公开(公告)号：WO02102990A8

公开(公告)日：2003-12-24

申请号：PCT/US0219400

申请日：2002-06-17

Applicant: CURAGEN CORP ,  SHIMKETS RICHARD A ,  JEFFERS MICHAEL E ,  PRAYAGA SUDHIRDAS K ,  BOLDOG FERENC L ,  YANG MEIJIA ,  BURGESS CATHERINE E ,  FERNANDES ELMA R ,  HERRMANN JOHN L ,  LAROCHELLE WILLIAM J ,  LICHENSTEIN HENRI S ,  GORMAN LINDA ,  ZHONG MEI ,  PADIGARU MURALIDHARA ,  PENA CAROL E A ,  ALSOBROOK JOHN P II ,  LEPLEY DENISE M ,  RIEGER DANIEL K ,  GROSSE WILLIAM M

Inventor： SHIMKETS RICHARD A ,  JEFFERS MICHAEL E ,  PRAYAGA SUDHIRDAS K ,  BOLDOG FERENC L ,  YANG MEIJIA ,  BURGESS CATHERINE E ,  FERNANDES ELMA R ,  HERRMANN JOHN L ,  LAROCHELLE WILLIAM J ,  LICHENSTEIN HENRI S ,  GORMAN LINDA ,  ZHONG MEI ,  PADIGARU MURALIDHARA ,  PENA CAROL E A ,  ALSOBROOK JOHN P II ,  LEPLEY DENISE M ,  RIEGER DANIEL K ,  GROSSE WILLIAM M

IPC: G01N33/50 ,  A61K38/27 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P1/00 ,  A61P9/00 ,  A61P17/02 ,  A61P17/14 ,  A61P35/00 ,  C07K14/50 ,  C07K16/22 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C07H21/04 ,  C07K5/00 ,  C07K17/00 ,  C12N15/11 ,  C12N15/85 ,  C12N15/86

CPC classification number: C07K14/50

Abstract: The present invention provides FGF-CX, a novel isolated polypeptide, as well as a polynucleotide encoding FGF-CX and antibodies that immunospecifically bind to FGF-CX or any derivative, variant, mutant, or fragment of the FGF-CX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FGF-CX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as other uses.

Abstract translation: 本发明提供了FGF-CX（一种新的分离的多肽）以及编码FGF-CX的多核苷酸和免疫特异性结合FGF-CX或FGF-CX多肽，多核苷酸或其片段的任何衍生物，变体，突变体或片段的抗体 抗体。 本发明另外提供了其中将FGF-CX多肽，多核苷酸和抗体用于检测和治疗广泛范围的病理状态以及其它用途的方法。

公开(公告)号：WO2003085124A2

公开(公告)日：2003-10-16

申请号：PCT/US2003/009775

申请日：2003-04-01

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P. II ,  BENTO, Patricia ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  CRABTREE-BOKOR, Julie, R. ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen ,  FERNANDES, Elma, R. ,  GERLACH, Valerie, L. ,  GROSSE, William, M. ,  GUNTHER, Erik ,  GUSEV, Vladimir, Y. ,  HEYES, Melvyn, P. ,  LEPLEY, Denise, M. ,  LI, Li ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MILLET, Isabelle ,  PATTURAJAN, Meera ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, D. ,  SMITHSON, Glennda ,  STONE, David, J. ,  VERNET, Corine, A. M. ,  VOSS, Edward, Z.

Inventor： ALSOBROOK, John, P. II ,  BENTO, Patricia ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  CRABTREE-BOKOR, Julie, R. ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen ,  FERNANDES, Elma, R. ,  GERLACH, Valerie, L. ,  GROSSE, William, M. ,  GUNTHER, Erik ,  GUSEV, Vladimir, Y. ,  HEYES, Melvyn, P. ,  LEPLEY, Denise, M. ,  LI, Li ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MILLET, Isabelle ,  PATTURAJAN, Meera ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, D. ,  SMITHSON, Glennda ,  STONE, David, J. ,  VERNET, Corine, A. M. ,  VOSS, Edward, Z.

IPC: C12Q

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO2003085096A3

公开(公告)日：2003-10-16

申请号：PCT/US2003/009929

申请日：2003-04-01

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  EDINGER, Shlomit, R. ,  GERLACH, Valerie, L. ,  GROSSE, William, M. ,  GUO, Xiajia ,  GUSEV, Vladimir, Y. ,  JI, Weizhen ,  LAROCHELLE, William, J. ,  LEPLEY, Denise, M. ,  LI, Li ,  LIU, Xiaohong ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MILLET, Isabelle ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  ROTHENBERG, Mark, E. ,  SHIMKETS, Richard, A. ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr. ,  VERNET, Corine, A., M. ,  ZERHUSEN, Bryan, D.

Inventor： ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  EDINGER, Shlomit, R. ,  GERLACH, Valerie, L. ,  GROSSE, William, M. ,  GUO, Xiajia ,  GUSEV, Vladimir, Y. ,  JI, Weizhen ,  LAROCHELLE, William, J. ,  LEPLEY, Denise, M. ,  LI, Li ,  LIU, Xiaohong ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MILLET, Isabelle ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  ROTHENBERG, Mark, E. ,  SHIMKETS, Richard, A. ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr. ,  VERNET, Corine, A., M. ,  ZERHUSEN, Bryan, D.

IPC: A61K38/04

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO2003080856A3

公开(公告)日：2003-10-02

申请号：PCT/US2003/008490

申请日：2003-03-19

Applicant: CURAGEN CORPORATION ,  LEPLEY, Denise, M. ,  RIEGER, Daniel, K. ,  TSE, Kam-Fai ,  RASTELLI, Luca ,  SMITHSON, Glennda ,  MESRI, Mehdi ,  OOI, Chean, Eng ,  ANDERSON, David, W. ,  GUO, Xiaojia ,  GIOT, Loic ,  STARLING, Gary

Inventor： LEPLEY, Denise, M. ,  RIEGER, Daniel, K. ,  TSE, Kam-Fai ,  RASTELLI, Luca ,  SMITHSON, Glennda ,  MESRI, Mehdi ,  OOI, Chean, Eng ,  ANDERSON, David, W. ,  GUO, Xiaojia ,  GIOT, Loic ,  STARLING, Gary

IPC: A61K38/17 ,  A61K39/395 ,  C07H21/02 ,  C07H21/04 ,  C07K14/00 ,  C07K16/00 ,  C12N5/10 ,  C12N15/63 ,  C12P21/06 ,  C12Q1/68 ,  G01N33/00 ,  G01N33/53

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO2003023002A2

公开(公告)日：2003-03-20

申请号：PCT/US2002/028539

申请日：2002-09-09

Applicant: CURAGEN CORPORATION ,  SPYTEK, Kimberly, A. ,  PATTURAJAN, Meera ,  GORMAN, Linda ,  LI, Li ,  ANDERSON, David, W. ,  ZHONG, Mei ,  GERLACH, Valerie, L. ,  VERNET, Corine, A., M. ,  ELLERMAN, Karen ,  BERGHS, Constance ,  ROTHENBERG, Mark, E. ,  GUO, Xiaojia ,  SHIMKETS, Richard, A. ,  LEACH, Martin, D. ,  CATTERTON, Elina ,  KEKUDA, Ramesh ,  JI, Weizhen ,  MILLER, Charles, E. ,  RIEGER, Daniel, K. ,  TAUPIER, Raymond, J., Jr. ,  SHENOY, Suresh, G. ,  LIU, Xiaohong ,  PADIGARU, Muralidhara ,  ALSOBROOK, John, P., II ,  LEPLEY, Denise, M. ,  EDINGER, Shlomit, R. ,  BURGESS, Catherine, E.

Inventor： SPYTEK, Kimberly, A. ,  PATTURAJAN, Meera ,  GORMAN, Linda ,  LI, Li ,  ANDERSON, David, W. ,  ZHONG, Mei ,  GERLACH, Valerie, L. ,  VERNET, Corine, A., M. ,  ELLERMAN, Karen ,  BERGHS, Constance ,  ROTHENBERG, Mark, E. ,  GUO, Xiaojia ,  SHIMKETS, Richard, A. ,  LEACH, Martin, D. ,  CATTERTON, Elina ,  KEKUDA, Ramesh ,  JI, Weizhen ,  MILLER, Charles, E. ,  RIEGER, Daniel, K. ,  TAUPIER, Raymond, J., Jr. ,  SHENOY, Suresh, G. ,  LIU, Xiaohong ,  PADIGARU, Muralidhara ,  ALSOBROOK, John, P., II ,  LEPLEY, Denise, M. ,  EDINGER, Shlomit, R. ,  BURGESS, Catherine, E.

IPC: C12N

CPC classification number: C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/775

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO2003003984A9

公开(公告)日：2003-01-16

申请号：PCT/US2002/021268

申请日：2002-07-03

Applicant: CURAGEN CORPORATION ,  FERNANDES, Elma, R. ,  VERNET, Corine, A., M. ,  SHIMKETS, Richard, A. ,  ANDERSON, David, W. ,  PADIGARU, Muralidhara ,  BOLDOG, Ferenc, L. ,  LI, Li ,  SHENOY, Suresh, G. ,  CASMAN, Stacie, J. ,  RASTELLI, Luca ,  ALSOBROOK, John, P., II ,  BURGESS, Catherine, E. ,  GROSSE, William, M. ,  GUSEV, Vladimir, Y. ,  JI, Weizhen ,  LEPLEY, Denise, M. ,  LIU, Xiaohong ,  MEZICK, Amanda, J. ,  PATTURAJAN, Meera ,  SHEN, Lei ,  SPADERNA, Steven, K. ,  SPYTEK, Kimberly, A. ,  SZEKERES, Edward, S., Jr. ,  TAUPIER, Raymond, J., Jr. ,  TCHERNEV, Velizar, T. ,  ZERHUSEN, Bryan, D. ,  VOSS, Edward, Z.

Inventor： FERNANDES, Elma, R. ,  VERNET, Corine, A., M. ,  SHIMKETS, Richard, A. ,  ANDERSON, David, W. ,  PADIGARU, Muralidhara ,  BOLDOG, Ferenc, L. ,  LI, Li ,  SHENOY, Suresh, G. ,  CASMAN, Stacie, J. ,  RASTELLI, Luca ,  ALSOBROOK, John, P., II ,  BURGESS, Catherine, E. ,  GROSSE, William, M. ,  GUSEV, Vladimir, Y. ,  JI, Weizhen ,  LEPLEY, Denise, M. ,  LIU, Xiaohong ,  MEZICK, Amanda, J. ,  PATTURAJAN, Meera ,  SHEN, Lei ,  SPADERNA, Steven, K. ,  SPYTEK, Kimberly, A. ,  SZEKERES, Edward, S., Jr. ,  TAUPIER, Raymond, J., Jr. ,  TCHERNEV, Velizar, T. ,  ZERHUSEN, Bryan, D. ,  VOSS, Edward, Z.

公开(公告)号：WO2003000918A3

公开(公告)日：2003-01-03

申请号：PCT/US2002/019650

申请日：2002-06-21

Applicant: CURAGEN CORPORATION ,  GROSSE, William, M. ,  ALSOBROOK, John, P., II ,  LEPLEY, Denise, M. ,  BURGESS, Catherine, E. ,  BADER, Joel, S. ,  BANSAL, Aruna ,  PENA, Carol, E., A. ,  SHIMKETS, Richard, A.

Inventor： GROSSE, William, M. ,  ALSOBROOK, John, P., II ,  LEPLEY, Denise, M. ,  BURGESS, Catherine, E. ,  BADER, Joel, S. ,  BANSAL, Aruna ,  PENA, Carol, E., A. ,  SHIMKETS, Richard, A.

IPC: C12N9/12

Abstract: Disclosed herein is a nucleic acid sequence that encodes a novel polypeptide. Also disclosed is a polypeptide encoded by the nucleic acid sequence, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving this novel human nucleic acid and protein. The invention also provides nucleic acids containing single-nucleotide polymorphisms identified for transcribed human sequnces, as well as methods of using the nucleic acids.

公开(公告)号：WO2002068647A2

公开(公告)日：2002-09-06

申请号：PCT/US2002/001311

申请日：2002-01-16

Applicant: CURAGEN CORPORATION ,  PADIGARU, Muralidhara ,  ALSOBROOK, John, P., II ,  COLMAN, Steven, D. ,  SPYTEK, Kimberly, A. ,  BOLDOG, Ferenc ,  VERNET, Corine, A., M. ,  LI, Li ,  SHENOY, Suresh ,  CASMAN, Stacie ,  GUO, Xiaojia ,  EDINGER, Scholmit ,  MACDOUGALL, John ,  MALYANKAR, Uriel ,  PATTURAJAN, Meera ,  SHIMKETS, Richard, A. ,  PENA, Carol ,  TCHERNEV, Velizar ,  ZERHUSEN, Bryan, D. ,  MILLETT, Isabelle ,  MILLER, Charles ,  LEPLEY, Denise, M. ,  SMITHSON, Glennda ,  BAUMGARTNER, Jason ,  HERRMANN, John ,  PEYMAN, John, A. ,  GORMAN, Linda ,  MEZES, Peter ,  KEKUDA, Ramesh ,  TAUPIER, Raymond, J., Jr. ,  GERLACH, Valerie ,  GROSSE, William, M. ,  LIU, Xiaohong ,  ELLERMAN, Karen ,  ROTHENBERG, Mark ,  STONE, David, J. ,  BURGESS, Catherine, E.

Inventor： PADIGARU, Muralidhara ,  ALSOBROOK, John, P., II ,  COLMAN, Steven, D. ,  SPYTEK, Kimberly, A. ,  BOLDOG, Ferenc ,  VERNET, Corine, A., M. ,  LI, Li ,  SHENOY, Suresh ,  CASMAN, Stacie ,  GUO, Xiaojia ,  EDINGER, Scholmit ,  MACDOUGALL, John ,  MALYANKAR, Uriel ,  PATTURAJAN, Meera ,  SHIMKETS, Richard, A. ,  PENA, Carol ,  TCHERNEV, Velizar ,  ZERHUSEN, Bryan, D. ,  MILLETT, Isabelle ,  MILLER, Charles ,  LEPLEY, Denise, M. ,  SMITHSON, Glennda ,  BAUMGARTNER, Jason ,  HERRMANN, John ,  PEYMAN, John, A. ,  GORMAN, Linda ,  MEZES, Peter ,  KEKUDA, Ramesh ,  TAUPIER, Raymond, J., Jr. ,  GERLACH, Valerie ,  GROSSE, William, M. ,  LIU, Xiaohong ,  ELLERMAN, Karen ,  ROTHENBERG, Mark ,  STONE, David, J. ,  BURGESS, Catherine, E.

IPC: C12N15/12

CPC classification number: C07K14/705 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽和与多肽免疫特异性结合的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：WO0236632A8

公开(公告)日：2002-09-06

申请号：PCT/US0131744

申请日：2001-10-09

Applicant: CURAGEN CORP ,  ALSOBROOK JOHN P II ,  BURGESS CATHERINE E ,  GROSSE WILLIAM M ,  LEPLEY DENISE M ,  PADIGARU MURALIDHARA ,  SPYTEK KIMBERLY A

Inventor： ALSOBROOK JOHN P II ,  BURGESS CATHERINE E ,  GROSSE WILLIAM M ,  LEPLEY DENISE M ,  PADIGARU MURALIDHARA ,  SPYTEK KIMBERLY A

IPC: C07K14/705 ,  C07K14/72 ,  C12N15/12 ,  G01N33/566 ,  G01N33/68

CPC classification number: G01N33/566 ,  A01K2217/05 ,  C07K14/705 ,  C07K14/723 ,  G01N33/6893

Abstract: The present invention provides novel isolated nucleic acid sequences having single nucleotide polymorphisms that encode olfactory receptor-like polypeptides and the polypeptides so encoded. Also provided are the antibodies that immunospecifically bind to these polypeptides or any derivative, variant, mutant or fragment of the polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.

Abstract translation: 本发明提供具有编码嗅觉受体样多肽和如此编码的多肽的单核苷酸多态性的新型分离的核酸序列。 还提供了免疫特异性结合这些多肽或多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体。 本发明还提供了多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。

公开(公告)号：WO2002064791A2

公开(公告)日：2002-08-22

申请号：PCT/US2001/048369

申请日：2001-12-10

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BURGESS, Catherine, E. ,  BOLDOG, Ference, L. ,  CASMAN, Stacie, J. ,  COLMAN, Steven, D. ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen ,  GERLACH, Valerie ,  GORMAN, Linda ,  GROSSE, William, M. ,  GUO, Xiaojia ,  HERRMANN, John, L. ,  KEKUDA, Ramesh ,  LEPLEY, Denise, M. ,  LI, Li ,  MACDOUGALL, John, R. ,  MILLET, Isabelle ,  PENA, Carol, E., A. ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGER, Danier, K. ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TCHERNEV, Velizar, T. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Haihong ,  ZHONG, Mei

Inventor： ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BURGESS, Catherine, E. ,  BOLDOG, Ference, L. ,  CASMAN, Stacie, J. ,  COLMAN, Steven, D. ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen ,  GERLACH, Valerie ,  GORMAN, Linda ,  GROSSE, William, M. ,  GUO, Xiaojia ,  HERRMANN, John, L. ,  KEKUDA, Ramesh ,  LEPLEY, Denise, M. ,  LI, Li ,  MACDOUGALL, John, R. ,  MILLET, Isabelle ,  PENA, Carol, E., A. ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGER, Danier, K. ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TCHERNEV, Velizar, T. ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Haihong ,  ZHONG, Mei

IPC: C12N15/12

CPC classification number: G01N33/57484 ,  A61K38/00 ,  C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/574 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2500/00

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further disclose therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防涉及这些新型人核酸和蛋白质中的任何一种的病症的治疗，诊断和研究方法。