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    Microscope system, specimen observation method, and program
    21.
    发明专利
    Microscope system, specimen observation method, and program 有权
    微观系统，样本观察方法和程序

    公开(公告)号：JP2011179924A

    公开(公告)日：2011-09-15

    申请号：JP2010043441

    申请日：2010-02-26

    Applicant: Japanese Foundation For Cancer Research ,  Olympus Corp ,  オリンパス株式会社 ,  公益財団法人がん研究会

    Inventor： YAMADA TATSUYOSHI ,  ISHIKAWA YUICHI ,  TAKEUCHI KENGO

    IPC: G01N21/17 ,  G01N33/48

    CPC classification number: G02B21/365 ,  G01N1/30

    Abstract: PROBLEM TO BE SOLVED: To properly specify an area of a desired cell constituent element and to display the presence or absence of expression of a desired target molecule on this cell constituent element with a good visibility.
    SOLUTION: In the microscope system 1, a high resolution image acquisition processing unit 453 acquires a VS image of a target specimen S stained with a staining dye containing a dye for cell component identification and a molecule target dye. A dye amount calculation unit 457 calculates, for each pixel of the VS image, a dye amount of each staining dye that stains corresponding positions on the specimen. A cell component identification processing unit 458 identifies a cell component based on the dye amount of the dye for cell component identification. An extraction condition setting unit 459 sets the presence or absence of a target molecule in the area of the cell component as an extraction condition. A target portion extraction unit 460 extracts an area of a target portion in the target specimen S that satisfies the extraction condition. A display image generator 462 generates a display image of the VS image representing the area of the target portion.
    COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 要解决的问题：为了适当地指定期望的细胞构成元件的面积并且在该细胞构成元件上显示出具有良好可见度的期望目标分子的表达的存在或不存在。 解决方案：在显微镜系统1中，高分辨率图像获取处理单元453获取用含有细胞成分鉴定用染料和分子靶染料的染色染料染色的目标样品S的VS图像。 染色量计算单元457针对VS图像的每个像素计算染色样品上的相应位置的染色量。 细胞成分识别处理部458基于细胞成分鉴定用染料的染色量来鉴定细胞成分。 提取条件设定部459将细胞成分的区域中的目标分子的存在或不存在作为提取条件。 目标部分提取单元460提取满足提取条件的目标样本S中的目标部分的区域。 显示图像生成器462生成表示目标部分的区域的VS图像的显示图像。 版权所有（C）2011，JPO＆INPIT

    Platelet aggregation inhibitor having 3-aryloxychromone compound as active ingredient
    22.
    发明专利
    Platelet aggregation inhibitor having 3-aryloxychromone compound as active ingredient 审中-公开
    具有作为活性成分的3-氰基酮化合物的平板聚集抑制剂

    公开(公告)号：JP2013071916A

    公开(公告)日：2013-04-22

    申请号：JP2011212891

    申请日：2011-09-28

    Applicant: General Incorporated Association Pharma Valley Project Supporting Organization ,  一般社団法人ファルマバレープロジェクト支援機構 ,  Japanese Foundation For Cancer Research ,  公益財団法人がん研究会

    Inventor： FUJITA NAOYA ,  TAKAGI SATOSHI ,  OGO NAOHISA

    IPC: C07D311/36 ,  A61K31/353 ,  A61P7/02 ,  A61P7/04 ,  A61P9/00 ,  A61P9/10 ,  A61P35/00

    Abstract: PROBLEM TO BE SOLVED: To provide a platelet aggregation inhibitor taking Aggrus as a target and having 3-phenoxychromone compound as an active ingredient, and a pharmaceutical composition containing such platelet aggregation inhibitor, used for inhibiting platelet aggregation and for the prevention and/or treatment of cancerous tumor.SOLUTION: By screening low molecular weight compounds inhibiting the Aggrus-dependent platelet aggregation and also bonding with the Aggrus and inhibiting the interaction with CLEC-2, the 3-phenoxychromone compounds, especially a 3-phenoxychromone compound having carboxyalkyleneoxy group at the 7 position is found to have an excellent behavior. Also provided are the platelet aggregation inhibitor containing the compound as the active ingredient and the pharmaceutical composition containing such platelet aggregation inhibitor, used for inhibiting the platelet aggregation and for the prevention and/or treatment of the cancerous tumor.

    Abstract translation: 待解决的问题：提供以Aggrus为靶并具有3-苯氧基苯并吡喃酮化合物作为活性成分的血小板聚集抑制剂，以及含有这样的血小板聚集抑制剂的药物组合物，其用于抑制血小板聚集和预防和/ /或治疗癌性肿瘤。 解决方案：通过筛选抑制Aggrus依赖性血小板聚集的低分子量化合物，并且还与Aggrus结合并抑制与CLEC-2的相互作用，3-苯氧基苯并吡喃化合物，特别是具有羧基亚烷基氧基的3-苯氧基苯并噻唑化合物 7位发现有一个很好的行为。 还提供了含有化合物作为活性成分的血小板聚集抑制剂和含有这种血小板聚集抑制剂的药物组合物，其用于抑制血小板聚集和预防和/或治疗癌性肿瘤。 版权所有（C）2013，JPO＆INPIT

    Method of screening anticancer agent
    23.
    发明专利
    Method of screening anticancer agent 审中-公开
    筛选抗原剂的方法

    公开(公告)号：JP2012005479A

    公开(公告)日：2012-01-12

    申请号：JP2011115608

    申请日：2011-05-24

    Applicant: Japanese Foundation For Cancer Research ,  公益財団法人がん研究会

    Inventor： YAO RYOJI ,  NODA TETSUO

    IPC: C12Q1/02 ,  A61K31/713 ,  A61K48/00 ,  A61P15/00 ,  A61P35/00 ,  C12N15/09 ,  G01N33/15 ,  G01N33/50 ,  G01N33/68

    Abstract: PROBLEM TO BE SOLVED: To provide a new anticancer agent and a new method of screening an anticancer agent.SOLUTION: This method of screening the anticancer agent includes: a process of bringing a cancer cell manifesting TACC3 protein and a candidate substance into contact with each other; a process of measuring the percentage of a mitotic cell for the cell brought into contact with the substance; and a process of measuring the manifestation or function of the TACC3 protein in the cell brought into contact with the substance. An anticancer agent to at least one selected from a group including lymphoma, angiosarcoma, non-small cell lung cancer, breast cancer, digestive tract tumor and ovarian cancer contains shRNA or siRNA to the TACC3 taking at least one array selected from a group including specific arrays as a target.

    Abstract translation: 要解决的问题：提供新的抗癌剂和筛选抗癌剂的新方法。 解决方案：该抗癌剂的筛选方法包括：使表现TACC3蛋白和候选物质的癌细胞相互接触的方法; 测量与物质接触的细胞的有丝分裂细胞的百分比的过程; 以及测量与物质接触的细胞中TACC3蛋白的表现或功能的过程。 将选自包括淋巴瘤，血管肉瘤，非小细胞肺癌，乳腺癌，消化道肿瘤和卵巢癌的组中的至少一种的抗癌剂含有至少一种选自包含特异性的组的阵列的TACC3的shRNA或siRNA 数组作为目标。 版权所有（C）2012，JPO＆INPIT

    Apparatus and method for processing image, and program
    24.
    发明专利
    Apparatus and method for processing image, and program 有权
    用于处理图像和程序的装置和方法

    公开(公告)号：JP2011215061A

    公开(公告)日：2011-10-27

    申请号：JP2010084755

    申请日：2010-04-01

    Applicant: Japanese Foundation For Cancer Research ,  Sony Corp ,  ソニー株式会社 ,  公益財団法人がん研究会

    Inventor： OHASHI TAKESHI

    IPC: G01N21/17 ,  G06T1/00

    CPC classification number: G06K9/38 ,  G06K9/0014

    Abstract: PROBLEM TO BE SOLVED: To provide an image processing apparatus, an image processing method and programs for accurately detecting any notable cellular tissue area on pathological images.SOLUTION: The image processing method includes the step S11 to compute luminance difference characteristic of each pixel in a low resolution pathological image, and categorize low resolution pathological images into cellular tissue area and anything else based on the computed luminance difference characteristic; the step S12 to expand the cellular tissue area; the step S13 to separately-label each cellular tissue area (with expansion process completed); the step S14 to compute star part level score SA of each cellular tissue area and then determine each area as a star or a non-star; and the step S15 to establish rectangular area (rectangle cellular tissue area) to be inscribed with the cellular tissue area determined as a star. This invention is applicable to analysis of pathological images.

    Abstract translation: 要解决的问题：提供一种用于在病理图像上准确检测任何显着的细胞组织区域的图像处理装置，图像处理方法和程序。解决方案：图像处理方法包括步骤S11，用于计算图像中每个像素的亮度差特性 低分辨率病理图像，并根据计算的亮度差异特征将低分辨率病理图像分类到细胞组织区域和任何其他图像; 步骤S12以扩大细胞组织面积; 步骤S13分别标记每个细胞组织区域（完成扩张过程）; 步骤S14计算每个细胞组织区域的星形部分水平分数SA，然后确定每个区域为星形或非星形; 以及步骤S15，以建立要被确定为星形的细胞组织区域的矩形区域（矩形细胞组织区域）。 本发明适用于病理图像分析。

    CELL PROLIFERATION INHIBITOR
    25.
    发明申请
    CELL PROLIFERATION INHIBITOR 审中-公开
    细胞增殖抑制剂

    公开(公告)号：WO1997037019A1

    公开(公告)日：1997-10-09

    申请号：PCT/JP1997001087

    申请日：1997-03-28

    Applicant: JAPAN represented by DIRECTOR GENERAL OF NATION AL INSTITUTE OF HEALTH SCIENCES ,  JURIDICAL FOUNDATION, JAPANESE FOUNDATION FOR CANCER RESEARCH ,  MASUI, Tohru ,  YAMAGUCHI, Satoshi

    Inventor： JAPAN represented by DIRECTOR GENERAL OF NATION AL INSTITUTE OF HEALTH SCIENCES ,  JURIDICAL FOUNDATION, JAPANESE FOUNDATION FOR CANCER RESEARCH

    IPC: C12N15/12

    CPC classification number: C07K14/475 ,  A61K38/00 ,  C07K14/4703

    Abstract: A polypeptide that has the amino acid sequence represented by SEQ ID NO:1 or that has an amino acid sequence resulting from amino acid deletion, substitution or addition in the above amino acid sequence and has a cell proliferation inhibitory activity; a DNA encoding the polypeptide; a DNA that has a base sequence represented by SEQ ID NO:1 or 2, or that hybridizes with an oligonucleotide probe prepared on the basis of the above base sequence; a recombinant vector comprising the DNA; a transformant prepared by introducing the vector into host cells; a process for producing the polypeptide by culturing the transformant in a medium; medicines containing the polypeptide as the active ingredient, preferably antitumor agents; a method of preventing or curing tumors by administering the polypeptide in an efficacious quantity; and the use of the polypeptide for producing pharmacological compositions efficacious in tumor prevention or curing.

    Abstract translation: 具有由SEQ ID NO：1表示的氨基酸序列或者具有由上述氨基酸序列中的氨基酸缺失，取代或添加得到的氨基酸序列，具有细胞增殖抑制活性的多肽; 编码该多肽的DNA; 具有由SEQ ID NO：1或2表示的碱基序列的DNA，或者与基于上述碱基序列制备的寡核苷酸探针杂交; 包含该DNA的重组载体; 通过将载体导入宿主细胞而制备的转化体; 通过在培养基中培养转化体来生产多肽的方法; 含有多肽作为活性成分的药物，优选抗肿瘤剂; 通过以有效量施用多肽来预防或治愈肿瘤的方法; 并且多肽用于制备药物组合物在肿瘤预防或治愈中有效。

    CYTOSTATIC FACTORS
    26.
    发明申请
    CYTOSTATIC FACTORS 审中-公开
    细胞因子

    公开(公告)号：WO1997037017A1

    公开(公告)日：1997-10-09

    申请号：PCT/JP1996000838

    申请日：1996-03-29

    Applicant: JAPAN, represented by DIRECTOR GENERAL OF NATIONAL INSTITUTE OF HEALTH SCIENCES ,  JURIDICAL FOUNDATION, JAPANESE FOUNDATION FOR CANCER RESEARCH ,  MASUI, Tohru ,  YAMAGUCHI, Satoshi

    Inventor： JAPAN, represented by DIRECTOR GENERAL OF NATIONAL INSTITUTE OF HEALTH SCIENCES ,  JURIDICAL FOUNDATION, JAPANESE FOUNDATION FOR CANCER RESEARCH

    IPC: C12N15/12

    CPC classification number: C07K14/475 ,  A61K38/00 ,  C07K14/4703

    Abstract: A polypeptide which comprises an amino acid sequence represented by a specific sequence (hereinafter referred to as ETI-1); a polypeptide having a cytostatic activity which is a homolog of ETI-1, a fragment of ETI-1 or a homolog of a fragment of ETI-1; a DNA encoding the above-mentioned polypeptides; a DNA which comprises a base sequence represented by a specific sequence; a DNA hybridizable with the above-mentioned DNA; a recombination vector containing the above-mentioned DNA; a transformant obtained by introducing this recombination vector into a host; a process for producing the above-mentioned polypeptide which comprises incubating this transformant in a medium; a drug (preferably an antitumor agent) comprising the above-mentioned polypeptide as the active ingredient; a method for preventing or treating tumors which comprises administering the above-mentioned polypeptide in an efficacious dose; and the use of the above-mentioned polypeptide in the production of a pharmacological composition which is efficacious in the prevention or treatment of tumors.

    Abstract translation: 包含由特定序列表示的氨基酸序列（以下称为ETI-1）的多肽; 具有ETI-1的同源物，ETI-1的片段或ETI-1片段的同系物的细胞生长抑制活性的多肽; 编码上述多肽的DNA; 包含由特定序列表示的碱基序列的DNA; 可与上述DNA杂交的DNA; 含有上述DNA的重组载体; 通过将该重组载体引入宿主获得的转化体; 一种生产上述多肽的方法，包括将该转化体在培养基中孵育; 包含上述多肽作为有效成分的药物（优选抗肿瘤剂） 一种预防或治疗肿瘤的方法，包括以有效剂量施用上述多肽; 以及上述多肽在制备有效预防或治疗肿瘤的药理组合物中的用途。

    GENE THERAPY DRUG FOR CANCER, MEDICINAL COMPOSITION, AND THERAPEUTIC METHOD
    27.
    发明申请
    GENE THERAPY DRUG FOR CANCER, MEDICINAL COMPOSITION, AND THERAPEUTIC METHOD 审中-公开
    用于癌症，药物组合物和治疗方法的基因治疗药物

    公开(公告)号：WO1996007433A1

    公开(公告)日：1996-03-14

    申请号：PCT/JP1995001785

    申请日：1995-09-08

    Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH ,  HAMADA, Hirofumi ,  SUGANO, Haruo

    Inventor： JAPANESE FOUNDATION FOR CANCER RESEARCH

    IPC: A61K48/00

    CPC classification number: A61K38/19 ,  A61K39/0011 ,  A61K48/00

    Abstract: A gene therapy drug for cancer containing effector cells having cytokine genes introduced thereinto and tumor vaccines comprising tumor cells having cytokine genes introduced thereinto; a method of gene therapy for cancers by administering a pharmaceutical preparation containing the effector cells and a pharmaceutical preparation containing the tumor vaccines to a patient with cancer; and a medicinal composition containing a combination of the effector cells and the tumor vaccines. The drug, composition and method produce a high antitumor effect, have the effect of inhibiting cancer metastasis, and are useful for treating micrometastatic cancer.

    Abstract translation: 一种用于含有引入其中具有细胞因子基因的效应细胞的癌基因治疗药物和包含引入细胞因子基因的肿瘤细胞的肿瘤疫苗; 通过向患有癌症的患者施用含有效应细胞的药物制剂和含有肿瘤疫苗的药物制剂来对癌症进行基因治疗的方法; 以及含有效应细胞和肿瘤疫苗的组合的药物组合物。 药物，组合物和方法产生高抗肿瘤作用，具有抑制癌转移的作用，可用于治疗微转移性癌症。

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