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公开(公告)号：US6030663A
公开(公告)日：2000-02-29
申请号：US90330
申请日：1998-05-29
Applicant: James B. McClain , Timothy J. Romack , James P. DeYoung
Inventor： James B. McClain , Timothy J. Romack , James P. DeYoung
IPC: B08B17/02 , B05D1/18 , C23C26/00 , C23C30/00 , D06M15/277 , D06M15/643 , D06M23/06 , D06M23/10 , B05D1/00
CPC classification number: C23C30/00 , B05D1/18 , C23C26/00 , D06M15/277 , D06M15/643 , D06M23/10 , D06M23/105 , B05D2401/90 , D06M2101/06 , D06M2101/08 , D06M2101/12 , D06M2101/32 , D06M2101/34 , D06M2200/12
Abstract: A method of treating a substrate comprises contacting a surface of said substrate, with a pressurized fluid comprising carbon dioxide and a surface treatment component, the surface treatment component being entrained in the pressurized fluid and contacting the surface so that the surface treatment component lowers the surface tension of the surface of the substrate and treats the substrate. The contacting step is preferably carried out by immersion, the fluid is preferably a liquid or supercritical fluid, the substrate is preferably a metal or fabric substrate, and the surface treatment component is preferably a fluoroacrylate polymer.
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22.发明授权Cleaning process using carbon dioxide as a solvent and employing molecularly engineered surfactants 失效使用二氧化碳作为溶剂并使用分子工程表面活性剂的清洁方法
公开(公告)号：US5866005A
公开(公告)日：1999-02-02
申请号：US742027
申请日：1996-11-01
Applicant: Joseph M. DeSimone , Timothy J. Romack , Douglas E. Betts , James B. McClain
Inventor： Joseph M. DeSimone , Timothy J. Romack , Douglas E. Betts , James B. McClain
IPC: B08B5/00 , B08B3/12 , B08B7/00 , C11D3/02 , C11D3/37 , C11D3/43 , C11D7/02 , C11D7/50 , C11D11/00 , D06L1/00 , B01D11/00
CPC classification number: C11D3/3757 , B08B3/12 , B08B7/0021 , B08B7/0092 , C11D11/0023 , C11D11/0041 , C11D3/02 , C11D3/37 , C11D3/43 , C11D7/02 , C11D7/50 , D06L1/00
Abstract: The separation of a contaminant from a substrate that carries the contaminant is disclosed. The process comprises contacting the substrate to a carbon dioxide fluid containing an amphiphilic species wherein the contaminant associates with the amphiphilic species and becomes entrained in the carbon dioxide fluid. The substrate is then separated from the carbon dioxide fluid, and then the contaminant is separated from the carbon dioxide fluid.
Abstract translation: 公开了污染物与携带污染物的基质的分离。 该方法包括使底物与含有两亲物质的二氧化碳流体接触，其中污染物与两亲物质缔合并被夹带在二氧化碳流体中。 然后将基底与二氧化碳流体分离，然后将污染物与二氧化碳流体分离。
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公开(公告)号：US10117972B2
公开(公告)日：2018-11-06
申请号：US14131878
申请日：2012-07-12
Applicant: James B. McClain , Charles Douglas Taylor , Brett G. Zani , John Neet , Timothy Charles Kiorpes
Inventor： James B. McClain , Charles Douglas Taylor , Brett G. Zani , John Neet , Timothy Charles Kiorpes
Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.
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24.发明申请SYSTEM AND PROCESS FOR FORMATION OF A TIME-RELEASED, DRUG-ELUTING TRANSFERABLE COATING 审中-公开用于形成时间释放的药物可转移涂层的系统和方法公开(公告)号：US20150024116A1
公开(公告)日：2015-01-22
申请号：US14122862
申请日：2012-05-30
Applicant: Dean W. Matson , Clement R. Yonker , John L. Fulton , George S. Deverman , Barbara J. Tarasevich , Wendy J. Shaw , Leonard S. Fifield , Krys Wallace , C. Douglas Taylor , James B. McClain
Inventor： Dean W. Matson , Clement R. Yonker , John L. Fulton , George S. Deverman , Barbara J. Tarasevich , Wendy J. Shaw , Leonard S. Fifield , Krys Wallace , C. Douglas Taylor , James B. McClain
Abstract: A system and method are disclosed for coating surfaces of expandable medical devices with composite coatings. Coatings are composed of various materials including, e.g., polymers and drugs. Transfer of the coatings within a patient or other host forms a drug-eluting coating that delivers time-released drugs over time for treatment of a medical condition.
Abstract translation: 公开了用于涂覆具有复合涂层的可扩张医疗装置的表面的系统和方法。 涂料由各种材料组成，包括例如聚合物和药物。 患者或其他宿主内的涂层转移形成药物洗脱涂层，随时间推移释放药物以治疗医疗状况。
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25.发明授权公开(公告)号：US08795762B2
公开(公告)日：2014-08-05
申请号：US12748134
申请日：2010-03-26
Applicant: John L. Fulton , George S. Deverman , Dean W. Matson , Clement R. Yonker , C. Douglas Taylor , James B. McClain , Joseph M. Crowley
Inventor： John L. Fulton , George S. Deverman , Dean W. Matson , Clement R. Yonker , C. Douglas Taylor , James B. McClain , Joseph M. Crowley
CPC classification number: B05B5/032 , B05D1/025 , B05D1/04 , B05D3/0486 , Y10T428/24372 , Y10T428/25 , Y10T428/31504 , Y10T428/31507 , Y10T428/31511 , Y10T428/31544 , Y10T428/31551 , Y10T428/31663 , Y10T428/31725 , Y10T428/31786 , Y10T428/31855 , Y10T428/31931 , Y10T428/31935 , Y10T428/31938
Abstract: This disclosure describes the application of a supplemental corona source to provide surface charge on submicrometer particles to enhance collection efficiency and micro-structural density during electrostatic collection.
Abstract translation: 本公开描述了补充电晕源的应用，以在亚微米颗粒上提供表面电荷，以增强静电收集期间的收集效率和微结构密度。
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Patent Agency Ranking
公开(公告)号：US20130172853A1
公开(公告)日：2013-07-04
申请号：US13809324
申请日：2011-07-15
Applicant: James B. McClain , Charles Douglas Taylor , Brett G. Zani , John Neet , Timothy Charles Kiorpes
Inventor： James B. McClain , Charles Douglas Taylor , Brett G. Zani , John Neet , Timothy Charles Kiorpes
IPC: A61M25/10
CPC classification number: A61M25/10 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61M25/1011
Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.
Abstract translation: 提供一种涂覆的可植入医疗装置，包括：基底; 以及涂层，其设置在所述基底上，其中所述涂层包含至少一种聚合物和至少一种治疗期望形态的药剂和/或至少一种活性生物剂和任选的一种或多种药物载体; 其中基本上所有的药剂和/或活性生物制剂都保留在涂层内和衬底上，直到可植入装置部署在受试者身体内部的介入部位，并且其中在将医疗装置部署在受试者的身体中时 一部分药剂和/或活性生物剂在干预部位与至少一部分聚合物和/或药物载体的至少一部分一起递送。
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公开(公告)号：US20110264190A1
公开(公告)日：2011-10-27
申请号：US13090525
申请日：2011-04-20
Applicant: James B. McClain , Arthur J. Benvenuto
Inventor： James B. McClain , Arthur J. Benvenuto
CPC classification number: A61L31/16 , A61L31/10 , A61L31/148 , A61L2300/30 , A61L2300/62 , A61L2420/02 , A61L2420/08 , C09D167/04
Abstract: Provided herein are devices comprising a stent; and a coating on said stent comprising a polymer and an active agent, wherein the active agent comprises at least one of: extracellular matrix and an extracellular matrix component. Provided herein are methods of preparing a device comprising a stent and a coating on said stent; said method comprising: providing a stent; and forming a plurality of layers on said stent; wherein the coating comprises a polymer and at least one of said layers comprises one or more active agents; wherein at least a portion of the active agent comprises at least one of extracellular matrix and an extracellular matrix component.
Abstract translation: 本文提供了包括支架的装置; 以及所述支架上的包含聚合物和活性剂的涂层，其中所述活性剂包括细胞外基质和细胞外基质组分中的至少一种。 本文提供了制备包括支架和在所述支架上的涂层的装置的方法; 所述方法包括：提供支架; 并在所述支架上形成多个层; 其中所述涂层包含聚合物，并且所述层中的至少一个包含一种或多种活性剂; 其中所述活性剂的至少一部分包含细胞外基质和细胞外基质组分中的至少一种。
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28.发明申请公开(公告)号：US20110190864A1
公开(公告)日：2011-08-04
申请号：US13014632
申请日：2011-01-26
Applicant: James B. McClain , Douglas Taylor , David Enscore
Inventor： James B. McClain , Douglas Taylor , David Enscore
CPC classification number: A61F2/958 , A61F2/0077 , A61F2002/826 , A61F2250/003
Abstract: Stent delivery systems having improved deliverability comprising an elongate member having an inflation lumen and a guidewire lumen therein; a balloon having an interior that is in fluid communication with the inflation lumen; and a stent comprising a coating mounted on the balloon. Methods for making stent delivery systems having improved deliverability. Methods for delivering two stent delivery systems concurrently through a guiding catheter, each stent delivery system comprising elongate member having an inflation lumen and a guidewire lumen therein, a balloon having an interior that is in fluid communication with the inflation lumen, and a stent comprising a coating mounted on the balloon. Stent coatings may comprise a pharmaceutical agent at least a portion of which is in crystalline form.
Abstract translation: 具有改善的输送能力的支架输送系统包括具有充气腔和其中的导丝腔的细长构件; 具有与膨胀腔流体连通的内部的气囊; 以及支架，其包括安装在气囊上的涂层。 用于制备具有改善的输送性的支架输送系统的方法。 用于通过引导导管同时递送两个支架输送系统的方法，每个支架输送系统包括具有充气腔和其中的导丝腔的细长构件，具有与充气腔流体连通的内部的球囊，以及支架， 涂层安装在气球上。 支架涂层可以包含至少一部分为结晶形式的药剂。
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公开(公告)号：US20100272778A1
公开(公告)日：2010-10-28
申请号：US12762007
申请日：2010-04-16
Applicant: James B. McClain , Douglas Taylor
Inventor： James B. McClain , Douglas Taylor
IPC: A61F2/00 , A61K31/436 , A61P7/00
CPC classification number: A61F2/86 , A61F2/82 , A61F2210/0004 , A61F2250/0067 , A61K31/436 , A61L31/022 , A61L31/06 , A61L31/08 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/204 , A61L2300/416 , A61L2300/426 , A61L2300/602 , A61L2300/604 , A61L2300/608 , A61L2300/63 , A61L2420/08 , C08L67/04
Abstract: Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.
Abstract translation: 本文提供的装置包括：a。 支架; b。 在所述支架框架上的多个层以形成所述装置; 其中所述层中的至少一层包含生物可吸收聚合物，并且所述层中的至少一层包含一种或多种活性剂; 其中至少部分活性剂为结晶形式。
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公开(公告)号：US20100211164A1
公开(公告)日：2010-08-19
申请号：US12595848
申请日：2008-04-17
Applicant: James B. McClain , Douglas Taylor
Inventor： James B. McClain , Douglas Taylor
CPC classification number: A61L31/10 , A61F2/82 , A61F2230/0069 , A61F2250/0067 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/608 , A61L2300/63 , A61L2420/02 , A61L2420/08 , C08L67/04
Abstract: Provided herein is a coated coronary stent, comprising: a. stent framework; b. a plurality of layers deposited on said stent framework to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.
Abstract translation: 本文提供了一种涂覆的冠状动脉支架，包括：a。 支架框架; b。 沉积在所述支架框架上以形成所述冠状动脉支架的多个层; 其中所述层中的至少一层包含生物可吸收聚合物，并且所述层中的至少一层包含一种或多种活性剂; 其中至少部分活性剂为结晶形式。
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