公开(公告)号：WO2012146643A1

公开(公告)日：2012-11-01

申请号：PCT/EP2012/057617

申请日：2012-04-26

Applicant: MOEHS IBERICA S.L. ,  PÉREZ CABRÉ, Montserrat ,  LLOVERAS SERRACANTA, Isabel ,  LÓPEZ PÉREZ, Marc

Inventor： PÉREZ CABRÉ, Montserrat ,  LLOVERAS SERRACANTA, Isabel ,  LÓPEZ PÉREZ, Marc

IPC: C07D401/12

CPC classification number: C07D401/12

Abstract: The present invention relates to a new process for obtaining the amorphous form of rabeprazole sodium salt from the acetone solvate of said salt by means of the treatment in a solvent system formed by a C 6 -C 8 alkane and water, and to the use of said process for obtaining rabeprazole sodium salt from the acetone solvate thereof.

Abstract translation: 本发明涉及通过在由C6-C8烷烃和水形成的溶剂体系中的处理，从所述盐的丙酮溶剂合物中获得雷贝拉唑钠盐的无定形形式的新方法，以及所述方法 用于从其丙酮溶剂化物中获得雷贝拉唑钠盐。

公开(公告)号：WO2011076915A8

公开(公告)日：2011-06-30

申请号：PCT/EP2010/070634

申请日：2010-12-23

Applicant: MOEHS IBERICA S.L. ,  SÁNCHEZ CASALS, Carles ,  DOBARRO RODRÍGUEZ, Alicia

Inventor： SÁNCHEZ CASALS, Carles ,  DOBARRO RODRÍGUEZ, Alicia

IPC: C07C229/08

Abstract: Method for the preparation of a salt (III) of pregabalin and (S)-mandelic acid with a (S, S) diastereomer content greater than 80% which comprises the following steps: (a) Hofmann reaction of (±)-3-(carbamoylmethyl)-5- methylhexanoic acid (I) to obtain racemic pregabalin (II), (b) addition of (S)-(+)-mandelic acid to obtain the corresponding diastereoisomeric salt (III) with a (S, S) diastereomer content greater than 80% (c)optionally, purification of the salt obtained in step (b); characterized in that step(b) is performed without isolating the product obtained in step(a).

公开(公告)号：WO2021083554A1

公开(公告)日：2021-05-06

申请号：PCT/EP2020/056368

申请日：2020-03-10

Applicant: MOEHS IBERICA, S.L.

Inventor： BALLETTE, Roberto ,  JIMÉNEZ ALONSO, Oscar ,  GARCÍA GARCÍA, Elena ,  DOBARRO RODRÍGUEZ, Alicia

IPC: C07D239/54

Abstract: The present invention relates to a new intermediate useful in the synthesis of elagolix, to a process for obtaining said intermediate, to the use of said intermediate for preparing elagolix, and to a process for preparing elagolix making use of said intermediate.

公开(公告)号：WO2021009034A1

公开(公告)日：2021-01-21

申请号：PCT/EP2020/069529

申请日：2020-07-10

Applicant: MOEHS IBERICA, S.L.

Inventor： BALLETTE, Roberto ,  JIMÉNEZ ALONSO, Oscar ,  DOBARRO RODRÍGUEZ, Alicia ,  GARCÍA GARCÍA, Elena

IPC: C07D239/54

Abstract: The present invention relates to a new intermediate useful in the synthesis of elagolix, to a process for obtaining same, to the use of said intermediate for preparing elagolix, and to a process for preparing elagolix making use of said intermediate.

公开(公告)号：WO2012004382A1

公开(公告)日：2012-01-12

申请号：PCT/EP2011/061616

申请日：2011-07-08

Applicant: MOEHS IBERICA S.L. ,  SÁNCHEZ CASALS, Carles ,  DOBARRO RODRÍGUEZ, Alicia ,  BOSCH CARTES, Juan ,  GARCÍA DÍAZ, Davinia

Inventor： SÁNCHEZ CASALS, Carles ,  DOBARRO RODRÍGUEZ, Alicia ,  BOSCH CARTES, Juan ,  GARCÍA DÍAZ, Davinia

IPC: C07D205/08 ,  C07D263/38

CPC classification number: C07D205/08 ,  A47C7/70 ,  C07D263/20

Abstract: The present invention relates to a new method for preparing ezetimibe comprising a step of cyclizing the compound (4S)-phenyl-3-[(5S)-(4-fluorophenyl)-(2R)-[(1S)-(4-fluorophenylamino)-1-(4-nitrophenyl)methyl]-5-hydroxypentanoyl]oxazolidin-2-one or the derivatives thereof in which the hydroxyl group is protected. The invention also relates to new intermediates used in this method.

Abstract translation: 本发明涉及一种制备依泽麦米的新方法，其包括使化合物（4S） - 苯基-3 - [（5S） - （4-氟苯基） - （2R） - [（1S） - （4-氟苯基氨基 ）-1-（4-硝基苯基）甲基] -5-羟基戊酰基]恶唑烷-2-酮或其衍生物，其中羟基被保护。 本发明还涉及用于该方法的新中间体。