公开(公告)号：WO2009131782A1

公开(公告)日：2009-10-29

申请号：PCT/US2009/038006

申请日：2009-03-24

Applicant: DOW GLOBAL TECHNOLOGIES INC. ,  FRYCEK, George, J. ,  JOHNSON, Martin, D. ,  FEIST, Shawn, D. ,  HOLDEN, Bruce, S. ,  JONES, Christopher, M. ,  FRANK, Timothy, C.

Inventor： FRYCEK, George, J. ,  JOHNSON, Martin, D. ,  FEIST, Shawn, D. ,  HOLDEN, Bruce, S. ,  JONES, Christopher, M. ,  FRANK, Timothy, C.

IPC: B01D53/00

CPC classification number: B01D53/00

Abstract: A process for removing water from a reactive monomer, such as an acrolein, wherein the reactive monomer, which is prone to polymerize under certain process conditions, remains substantially unreactive under process conditions of a hot gas pressure swing adsorption unit. The removal of water is advantageously accomplished without the use of any other solvents. Also, by allowing the reactive monomer such as acrolein to be recycled in the vapor phase, the addition of inhibitor and equipment for condensation of a reactive monomer, such as acrolein, is eliminated. The maintenance of a vapor phase reactive monomer such as an acrolein stream improves the operability of this process.

Abstract translation: 从反应性单体如丙烯醛中除去水的方法，其中在某些工艺条件下易于聚合的反应性单体在热气体变压吸附单元的工艺条件下基本上不起作用。 在不使用任何其它溶剂的情况下有利地实现水的除去。 此外，通过使诸如丙烯醛的反应性单体在气相中循环，消除了用于缩合反应性单体如丙烯醛的抑制剂和设备的添加。 气相反应性单体如丙烯醛流的维持改善了该方法的可操作性。

公开(公告)号：WO2008011079A3

公开(公告)日：2008-10-02

申请号：PCT/US2007016326

申请日：2007-07-18

Applicant: TENSYS MEDICAL INC ,  FINBURGH SIMON E ,  VIDISCHAK RONALD J ,  BUTLER ANTHONY T ,  JONES CHRISTOPHER M ,  ESHBAUGH DAVID L ,  KARTEN STUART ,  PIOREK STEVE

Inventor： FINBURGH SIMON E ,  VIDISCHAK RONALD J ,  BUTLER ANTHONY T ,  JONES CHRISTOPHER M ,  ESHBAUGH DAVID L ,  KARTEN STUART ,  PIOREK STEVE

IPC: A61B5/00

CPC classification number: A61B5/021 ,  A61B5/02028 ,  A61B5/681 ,  A61B5/6833 ,  A61B8/4272

Abstract: Improved apparatus and methods for non-invasively assessing one or more hemodynamic parameters associated with the circulatory system of a living organism. In one aspect, the invention comprises apparatus adapted to accurately place and maintain a sensor (e.g., tonometric pressure sensor) with respect to the anatomy of the subject, including an alignment apparatus which is separable from an adjustable fixture. The apparatus moveably captures the sensor to, inter alia, facilitate coupling thereof to an actuator used to position the sensor during measurements. In a second aspect, improved sensor apparatus is disclosed adapted to minimize the effects of shear during sensor movement and monitoring as well as maximize the lateral and proximal search area available to the sensor within the apparatus. Methods for positioning the alignment apparatus and sensor are also disclosed.

Abstract translation: 用于非侵入性评估与生物体的循环系统相关的一个或多个血液动力学参数的改进的装置和方法。 在一个方面，本发明包括适于相对于对象的解剖结构精确地放置和维持传感器（例如，压力测量压力传感器）的装置，包括可调节固定装置的对准装置。 该装置可移动地捕获传感器，尤其是便于将其耦合到用于在测量期间定位传感器的致动器。 在第二方面，公开了一种改进的传感器装置，其适于在传感器移动和监测期间最小化剪切的影响，并且使设备内的传感器可用的横向和近侧搜索区域最大化。 还公开了用于定位对准装置和传感器的方法。

公开(公告)号：WO2007127316A2

公开(公告)日：2007-11-08

申请号：PCT/US2007/010154

申请日：2007-04-24

Applicant: DOW GLOBAL TECHNOLOGIES INC. ,  NORTH CAROLINA STATE UNIVERSITY ,  JONES, Christopher, M. ,  GHOVANLOO, Maysam ,  WHITE, Douglas, P. ,  MERCURE, Peter, K. ,  WARREN, III, Malcolm, W.

Inventor： JONES, Christopher, M. ,  GHOVANLOO, Maysam ,  WHITE, Douglas, P. ,  MERCURE, Peter, K. ,  WARREN, III, Malcolm, W.

IPC: A61B5/06 ,  A61J3/00

CPC classification number: A61B5/06 ,  A61B5/0002 ,  A61B5/4205 ,  A61B5/4833 ,  A61B5/4839 ,  A61B5/6822 ,  A61J3/007 ,  A61J2200/30

Abstract: A method to measure compliance with a pharmaceutical regimen, by the steps of: (a) ingesting a dose of a medication into the gastrointestinal tract of a person, the dose of medication comprising a drug formulation and a permanent magnet; (b) as a result of the ingestion of step (a), detecting passage of the permanent magnet past at least two magnetic field sensors positioned apart from each other and adjacent to the gastrointestinal tract; and (c) measuring compliance with the pharmaceutical regimen by way of the detection of step (b). And, apparatus useful to measure compliance with a pharmaceutical regimen by detecting ingestion of a dose of medication comprising a drug formulation and a permanent magnet, the apparatus including at least two magnetic field sensors positioned apart from each other on a necklace, each magnetic field sensor being in electronic communication with a microprocessor for receiving signals from the magnetic field sensors to determine the passage of a permanent magnet between the magnetic field sensors.

Abstract translation: 通过以下步骤测量药物制剂的顺应性的方法：（a）将一剂药物摄入人的胃肠道，包括药物制剂和永久磁铁的药物剂量; （b）作为摄取步骤（a）的结果，检测永磁体经过位于彼此分开并邻近胃肠道的至少两个磁场传感器的通过; 和（c）通过检测步骤（b）测量药物方案的顺应性。 另外，通过检测摄入药物制剂和永久磁铁剂量的药物来测量药物方案的依从性的装置，该装置包括在项链上彼此分开定位的至少两个磁场传感器，每个磁场传感器 与微处理器电子通信，用于接收来自磁场传感器的信号，以确定永磁体在磁场传感器之间的通过。

公开(公告)号：WO2006127355A2

公开(公告)日：2006-11-30

申请号：PCT/US2006/019079

申请日：2006-05-18

Applicant: DOW GLOBAL TECHNOLOGIES INC. ,  MERCURE, Peter, Kip ,  JONES, Christopher, M. ,  WARREN, Malcolm, W. ,  BABINEC, Susan, J. ,  BERNIUS, Mark, T. ,  CASTILLO, Flor, A. ,  CRANLEY, Paul, E. ,  DANOWSKI, Kristine, L. ,  FELIX, Mark, SB ,  FLETCHER, Robert, B. ,  HALEY, Robert, Paul ,  KALANTAR, Thomas, H. ,  MCDOUGALL, Chris, W. ,  PRESSLER, Michelle, A. ,  ROSNER, Bettina, M. ,  SIMON, Jaime ,  STRAND, Deidre, A. ,  SUN, Larry ,  WHITE, Douglas, P.

Inventor： MERCURE, Peter, Kip ,  JONES, Christopher, M. ,  WARREN, Malcolm, W. ,  BABINEC, Susan, J. ,  BERNIUS, Mark, T. ,  CASTILLO, Flor, A. ,  CRANLEY, Paul, E. ,  DANOWSKI, Kristine, L. ,  FELIX, Mark, SB ,  FLETCHER, Robert, B. ,  HALEY, Robert, Paul ,  KALANTAR, Thomas, H. ,  MCDOUGALL, Chris, W. ,  PRESSLER, Michelle, A. ,  ROSNER, Bettina, M. ,  SIMON, Jaime ,  STRAND, Deidre, A. ,  SUN, Larry ,  WHITE, Douglas, P.

IPC: A61K9/48 ,  A61K9/20 ,  G06K19/077

CPC classification number: G06K19/04 ,  A01K11/007 ,  A61B5/4833 ,  A61J3/007 ,  A61J3/071 ,  A61J2200/30 ,  A61K9/0009 ,  A61K9/2072 ,  A61K9/4808 ,  G06K7/0008 ,  G06K7/10079 ,  G06K19/07327 ,  G06K19/07336 ,  G06K19/07345 ,  G06K19/07749 ,  H01Q1/2208 ,  H01Q1/273 ,  H01Q1/362 ,  H01Q7/00 ,  H01Q11/08

Abstract: A device useful for oral drug delivery device consisting of: (a) a capsule, tablet or pill designed to disperse in the gastrointestinal system; (b) an RFID tag positioned in the capsule, tablet or pill, the RFID tag comprising an antenna; (c) an object selected from the group consisting of a magnet, a ferromagnetic object, a ferrite object and an electromagnetic shielding object positioned within, over or adjacent the antenna of the RFID tag to alter the antenna characteristics of the RFID tag so that if the RFID tag is interrogated before the capsule, tablet or pill disperses in the gastrointestinal system, the response of the RFID tag is sufficiently altered or attenuated to determine that the capsule, tablet or pill has not dispersed in the gastrointestinal system and so that if the RFID tag is interrogated after the capsule, tablet or pill has dispersed in the gastrointestinal system, the object separates from the RFID tag so that the response of the RFID tag is sufficiently detectable to determine that the capsule, tablet or pill has dispersed in the gastrointestinal system. Alternatively, a switch can be used to signal ingestion of the device, and change the response of the device. In another embodiment, the instant invention is a device useful for oral drug delivery, consisting of: (a) a capsule, tablet or pill designed to disperse in the gastrointestinal system; (b) a first non-anti-collision RFID tag positioned in the capsule; (c) a second non-anti-collision RFID tag positioned in the capsule, so that if the RFID tags are interrogated by an RFID reader before the capsule, tablet or pill disperses in the gastrointestinal system, the response of the RFID tags collide and so that after the dispersible material of the capsule has dispersed in the gastrointestinal system thereby allowing the first and second non-anti-collision tags to separate from each other, then the response of the RFID tags is sufficiently different from each other to determine that the capsule has dispersed in the gastrointestinal system.

Abstract translation: 用于口服药物递送装置的装置包括：（a）设计成分散在胃肠系统中的胶囊，片剂或药丸; （b）定位在胶囊，药片或药丸中的RFID标签，RFID标签包括天线; （c）选自位于RFID标签的天线之内或之上的磁铁，铁磁体，铁氧体物体和电磁屏蔽物体的物体，以改变RFID标签的天线特性，使得如果 在胶囊，片剂或药丸分散在胃肠系统中之前询问RFID标签，RFID标签的反应被充分改变或减弱，以确定胶囊，片剂或药片未分散在胃肠系统中，并且如果 在胶囊，片剂或药丸已经分散在胃肠系统中之后，RFID标签被询问，物体与RFID标签分离，使得RFID标签的反应足够可检测，以确定胶囊，片剂或药片已经分散在胃肠道 系统。 或者，可以使用开关来信号摄取设备，并且改变设备的响应。 在另一个实施方案中，本发明是用于口服药物递送的装置，其包括：（a）设计成分散在胃肠系统中的胶囊，片剂或药丸; （b）位于所述胶囊中的第一非防撞RFID标签; （c）定位在胶囊中的第二个非防撞RFID标签，使得如果在胶囊，片剂或药丸分散在胃肠系统中之前RFID读写器询问RFID标签，则RFID标签的响应与 使得在胶囊的可分散材料已经分散在胃肠系统中，从而允许第一和第二非抗冲突标签彼此分离，则RFID标签的响应彼此充分地不同，以确定 胶囊已经分散在胃肠系统中。

公开(公告)号：WO2005017490A3

公开(公告)日：2005-02-24

申请号：PCT/US2004/022229

申请日：2004-07-09

Applicant: HALLIBURTON ENERGY SERVICES, INC. ,  JONES, Christopher, M.

Inventor： JONES, Christopher, M.

IPC: B23K26/00

Abstract: A method for pelletizing and taking intensive measurements of a raw sample. The raw sample is mixed with several solutions containing epoxies and activators based in carrier solutions or solvents, and ground to a fine powder or gel, and partially dried and conformed to a pellet shape (30). The pellet (30) is then cured such that the epoxy and activator solutions react and form a binding agent capable of maintaining the structural integrity of the pellet (30) during intensive analysis. An intensive analysis instrument, such as LIBS, which includes using a high power laser pulse (20) at a test point (22) to generate a plasma plume (26), the atomic emission (24) of which is collected and analyzed.

公开(公告)号：WO2012005725A1

公开(公告)日：2012-01-12

申请号：PCT/US2010/041273

申请日：2010-07-08

Applicant: HALLIBURTON ENERGY SERVICES, INC. ,  PELLETIER, Michael T. ,  JONES, Christopher M.

Inventor： PELLETIER, Michael T. ,  JONES, Christopher M.

IPC: G01V3/26 ,  G01V3/08 ,  E21B49/08 ,  E21B47/00

CPC classification number: E21B47/00 ,  E21B49/10 ,  G01N21/1702 ,  G01N29/036 ,  G01N29/222 ,  G01N29/2425 ,  G01N33/2823 ,  G01N2291/0224 ,  G01N2291/02433 ,  G01V3/30 ,  G01V8/02

Abstract: Determining constituent components of a fluid sample. At least some of the illustrative embodiments are methods including: creating electromagnetic energy with a wavelength in the infrared region; directing the electromagnetic energy into a fluid sample; modulating the electromagnetic energy at a modulation frequency; directing the electromagnetic energy that passes through the fluid sample to a first resonant chamber, the first resonant chamber has an acoustic resonant frequency substantially equal to the modulation frequency; absorbing at least a portion of the electromagnetic energy by a detector fluid within the first resonant chamber; detecting acoustic energy within the first resonant chamber; and determining a first constituent component of the fluid sample based on the acoustic energy within the first resonant chamber.

Abstract translation: 确定流体样品的构成成分。 至少一些说明性实施例是一种方法，包括：产生具有红外区域中的波长的电磁能; 将电磁能引导到流体样品中; 以调制频率调制电磁能; 将通过流体样品的电磁能引导到第一谐振室，第一谐振室具有基本上等于调制频率的声学共振频率; 通过第一谐振室内的检测器流体吸收至少一部分电磁能; 检测所述第一谐振室内的声能; 以及基于所述第一谐振室内的声能确定所述流体样品的第一组成成分。

公开(公告)号：WO2011094134A2

公开(公告)日：2011-08-04

申请号：PCT/US2011/022104

申请日：2011-01-21

Applicant: HALLIBURTON ENERGY SERVICES, INC. ,  ATKINSON, Robert ,  JONES, Christopher, M. ,  PELLETIER, Michael, T. ,  HARDER, Nathan ,  MURPHY, Robert, J.

Inventor： ATKINSON, Robert ,  JONES, Christopher, M. ,  PELLETIER, Michael, T. ,  HARDER, Nathan ,  MURPHY, Robert, J.

IPC: G01V8/10 ,  E21B47/00 ,  G01V13/00

CPC classification number: G01V8/02 ,  E21B47/011 ,  F16J15/184 ,  G01N21/0303 ,  G01N21/05

Abstract: Optical measurement devices including one or more sealing assemblies are described. The sealing assemblies are configured for use at relatively high temperatures and pressures, such as temperatures over 200 degrees F and pressures over 10,000 psi. The sealing assemblies can include a deformable seal element surrounded on each side by a backup seal element. In some examples, the deformable seal element is formed of a material selected from a group consisting of a fluoroelastomer or polytetrafluoroethylene, and the backup seal elements are formed of a material selected from a group consisting of flexible graphite or metal foil. Optionally, at least one additional seal element functioning as an extrusion barrier can be placed on the opposite side of one or both backup seal elements from the deformable seal element. The additional seal element can be formed of polyether ether ketone or flexible graphite, for example. Additional devices and assemblies are described.

Abstract translation: 描述包括一个或多个密封组件的光学测量装置。 密封组件被配置为在相对较高的温度和压力下使用，例如超过200华氏度的温度和超过10,000psi的压力。 密封组件可包括通过备用密封元件在每一侧上包围的可变形密封件。 在一些示例中，可变形密封元件由选自含氟弹性体或聚四氟乙烯的材料形成，并且备用密封元件由选自柔性石墨或金属箔的材料形成。 可选地，用作挤压障碍物的至少一个附加的密封元件可以放置在一个或两个支承密封件与可变形密封元件相反的一侧。 附加的密封元件例如可由聚醚醚酮或柔性石墨形成。 描述了附加设备和组件。

公开(公告)号：WO2011014144A1

公开(公告)日：2011-02-03

申请号：PCT/US2009/004401

申请日：2009-07-30

Applicant: HALLIBURTON ENERGY SERVICES, INC. ,  JONES, Christopher, M. ,  PELLETIER, Michael, T. ,  ATKINSON, Robert ,  ZHANG, Wei ,  GAO, Li

Inventor： JONES, Christopher, M. ,  PELLETIER, Michael, T. ,  ATKINSON, Robert ,  ZHANG, Wei ,  GAO, Li

IPC: G01J3/30

CPC classification number: G01N21/59 ,  E21B49/08

Abstract: Apparatus, systems, and methods may operate to receive incident energy within a chamber defining a first part of an interaction volume that attenuates the incident energy as a function of path length to provide attenuated energy. Additional activity may include simultaneously transforming the attenuated energy characterized by a substantially exponential intensity function into resultant energy characterized by a substantially polynomial intensity function. The transformation may be accomplished using an interacted energy transformation element that defines a second part of the interaction volume, the transformation element operating to intercept the attenuated energy along a plurality of path lengths. Other activity may include transmitting the resultant energy to a receiver. Additional apparatus, systems, and methods are disclosed.

Abstract translation: 设备，系统和方法可以操作以在腔室内接收限定相互作用体积的第一部分的入射能量，该相互作用体积的衰减作为路径长度的函数来衰减入射能量以提供衰减的能量。 附加活动可以包括同时将基本上指数强度函数表征的衰减能量转换成由基本上多项式强度函数表征的合成能量。 可以使用界定相互作用体积的第二部分的相互作用的能量转换元件来实现变换，该变换元件用于沿着多个路径长度截取衰减的能量。 其他活动可以包括将合成的能量传输到接收器。 公开了附加装置，系统和方法。

公开(公告)号：WO2007084695A3

公开(公告)日：2008-01-10

申请号：PCT/US2007001488

申请日：2007-01-19

Applicant: TENSYS MEDICAL INC ,  HEMPSTEAD RUSSELL D ,  BUTLER ANTHONY T ,  FINBURGH SIMON E ,  VIDISCHAK RONALD J ,  JONES CHRISTOPHER M

Inventor： HEMPSTEAD RUSSELL D ,  BUTLER ANTHONY T ,  FINBURGH SIMON E ,  VIDISCHAK RONALD J ,  JONES CHRISTOPHER M

IPC: A61B5/02

CPC classification number: A61B5/021 ,  A61B5/02028 ,  A61B5/061 ,  A61B5/6824 ,  A61B5/6841 ,  A61B2560/0261 ,  A61B2560/04 ,  A61B2560/0406

Abstract: Improved apparatus and methods for non-invasively assessing one or more hemodynamic parameters associated with the circulatory system of a living organism. In one aspect, the invention comprises apparatus adapted to accurately place and maintain a sensor (e.g., tonometric pressure sensor) with respect to the anatomy of the subject, including an alignment apparatus which is separable from an adjustable fixture. The alignment apparatus moveably captures the sensor to, inter alia, facilitate coupling thereof to an actuator used to position the sensor during measurements. The alignment apparatus also advantageously allows the sensor position to be maintained when the fixture is removed from the subject, such as during patient transport. Methods for positioning the alignment apparatus and sensor, correcting for hydrostatic pressure effects, and providing treatment to the subject are also disclosed.

Abstract translation: 用于非侵入性评估与生物体的循环系统相关的一个或多个血液动力学参数的改进的装置和方法。 在一个方面，本发明包括适于相对于对象的解剖结构精确地放置和维持传感器（例如，压力测量压力传感器）的装置，包括可调节固定装置的对准装置。 对准装置可移动地捕获传感器，尤其是便于将其耦合到用于在测量期间定位传感器的致动器。 对准装置还有利地允许当夹具从受试者移除时（例如在患者运送期间）保持传感器位置。 还公开了用于定位对准装置和传感器，校正静水压力效应以及为受试者提供治疗的方法。

公开(公告)号：WO2005017490A2

公开(公告)日：2005-02-24

申请号：PCT/US2004022229

申请日：2004-07-09

Applicant: HALLIBURTON ENERGY SERV INC ,  JONES CHRISTOPHER M

Inventor： JONES CHRISTOPHER M

IPC: B23K26/00 ,  B29B9/00 ,  C08G59/00 ,  C08L63/00 ,  G01J3/30 ,  G01N20060101 ,  G01N1/28 ,  H01S3/00 ,  G01N

CPC classification number: C08L63/00

Abstract: A method for pelletizing and taking intensive measurements of a raw sample is disclosed. The method includes homogenizing and pelletizing the sample that is to be subjected to compositional or intensive analysis. The raw sample is mixed with several solutions containing epoxies and activators based in carrier solutions or solvents, and ground to a fine powder or gel. The gel is partially dried and conformed to a pellet shape. The pellet is then cured such that the epoxy and activator solutions react and form a binding agent capable of maintaining the structural integrity of the sample pellet during intensive analysis. An intensive analysis instrument, such as LIBS, may then be used to ablate the surface of the pellet. The pellet provides consistent ablation of the sample material for accurate intensive measurements.

Abstract translation: 公开了一种用于造粒并对原始样品进行大量测量的方法。 该方法包括对待进行成分或密集分析的样品进行均化和造粒。 将原始样品与包含基于载体溶液或溶剂的环氧化物和活化剂的几种溶液混合，并研磨成细粉末或凝胶。 凝胶被部分干燥并且符合颗粒形状。 然后将颗粒固化，使得环氧树脂和活化剂溶液在强化分析期间反应并形成能够保持样品沉淀物的结构完整性的粘合剂。 然后可以使用密集分析仪器（例如LIBS）来烧蚀沉淀物的表面。 颗粒提供样品材料的一致消融以进行精确的密集测量。