公开(公告)号：WO2022063788A1

公开(公告)日：2022-03-31

申请号：PCT/EP2021/075965

申请日：2021-09-21

Applicant: ROTH, Johannes

Inventor： ROTH, Johannes

IPC: A61B18/14 ,  A61B18/00

Abstract: Die vorliegende Erfindung betrifft eine Schlinge zur hochfrequenz-chirurgischen Entfernung von krankhaftem Gewebe aus hohlen Körperorganen und zur Entfernung aller Arten von Fremdkörpern aus hohlen Körperorganen dadurch gekennzeichnet, dass die Schlinge aus zwei getrennten Hälften, einer ersten Schlingenhälfte (A) und einer zweiten Schlingenhälfte (B), besteht, wobei die erste (A) und die zweite Schlingenhälfte (B) durch Schließen dieser beiden Hälften zu einer komplett verbundenen Schlinge adaptierbar sind; und wobei sich an wenigstens einer Schlingenhälfte (A, B) zusätzlich eine Kamera (E) befindet, über die ein entsprechendes Kamerabild auf einen Monitor übertragen werden kann.

公开(公告)号：WO2012143124A3

公开(公告)日：2013-04-04

申请号：PCT/EP2012001670

申请日：2012-04-18

Applicant: ROTH & WEBER GMBH ,  ROTH JOHANNES ,  ERMERT GERD

Inventor： ROTH JOHANNES ,  ERMERT GERD

IPC: H04N1/04 ,  H04N1/19 ,  H04N1/193 ,  H04N1/387

CPC classification number: H04N1/10 ,  H04N1/04 ,  H04N1/1903 ,  H04N1/1933 ,  H04N1/387 ,  H04N1/3876 ,  H04N2201/0456

Abstract: The invention relates to a large-format scanning system (1) comprising at least two image acquisition elements (2) in a cascade arrangement, at least one platen, preferably a glass plate (3), arranged upstream thereof, and at least two reflector rolls (5) arranged opposite the at least two image acquisition elements (2) in a cascade arrangement, said reflector rolls being pressed against the glass plate (3) and/or a copy (4) to be scanned by means of resilient elements (6) that are arranged at the sides of the reflector rolls (5). According to the invention, the side portions (7) of the reflector rolls (5) are designed such that they touch the glass plate (3) only outside the reading area of the image acquisition elements (2) for the copy to be scanned (4) and that the copy to be scanned (4) rests on the glass plate (3) in the center area (8) of the reflector rolls (5).

Abstract translation: 本发明涉及一种大幅面扫描仪系统（1）具有至少两个级联的图像感测元件（2），至少一个布置在所述文档支持的前面，优选地布置玻璃（3）的面板中，并用至少两个级联的图像感测元件（2）相反，镜面辊（ 5），其通过的装置，被布置（在所述反射器辊5）的弹性元件被压在玻璃板（3）和/或（4）的扫描模板（6）的侧面上。 根据本发明，在它们的侧部区域（7）的反射器辊子（5）被设计成使得它们只触摸图像感测元件（2），用于在扫描模板的读取范围外（4）的玻璃板（3），并且所述扫描模板（4） 在中心区域（8）的反射器辊（5）与玻璃板（3）。

公开(公告)号：WO2011117392A2

公开(公告)日：2011-09-29

申请号：PCT/EP2011054630

申请日：2011-03-25

Applicant: UNIVERSITAETSKLINIKUM MUENSTER ,  EHRCHEN JAN ,  VARGA GEORG ,  ROTH JOHANNES ,  SUNDERKOETTER CORD

Inventor： EHRCHEN JAN ,  VARGA GEORG ,  ROTH JOHANNES ,  SUNDERKOETTER CORD

IPC: G01N33/50

CPC classification number: A61K35/15 ,  A61K45/06 ,  A61K2035/122 ,  A61K2035/124 ,  C12N5/0645 ,  C12N2501/22 ,  C12N2501/39 ,  G01N33/5047

Abstract: The present invention relates to a pharmaceutical composition comprising glucocorticoid (GC)-induced human monocytes, and optionally a pharmaceutically acceptable carrier. The present invention further relates to a pharmaceutical composition comprising GC and optionally a pharmaceutically acceptable carrier, for use in the treatment of a disease which is GC-responsive, wherein said pharmaceutical composition is to be administered to human monocytes ex vivo. The pharmaceutical composition may be used for treatment of a disease which is GC-responsive. In another aspect, the present invention relates to the use of GC for the preparation of a pharmaceutical composition for the treatment of a patient in need of a GC-therapy, wherein said GC is to be administered to monocytes of said patient ex vivo. In a further embodiment, the present invention relates to a method for the preparation of a pharmaceutical composition comprising the step of contacting human monocytes ex vivo with a GC. A teflon container (e.g. a teflon bag) comprising a glucocorticoid and optionally a colony-stimulating factor (CSF) is also envisaged. In an even further embodiment, the present invention relates to a method of screening for a compound which is suitable for the treatment of a GC-responsive disease, said method comprising: a) contacting a monocyte with a compound to be tested; b) evaluating whether the monocyte is GC-induced; and thereby, c) identifying compounds which are suitable for the treatment of a GC-responsive disease.

Abstract translation: 本发明涉及包含糖皮质激素（GC）诱导的人单核细胞和任选的药学上可接受的载体的药物组合物。 本发明还涉及包含GC和任选的药学上可接受的载体的药物组合物，其用于治疗GC反应性疾病，其中所述药物组合物将离体施用于人单核细胞。 药物组合物可用于治疗GC反应性疾病。 另一方面，本发明涉及GC用于制备用于治疗需要GC治疗的患者的药物组合物的用途，其中所述GC将离体施用于所述患者的单核细胞。 在另一个实施方案中，本发明涉及制备药物组合物的方法，其包括使人单核细胞离体与GC接触的步骤。 还设想了包含糖皮质激素和任选的集落刺激因子（CSF）的特氟隆容器（例如聚四氟乙烯袋）。 在另一个实施方案中，本发明涉及一种筛选适合于治疗GC-应答疾病的化合物的方法，所述方法包括：a）使单核细胞与待测化合物接触; b）评估单核细胞是否是GC诱导的; 因此，c）鉴定适合于治疗GC-应答性疾病的化合物。

公开(公告)号：WO2011117392A3

公开(公告)日：2011-09-29

申请号：PCT/EP2011/054630

申请日：2011-03-25

Applicant: UNIVERSITAETSKLINIKUM MUENSTER ,  EHRCHEN, Jan ,  VARGA, Georg ,  ROTH, Johannes ,  SUNDERKOETTER, Cord

Inventor： EHRCHEN, Jan ,  VARGA, Georg ,  ROTH, Johannes ,  SUNDERKOETTER, Cord

IPC: G01N33/50

Abstract: The present invention relates to a pharmaceutical composition comprising glucocorticoid (GC)-induced human monocytes, and optionally a pharmaceutically acceptable carrier. The present invention further relates to a pharmaceutical composition comprising GC and optionally a pharmaceutically acceptable carrier, for use in the treatment of a disease which is GC-responsive, wherein said pharmaceutical composition is to be administered to human monocytes ex vivo. The pharmaceutical composition may be used for treatment of a disease which is GC-responsive. In another aspect, the present invention relates to the use of GC for the preparation of a pharmaceutical composition for the treatment of a patient in need of a GC-therapy, wherein said GC is to be administered to monocytes of said patient ex vivo. In a further embodiment, the present invention relates to a method for the preparation of a pharmaceutical composition comprising the step of contacting human monocytes ex vivo with a GC. A teflon container (e.g. a teflon bag) comprising a glucocorticoid and optionally a colony-stimulating factor (CSF) is also envisaged. In an even further embodiment, the present invention relates to a method of screening for a compound which is suitable for the treatment of a GC-responsive disease, said method comprising: a) contacting a monocyte with a compound to be tested; b) evaluating whether the monocyte is GC-induced; and thereby, c) identifying compounds which are suitable for the treatment of a GC-responsive disease.

公开(公告)号：WO2012143124A2

公开(公告)日：2012-10-26

申请号：PCT/EP2012/001670

申请日：2012-04-18

Applicant: ROTH + WEBER GMBH ,  ROTH, Johannes ,  ERMERT, Gerd

Inventor： ROTH, Johannes ,  ERMERT, Gerd

CPC classification number: H04N1/10 ,  H04N1/04 ,  H04N1/1903 ,  H04N1/1933 ,  H04N1/387 ,  H04N1/3876 ,  H04N2201/0456

Abstract: Die Erfindung betrifft ein großformatiges Scanner-System (1 ) mit wenigstens zwei kaskadenförmig angeordneten Bilderfassungselementen (2), wenigstens einer davor angeordneten Vorlagenträger, vorzugsweise eine Glasscheibe (3), sowie mit den wenigstens zwei kaskadenförmig angeordneten Bilderfassungselementen (2) gegenüber angeordneten, Reflektorwalzen (5), die mittels an den Seiten der Reflektorwalzen (5) angeordneter federnder Elemente (6) gegen die Glasscheibe (3) und/oder eine Scan-Vorlage (4) gedrückt werden. Erfindungsgemäß sind die Reflektorwalzen (5) an ihren Seitenbereichen (7) derart ausgebildet, dass sie nur außerhalb des Lesebereichs der Bilderfassungselemente (2) für die Scan-Vorlage (4) die Glasscheibe (3) berühren und dass die Scan-Vorlage (4) im Mittenbereich (8) der Reflektorwalzen (5) an der Glasscheibe (3) anliegt.

Abstract translation: 本发明涉及一种大幅面扫描仪系统（1）具有至少两个级联的图像感测元件（2），至少一个布置在所述文档支持的前面，优选地布置玻璃（3）的面板中，并用至少两个级联的图像感测元件（2）相反，镜面辊（ 5），其通过的装置，被布置（在所述反射器辊5）的弹性元件被压在玻璃板（3）和/或（4）的扫描模板（6）的侧面上。 根据本发明，在它们的侧部区域（7）的反射器辊子（5）被设计成使得它们只触摸图像感测元件（2），用于在扫描模板的读取范围外（4）的玻璃板（3），并且所述扫描模板（4） 在中心区域（8）的反射器辊（5）与玻璃板（3）。

公开(公告)号：ES2394962T3

公开(公告)日：2013-02-07

申请号：ES03708103

申请日：2003-02-17

Applicant: SORG CLEMENS ,  ROTH JOHANNES ,  UNIV MUENSTER WILHELMS

Inventor： SORG CLEMENS ,  ROTH JOHANNES

IPC: G01N33/53 ,  G01N33/564 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/577 ,  G01N33/68

Abstract: Método para el diagnóstico de enfermedades inflamatorias seleccionadas de artritis reumatoide, artritisseronegativa, artritis juvenil y artritis reumatoide juvenil de comienzo sistémico (ARJS), que comprende lasetapas dea) determinar la cantidad y/o concentración de polipéptido de calgranulina C en una muestra de suero de unpaciente; yb) comparar la cantidad y/o concentración de polipéptido de calgranulina C determinada en dicha muestrade suero con la cantidad y/o concentración de polipéptido de calgranulina C determinada en una muestracontrol de suero,en el que un aumento en la cantidad de polipéptido de calgranulina C en la muestra de suero encomparación con la muestra control es indicativo de dicha enfermedad

公开(公告)号：DE10056072A1

公开(公告)日：2002-05-29

申请号：DE10056072

申请日：2000-11-08

Applicant: ROTH JOHANNES

Inventor： ROTH JOHANNES

IPC: A61B5/00 ,  A61B5/0205 ,  G06F19/00 ,  G08B21/04 ,  G08B21/02 ,  G08C17/02

Abstract: The device has an electrical energy storage device for mobile use, an interface to at least one physiological data sensor, an electronic computer unit, an electronic memory for storing a control program and physiological data, a geographic position determination arrangement and an arrangement for wireless transmission of at least some data under the control of the control program taking into account physiological data and stored boundary values. The device has an electrical energy storage device (3) for mobile portable operation, an interface to at least one physiological data sensor (7), an electronic computer unit (6), an electronic memory (8) for storing a control program and physiological data, a geographic position determination arrangement (9) and an arrangement (4) for wireless transmission of at least some data, e.g. as an emergency call, under the control of the control program taking into account the physiological data and stored boundary values. Independent claims are also included for the following: a method of recording and forwarding physiological data.

公开(公告)号：AT120631B

公开(公告)日：1931-01-10

申请号：AT120631D

申请日：1929-03-23

Applicant: ROTH JOHANNES ING

Inventor： ROTH JOHANNES ING

公开(公告)号：US1015588A

公开(公告)日：1912-01-23

申请号：US1910591002

申请日：1910-11-07

Applicant: ROTH JOHANNES

Inventor： ROTH JOHANNES

CPC classification number: B28B11/12