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    PEPTIDE HAVING BINDING CAPABILITY TO EpCAM
    3.
    发明专利
    PEPTIDE HAVING BINDING CAPABILITY TO EpCAM 审中-公开
    具有与EpCAM结合能力的肽

    公开(公告)号：JP2011193728A

    公开(公告)日：2011-10-06

    申请号：JP2008185819

    申请日：2008-07-17

    Applicant: Japanese Foundation For Cancer Research ,  Murata Mfg Co Ltd ,  公益財団法人がん研究会 ,  株式会社村田製作所

    Inventor： KASHIWAGI KENJI ,  SHIBA KIYOTAKA ,  KAWAMURA HIDEKI

    IPC: C12N15/09 ,  A61K38/00 ,  A61P35/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/82 ,  C07K16/44 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/07 ,  C12N5/10 ,  C12N7/00 ,  G01N33/68

    CPC classification number: C07K7/08 ,  C12N2795/00011 ,  C12N2795/00022

    Abstract: PROBLEM TO BE SOLVED: To provide a new peptide which can be easily produced by a chemical synthetic method or a genetic engineering procedure and has binding capability to EpCAM (epithelial cell adhesion molecule).SOLUTION: A phage group presenting a variety of peptide sequences on phage particles is brought into contact with a solid-phased EpCAM protein. Thus, the phage particles bound to the EpCAM protein are collected and the obtained phage particles are proliferated in an Escherichia coli bacterium. Then a phage clone specifically binding to EpCAM is successfully obtained by repeating a panning operation in which these proliferated phage particles are brought into contact with the EpCAM protein again. An amino acid sequence specifically binding to EpCAM is specified by analyzing a DNA sequence of the phage clone.

    Abstract translation: 要解决的问题：提供可以通过化学合成方法或遗传工程程序容易地生产并具有对EpCAM（上皮细胞粘附分子）的结合能力的新肽。解决方案：呈现多种肽序列的噬菌体组 使噬菌体颗粒与固相EpCAM蛋白质接触。 因此，收集与EpCAM蛋白结合的噬菌体颗粒，并将获得的噬菌体颗粒在大肠杆菌细菌中增殖。 然后通过重复平移操作成功获得特异性结合EpCAM的噬菌体克隆，其中这些增殖的噬菌体颗粒再次与EpCAM蛋白质接触。 通过分析噬菌体克隆的DNA序列来指定与EpCAM特异性结合的氨基酸序列。

    Igf-1r-binding peptide
    5.
    发明专利
    Igf-1r-binding peptide 审中-公开
    IGF-1R-结合肽

    公开(公告)号：JP2014156401A

    公开(公告)日：2014-08-28

    申请号：JP2011117441

    申请日：2011-05-25

    Applicant: Hoya Corp ,  Hoya株式会社 ,  Japanese Foundation For Cancer Research ,  公益財団法人がん研究会

    Inventor： IIMORI YUSUKE ,  YAMAGATA MIZUE ,  SHIONO TOMOTAKA ,  SHIBA KIYOTAKA

    IPC: C07K7/08 ,  A61K38/00 ,  A61K49/00 ,  A61P35/00 ,  C07K7/06 ,  C12N15/09 ,  G01N33/574

    CPC classification number: G01N33/57423 ,  A61K38/00 ,  C07K7/06 ,  C07K7/08 ,  G01N33/57415 ,  G01N33/57434 ,  G01N33/57438

    Abstract: PROBLEM TO BE SOLVED: To provide a binding material specific to IGF-1R with high affinity and a medicine containing the same.SOLUTION: Disclosed is a peptide with 8-50 amino acids, having an amino acid sequence expressed by at least a following formula (1), wherein, Xis Tyr, Trp, Phe, or His, Xis Ser, Ala, Thr, Gly, Asn, Asp, Glu, Arg, or Lys, Xis Met, Leu, Ile, Val, Ala, Phe, Tyr, Trp, or Cys, Xis Leu, Ile, Val, or Met, Xis Gln, Asn, Asp, Glu, Ala, Ser, Thr, Leu, Met, Lys, or Arg, Xis Arg, Lys, His, Asn, Gln, Ser, Thr, Asp, Glu, or Ala, and Xis Leu, Ile, Val, or Met.

    Abstract translation: 要解决的问题：提供具有高亲和力的IGF-1R特异性的结合材料和含有该结合材料的药物。解决方案：公开了具有8-50个氨基酸的肽，其具有至少由下式表示的氨基酸序列 （1），其中，Xis Tyr，Trp，Phe或His，Xis Ser，Ala，Thr，Gly，Asn，Asp，Glu，Arg或Lys，Xis Met，Leu，Ile，Val，Ala，Phe，Tyr ，Trp或Cys，Xis Leu，Ile，Val或Met，Xis Gln，Asn，Asp，Glu，Ala，Ser，Thr，Leu，Met，Lys或Arg，Xis Arg，Lys，His，Asn，Gln ，Ser，Thr，Asp，Glu或Ala，以及Xis Leu，Ile，Val或Met。

    Image processing device, image processing method, recording medium, and program
    6.
    发明专利
    Image processing device, image processing method, recording medium, and program 审中-公开
    图像处理装置，图像处理方法，记录媒体和程序

    公开(公告)号：JP2012252559A

    公开(公告)日：2012-12-20

    申请号：JP2011125100

    申请日：2011-06-03

    Applicant: Sony Corp ,  ソニー株式会社 ,  Japanese Foundation For Cancer Research ,  公益財団法人がん研究会

    Inventor： OHASHI TAKESHI ,  YOKONO JUN ,  NARIHIRA TAKUYA

    IPC: G06F3/048

    CPC classification number: G09G5/34 ,  G09G2380/08

    Abstract: PROBLEM TO BE SOLVED: To make it possible to observe an image reliably with simple operation.SOLUTION: A movement section scrolls a medical image on a screen. In a case where the medical image is scrolled on the screen, a display section displays the medical image in a manner that an observation reference position of a diagnosis target region of the medical image passes through a display reference position of a display region of the screen. This technique can be applied to an image processing device for processing a medical image.

    Abstract translation: 要解决的问题：通过简单的操作，可以可靠地观察图像。

    解决方案：运动部分滚动屏幕上的医疗图像。 在医疗图像在屏幕上滚动的情况下，显示部以医疗图像的诊断对象区域的观察参考位置通过屏幕的显示区域的显示基准位置的方式显示医疗图像 。 该技术可以应用于用于处理医学图像的图像处理装置。 版权所有（C）2013，JPO＆INPIT

    Method and device for mass spectrometry data processing
    7.
    发明专利
    Method and device for mass spectrometry data processing 有权
    用于质谱分析数据处理的方法和装置

    公开(公告)号：JP2012237753A

    公开(公告)日：2012-12-06

    申请号：JP2012102636

    申请日：2012-04-27

    Applicant: Japanese Foundation For Cancer Research ,  公益財団法人がん研究会 ,  Keio Gijuku ,  学校法人慶應義塾 ,  Hamamatsu Univ School Of Medicine ,  国立大学法人浜松医科大学 ,  Shimadzu Corp ,  株式会社島津製作所

    Inventor： MATSUURA MASAAKI ,  USHIJIMA MASARU ,  WAKUI MASATOSHI ,  SETO MITSUTOSHI ,  KAJIWARA SHIGEKI ,  OGAWA KIYOSHI

    IPC: G01N27/62

    CPC classification number: G01N1/28 ,  G06F15/00 ,  H01J49/0004 ,  H01J49/0027

    Abstract: PROBLEM TO BE SOLVED: To collect region-specific expression information characterizing each piece of biological tissue, from imaging mass spectrometry data by effectively utilizing an optical microscope image on a sample.SOLUTION: An optical microscope image of a two-dimensional measurement object region on a sample is displayed, and an analyst visually determines a difference or the like of tissues and designates a plurality of small regions (A, B, and C) regarded as the same tissue. When data processing is started, peak information (m/z and intensity) is extracted from mass spectrum data at all measurement points with respect to each of the designated small regions, and important peak information of high commonality in each region is extracted by a common peak method. When comparison among a plurality of small regions is instructed by the analyst, important peak information of these small regions is collected, and region-specific peak information (expression information) characterizing respective small regions are obtained by comparison of important peak information of different small regions using a determination method like a machine learning algorithm and are stored. The region-specific expression information has high accuracy because visual determination using the optical microscope image is incorporated in this information.

    Abstract translation: 要解决的问题：通过有效地利用样品上的光学显微镜图像，从成像质谱数据收集表征每个生物组织的区域特异性表达信息。 解决方案：显示样品上的二维测量对象区域的光学显微镜图像，分析人员目视确定组织的差异等，并指定多个小区域（A，B和C） 被认为是相同的组织。 当开始数据处理时，相对于每个指定的小区域，在所有测量点的质谱数据中提取峰值信息（m / z和强度），并且每个区域中的高共通性的重要峰值信息通过公共 峰值法。 当分析者指示多个小区域之间的比较时，收集这些小区域的重要峰值信息，并且通过比较不同小区域的重要峰值信息来获得表征各个小区域的区域特定峰值信息（表达信息） 使用诸如机器学习算法的确定方法并被存储。 区域特异性表达信息具有高精度，因为使用光学显微镜图像的视觉确定被并入该信息。 版权所有（C）2013，JPO＆INPIT

    Method for analyzing cell with genetic defect
    8.
    发明专利
    Method for analyzing cell with genetic defect 有权
    用遗传缺陷分析细胞的方法

    公开(公告)号：JP2012103077A

    公开(公告)日：2012-05-31

    申请号：JP2010251107

    申请日：2010-11-09

    Applicant: Japanese Foundation For Cancer Research ,  Olympus Corp ,  オリンパス株式会社 ,  公益財団法人がん研究会

    Inventor： MISHIMA YUJI ,  HATAKE KIYOHIKO ,  ABE TAKASHI

    IPC: G01N33/53 ,  C12Q1/02 ,  C12Q1/37 ,  C12Q1/68 ,  G01N21/64 ,  G01N21/78 ,  G01N33/48 ,  G01N33/483

    CPC classification number: C12Q1/6841 ,  C12Q1/6886

    Abstract: PROBLEM TO BE SOLVED: To provide a method for accurately and simply detecting and analyzing a cell in which a genetic defect occurs by using FISH.SOLUTION: A method for analyzing a cell with a genetic defect has processes of: a) preparing a cell sample containing an eukaryotic cell; b) performing an antigen-antibody reaction to a cell in the cell sample by using one type or two or more types of antibodies to molecules existing on the cell surface of the eukaryotic cell after the process (a); c) performing infiltration treatment to the cell in the cell sample after the process b; d) performing fixation treatment to the cell in the cell sample after the process b; e) performing FISH to the cell in the cell sample by using one type or two or more types of nucleic acid probes after the process d; f) analyzing fluorescence signals from the nucleic acid probes in the cell contained in the cell sample by using a three-dimensional image analysis method after the process e; and g) discriminating whether or not the cell in the cell sample is the cell with the genetic defect from results of the process b and the process f.

    Abstract translation: 要解决的问题：提供一种通过使用FISH来准确且简单地检测和分析遗传缺陷发生的细胞的方法。 解决方案：用于分析具有遗传缺陷的细胞的方法具有以下过程：a）制备含有真核细胞的细胞样品; b）在方法（a）之后，通过使用存在于真核细胞的细胞表面上的分子的一种或两种或更多种抗体，对细胞样品中的细胞进行抗原 - 抗体反应; c）在方法b之后对细胞样品中的细胞进行渗透处理; d）在方法b之后对细胞样品中的细胞进行定影处理; e）在方法d之后使用一种或两种或更多种类型的核酸探针，对细胞样品中的细胞进行FISH; f）通过在处理e之后使用三维图像分析方法分析细胞样品中包含的细胞中的核酸探针的荧光信号; 以及g）鉴别细胞样本中的细胞是否是来自过程b和方法f的结果的遗传缺陷的细胞。 版权所有（C）2012，JPO＆INPIT

    PREVENTIVE AND THERAPEUTIC AGENT OF DISEASE CONTAINING INHIBITOR OF PROTEIN RICIN METHYLATION ENZYME Set 7/9
    9.
    发明专利
    PREVENTIVE AND THERAPEUTIC AGENT OF DISEASE CONTAINING INHIBITOR OF PROTEIN RICIN METHYLATION ENZYME Set 7/9 审中-公开
    含有蛋白质甲基化酶抑制剂的疾病预防和治疗药物组7/9

    公开(公告)号：JP2012102087A

    公开(公告)日：2012-05-31

    申请号：JP2011224604

    申请日：2011-10-12

    Applicant: Japanese Foundation For Cancer Research ,  Kyushu Institute Of Technology ,  公益財団法人がん研究会 ,  国立大学法人九州工業大学

    Inventor： NISHINO NORIKAZU ,  TAKEMOTO YASUSHI ,  ITO AKIHIRO ,  YOSHIDA MINORU ,  YAMORI TAKAO

    IPC: A61K31/4418 ,  A61P15/00 ,  A61P35/00 ,  A61P43/00 ,  C07D211/70

    Abstract: PROBLEM TO BE SOLVED: To provide a histone methylation enzyme Set7/9 inhibitor, a cancer cell growth inhibitor, and a preventive and therapeutic agent of a disease resulting from an excess of an estrogen acceptor.SOLUTION: In order to solve the problem, screening is performed by using a high-throughput HMT activity measurement method which has been uniquely developed by this inventor, and cyproheptadine is defined as an inhibitor substance of Set7/9. Furthermore, the cyproheptadine selectively inhibits the Set7/9 in in-vitro, lowers an observation level of the ERα of a breast cancer cell, and inhibits the estrogen anaclitic growth of the breast cancer cell. By this, it is found that the Set7/9 inhibitor substance can be the preventive and therapeutic agent of the disease resulting from the excess of the estrogen acceptor, thus completing this invention.

    Abstract translation: 要解决的问题：提供组蛋白甲基化酶Set7 / 9抑制剂，癌细胞生长抑制剂以及由过量雌激素受体引起的疾病的预防和治疗剂。 解决方案：为了解决问题，通过使用本发明人独特开发的高通量HMT活性测定方法进行筛选，赛庚啶定义为Set7 / 9的抑制剂物质。 此外，赛庚啶可以体外选择性抑制Set7 / 9，降低了乳腺癌细胞的ERα的观察水平，抑制了乳腺癌细胞的雌激素神经节细胞生长。 由此发现，Set7 / 9抑制剂物质可以是由雌激素受体过量引起的疾病的预防和治疗剂，从而完成了本发明。 版权所有（C）2012，JPO＆INPIT

    Information processing apparatus, method, and program
    10.
    发明专利
    Information processing apparatus, method, and program 有权
    信息处理设备，方法和程序

    公开(公告)号：JP2012088828A

    公开(公告)日：2012-05-10

    申请号：JP2010233279

    申请日：2010-10-18

    Applicant: Japanese Foundation For Cancer Research ,  Sony Corp ,  ソニー株式会社 ,  公益財団法人がん研究会

    Inventor： OHASHI TAKESHI

    IPC: G06Q50/24

    CPC classification number: G06T7/0014 ,  G06T2207/10081 ,  G06T2207/20081 ,  G06T2207/30096

    Abstract: PROBLEM TO BE SOLVED: To improve an efficiency of a diagnosis of a doctor.SOLUTION: A lesion recognition unit 12 calculates a luminance difference feature amount as a feature amount of each image of a plurality of input medical images, and recognizes a lesion progress degree and a lesion type based on the luminance difference feature amount using a lesion progress degree recognition device 21 and a lesion type recognition device 22 having learned previously. A doctor determination unit 13 refers to a doctors' specialized field database 14 to determine a doctor in attendance handling a medical image corresponding to the lesion type. An image rearrangement unit 15 rearranges the medical images for every determined doctor in attendance in order of high score of lesion progress degree recognized by the lesion progress degree recognition device 21. An image presentation unit 16 sequentially presents the rearranged medical images. This invention can be applied to, for example, a medical image processing apparatus.

    Abstract translation: 要解决的问题：提高医生诊断的效率。 解决方案：病变识别单元12计算亮度差特征量作为多个输入医学图像的每个图像的特征量，并且使用基于亮度差异特征量的识别病变进展程度和病变类型 病变进展度识别装置21和病变型识别装置22。 医生确定单元13参考医生的专业现场数据库14，以确定出勤处理对应于病变类型的医学图像的医生。 图像重新排列单元15按照由病变进展度识别装置21识别的病变进展程度的高得分的顺序重新排列每位确定的医生的医疗图像。图像呈现单元16顺序呈现重新布置的医学图像。 本发明可以应用于例如医疗图像处理装置。 版权所有（C）2012，JPO＆INPIT

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