公开(公告)号：WO2005113809A2

公开(公告)日：2005-12-01

申请号：PCT/US2005/010731

申请日：2005-03-29

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John II ,  BOLDOG, Ferenc, L. ,  JEFFERS, Michael, E. ,  LAROCHELLE, William, J. ,  LEPLEY, Denise, M. ,  LICHENSTEIN, Henri ,  SHIMKETS, Richard, A. ,  YANG, Meijia ,  RUIZ-MARTINEZ, Marie ,  CHERNAYA, Galina ,  PADIGARU, Muralidhara ,  PRAYAGA, Sudhirdas ,  ZHONG, Mei

Inventor： ALSOBROOK, John II ,  BOLDOG, Ferenc, L. ,  JEFFERS, Michael, E. ,  LAROCHELLE, William, J. ,  LEPLEY, Denise, M. ,  LICHENSTEIN, Henri ,  SHIMKETS, Richard, A. ,  YANG, Meijia ,  RUIZ-MARTINEZ, Marie ,  CHERNAYA, Galina ,  PADIGARU, Muralidhara ,  PRAYAGA, Sudhirdas ,  ZHONG, Mei

IPC: C12Q1/68

CPC classification number: A61K38/1825 ,  C07K14/50

Abstract: The present invention generally relates to nucleic acids, proteins, and antibodies. The invention relates more particularly to nucleic acid molecules, proteins, and antibodies of Fibroblast Growth Factor-20 (FGF-20), or its fragments, derivatives, variants, homologs, analogs, or a combination thereof.

Abstract translation: 本发明一般涉及核酸，蛋白质和抗体。 本发明更具体涉及成纤维细胞生长因子-20（FGF-20）或其片段，衍生物，变体，同系物，类似物或其组合的核酸分子，蛋白质和抗体。

公开(公告)号：WO2003085124A3

公开(公告)日：2003-10-16

申请号：PCT/US2003/009775

申请日：2003-04-01

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P. II ,  BENTO, Patricia ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  CRABTREE-BOKOR, Julie, R. ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen ,  FERNANDES, Elma, R. ,  GERLACH, Valerie, L. ,  GROSSE, William, M. ,  GUNTHER, Erik ,  GUSEV, Vladimir, Y. ,  HEYES, Melvyn, P. ,  LEPLEY, Denise, M. ,  LI, Li ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MILLET, Isabelle ,  PATTURAJAN, Meera ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, D. ,  SMITHSON, Glennda ,  STONE, David, J. ,  VERNET, Corine, A. M. ,  VOSS, Edward, Z.

Inventor： ALSOBROOK, John, P. II ,  BENTO, Patricia ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  CRABTREE-BOKOR, Julie, R. ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen ,  FERNANDES, Elma, R. ,  GERLACH, Valerie, L. ,  GROSSE, William, M. ,  GUNTHER, Erik ,  GUSEV, Vladimir, Y. ,  HEYES, Melvyn, P. ,  LEPLEY, Denise, M. ,  LI, Li ,  MACDOUGALL, John, R. ,  MALYANKAR, Uriel, M. ,  MILLET, Isabelle ,  PATTURAJAN, Meera ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, D. ,  SMITHSON, Glennda ,  STONE, David, J. ,  VERNET, Corine, A. M. ,  VOSS, Edward, Z.

IPC: C07K14/00

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO0210216A3

公开(公告)日：2003-05-08

申请号：PCT/US0124225

申请日：2001-07-30

Applicant: CURAGEN CORP ,  PADIGARU MURALIDHARA ,  MEZES PETER ,  MISHRA VISHNU ,  BURGESS CATHERINE ,  CASMAN STACIE ,  GROSSE WILLIAM M ,  ALSOBROOK JOHN P II ,  LEPLEY DENISE M ,  GERLACH VALERIE L ,  MACDOUGALL JOHN R ,  SMITHSON GLENNDA

Inventor： PADIGARU MURALIDHARA ,  MEZES PETER ,  MISHRA VISHNU ,  BURGESS CATHERINE ,  CASMAN STACIE ,  GROSSE WILLIAM M ,  ALSOBROOK JOHN P II ,  LEPLEY DENISE M ,  GERLACH VALERIE L ,  MACDOUGALL JOHN R ,  SMITHSON GLENNDA

IPC: C12N15/09 ,  A61K31/7052 ,  A61K38/00 ,  A61K39/395 ,  A61K48/00 ,  A61P1/16 ,  A61P3/04 ,  A61P3/10 ,  A61P3/14 ,  A61P7/04 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P9/14 ,  A61P13/12 ,  A61P17/00 ,  A61P25/02 ,  A61P25/08 ,  A61P25/14 ,  A61P25/22 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07H21/04 ,  C07K14/435 ,  C07K14/47 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/06 ,  C12N5/10 ,  C12N9/00 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  A61K38/17 ,  G01N33/50 ,  G01N33/53 ,  G01N33/574 ,  G01N33/68

CPC classification number: C07K14/47

Abstract: Disclosed herein are nucleic acid sequences that encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further disclosed therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these human nucleic acids and proteins.

Abstract translation: 本文公开了编码多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明进一步公开了用于诊断，治疗和预防涉及这些人核酸和蛋白质中的任一种的病症的治疗，诊断和研究方法。

公开(公告)号：WO2003031572A3

公开(公告)日：2003-04-17

申请号：PCT/US2002/031359

申请日：2002-10-02

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P., II ,  BURGESS, Catherine, E. ,  GORMAN, Linda ,  GUO, Xiaojia ,  LEPLEY, Denise, M. ,  PATTURAJAN, Meera ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  SPYTEK, Kimberly, A. ,  ZHONG, Mei

Inventor： ALSOBROOK, John, P., II ,  BURGESS, Catherine, E. ,  GORMAN, Linda ,  GUO, Xiaojia ,  LEPLEY, Denise, M. ,  PATTURAJAN, Meera ,  RASTELLI, Luca ,  RIEGER, Daniel, K. ,  SPYTEK, Kimberly, A. ,  ZHONG, Mei

IPC: C07K17/00 ,  C12P21/08 ,  C12P21/06 ,  A61K38/00 ,  G01N33/53 ,  C12N15/00 ,  C12N5/02 ,  C07H21/02 ,  C07H21/04

Abstract: The present invention relates to novel polypeptides, and the nucleic acids encoding them, having properties related to stimulation of biochemical or physiological responses in a cell, a tissue, an organ or an organism. More particularly, the novel polypeptides are gene products of novel genes, or are specified biologically active fragments or derivatives thereof. Methods of use encompass diagnostic and prognostic assay procedures as well as methods of treating diverse pathological conditions.

公开(公告)号：WO0230974A3

公开(公告)日：2003-04-17

申请号：PCT/US0131922

申请日：2001-10-12

Applicant: CURAGEN CORP ,  GROSSE WILLIAM M ,  ALSOBROOK JOHN P II ,  LEPLEY DENISE M ,  BURGESS CATHERINE E ,  MISHRA VISHNU ,  KEKUDA RAMESH ,  LI LI ,  PADIGARU MURALIDHARA ,  SHIMKETS RICHARD A ,  ZERHUSEN BRYAN D ,  SPYTEK KIMBERLY A ,  EDINGER SHLOMIT ,  GERLACH VALERIE ,  MACDOUGALL JOHN ,  MILLET ISABELLE ,  STONE DAVID ,  GUNTHER ERIK ,  ELLERMAN KAREN

Inventor： GROSSE WILLIAM M ,  ALSOBROOK JOHN P II ,  LEPLEY DENISE M ,  BURGESS CATHERINE E ,  MISHRA VISHNU ,  KEKUDA RAMESH ,  LI LI ,  PADIGARU MURALIDHARA ,  SHIMKETS RICHARD A ,  ZERHUSEN BRYAN D ,  SPYTEK KIMBERLY A ,  EDINGER SHLOMIT ,  GERLACH VALERIE ,  MACDOUGALL JOHN ,  STONE DAVID ,  GUNTHER ERIK ,  ELLERMAN KAREN

IPC: A61K48/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/78 ,  C07K14/81 ,  C12N1/21 ,  C12N9/12 ,  C12N15/12 ,  C12N15/54 ,  A61K38/00 ,  C07K16/18 ,  C07K16/42 ,  C12N15/70 ,  C12Q1/68 ,  G01N33/577 ,  G01N33/68

CPC classification number: C12N9/12 ,  A61K48/00 ,  C07K14/47 ,  C07K14/4741 ,  C07K14/70571 ,  C07K14/70596 ,  C07K14/78 ,  C07K14/8139

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：WO2003023001A3

公开(公告)日：2003-03-20

申请号：PCT/US2002/028538

申请日：2002-09-09

Applicant: CURAGEN CORPORATION ,  AGEE, Michele, L. ,  ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BERGHS, Constance ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  CATTERTON, Elina ,  CHANT, John, S. ,  CHAUDHURI, Amitabha ,  CRABTREE, Julie ,  DIPIPPO, Vincent, A. ,  EDINGER, Shlomit, R. ,  EISEN, Andrew ,  ELLERMAN, Karen ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GIOT, Loic ,  GORMAN, Linda ,  GUO, Xiaojia ,  GUSEV, Vladimir, Y. ,  JI, Weizhen ,  KEKUDA, Ramesh ,  KHRAMTSOV, Nikolai, V. ,  LEACH, Martin, D. ,  LEPLEY, Denise, M. ,  LI, Li ,  LIU, Xiaohong ,  MALYANKAR, Uriel, M. ,  MILLER, Charles, E. ,  OOI, Chean, Eng ,  ORT, Tatiana ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  RIEGER, Daniel, K. ,  ROTHENBERG, Mark, E. ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, A. ,  SPADERNA, Steven, K. ,  SPYTEK, Kimberly, A. ,  TAUPIER, Raymond, J., Jr. ,  TWOMLOW, Nancy ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Mei

Inventor： AGEE, Michele, L. ,  ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BERGHS, Constance ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  CATTERTON, Elina ,  CHANT, John, S. ,  CHAUDHURI, Amitabha ,  CRABTREE, Julie ,  DIPIPPO, Vincent, A. ,  EDINGER, Shlomit, R. ,  EISEN, Andrew ,  ELLERMAN, Karen ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GIOT, Loic ,  GORMAN, Linda ,  GUO, Xiaojia ,  GUSEV, Vladimir, Y. ,  JI, Weizhen ,  KEKUDA, Ramesh ,  KHRAMTSOV, Nikolai, V. ,  LEACH, Martin, D. ,  LEPLEY, Denise, M. ,  LI, Li ,  LIU, Xiaohong ,  MALYANKAR, Uriel, M. ,  MILLER, Charles, E. ,  OOI, Chean, Eng ,  ORT, Tatiana ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  RIEGER, Daniel, K. ,  ROTHENBERG, Mark, E. ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, A. ,  SPADERNA, Steven, K. ,  SPYTEK, Kimberly, A. ,  TAUPIER, Raymond, J., Jr. ,  TWOMLOW, Nancy ,  VERNET, Corine, A., M. ,  VOSS, Edward, Z. ,  ZERHUSEN, Bryan, D. ,  ZHONG, Mei

IPC: A61K38/00 ,  C07K1/00

Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO2003003984A2

公开(公告)日：2003-01-16

申请号：PCT/US2002/021268

申请日：2002-07-03

Applicant: CURAGEN CORPORATION ,  FERNANDES, Elma, R. ,  VERNET, Corine, A., M. ,  SHIMKETS, Richard, A. ,  ANDERSON, David, W. ,  PADIGARU, Muralidhara ,  BOLDOG, Ferenc, L. ,  LI, Li ,  SHENOY, Suresh, G. ,  CASMAN, Stacie, J. ,  RASTELLI, Luca ,  ALSOBROOK, John, P., II ,  BURGESS, Catherine, E. ,  GROSSE, William, M. ,  GUSEV, Vladimir, Y. ,  JI, Weizhen ,  LEPLEY, Denise, M. ,  LIU, Xiaohong ,  MEZICK, Amanda, J. ,  PATTURAJAN, Meera ,  SHEN, Lei ,  SPADERNA, Steven, K. ,  SPYTEK, Kimberly, A. ,  SZEKERES, Edward, S., Jr. ,  TAUPIER, Raymond, J., Jr. ,  TCHERNEV, Velizar, T. ,  ZERHUSEN, Bryan, D. ,  VOSS, Edward, Z.

Inventor： FERNANDES, Elma, R. ,  VERNET, Corine, A., M. ,  SHIMKETS, Richard, A. ,  ANDERSON, David, W. ,  PADIGARU, Muralidhara ,  BOLDOG, Ferenc, L. ,  LI, Li ,  SHENOY, Suresh, G. ,  CASMAN, Stacie, J. ,  RASTELLI, Luca ,  ALSOBROOK, John, P., II ,  BURGESS, Catherine, E. ,  GROSSE, William, M. ,  GUSEV, Vladimir, Y. ,  JI, Weizhen ,  LEPLEY, Denise, M. ,  LIU, Xiaohong ,  MEZICK, Amanda, J. ,  PATTURAJAN, Meera ,  SHEN, Lei ,  SPADERNA, Steven, K. ,  SPYTEK, Kimberly, A. ,  SZEKERES, Edward, S., Jr. ,  TAUPIER, Raymond, J., Jr. ,  TCHERNEV, Velizar, T. ,  ZERHUSEN, Bryan, D. ,  VOSS, Edward, Z.

IPC: A61K

CPC classification number: C07K14/47

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving anyone of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防涉及任何这些新型人核酸和蛋白质的病症的治疗，诊断和研究方法。

公开(公告)号：WO2002029058A3

公开(公告)日：2002-04-11

申请号：PCT/US2001/031248

申请日：2001-10-05

Applicant: CURAGEN CORPORATION ,  SHIMKETS, Richard, A. ,  TAUPIER, Raymond, J., Jr. ,  BURGESS, Catherine, E. ,  ZERHUSEN, Bryan, D. ,  MEZES, Peter, S. ,  RASTELLI, Luca ,  MALYANKAR, Uriel, M. ,  GROSSE, William, M. ,  ALSOBROOK, John, P., II ,  LEPLEY, Denise, M. ,  SPYTEK, Kimberly, Ann ,  LI, Li ,  EDINGER, Shlomit ,  GERLACH, Valerie ,  ELLERMAN, Karen ,  MACDOUGALL, John ,  GUNTHER, Erik ,  MILLET, Isabelle ,  STONE, David ,  SMITHSON, Glennda ,  SZEKERES, Edward, S., Jr.

Inventor： SHIMKETS, Richard, A. ,  TAUPIER, Raymond, J., Jr. ,  BURGESS, Catherine, E. ,  ZERHUSEN, Bryan, D. ,  MEZES, Peter, S. ,  RASTELLI, Luca ,  MALYANKAR, Uriel, M. ,  GROSSE, William, M. ,  ALSOBROOK, John, P., II ,  LEPLEY, Denise, M. ,  SPYTEK, Kimberly, Ann ,  LI, Li ,  EDINGER, Shlomit ,  GERLACH, Valerie ,  ELLERMAN, Karen ,  MACDOUGALL, John ,  GUNTHER, Erik ,  MILLET, Isabelle ,  STONE, David ,  SMITHSON, Glennda ,  SZEKERES, Edward, S., Jr.

IPC: C12N15/12

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO2005044991A2

公开(公告)日：2005-05-19

申请号：PCT/US2004/036478

申请日：2004-11-03

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, II ,  EICHEN, Joseph ,  LEPLEY, Denise, M. ,  MILLER, Charles, E. ,  MEZES, Peter

Inventor： ALSOBROOK, John, II ,  EICHEN, Joseph ,  LEPLEY, Denise, M. ,  MILLER, Charles, E. ,  MEZES, Peter

IPC: C12N

CPC classification number: C07K14/50

Abstract: The present invention generally relates to compositions and methods of use for a fibroblast growth factor ("FGF"). More particularly, the present invention relates to a nucleotide polymorphism (SNP) of FGF-20, and its fragments, derivatives, variants, homologs, and analogs, as well as their uses in wound healing, and prevention and/or treatment of certain diseases, including but are not limited to, stroke, radiation sickness, mucositis, inflammatory bowel disease, and inflammation (osteoarthritis and rheumatoid arthritis).

Abstract translation: 本发明一般涉及用于成纤维细胞生长因子（“FGF”）的组合物和方法。 更具体地，本发明涉及FGF-20的核苷酸多态性（SNP）及其片段，衍生物，变体，同系物和类似物，以及它们在伤口愈合中的用途，以及预防和/或治疗某些疾病 包括但不限于中风，放射病，粘膜炎，炎性肠病和炎症（骨关节炎和类风湿性关节炎）。

公开(公告)号：WO0234782A3

公开(公告)日：2004-02-26

申请号：PCT/US0146005

申请日：2001-10-23

Applicant: CURAGEN CORP ,  GERLACH VALERIE ,  MACDOUGALL JOHN R ,  MILLET ISABELLE ,  GUNTHER ERIK ,  ELLERMAN KAREN ,  GROSSE WILLIAM M ,  ALSOBROOK JOHN P II ,  LEPLEY DENISE M ,  BURGESS CATHERINE E ,  VERNAT CORINE A M ,  SHENOY SURESH ,  SPYTEK KIMBERLY ANN ,  MISHRA VISHNU ,  PADIGARU MURALIDHARA

Inventor： GERLACH VALERIE ,  MACDOUGALL JOHN R ,  MILLET ISABELLE ,  GUNTHER ERIK ,  ELLERMAN KAREN ,  GROSSE WILLIAM M ,  ALSOBROOK JOHN P II ,  LEPLEY DENISE M ,  BURGESS CATHERINE E ,  VERNAT CORINE A M ,  SHENOY SURESH ,  SPYTEK KIMBERLY ANN ,  MISHRA VISHNU ,  PADIGARU MURALIDHARA

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C12N15/12 ,  C07K14/705 ,  A61K38/17 ,  A61K39/395 ,  C07K16/28 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/53

CPC classification number: C07K14/47 ,  A61K38/00 ,  A61K39/00

Abstract: Disclosed herein is a nucleic acid sequence that encodes a novel endozepine-like polypeptide, NOV1. Also disclosed are antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving these novel human nucleic acids and proteins.

Abstract translation: 本文公开的是编码新型内切扎皮多肽NOV1的核酸序列。 还公开了免疫特异性结合多肽的抗体，以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防涉及这些新型人类核酸和蛋白质的病症的治疗，诊断和研究方法。