公开(公告)号：EP0889951B1

公开(公告)日：2004-05-19

申请号：EP97917270.7

申请日：1997-03-14

Applicant: RADIOMETER MEDICAL A/S

Inventor： CLAUSEN, Lydia, Dahl ,  BYRNARD, Allan Milton ,  KRISTENSEN, Jesper Svenning

IPC: C12M1/40 ,  B01D67/00

CPC classification number: B01D67/0093 ,  C12Q1/002

Abstract: In a sensor for measuring an analyte in a biological sample whose measuring surface is covered by or comprises a membrane, the membrane has free groups on the surface facing the sample. The surface is modified such that a hydrophilic component is immobilised on the surface in such a manner that chains of the hydrophilic component are chemically bonded to free groups on the surface. Thus, the surface is provided with a more hydrophilic character relative to its unmodified state.

公开(公告)号：EP0944731A1

公开(公告)日：1999-09-29

申请号：EP97912066.0

申请日：1997-11-07

Applicant: RADIOMETER MEDICAL A/S

Inventor： AHL, Thomas ,  BYRNARD, Allan, Milton

IPC: C12M1 ,  C12N11 ,  C12Q1

CPC classification number: C12Q1/002 ,  C12N11/02 ,  C12Q1/005 ,  Y10S435/963 ,  Y10S435/973

Abstract: The present invention relates to an enzyme sensor for measuring the concentration or activity of an analyte of a test fluid. The sensor has at least one enzyme layer comprising an immobilised enzyme for which the analyte is a substrate. The immobilised enzyme is obtained by formation of one or more covalent link(s), optionally by using a cross-linking agent, between the enzyme and at least one type of macromolecule in the presence of a competitive inhibitor for said enzyme. The present invention also relates to a membrane for an enzyme sensor. Furthermore, the invention relates to a method for stabilising the enzymatic activity of an enzyme sensor.

公开(公告)号：EP0847531A1

公开(公告)日：1998-06-17

申请号：EP96928349.0

申请日：1996-08-29

Applicant: RADIOMETER MEDICAL A/S

Inventor： SPORK, Allan ,  PEDERSEN, Bent ,  FREMMING, Niels ,  HVIDTFELDT, Kristian, Jacob

IPC: B01L3 ,  G01N1 ,  G01N33 ,  G01N35

CPC classification number: G01N33/4925 ,  Y10T436/119163 ,  Y10T436/2575

Abstract: The apparatus is for example an apparatus for blood gas analysis and has equipment for automatic introduction of reference fluid for the apparatus, comprising a holder (81) for concurrent hold of several ampoules (10) with reference fluid, for bringing a selected container into a specific position in relation to means (28) for opening the container, for bringing the opened container into a specific position in relation to an inlet aggregate for introduction of fluid from the container into the apparatus, and after activation of the inlet aggregate, for removing the container and the inlet aggregate from each other. The ampoule (10) is opened by pressing down a cap. Another ampoule (10) has a planar membrane comprising one or several glass layers.

公开(公告)号：EP0514468B1

公开(公告)日：1996-06-19

申请号：EP91904508.8

申请日：1991-02-04

Applicant: RADIOMETER MEDICAL A/S

Inventor： ROED, Gjerloff ,  LINNET, Niels, Dürkopp

IPC: G01N27/36

CPC classification number: G01N27/36

Abstract: The glass electrode comprises a membrane of ion sensitive glass. The membrane comprises a composite material consisting of a matrix of ion sensitive glass and a dispersed filling material therein having higher tensile strength than the matrix. The membrane of the glass electrode is particularly resistant to mechanical stress and the glass electrode is i.a. applicable in a tc Pco2 electrode of the Severinghaus-type.

公开(公告)号：EP0705241A1

公开(公告)日：1996-04-10

申请号：EP94919563.0

申请日：1994-06-22

Applicant: RADIOMETER MEDICAL A/S

Inventor： BYRNARD, Allan, Milton ,  UNGARO, Rocco ,  POCHINI, Andrea

IPC: G01N21 ,  C07C59 ,  C07C69 ,  C07C205 ,  C07C235 ,  C07C245 ,  C07C255 ,  C07C309 ,  C07C311 ,  C07C317 ,  C07C409 ,  C07D213 ,  C09B29 ,  G01N27 ,  G01N33

CPC classification number: C07C245/10 ,  G01N33/84

Abstract: A novel calix[4]arene compound, application of the compounds as an active component in a calcium sensitive sensor, and a calcium sensitive sensor containing the compound. The calix[4]arene compound has general formula (I). The sensor is not very sensitive to sodium and potassium ions.

公开(公告)号：EP0568602B1

公开(公告)日：1996-03-13

申请号：EP92904139.0

申请日：1992-01-21

Applicant: RADIOMETER MEDICAL A/S

Inventor： KROGH, Soren-Christian ,  AKSBRO, Erik

IPC: A61B5/06 ,  G01V3/10 ,  A61M25/01

CPC classification number: A61B5/1477 ,  A61B5/062 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/1491

Abstract: When performing the method a sensor (1) is used with a coil (15) integrated in a coil circuit. In the coil circuit a magnetic field is generated so that mutual induction can develop between the coil circuit and the surroundings of the sensor (1). The magnetic field in the coil circuit is detected intermittently, and a developed mutual induction is detected as a change of the magnetic field. The position of the sensor is monitored on the basis of said intermittent detection of the magnetic field in the coil circuit. The change of the magnetic field in the coil circuit can be detected in several ways. If the magnetic field is varying, the change may for example be detected as a change of the peak value of the voltage across or the current intensity through the coil circuit or be detected as a phase shift of one of these parameters. The method is used especially to ensure that calibration of the sensor (1) is performed only when the sensor (1) is located in a related calibration chamber (24). The detectable mutual induction is developed between the coil circuit with the coil (15) and an aluminum cup (22) constituting the calibration chamber (24).

Abstract translation: PCT No.PCT / DK92 / 00014 Sec。 371日期：1993年7月23日 102（e）日期1993年7月23日PCT提交1992年1月21日PCT公布。 公开号WO92 / 12670 日期为1992年8月6日。当执行该方法时，传感器（1）与集成在线圈电路中的线圈（15）一起使用。 在线圈电路中产生磁场，使得在线圈电路和传感器（1）周围之间可以产生互感。 断续地检测线圈电路中的磁场，并且检测出显影的相互感应作为磁场的变化。 基于线圈电路中的所述磁场的间歇检测来监测传感器的位置。 线圈电路中的磁场变化可以通过多种方式进行检测。 如果磁场发生变化，则该变化例如可以被检测为跨过线圈电路的电压峰值或电流强度的变化，或者被检测为这些参数之一的相移。 该方法特别用于确保仅当传感器（1）位于相关的校准室（24）中时才执行传感器（1）的校准。 在与线圈（15）的线圈电路和构成校准室（24）的铝杯（22）之间形成可检测的互感。

公开(公告)号：EP0656760A1

公开(公告)日：1995-06-14

申请号：EP93914658.0

申请日：1993-07-12

Applicant: RADIOMETER MEDICAL A/S

Inventor： PEDERSEN, Knud Grönlund

IPC: A61B5

CPC classification number: A61B5/14542 ,  A61B5/1477 ,  A61B5/1491

Abstract: The sensor (1) comprises a sensor body (3) thermostatable by means of a first thermostating system (14, 15) and having an outer surface (3a, 40a) for application to the human body (28) in heat conductive relationship therewith, said outer surface (3a, 40a) forming the measuring surface of the sensor (1). The sensor (1) further comprises analyte sensing means (7, 8) arranged in said sensor body (3) and being thermostated through said body (3) by means of the first thermostating system (14, 15). The sensor (1) further comprises means (16, 41) arranged in the sensor body (3) in heat insulated relationship therewith while in heat conductive relationship with a delimited surface part of the sensor measuring surface (3a, 40a). The means (16, 41) is thermostatable by means of a second thermostating system. The delimited surface part is located within the outer periphery of the sensor measuring surface (3a, 40a). When using the sensor (1) the heat flux (34) from the measuring surface surrounding said delimited surface part provides a heat shield in the tissue, said heat shield surrounding the heat flux (35) from the delimited surface part. Thus, the heat flux (35) from the delimited surface part will be guided substantially unidirectionally to the tissue (28) located directly beneath the delimited surface part and absorbed therein.

公开(公告)号：EP1583952A1

公开(公告)日：2005-10-12

申请号：EP02795053.4

申请日：2002-12-20

Applicant: RADIOMETER MEDICAL A/S

Inventor： HVIDTFELDT, Kristian, Jacob ,  AAS, Flemming ,  FREDERIKSEN, Caspar, Buchholtz ,  HANSEN, Erik, Kjoelbye

IPC: G01N1/16 ,  B01F13/08

CPC classification number: G01N35/0098 ,  B01F13/0818 ,  B01F2215/0037

Abstract: A blood analyzer has a control system controlling the operation of the analyzer, a sensor measuring a parameter of a blood sample, exposure means exposing the sensor to the blood sample, reporting means reporting the parameter of the blood sample, and a sample handler. The sample handler comprises a sampler bed receiving a blood sampler which contains the blood sample and a stirring element. The sample handler further comprises moving means moving the stirring element in the blood sampler when the sampler is arranged in the sampler bed. The blood analyzer is capable of handling and analyzing blood samples. A blood sample handler is provided as well, as are methods for handling and analyzing of a blood sample. The moving means moving the stirring element is preferably a magnet and the stirring element is magnetic.

公开(公告)号：EP1549385A1

公开(公告)日：2005-07-06

申请号：EP03732248.4

申请日：2003-06-20

Applicant: RADIOMETER MEDICAL A/S

Inventor： FREMMING, Niels ,  ANDERSEN, Joergen

IPC: A61M39/20

Abstract: A sampler cap includes a sampler connector, an analyzer connector and a liquid impermeable closure member, which may be a membrane or a filter. The sampler cap may be used to transfer a test sample to an analyzer without removing the sampler cap from the sampler.

公开(公告)号：EP1273920A3

公开(公告)日：2004-06-30

申请号：EP02022484.6

申请日：1996-08-29

Applicant: RADIOMETER MEDICAL A/S

Inventor： Spork, Allan ,  Pedersen, Bent ,  Fremming, Niels ,  Hvidtfeldt, Kristian Jacob

IPC: G01N35/10 ,  B01L3/00 ,  G01N33/49 ,  G01N33/487

CPC classification number: G01N33/4925 ,  Y10T436/119163 ,  Y10T436/2575

Abstract: The apparatus for analysis has means for automatic introduction of reference fluid for the apparatus. The apparatus comprises an inlet member with a displaceable inlet tube, programmable control means for control of the introduction of fluid into the apparatus, a holder for simultaneously holding several sealed containers with reference fluid, and opening means for opening a sealed container. The apparatus further comprises first movement means for bringing a container selected by the programmable control means and the opening means into position in relation to each other, second movement means for bringing the opened container and the inlet member into position in relation to each other, displacement means for displacing the inlet tube into the reference fluid, and third movement means for removing the container and the inlet member from each other. The containers comprise a container body and a cap having a penetration part provided with a through hole and being arranged for breaking open the sealed container when the cap is moved relative to the container body. The opening means comprises a press element for moving the cap of a container relative to the container body in order to break open the sealed container by pressing the penetration part of the cap into the container.