中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

92 records (took 0.03 seconds)

    Microvolume liquid handling system
    21.
    发明公开
    Microvolume liquid handling system 失效
    Vorrichtung zur Handhabung vonMikroflüssigkeitsmengen

    公开(公告)号：EP1512975A2

    公开(公告)日：2005-03-09

    申请号：EP04028043.0

    申请日：1998-04-08

    Applicant: Packard Instrument Company, Inc.

    Inventor： Pelc, Richard E. ,  Chibucos, Nicholas S. ,  Papen, Roeland F. ,  Mayer, Wilhelm

    IPC: G01N35/10 ,  B01L3/02

    CPC classification number: B01L3/0268 ,  B01J2219/00378 ,  B01L3/5085 ,  B01L2200/025 ,  B01L2200/146 ,  B01L2300/0838 ,  B01L2400/0439 ,  B01L2400/0487 ,  C40B60/14

    Abstract: A system for dispensing precise quantities of a transfer liquid (24) is described. The system comprises an enclosed space (214, 234, 235) containing a fluid column, the fluid column including the transfer liquid (24) and a system liquid (20). The enclosed space has an outlet (36) and the column is arranged with the transfer liquid (24) being adjacent to the outlet (63) and the system liquid (20) being distant to the outlet (63). Means (218) are provided for supplying the system liquid (20) into the fluid column (24, 20); and means are present for providing the transfer liquid (24) into the enclosed space (214, 234, 236). The system further includes means (212) for dispensing a quantity of the transfer liquid (24) as at least one droplet out of the outlet (63) without introducing any fluid into the enclosed space (214, 234, 236) during dispensing, means (244) for sensing pressure change in the enclosed space resulting from the volume of the transfer liquid being dispensed and means (224) for converting the pressure change to a volume of the transfer liquid (24) dispensed by the dispensing means (212), wherein ejection of individual drops of the transfer liquid (24) can be detected by the means for sensing pressure change (244).

    Abstract translation: 描述了用于分配精确量的转移液体（24）的系统。 所述系统包括容纳流体柱的封闭空间（214,234,235），所述流体柱包括所述转移液体（24）和系统液体（20）。 所述封闭空间具有出口（36），并且所述柱布置成与所述出口（63）相邻的所述转移液体（24）和所述系统液体（20）远离所述出口（63）。 提供装置（218）用于将系统液体（20）供应到流体柱（24,20）中; 并且存在用于将转移液体（24）提供到封闭空间（214,234,236）中的装置。 该系统还包括用于在分配期间将一定数量的转移液体（24）作为至少一个液滴排出出口（63）而不将任何流体引入封闭空间（214,234,236）中的装置（212） （244），用于感测由所分配的转印液体的体积导致的封闭空间中的压力变化;以及用于将压力变化转换成由分配装置（212）分配的转印液体的体积的装置（224） 其中可以通过用于感测压力变化的装置（244）来检测转移液体（24）的单个液滴的喷射。

    METHOD AND APPARATUS FOR DISPENSING MICRODROPLETS
    24.
    发明公开
    METHOD AND APPARATUS FOR DISPENSING MICRODROPLETS 有权
    方法和装置DROP微分配

    公开(公告)号：EP1356252A2

    公开(公告)日：2003-10-29

    申请号：EP02703210.1

    申请日：2002-01-23

    Applicant: Packard Instrument Company, Inc.

    Inventor： ZWEIFEL, Ronald, A. ,  HAHN, Christopher, M.

    IPC: G01F1/00

    CPC classification number: B01L3/0268 ,  B01L3/0262 ,  G01N35/1011 ,  G01N35/1016 ,  G01N2035/1039 ,  Y10T436/11

    Abstract: A method and apparatus for preventing or limiting damage to capillaries used to dispense microdrops measures the voltage produced by a piezoelectric transducer when the capillary contacts a solid surface or the phase shift occurring when the piezoelectric transducer is operated at its resonant frequency. After distinguishing the voltage created from such contact from the voltage produced from unrelated random sources, corrective action is taken, in one aspect by stopping the relative movement of the capillary and the surface being contacted. The method and apparatus may also be employed to determine the position of a solid or liquid surface.

    SCINTILLATION COUNTER
    27.
    发明公开
    SCINTILLATION COUNTER 失效
    SZINTILLATIONSZÄHLER

    公开(公告)号：EP0721596A1

    公开(公告)日：1996-07-17

    申请号：EP95928690.0

    申请日：1995-07-31

    Applicant: PACKARD INSTRUMENT COMPANY, INC.

    Inventor： VALENTA, Robert, J.

    IPC: G01T1

    CPC classification number: G01T1/204

    Abstract: A scintillation measurement system for measuring optical events produced by scintillators (19) in response to the radioactive decay of a constituent or constituents of a sample (10) to be measured comprises a sample support for positioning a sample in a sample well (11); a bismuth germanate (BGO) scintillation crystal (19), such as Bi4Ge3O12, located adjacent the sample well; a plurality of photodetectors (16, 18) located outside the bismuth germanate crystal (19) for detecting optical events occuring in the sample well (11) or in the bismuth germanate crystal (19) and converting those optical events into electrical pulses; and a pulse analyzing system (40) for receiving the electrical pulses from the photodetectors and determining whether such pulses represent alpha, beta or gamma events. This system can be used with samples containing alpha, beta or gamma emitters, or any combination thereof.

    Improved liquid scintillation measurement with active guard shield
    28.
    发明公开
    Improved liquid scintillation measurement with active guard shield 失效
    改进的液体扫描测量与主动防护罩

    公开(公告)号：EP0399436A3

    公开(公告)日：1991-07-24

    申请号：EP90109608.1

    申请日：1990-05-21

    Applicant: Packard Instrument Company, Inc.

    Inventor： Valenta, Robert J. ,  Noakes, John E.

    IPC: G01T1/172

    CPC classification number: G01T1/172 ,  G01T1/202 ,  G01T1/204

    Abstract: A low-level liquid scintillation measurement system for counting sample optical events resulting from the radioactive decay of a constituent of a sample to be measured while reducing the counting of background optical events which are optical events produced by background radiation and which create electrical pulses other than pulses representing a sample optical event. This system includes detection means located adjacent the sample for detecting optical events and for converting optical events into electrical pulses, coincidence sensing means for receiving the electrical pulses from the detection means and producing a trigger pulse when the electrical pulses from the detection means coincide with each other, burst detection means for receiving the trigger pulses from the coincidence sensing means and the electrical pulses from the detection means for determining the number of electrical pulses present in a selected interval following each of the trigger pulses, evaluation means connected to the burst detection means for determining, in response to the number of pulses detected in the selected interval, the extent to which the optical event represented by the corresponding trigger pulse should be treated as a sample optical event or a background event, and an active guard shield arrangement comprising an auxiliary scintillator optically coupled to the detection means. The shield is adapted to be excited by background radiation and to effectively increase the number of electrical pulses present in the selected interval following a trigger pulse generated as a result of the coincident pulses produced due to the background radiation. The auxiliary scintillator is a glass comprising oxides of lithium, magnesium, silicon and cerium.

    Improved liquid scintillation measurement with active guard shield
    29.
    发明公开
    Improved liquid scintillation measurement with active guard shield 失效
    Messen mit einemflüssigenSzintillator unter Verwendung eines aktiven Schutzschirms。

    公开(公告)号：EP0399436A2

    公开(公告)日：1990-11-28

    申请号：EP90109608.1

    申请日：1990-05-21

    Applicant: Packard Instrument Company, Inc.

    Inventor： Valenta, Robert J. ,  Noakes, John E.

    IPC: G01T1/172

    CPC classification number: G01T1/172 ,  G01T1/202 ,  G01T1/204

    Abstract: A low-level liquid scintillation measurement system for counting sample optical events resulting from the radioactive decay of a constituent of a sample to be measured while reducing the counting of background optical events which are optical events produced by background radiation and which create electrical pulses other than pulses representing a sample optical event. This system includes detection means located adjacent the sample for detecting optical events and for converting optical events into electrical pulses, coincidence sensing means for receiving the electrical pulses from the detection means and producing a trigger pulse when the electrical pulses from the detection means coincide with each other, burst detection means for receiving the trigger pulses from the coincidence sensing means and the electrical pulses from the detection means for determining the number of electrical pulses present in a selected interval following each of the trigger pulses, evaluation means connected to the burst detection means for determining, in response to the number of pulses detected in the selected interval, the extent to which the optical event represented by the corresponding trigger pulse should be treated as a sample optical event or a background event, and an active guard shield arrangement comprising an auxiliary scintillator optically coupled to the detection means. The shield is adapted to be excited by background radiation and to effectively increase the number of electrical pulses present in the selected interval following a trigger pulse generated as a result of the coincident pulses produced due to the background radiation. The auxiliary scintillator is a glass comprising oxides of lithium, magnesium, silicon and cerium.

    Abstract translation: 一种低级液体闪烁测量系统，用于计数由待测量的样品的成分的放射性衰变引起的样品光学事件，同时减少背景光学事件的计数，该背景光学事件是由背景辐射产生的光学事件，并产生除了 代表样品光学事件的脉冲。 该系统包括位于样本附近的用于检测光学事件并将光学事件转换成电脉冲的检测装置，用于从检测装置接收电脉冲并产生触发脉冲的符合检测装置，当来自检测装置的电脉冲与每个 另外，用于从一致检测装置接收触发脉冲的脉冲串检测装置和用于确定在每个触发脉冲之后的所选间隔中存在的电脉冲数的来自检测装置的电脉冲，连接到脉冲串检测装置的评估装置 用于响应于在所选择的间隔中检测的脉冲数来确定由对应的触发脉冲表示的光学事件应被视为样本光学事件或背景事件的程度，以及主动防护屏蔽装置，其包括 辅助闪烁体与光耦合 e检测手段。 屏蔽适于被背景辐射激发，并且在作为由于背景辐射产生的重合脉冲的结果产生的触发脉冲之后有效地增加存在于所选间隔中的电脉冲的数量。 辅助闪烁体是包含锂，镁，硅和铈的氧化物的玻璃。

    Improved liquid scintillation measurement system with active guard shield
    30.
    发明公开
    Improved liquid scintillation measurement system with active guard shield 失效
    改进液体扫描测量系统与主动防护罩

    公开(公告)号：EP0334528A3

    公开(公告)日：1989-10-11

    申请号：EP89302483.6

    申请日：1989-03-14

    Applicant: Packard Instrument Company, Inc.

    Inventor： Valenta, Robert J. ,  Noakes, John E.

    IPC: G01T1/204

    CPC classification number: G01T1/172 ,  G01T1/202 ,  G01T1/204

    Abstract: A low-level liquid scintillation measurement system for counting sample optical events resulting from the radioactive decay of a constituent of a sample to be measured while reducing the counting of background optical events which are optical events produced by background radiation and which create electrical pulses other than pulses representing a sample optical event. This system includes detection means (12,14,16,18) located adjacent the sample for detecting optical events and for converting optical events into electrical pulses, coincidence sensing means (24) for receiving the electrical pulses from the detection means (12,14,16,18) and producing a trigger pulse when the electrical pulses from the detection means (12,14,16,18) coincide with each other, burst detection means (30) for receiving the trigger pulses from the coincidence sensing means (20) and the electrical pulses from the detection means (12,14,16,18) for determining the number of electrical pulses present in a selected interval following each of the trigger pulses, evaluation means (32) connected to the burst detection means (30) for determining, in response to the number of pulses detected in the selected interval, the extent to which the optical event represented by the corresponding trigger pulse should be treated as a sample optical event or a background event, and an active guard shield arrangement (100) comprising an auxiliary scintillator (104) optically coupled to the detection means (12,14,16,18). The shield (100) is adapted to be excited by background radiation and to effectively increase the number of electrical pulses present in the selected interval following a trigger pulse generated as a result of the coincident pulses produced due to the background radiation. This allows the measurement system to accurately evaluate the number of pulses detected in the selected interval and determine the extent to which a trigger pulse is to be treated as a sample optical event.

Patent Agency Ranking