公开(公告)号：US09694301B2

公开(公告)日：2017-07-04

申请号：US14400312

申请日：2012-05-10

Applicant: Konstantin Choikhet ,  Klaus Witt

Inventor： Konstantin Choikhet ,  Klaus Witt

IPC: B01D15/18 ,  G01N30/32 ,  G01N30/46 ,  G01N27/447 ,  G01N30/72 ,  G01N30/34 ,  G01N30/60

CPC classification number: B01D15/18 ,  G01N27/44704 ,  G01N30/32 ,  G01N30/34 ,  G01N30/463 ,  G01N30/465 ,  G01N30/6095 ,  G01N30/72 ,  G01N2030/322 ,  G01N2030/328

Abstract: A sample separation apparatus for separating a liquid sample includes a first separation unit for separating the sample, a first fluid drive for conducting the sample to be separated through the first separation unit, a second separation unit, arranged downstream of the first separation unit, for further separating the sample, a second fluid drive for at least partially conducting the sample through the second separation unit, and a fluidic valve having interfaces fluidically coupled to the first and second fluid drives and being switchable for performing the separation of the sample. The apparatus is configured for adjusting a pressure at a predefined position to a predefined value, wherein the predefined position is in a fluidic path between an outlet of the first separation unit and an inlet of the second separation unit or in fluid communication with this fluidic path.

公开(公告)号：US20150059451A1

公开(公告)日：2015-03-05

申请号：US14396938

申请日：2012-04-25

Applicant: Klaus Witt ,  Konstantin Choikhet

Inventor： Klaus Witt ,  Konstantin Choikhet

IPC: B01D15/12 ,  G01N30/16

CPC classification number: B01D15/12 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2400/0487 ,  B01L2400/0644 ,  G01N30/16 ,  G01N30/34

Abstract: A fluid supply system (150) configured for supplying fluids, the fluid supply system (150) comprising a fluid packet supply unit (180) configured for controlling supply of a sequence (250) of fluid packets (222 to 230), the fluid packets (222 to 230) comprising a packet of first fluid (223) and a packet of second fluid (225), wherein the first fluid and the second fluid are media being prone to a phase separation upon direct interaction between the packet of first fluid (223) and the packet of second fluid (225), and a phase separation inhibiting unit (190) configured for inhibiting phase separation by inserting an intermediate fluid packet (224) between the packet of first fluid (223) and the packet of second fluid (225) to 230 to 230

Abstract translation: 一种构造成供应流体的流体供应系统（150），所述流体供应系统（150）包括被配置为控制流体包（222至230）的序列（250）的供应的流体包供应单元（180），所述流体包 （222至230），包括第一流体（223）和第二流体（225）的包装，其中所述第一流体和所述第二流体是介质在所述第一流体包之间的直接相互作用时易于相分离 223）和第二流体（225）的分组，以及相分离禁止单元（190），其被配置为通过在第一流体（223）的包和第二流体包之间插入中间流体包（224）来抑制相分离 （225）至230至230

公开(公告)号：US08641267B2

公开(公告)日：2014-02-04

申请号：US12102444

申请日：2008-04-14

Applicant: Martin Baeuerle ,  Konstantin Choikhet

Inventor： Martin Baeuerle ,  Konstantin Choikhet

IPC: B01F5/06

CPC classification number: B01F5/061 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/065 ,  B01F2005/0621 ,  B01F2005/0636 ,  G01N30/6086 ,  G01N30/6095 ,  Y10T137/87619 ,  Y10T137/87652

Abstract: A fluidic device, the fluidic device comprising a planar fluidic conduit for conducting a fluid, wherein the fluidic conduit has a plurality of fluidic disturbance features located along at least a section of the fluidic conduit for disturbing a laminar flow of the fluid along the section.

Abstract translation: 一种流体装置，流体装置包括用于传导流体的平面流体导管，其中流体导管具有沿着流体导管的至少一部分定位的多个流体扰动特征，用于干扰流体沿该部分的层流。

公开(公告)号：US20120198919A1

公开(公告)日：2012-08-09

申请号：US13346092

申请日：2012-01-09

Applicant: Klaus Witt ,  Konstantin Choikhet ,  Philip Herzog

Inventor： Klaus Witt ,  Konstantin Choikhet ,  Philip Herzog

IPC: G01N11/00

CPC classification number: G01N30/34

Abstract: A method for metering two or more liquids in controlled proportions in a liquid supply system and for supplying a resultant mixture, in which the liquid supply system includes a plurality of solvent supply lines, a proportioning valve interposed between the solvent supply lines and an inlet of a pumping unit, the method includes drawing in a first liquid into the pumping unit via a first solvent supply line; determining one or more switching points of time for switching between different solvent supply lines, the switching points of time being determined in a way that at said switching points of time, the liquid supplied to the pumping unit is in a predefined pressure range; switching from the first solvent supply line to a second solvent supply line at one of said switching points of time; drawing in a second liquid into the pumping unit via the second solvent supply line.

Abstract translation: 一种用于在液体供应系统中以可控比例计量两种或多种液体并用于供应所得混合物的方法，其中所述液体供应系统包括多个溶剂供应管线，配置阀插入在所述溶剂供应管线之间， 抽吸单元，该方法包括经由第一溶剂供应管线将第一液体引入泵送单元; 确定用于在不同溶剂供应管线之间切换的一个或多个切换点，所述切换点的时间是以在所述切换时间点被供应到所述泵送单元的液体处于预定压力范围内的方式确定的; 在所述切换点之一从第一溶剂供应管线切换到第二溶剂供应管线; 通过第二溶剂供应管线将第二液体吸入泵送单元。

公开(公告)号：US20070263049A1

公开(公告)日：2007-11-15

申请号：US11804093

申请日：2007-05-17

Applicant: Tobias Preckel ,  Hans-Peter Zimmermann ,  Konstantin Choikhet

Inventor： Tobias Preckel ,  Hans-Peter Zimmermann ,  Konstantin Choikhet

IPC: B41J2/175

CPC classification number: B01L3/502715 ,  B01F5/0683 ,  B01F5/0689 ,  B01F11/0045 ,  B01F11/0071 ,  B01F15/0205 ,  B01F15/0212 ,  B01L3/502738 ,  B01L3/505 ,  B01L2200/0642 ,  B01L2400/0481 ,  B01L2400/0638

Abstract: A supply arrangement includes a supply reservoir element and a microfluidic device, wherein the supply reservoir element has a first reservoir unit having a prefilled liquid reagent therein, and the microfluidic device has a reception device adapted for receiving the liquid reagent from the first reservoir unit. The supply reservoir element is coupled to the microfluidic device. One of the supply reservoir element and the microfluidic device includes a puncturing element in order to cause fluid flow of the liquid reagent from the first reservoir unit to the reception device when the puncturing element is operated. The supply reservoir element has a basal plane, and the first reservoir unit has a first blister element arranged on the basal plane.

Abstract translation: 供应装置包括供应储存器元件和微流体装置，其中所述供应储存器元件具有其中具有预充式液体试剂的第一储存器单元，并且所述微流体装置具有适于从所述第一储存器单元接收所述液体试剂的接收装置。 供应储存器元件联接到微流体装置。 供应储存器元件和微流体装置中的一个包括穿刺元件，以便当穿刺元件操作时使液体试剂从第一储存器单元流体流向接收装置。 供给储存元件具有基面，第一储存器单元具有布置在基面上的第一泡罩元件。

公开(公告)号：US09335309B2

公开(公告)日：2016-05-10

申请号：US14411276

申请日：2012-06-26

Applicant: Klaus Witt ,  Konstantin Choikhet

Inventor： Klaus Witt ,  Konstantin Choikhet

IPC: G01N33/00 ,  G01N30/80 ,  G01N30/20 ,  G01N27/447 ,  G01N30/06 ,  B01D15/18 ,  G01N30/46 ,  G01N30/60

CPC classification number: G01N30/80 ,  B01D15/1871 ,  G01N27/447 ,  G01N30/06 ,  G01N30/20 ,  G01N30/461 ,  G01N30/6039 ,  G01N2030/208

Abstract: A sample separation apparatus includes a fluidic valve including a first inlet fluidically coupled to one of a first fluid drive and a second fluid drive, and a second inlet fluidically coupled to the other of the first fluid drive and the second fluid drive. The fluidic valve includes at least two different sets of storage paths, wherein each set of storage paths comprises a first storage path. The first storage path of a first set of said at least two sets of storage paths has a first volume, and the first storage path of a second set of said at least two sets of storage paths has a second volume different from the first volume. The fluidic valve is configured for selectively switching one set of the least two sets of storage paths to the first inlet and the second inlet.

Abstract translation: 样品分离装置包括流体阀，其包括流体耦合到第一流体驱动器和第二流体驱动器中的一个的第一入口，以及与第一流体驱动器和第二流体驱动器中的另一个流体连接的第二入口。 流体阀包括至少两组不同的存储路径，其中每组存储路径包括第一存储路径。 所述至少两组存储路径的第一组的第一存储路径具有第一卷，并且所述至少两组存储路径的第二组的第一存储路径具有不同于第一卷的第二卷。 流体阀构造成用于选择性地将一组至少两组存储路径切换到第一入口和第二入口。

公开(公告)号：US20120096919A1

公开(公告)日：2012-04-26

申请号：US13378376

申请日：2009-06-30

Applicant: Konstantin Choikhet ,  Klaus Witt

Inventor： Konstantin Choikhet ,  Klaus Witt

IPC: G01N30/02

CPC classification number: G01N30/86 ,  G01N30/24 ,  G01N30/88

Abstract: A liquid chromatography device (200) being controllable for executing a chromatographic method (402) defined by a set of target parameters and by a corresponding target sequence of operation procedures, the device comprising a method execution unit (202) configured for executing the chromatographic method (402) by applying the set of target parameters and by running the corresponding target sequence of operation procedures within the liquid chromatography device (200), a determining unit (204) configured for determining a deviation of an actual result of the chromatographic method (402) from an expected target result, wherein the expected target result of the chromatographic method (402) represents a desired behavior of the liquid chromatography device (200) and wherein the actual result of the chromatographic method (402) is obtained by executing the chromatographic method (402) and represents an actual behavior of the liquid chromatography device (200), and an adjusting unit (206) configured for adjusting at least one operation property of the liquid chromatography device (200) based on the determined deviation to thereby at least partially compensate a difference between the expected target result and the actual result while maintaining the chromatographic method (402) unchanged.

Abstract translation: 可控液相色谱装置（200），用于执行由一组目标参数和相应的目标操作程序定义的色谱方法（402），所述装置包括方法执行单元（202），其被配置为执行色谱法 （402），通过应用所述目标参数集合并且通过在所述液相色谱装置（200）内运行相应的目标操作程序序列来确定所述色谱方法（402）的实际结果的偏差的确定单元（204） ），其中色谱方法（402）的预期目标结果表示液相色谱装置（200）的期望行为，并且其中色谱法（402）的实际结果是通过执行色谱法获得的 （402）并且表示液相色谱装置（200）的实际行为，以及调节单元（206） 根据所确定的偏差设计用于调节液相色谱装置（200）的至少一个操作属性，从而至少部分地补偿预期目标结果与实际结果之间的差异，同时保持色谱方法（402）不变。

公开(公告)号：US20100299079A1

公开(公告)日：2010-11-25

申请号：US12763806

申请日：2010-04-20

Applicant: Manfred Berndt ,  Konstantin Choikhet ,  Philip Herzog

Inventor： Manfred Berndt ,  Konstantin Choikhet ,  Philip Herzog

IPC: G01N30/02 ,  F04B49/10 ,  F04B49/00

CPC classification number: F04B23/06 ,  F04B11/0075 ,  F04B53/08 ,  F04B2205/10 ,  F04B2205/112 ,  G01N30/24 ,  G01N30/30

Abstract: A pump unit comprises a primary piston pump, a secondary piston pump, and a flow path adapted for fluidically connecting in series the primary piston pump and the secondary piston pump. The pump unit's duty cycle comprises a delivery-and-fill phase, in which the primary piston pump supplies a flow of liquid to the secondary piston pump, and during the delivery-and-fill phase, the flow of liquid supplied by the primary piston pump is partly used for filling up the secondary piston pump and partly used for maintaining another flow of liquid dispensed across the secondary piston pump. The flow path comprises a heat exchanger, wherein liquid supplied by the primary piston pump passes through the heat exchanger before being supplied to the secondary piston pump. The heat exchanger is adapted for reducing a temperature difference between a temperature of liquid supplied to heat exchanger and a temperature of the secondary piston pump, in that the heat exchanger is kept at a temperature of the secondary piston pump, so that after having passed the heat exchanger, liquid supplied to the secondary piston pump has substantially the same temperature as the secondary piston pump itself.

Abstract translation: 泵单元包括主活塞泵，次级活塞泵和适于串联流体连接主活塞泵和次级活塞泵的流路。 泵单元的占空比包括输送和填充阶段，其中主活塞泵将液体流供应到次级活塞泵，并且在输送和填充阶段期间，由主活塞泵供应的液体流 泵部分地用于填充次级活塞泵，并且部分地用于保持分配在次级活塞泵上的另外的液体流。 流路包括热交换器，其中由主活塞泵供应的液体在被供应到次级活塞泵之前通过热交换器。 热交换器适于减少供应到热交换器的液体的温度与次级活塞泵的温度之间的温度差，因为热交换器保持在次级活塞泵的温度，使得在通过 热交换器，供应到次级活塞泵的液体具有与次级活塞泵本身基本相同的温度。

公开(公告)号：US07685866B2

公开(公告)日：2010-03-30

申请号：US11221158

申请日：2005-09-07

Applicant: Alexander Bierbaum ,  Hans-Georg Weissgerber ,  Konstantin Choikhet

Inventor： Alexander Bierbaum ,  Hans-Georg Weissgerber ,  Konstantin Choikhet

IPC: G01M3/08

CPC classification number: G01N30/32 ,  F04B11/0075 ,  G01N2030/324 ,  G01N2030/326

Abstract: A liquid delivery system having at least one channel, at least one valve within that channel, at least one flow sensing device within that channel, and a pressure source downstream of the valve capable for generating variable pressures.

Abstract translation: 具有至少一个通道的液体输送系统，该通道内的至少一个阀，该通道内的至少一个流量感测装置，以及能够产生可变压力的阀下游的压力源。

公开(公告)号：US20070116609A1

公开(公告)日：2007-05-24

申请号：US11654210

申请日：2007-01-17

Applicant: Martin Baeuerle ,  Hans-Peter Zimmermann ,  Konstantin Choikhet ,  Tobias Preckel

Inventor： Martin Baeuerle ,  Hans-Peter Zimmermann ,  Konstantin Choikhet ,  Tobias Preckel

IPC: B01L3/02

CPC classification number: G01N30/74 ,  B01L3/502715 ,  B01L9/527 ,  B01L2200/027 ,  B01L2300/0654 ,  B01L2300/0877 ,  B01L2300/168 ,  G01N21/05 ,  G01N2021/0346 ,  G01N2030/746 ,  G01N30/6095

Abstract: A microfluidic arrangement (1) for the optical detection of fluids is provided, comprising a microfluidic device (2) having at least one first channel (3) with an opening (4) which is in fluid communication with an optical detection unit (6) of an optical device (5); the microfluidic device (2) being operatively detachably coupled with the optical device (5) whereby an extension of the part (7,7′) of relevance of the optical detection path (17) is provided. A method for detecting fluids using the arrangement of the present invention is provided.

Abstract translation: 提供了一种用于流体光学检测的微流体装置（1），包括具有至少一个具有与光学检测单元（6）流体连通的开口（4）的至少一个第一通道（3）的微流体装置（2） 的光学装置（5）; 所述微流体装置（2）可操作地与所述光学装置（5）耦合，由此提供所述光学检测路径（17）的相关部分（7,7'）的延伸。 提供了使用本发明的装置检测流体的方法。