,  IQBAL JAVED ,  PILLARISETTI SIVARAM

IPC: C07D487/04 ,  A61K31/221 ,  A61K31/415 ,  A61K31/437 ,  A61K31/519 ,  A61K31/5365 ,  C07D205/02 ,  C07D231/04 ,  C07D231/10 ,  C07D471/04

CPC classification number: C07D471/04 ,  C07D487/04

公开(公告)号：EP1814885A2

公开(公告)日：2007-08-08

申请号：EP05857024.3

申请日：2005-11-23

Applicant: Reddy US Therapeutics, Inc. ,  Pal, Manojit ,  Rao, Yeleswarapu Koteswar ,  Khanna, Ish Kumar ,  Swamy, Nalivela, Kumara ,  Subramanian, Venkataraman ,  Batchu, Venkateswara Rao ,  Iqbal, Javed ,  Pillarisetti, Sivaram

Inventor： Reddy US Therapeutics, Inc. ,  Pal, Manojit ,  Rao, Yeleswarapu Koteswar ,  Khanna, Ish Kumar ,  Swamy, Nalivela, Kumara ,  Subramanian, Venkataraman ,  Batchu, Venkateswara Rao ,  Iqbal, Javed ,  Pillarisetti, Sivaram

IPC: C07D487/04 ,  C07D471/04 ,  A61K31/519 ,  A61K31/5365 ,  C07D231/04 ,  C07D231/10 ,  C07D205/02 ,  A61K31/415 ,  A61K31/437 ,  A61K31/221

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: The present invention provides, among other things, new bicyclo heterocyclic compounds, compositions comprising these heterocyclic compounds, methods of making the heterocyclic compounds, and methods of using these heterocyclic compounds for treating a variety of conditions and disease states associated with, for example, cellular proliferation, inflammation, glycosidase expression, or the low expression of Perlecan.

公开(公告)号：WO2006034473A2

公开(公告)日：2006-03-30

申请号：PCT/US2005/034243

申请日：2005-09-23

Applicant: REDDY US THERAPEUTICS, INC. ,  KALLEDA, Srinivas ,  PADAKANTI, Srinivas ,  KUMAR SWAMY, Nalivela ,  YELESWARAPU, Koteswar, Rao ,  ALEXANDER, Christopher, W. ,  KHANNA, Ish, Kumar ,  IQBAL, Javed ,  PILLARISETTI, Sivaram ,  PAL, Manojit ,  BARANGE, Deepak

Inventor： KALLEDA, Srinivas ,  PADAKANTI, Srinivas ,  KUMAR SWAMY, Nalivela ,  YELESWARAPU, Koteswar, Rao ,  ALEXANDER, Christopher, W. ,  KHANNA, Ish, Kumar ,  IQBAL, Javed ,  PILLARISETTI, Sivaram ,  PAL, Manojit ,  BARANGE, Deepak

IPC: A61K31/541 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/4545 ,  A61K31/4439 ,  A61K31/44 ,  C07D417/02 ,  C07D403/02 ,  C07D413/02 ,  C07D401/02

CPC classification number: C07D405/14 ,  C07D239/30 ,  C07D239/40 ,  C07D239/42 ,  C07D239/46 ,  C07D239/47 ,  C07D239/48 ,  C07D239/50 ,  C07D239/54 ,  C07D401/04 ,  C07D403/12 ,  C07D405/12

Abstract: The present invention provides new heterocyclic compounds, particularly substituted pyrimidines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.

Abstract translation: 本发明提供了新的杂环化合物，特别是取代的嘧啶，制备和使用这些杂环化合物的方法和组合物，以及治疗多种疾病和疾病状态的方法，包括动脉粥样硬化，关节炎，再狭窄， 糖尿病性肾病或血脂异常，或由基底膜蛋白低表达介导的疾病状态。