公开(公告)号：US09360006B2

公开(公告)日：2016-06-07

申请号：US13464309

申请日：2012-05-04

Applicant: Philip Herzog ,  Konstantin Choikhet ,  Klaus Witt ,  Herbert Anderer

Inventor： Philip Herzog ,  Konstantin Choikhet ,  Klaus Witt ,  Herbert Anderer

IPC: F04B11/00 ,  F04B49/08 ,  B01D15/14 ,  G01N30/32

CPC classification number: F04B49/08 ,  B01D15/14 ,  F04B11/0058 ,  F04B2201/0201 ,  F04B2205/05 ,  G01N30/32 ,  G01N2030/326 ,  Y10T137/794

Abstract: A method for controlling operation of a pump unit, where the pump unit includes a primary piston pump having a primary piston and a secondary piston pump having a secondary piston. The primary piston pump is fluidically connected with the secondary piston pump. The primary piston pump includes an inlet valve and an outlet valve, and the pump unit operates periodically according to a pump cycle. The method includes determining a fluid pressure of fluid dispensed by the pump unit, and performing a closed loop control of a position of the primary piston in dependence on the fluid pressure of the fluid dispensed by the pump unit during a first time interval of the pump cycle.

Abstract translation: 一种用于控制泵单元的操作的方法，其中所述泵单元包括具有主活塞的主活塞泵和具有次活塞的次级活塞泵。 主活塞泵与次级活塞泵流体连接。 主活塞泵包括入口阀和出口阀，并且泵单元根据泵循环周期性地运行。 该方法包括确定由泵单元分配的流体的流体压力，以及根据在泵的第一时间间隔期间由泵单元分配的流体的流体压力执行主活塞的位置的闭环控制 周期。

公开(公告)号：US20150000416A1

公开(公告)日：2015-01-01

申请号：US14344113

申请日：2011-09-15

Applicant: Martin Baeuerle ,  Konstantin Choikhet

Inventor： Martin Baeuerle ,  Konstantin Choikhet

IPC: G01N30/32 ,  B01D53/02 ,  G01N30/36 ,  G01L13/02 ,  G01L13/06 ,  G01L27/00 ,  B01D15/10 ,  B01D57/02

CPC classification number: G01N30/32 ,  B01D15/10 ,  B01D53/025 ,  B01D57/02 ,  B01L3/5027 ,  B01L2200/146 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/14 ,  B01L2400/0487 ,  G01L13/023 ,  G01L13/06 ,  G01L27/002 ,  G01N30/36 ,  G01N30/6095 ,  G01N2030/326

Abstract: A fluidic chip device configured for processing a fluid, wherein the fluidic chip device comprises a plurality of layers laminated to one another, wherein at least a part of the layers comprises a patterned section of an alternating sequence of bars and fluidic channels for conducting the fluid under pressure, the patterned section being configured for being displaceable in response to the pressure, and a pressure detector responding to the displacement of the patterned section by generating a detector signal being indicative of a value of the pressure.

Abstract translation: 一种构造成用于处理流体的流体芯片装置，其中所述流体芯片装置包括彼此层叠的多个层，其中所述层的至少一部分包括用于传导流体的条和流体通道的交替序列的图案化部分 在压力下，图案化部分被配置为响应于压力而移动;以及压力检测器，通过产生指示压力值的检测器信号来响应于图案化部分的位移。

公开(公告)号：US08182680B2

公开(公告)日：2012-05-22

申请号：US12431972

申请日：2009-04-29

Applicant: Philip Herzog ,  Konstantin Choikhet ,  Klaus Witt ,  Herbert Anderer

Inventor： Philip Herzog ,  Konstantin Choikhet ,  Klaus Witt ,  Herbert Anderer

IPC: B01D15/08

CPC classification number: F04B49/08 ,  B01D15/14 ,  F04B11/0058 ,  F04B2201/0201 ,  F04B2205/05 ,  G01N30/32 ,  G01N2030/326 ,  Y10T137/794

Abstract: A method for controlling operation of a pump unit, where the pump unit includes a primary piston pump having a primary piston and a secondary piston pump having a secondary piston. The primary piston pump is fluidically connected with the secondary piston pump. The primary piston pump includes an inlet valve and an outlet valve, and the pump unit operates periodically according to a pump cycle. The method includes determining a fluid pressure of fluid dispensed by the pump unit, and performing a closed loop control of a position of the primary piston in dependence on the fluid pressure of the fluid dispensed by the pump unit during a first time interval of the pump cycle.

Abstract translation: 一种用于控制泵单元的操作的方法，其中所述泵单元包括具有主活塞的主活塞泵和具有次活塞的次级活塞泵。 主活塞泵与二级活塞泵流体连接。 主活塞泵包括入口阀和出口阀，并且泵单元根据泵循环周期性地运行。 该方法包括确定由泵单元分配的流体的流体压力，以及根据在泵的第一时间间隔期间由泵单元分配的流体的流体压力执行主活塞的位置的闭环控制 周期。

公开(公告)号：US20110192217A1

公开(公告)日：2011-08-11

申请号：US12702147

申请日：2010-02-08

Applicant: Konstantin Choikhet ,  Klaus Witt ,  Martin Baeuerle

Inventor： Konstantin Choikhet ,  Klaus Witt ,  Martin Baeuerle

IPC: G01N30/84 ,  G01N1/28 ,  B01F15/02 ,  B01D15/08

CPC classification number: G01N30/34 ,  B01F5/064 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0059 ,  G01N2030/347

Abstract: A mixer for mixing a fluid having a property varying along a flow direction of the fluid includes an inlet configured for receiving an inlet flow, an outlet configured for providing an outlet flow, and a plurality of flow channels coupled between the inlet and the outlet. The mixer also includes a flow distributor for distributing the inlet flow into the plurality of flow channels so that each flow channel receives a partial flow from the inlet flow, and a flow combiner for combining the partial flows from the plurality of flow channels to the outlet flow. Each flow channel has a first flow section having a hydraulic resistance substantially representing a hydraulic resistance of the flow channel. One or more of the flow channels each have a second flow section coupled in series with the first flow section of the respective flow channel.

Abstract translation: 用于混合具有沿着流体的流动方向变化的性质的流体的混合器包括构造成用于接收入口流的入口，被配置为提供出口流的出口以及耦合在入口和出口之间的多个流动通道。 混合器还包括用于将入口流分配到多个流动通道中的流量分配器，使得每个流动通道接收来自入口流的部分流动，以及流动组合器，用于将来自多个流动通道的部分流合并到出口 流。 每个流动通道具有第一流动部分，其具有基本上表示流动通道的液压阻力的液压阻力。 一个或多个流动通道各自具有与相应流动通道的第一流动部分串联联接的第二流动部分。

公开(公告)号：US20110132463A1

公开(公告)日：2011-06-09

申请号：US12737677

申请日：2008-08-07

Applicant: Kaus Witt ,  Konstantin Choikhet

Inventor： Kaus Witt ,  Konstantin Choikhet

IPC: F15D1/00 ,  B01D15/16

CPC classification number: F04B11/0058 ,  F04B13/02 ,  F04B2203/0204 ,  Y10T137/0318 ,  Y10T137/86131

Abstract: A solvent supply system for supplying a composite solvent is described. The solvent supply system comprises a first supply flow path with a first pump unit, the first supply flow path being adapted for supplying a flow of a first solvent to a mixing unit, the first pump unit operating periodically, and a second supply flow path with a second pump unit, the second supply flow path being adapted for supplying a flow of a second solvent to the mixing unit, the second pump unit operating periodically. The mixing unit is adapted for mixing the first and the second solvent and for supplying a composite solvent. The solvent supply system further comprises a control unit adapted for controlling operation of the first and the second pump unit, the control unit being adapted to prevent at least one of a predefined phase relation and a predefined frequency relation between the first pump unit and the second pump unit.

Abstract translation: 描述了用于供应复合溶剂的溶剂供应系统。 所述溶剂供应系统包括具有第一泵单元的第一供应流动路径，所述第一供应流动路径适于将第一溶剂的流供应到混合单元，所述第一泵单元周期性地运行，以及第二供给流路， 第二泵单元，所述第二供应流路适于将第二溶剂的流供应到所述混合单元，所述第二泵单元周期性地运行。 混合单元适于混合第一和第二溶剂并供应复合溶剂。 所述溶剂供应系统还包括适于控制所述第一和第二泵单元的操作的控制单元，所述控制单元适于防止所述第一泵单元和所述第二泵单元之间的预定相位关系和预定频率关系中的至少一个 泵单元。

公开(公告)号：US20110116973A1

公开(公告)日：2011-05-19

申请号：US12619283

申请日：2009-11-16

Applicant: Konstantin Choikhet

Inventor： Konstantin Choikhet

IPC: G01N31/00

CPC classification number: G01N30/38 ,  G01N30/20 ,  G01N30/34 ,  G01N2030/347

Abstract: A sample separation device for separating a sample comprises a first fluid supply path for supplying a first fluid, a second fluid supply path for supplying a second fluid, a sample separation unit adapted for separating the sample, a sensor configured for determining a value of a parameter related to the fluid, and a valve configured for selectively coupling both of the first and second fluid supply paths to the sensor and to the sample separation unit, or coupling one of the first and second fluid supply paths to the sensor.

Abstract translation: 用于分离样品的样品分离装置包括用于供应第一流体的第一流体供应路径，用于供应第二流体的第二流体供应路径，适于分离样品的样品分离单元，被配置为确定 与流体相关的参数以及被配置为选择性地将第一和第二流体供应路径耦合到传感器和样品分离单元，或者将第一和第二流体供应路径之一耦合到传感器的阀。

公开(公告)号：US20090255601A1

公开(公告)日：2009-10-15

申请号：US12102444

申请日：2008-04-14

Applicant: Martin BAEUERLE ,  Konstantin CHOIKHET

Inventor： Martin BAEUERLE ,  Konstantin CHOIKHET

IPC: B01F5/04

CPC classification number: B01F5/061 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/065 ,  B01F2005/0621 ,  B01F2005/0636 ,  G01N30/6086 ,  G01N30/6095 ,  Y10T137/87619 ,  Y10T137/87652

Abstract: A fluidic device, the fluidic device comprising a planar fluidic conduit for conducting a fluid, wherein the fluidic conduit has a plurality of fluidic disturbance features located along at least a section of the fluidic conduit for disturbing a laminar flow of the fluid along the section.

Abstract translation: 一种流体装置，流体装置包括用于传导流体的平面流体导管，其中流体导管具有沿着流体导管的至少一部分定位的多个流体扰动特征，用于干扰流体沿该部分的层流。

公开(公告)号：US20060219618A1

公开(公告)日：2006-10-05

申请号：US11386978

申请日：2006-03-22

Applicant: Klaus Witt ,  Konstantin Choikhet ,  Alexander Bierbaum

Inventor： Klaus Witt ,  Konstantin Choikhet ,  Alexander Bierbaum

IPC: B01D15/08

CPC classification number: G01N30/32 ,  B01D15/163 ,  B01D15/166 ,  G01N2030/347 ,  Y10T137/0352 ,  Y10T137/2496

Abstract: A supply flow path for supplying a solvent is described. The supply flow path comprises a metering device with a piston, the metering device being adapted for metering the solvent. The supply flow path further comprises a control unit adapted for controlling the metering device's piston movement in accordance with solvent pressure, wherein a variation of the solvent pressure gives rise to a corresponding variation of a solvent volume contained in the supply flow path or a part thereof. The control unit is adapted for compensating for the variation of the solvent volume by a corresponding corrective movement of the piston.

Abstract translation: 描述用于供应溶剂的供应流动路径。 供应流路包括具有活塞的计量装置，计量装置适于计量溶剂。 供应流动路径还包括控制单元，其适于根据溶剂压力控制计量装置的活塞运动，其中溶剂压力的变化导致包含在供应流动路径或其一部分中的溶剂体积的相应变化 。 控制单元适于通过相应的活塞校正运动来补偿溶剂体积的变化。

公开(公告)号：US09459239B2

公开(公告)日：2016-10-04

申请号：US13178814

申请日：2011-07-08

Applicant: Klaus Witt ,  Konstantin Choikhet

Inventor： Klaus Witt ,  Konstantin Choikhet

IPC: G05D11/00 ,  G01N30/34

CPC classification number: G01N30/34 ,  Y10T137/2499

Abstract: A fluid supply system configured for metering two or more fluids in controlled proportions, including a plurality of solvent supply lines, a pumping unit configured for taking in fluids from selected solvent supply lines and for supplying a pressurized mixture, a proportioning valve configured for modulating solvent composition by sequentially coupling selected ones of the solvent supply lines with the inlet of the pumping unit, a sensor configured for sensing process information in the fluid supply system, an analysis entity configured for analyzing the process information for determining reciprocating element related information at a beginning of fluid intake, and a control unit configured for switching the proportioning valve to sequentially couple selected ones of the solvent supply lines to the inlet of the pumping unit at one or more switching points based on the given metering scheme and based on the reciprocating element related information.

Abstract translation: 一种流体供应系统，被配置为以受控比例计量两种或多种流体，包括多个溶剂供应管线，被配置用于从选定的溶剂供应管线吸入流体并用于供应加压混合物的泵送单元，配置用于调节溶剂的比例阀 通过将选定的溶剂供应管线与泵送单元的入口顺序耦合而构成的传感器，构造成用于感测流体供应系统中的过程信息的传感器，被配置为分析开始时确定往复元件相关信息的过程信息的分析实体 以及控制单元，其被配置用于切换所述比例阀，以基于给定的计量方案并且基于往复运动元件相关的顺序地将选定的溶剂供应管线连接到泵送单元的入口处的一个或多个切换点 信息。

公开(公告)号：US20150204828A1

公开(公告)日：2015-07-23

申请号：US14411276

申请日：2012-06-26

Applicant: Klaus Witt ,  Konstantin Choikhet

Inventor： Klaus Witt ,  Konstantin Choikhet

IPC: G01N30/80 ,  G01N30/06 ,  G01N30/20 ,  G01N27/447

CPC classification number: G01N30/80 ,  B01D15/1871 ,  G01N27/447 ,  G01N30/06 ,  G01N30/20 ,  G01N30/461 ,  G01N30/6039 ,  G01N2030/208

Abstract: A sample separation apparatus (100, 200) for separating a fluidic sample (104), the sample separation apparatus (100, 200) comprising: a first separation unit (102) for separating the fluidic sample (104); a first fluid drive (106) configured for generating a fluid flow for conducting the fluidic sample (104) to be separated through the first separation unit (102); a second separation unit (110), arranged downstream of the first separation unit (102), for further separating the fluidic sample (104) after treatment by the first separation unit (102); a second fluid drive (112) configured for generating a fluid flow for conducting the fluidic sample (104) or at least parts thereof, after treatment by the first separation unit (102), through the second separation unit (110); a fluidic valve (114) having a first inlet (116) fluidically coupled to one of the first fluid drive (106) and the second fluid drive (112); the fluidic valve (114) having a second inlet (118) fluidically coupled to the other of the first fluid drive (106) and the second fluid drive (112); the fluidic valve (114) comprising at least two different sets (131, 133) of storage paths, wherein each set of storage paths comprises a first storage path (128); and wherein the first storage path (128) of a first set (131) of said at least two sets of storage paths has a first volume and the first storage path (132) of a second set (133) of said at least two sets of storage paths has a second volume different from the first volume; the fluidic valve (114) being configured for selectively switching one set of said least two sets of storage paths to the first inlet (116) and the second inlet (118).

Abstract translation: 1.一种用于分离流体样品（104）的样品分离装置（100,200），所述样品分离装置（100,200）包括：用于分离流体样品（104）的第一分离单元（102） 第一流体驱动器（106），其被配置用于产生用于传导待通过所述第一分离单元（102）分离的所述流体样品（104）的流体流; 布置在第一分离单元（102）的下游的第二分离单元（110），用于在通过第一分离单元（102）处理之后进一步分离流体样品（104）; 第二流体驱动器（112），被配置为在通过第一分离单元（102）处理之后通过第二分离单元（110）产生用于传导流体样品（104）或其至少部分的流体流; 流体阀（114）具有流体耦合到第一流体驱动器（106）和第二流体驱动器（112）之一的第一入口（116）; 流体阀（114）具有与第一流体驱动器（106）和第二流体驱动器（112）中的另一个流体连接的第二入口（118）。 所述流体阀（114）包括至少两个不同的存储路径组（131,133），其中每组存储路径包括第一存储路径（128）; 并且其中所述至少两组存储路径中的第一组（131）的第一存储路径（128）具有第一卷，并且所述至少两个集合的第二集合（133）的第一存储路径（132） 的存储路径具有与第一卷不同的第二卷; 所述流体阀（114）构造成用于选择性地将一组所述至少两组存储路径切换到所述第一入口（116）和所述第二入口（118）。