公开(公告)号：NL2009517C2

公开(公告)日：2014-03-27

申请号：NL2009517

申请日：2012-09-25

Applicant: MICRONIT MICROFLUIDICS BV

Inventor： VROUWE ELWIN XANDER ,  DHINDSA MANJEET ,  OLDE RIEKERINK MARINUS BERNARDUS ,  OEVER RONNY ,  BLOM MARKO THEODOOR

IPC: F16K99/00 ,  B01L3/00

Abstract: The invention relates to a device (20), comprising: a liquid container (21) for containing a liquid; a capillary-stop valve (22) that is in medium through flow connection with said liquid container (21) for stopping said liquid in said container from flowing out of said container via said capillary-stop valve (22); a first electrode (7) being arranged such that in use said first electrode is in contact with said liquid in said liquid container; a second electrode (2) that is spaced apart from said capillary-stop valve by an electrically insulating medium gap (24), and a voltage source (V) connected to said first and second electrode which is activatable for applying an electric potential difference at the first and second electrode such that the liquid in the liquid container is attracted in the direction of said second electrode so as to allow the liquid to overcome the stopping effect of the capillary-stop valve for discharging liquid from said liquid container via said capillary-stop valve. The invention also relates to a method for activating a capillary-stop valve of a device.

公开(公告)号：AT527050T

公开(公告)日：2011-10-15

申请号：AT07834592

申请日：2007-11-05

Applicant: MICRONIT MICROFLUIDICS BV

Inventor： BLOM MARKO ,  MULDER MICHAEL CHRISTIAAN ,  MACLEOD MACINNES JORDAN ,  ALLEN RAYMOND WILLIAM KENNETH

IPC: B01F5/00 ,  B01F5/06 ,  B01F13/00

Abstract: A micromixing chamber, roughly in the form of an hourglass, having a first outer end with a tangential inflow opening and a second outer end with a tangential outflow opening. The mixing chamber in the overall flow direction first narrows more or less gradually and subsequently widens more or less abruptly. The micromixer may be made at least partially of glass, or at least partially of a plurality of glass plates. A micromixer having a plurality of such micromixing chambers connected fluidically in series is also disclosed. Methods for manufacturing such a micromixing chamber of such a micromixer, as well as method for mixing by means of such a micromixing chamber or by means of such a micromixer, are disclosed.

公开(公告)号：NL2016290B1

公开(公告)日：2017-09-20

申请号：NL2016290

申请日：2016-02-19

Applicant: MICRONIT MICROFLUIDICS BV

Inventor： RUI PEDRO RIJO DA COSTA CARVALHO ,  SIDHARAM PUNDLIK PUJARI ,  ELWIN XANDER VROUWE ,  JOHANNES TEUNIS ZUILHOF

IPC: B01L3/00

Abstract: A process for the modification of a solid material, said process comprising contacting a surface of the solid material comprising nucleophilic groups with a hydrosilane in a first step to produce a hydrosilanized surface, and contacting said hydrosilanized surface with at least one alkene and/or alkyne under irradiation with visible and/or ultraviolet light in a second step.

公开(公告)号：NL2015287B1

公开(公告)日：2017-02-28

申请号：NL2015287

申请日：2015-08-10

Applicant: MICRONIT MICROFLUIDICS BV ,  NXP BV ,  JANSSEN PHARMACEUTICA NV

Inventor： MARKO THEODOOR BLOM ,  MONICA BRIVIO ,  SIMONE TANZI ,  SIMON REUVEKAMP ,  BIEKE VAN DORST ,  LIEVEN JOZEF STUYVER ,  ELFRIED VAN DER SAR

IPC: B01L3/00

Abstract: The invention relates to a channel for trapping particles to be fed to said channel with a fluid, said channel comprising: - a first channel part; - a second channel part in fluid through flow connection with said first channel part and downstream of said first channel part; - an elevated structure provided in said channel that divides said channel in said first channel part and said second channel part and for trapping particles in said first channel part; - at least one flow gap provided by said elevated structure for providing said fluid through flow connection between the first channel part and the second channel part for allowing, in use, at least some fluid to flow past said elevated structure into said second channel part while trapping said particles in said first channel part; wherein said elevated structure has a substantially U-shaped shape having a base and two legs extending from the base in an upstream direction, wherein at least part of said U-shaped elevated structure defines at least part of a particle trapping area for trapping the particles to be fed to said channel.

公开(公告)号：NL2009757C2

公开(公告)日：2014-05-08

申请号：NL2009757

申请日：2012-11-05

Applicant: MICRONIT MICROFLUIDICS BV

Inventor： OEVER RONNY ,  BLOM MARKO THEODOOR ,  HANEVELD JEROEN ,  OONK JOHANNES ,  TIJSSEN PETER

IPC: H01L21/48 ,  H01L21/683 ,  H01L23/14

Abstract: A method for forming an electrically conductive via in a substrate that includes the steps of: forming a through hole in a first substrate; bringing a first surface of a second substrate into contact with the first surface of the first substrate, such that the through hole in the first substrate is covered by the first surface of the second substrate; filling the through hole in the first substrate with an electrically conductive material by electroplating to form the electrically conductive via, and removing the second substrate, wherein the first surface of the first and the second substrate each have a surface roughness Ra of less than 2 nm, preferably less than 1 nm, more preferably less than 0.5 nm, and the first surface of the first and the second substrate are brought in direct contact with each other, such that a direct bond is formed there between.

公开(公告)号：NL2003126C2

公开(公告)日：2014-05-08

申请号：NL2003126

申请日：2009-07-03

Applicant: MICRONIT MICROFLUIDICS BV

Inventor： OEVER RONNY ,  BLOM MARKO THEODOOR

IPC: B01L3/00

Abstract: The invention relates to a method for manufacturing and testing microfluidic chips having at least one capillary for through-flow of a fluid. The method comprises the following steps: - providing a starting material; - forming at least one shared capillary in the starting material; - arranging a plurality of functional elements in or over the shared capillary, thus forming a plurality of chips; - testing the chips by supplying a test fluid to the shared capillary; and - dividing the starting material into separate chips. The invention further relates to a device for testing microfluidic chips having at least one capillary for through-flow of a fluid. This device comprises a material holder for holding a starting material in a fixed position during testing, and an inlet connector for connecting a shared capillary formed in the starting material to a test fluid supply.

公开(公告)号：NL2003126A

公开(公告)日：2011-01-04

申请号：NL2003126

申请日：2009-07-03

Applicant: MICRONIT MICROFLUIDICS BV

Inventor： OEVER RONNY ,  BLOM MARKO THEODOOR

IPC: B01L3/00

Abstract: The invention relates to a method for manufacturing and testing microfluidic chips having at least one capillary for through-flow of a fluid. The method comprises the following steps: - providing a starting material; - forming at least one shared capillary in the starting material; - arranging a plurality of functional elements in or over the shared capillary, thus forming a plurality of chips; - testing the chips by supplying a test fluid to the shared capillary; and - dividing the starting material into separate chips. The invention further relates to a device for testing microfluidic chips having at least one capillary for through-flow of a fluid. This device comprises a material holder for holding a starting material in a fixed position during testing, and an inlet connector for connecting a shared capillary formed in the starting material to a test fluid supply.

公开(公告)号：NL1032816C2

公开(公告)日：2008-05-08

申请号：NL1032816

申请日：2006-11-06

Applicant: MICRONIT MICROFLUIDICS BV

Inventor： BLOM MARKO THEODOOR ,  MULDER MICHAEL CHRISTIAAN ,  MACINNES JORDAN MACLEOD ,  KENNETH RAYMOND WILLIAM

IPC: B01F13/00 ,  B01F5/00

公开(公告)号：AU2002353668A1

公开(公告)日：2003-06-30

申请号：AU2002353668

申请日：2002-12-19

Applicant: MICRONIT MICROFLUIDICS BV

Inventor： OEVER RONNY VAN T

IPC: B81C1/00 ,  H01L21/301

Abstract: The present invention relates to a method for dividing a substrate into a number of individual chip parts, comprising the steps of: forming a number of chip parts in the substrate, comprising, for each chip part, of arranging recesses in the substrate for containing fluid; arranging one or more breaking grooves in the substrate along individual chip parts; applying mechanical force to the substrate to break the substrate along the breaking grooves; wherein the steps of arranging recesses in the substrate and arranging breaking grooves in the substrate are performed substantially simultaneously, wherein the substrate comprises a first and a second substrate part, and the method comprises the steps of: a) arranging in the first substrate part at least one recess for containing fluid; b) arranging in the second substrate part passages to the recess in the first substrate part, wherein a first passage forms a fluid feed and a second passage forms a fluid discharge; c) arranging one or more breaking grooves in at least one of the substrate parts; d) placing the second substrate part on the first substrate part; e) breaking the substrate along the breaking grooves.