MAGNETIC FIELD ENHANCEMENT OF TUMOR TREATMENT

    公开(公告)号:WO2003030722A3

    公开(公告)日:2003-04-17

    申请号:PCT/US2002/032444

    申请日:2002-10-09

    Abstract: A method of treating a tumor, comprising creating an elevated concentration of free radicals in said tumor (22) and creating a magnetic field (20) that traverses said tumor (22) and that inhibits the recombination of said free radicals in said tumor. A magnetic field of 0.1 mTesla to 10 mTesla is generally used for this purpose.

    METHOD FOR INCREASING AND SUSTAINING FREE RADICAL LEVELS IN TISSUE OF INTEREST
    22.
    发明申请
    METHOD FOR INCREASING AND SUSTAINING FREE RADICAL LEVELS IN TISSUE OF INTEREST 审中-公开
    增加和维持感兴趣组织内自由基水平的方法

    公开(公告)号:WO2017132248A1

    公开(公告)日:2017-08-03

    申请号:PCT/US2017/014923

    申请日:2017-01-25

    Abstract: A method of creating and sustaining an elevated level of free radicals in a volume of targeted tissue that utilizes targeted nanostructures (16) that include a metallic component (26) that acts to amplify the effects of a free radical-producing stimulus; a magnetic component; and a binding component (24) that acts to bind to cellular components present in the targeted tissue. To practice the method, the targeted nanostructures are introduced into the targeted tissue and a free radical-producing stimulus, which may be in the form of a particle beam (20) is provided at the targeted tissue volume.

    Abstract translation: 一种利用靶向纳米结构(16)在一定体积的靶向组织中产生和维持升高水平的自由基的方法,所述靶向纳米结构(16)包括金属成分(26),所述金属成分起作用以放大游离 激进生产刺激; 一个磁性部件; 和结合组分(24),其起作用以结合目标组织中存在的细胞组分。 为了实践该方法,将有针对性的纳米结构引入目标组织,并且在目标组织体积处提供可以是粒子束(20)形式的产生自由基的刺激。

    TUMOR TREATMENT WITH FREE RADICAL LIFETIMES ENHANCED BY PERSISTANT LOW STRENGTH MAGNETIC FIELD
    23.
    发明申请
    TUMOR TREATMENT WITH FREE RADICAL LIFETIMES ENHANCED BY PERSISTANT LOW STRENGTH MAGNETIC FIELD 审中-公开
    具有自由低强度磁场增强的免费放射生物的肿瘤治疗

    公开(公告)号:WO2014066765A1

    公开(公告)日:2014-05-01

    申请号:PCT/US2013/066820

    申请日:2013-10-25

    CPC classification number: A61N2/002 A61N2/02 A61N2/06 A61N5/10 A61N5/1031 A61N7/00

    Abstract: In the treatment of a tumor (126) with radiation therapy (122) is enhanced by a weak magnetic field (130), the field strength time sequence of exposure and shape and contour of the magnetic field are varied to achieve desired results. In one separate aspect, exposure to a magnetic field (130) is continued after exposure to a free radical-creating therapy is ceased or diminished, thereby increasing the lifetimes of free radicals that have already been created. In another preferred embodiment a magnetic field (13) is strategically placed to avoid extending the lives of free radicals in tissue through which a free radical-creating beam must pass, to reach a tumor. This application discloses quantitative parameters for field strength and exposure time to create concentrations and reactivity of free radicals, including long-lived free radicals and discloses the use of shaped, contoured, and designed electromagnetic fields. A treatment planning station (200) is also disclosed.

    Abstract translation: 在用放射治疗(122)治疗肿瘤(126)时,由弱磁场(130)增强,暴露的场强时间序列和磁场的形状和轮廓变化,以达到预期的效果。 在一个单独的方面,在暴露于自由基产生疗法停止或减少之后,继续暴露于磁场(130),从而增加已经产生的自由基的寿命。 在另一个优选实施例中,策略性地放置磁场(13)以避免延长组织中自由基的寿命,通过自由基产生的束必须通过该自由基以达到肿瘤。 本申请公开了用于产生自由基(包括长寿命自由基)的浓度和反应性的场强和暴露时间的定量参数,并公开了使用形状,轮廓和设计的电磁场。 治疗计划站(200)也被披露。

    INTEGRATED LNG RE-GASIFICATION APPARATUS
    24.
    发明申请
    INTEGRATED LNG RE-GASIFICATION APPARATUS 审中-公开
    集成LNG再气化装置

    公开(公告)号:WO2009070379A1

    公开(公告)日:2009-06-04

    申请号:PCT/US2008/078754

    申请日:2008-10-03

    Abstract: The described invention relates to an integrated LNG re-gasification apparatus suitable for broad use and effective utilization of LNG containers comprising: a) modular storage tank holding structures adapted for storing and accessing LNG containerized in one or more storage tanks; b) a heat exchange re-gasification chamber adapted for converting said LNG to natural gas using a working fluid of higher temperature than the LNG; c) fluid transfer means for transporting the LNG from said storage tanks to the at least one heat exchange re-gasification chamber; d) at least one working fluid holding tank; e) fluid transfer means for transporting the working fluid from said holding tank to the at least one heat exchange re-gasification chamber; f) fluid transfer means for transporting a cooled working fluid, to one or more ancillary refrigeration or air conditioning units.

    Abstract translation: 所述本发明涉及适用于LNG容器的广泛使用和有效利用的集成LNG再气化装置,其包括:a)适于存储和接入容纳在一个或多个储罐中的LNG的模块化储存罐保持结构; b)热交换再气化室,其适于使用比LNG高的工作流体将所述LNG转化为天然气; c)流体转移装置,用于将LNG从所述储罐运输到所述至少一个热交换再气化室; d)至少一个工作流体储存罐; e)流体转移装置,用于将工作流体从所述储存罐输送到所述至少一个热交换再气化室; f)用于将冷却的工作流体输送到一个或多个辅助制冷或空调单元的流体输送装置。

    METHOD AND APPARATUS FOR DETECTION OF A LIQUID UNDER A SURFACE
    25.
    发明申请
    METHOD AND APPARATUS FOR DETECTION OF A LIQUID UNDER A SURFACE 审中-公开
    用于检测表面下的液体的方法和装置

    公开(公告)号:WO2009045670A1

    公开(公告)日:2009-04-09

    申请号:PCT/US2008/074874

    申请日:2008-08-29

    CPC classification number: G01V3/175 G01N24/08 G01N24/081 G01R33/50 Y02A90/344

    Abstract: Methods for detecting a liquid under a surface and characterizing Ice are provided The liquid may be a liquid hydrocarbon such as crude oil or fuel oil or mineral oil The surface may be ice, snow, or water, and the method may be practiced in an arctic region to detect oil spills, leaks, or seepages The methods may be used with a range finder to characterize marine ice The methods may include a nuclear magnetic resonance (NMR) tool with antenna to send a radio-frequency (RF) excitation pulse or signal into volume of substances being detected, detect an NMR response signal to determine the presence of the liquid of interest The NMR response may include a relaxation time element and an intensity level and may include a free induction signal (T2*), a spin echo signal (T2), a train of spin echo signals (T2), or a thermal equilibrium signal (T 1).

    Abstract translation: 提供用于检测表面下的液体并表征冰的方法液体可以是诸如原油或燃料油或矿物油的液体烃。表面可以是冰,雪或水,并且该方法可以在北极 检测漏油,泄漏或泄漏的方法可以与测距仪一起使用以表征海洋冰。该方法可以包括具有天线的核磁共振(NMR)工具以发送射频(RF)激发脉冲或信号 检测到的物质的体积,检测NMR响应信号以确定感兴趣的液体的存在。NMR响应可以包括弛豫时间元素和强度水平,并且可以包括自由感应信号(T2 *),自旋回波信号 (T2),一系列自旋回波信号(T2)或热平衡信号(T 1)。

    LNG SLOSHING IMPACT REDUCTION SYSTEM
    26.
    发明申请
    LNG SLOSHING IMPACT REDUCTION SYSTEM 审中-公开
    液化天然气减震系统

    公开(公告)号:WO2006014301A1

    公开(公告)日:2006-02-09

    申请号:PCT/US2005/023195

    申请日:2005-06-28

    Abstract: A tank is provided that reduces sloshing pressures in the corner sections of a tank, such as an LNG membrane tank. The tank includes a sloshing impact reduction system placed in selected corner sections within the tank. The system serves as a slosh attenuation system, and reduces the severity of the corner geometry and improves the flow of fluids into the tank corner. In one embodiment, an impermeable structure is disposed in an internal corner section of the tank. The impermeable structure may be a triangular planar surface, or a non-planar structural surface. The non-planar structural surface may be a concave surface or other curved surface. In another arrangement, a permeable structure is placed in an internal corner section of the tank. Such a permeable structure would enable fluid to pass through the device, but would reduce the fluid velocities and accelerations via friction or eddies. The permeable structure may be either rigid or flexible.

    Abstract translation: 提供了一个罐,可以减少诸如LNG膜箱之类的罐的拐角部分的晃动压力。 油箱包括放置在油箱内选定角落部分的晃动减震系统。 该系统用作晃动衰减系统,并减少角几何形状的严重性,并改善流体进入油罐角的流量。 在一个实施例中,不透水结构设置在罐的内角部。 不透水结构可以是三角形平面表面或非平面结构表面。 非平面结构表面可以是凹面或其它弯曲表面。 在另一种布置中,可渗透结构被放置在罐的内角部。 这种可渗透结构将使流体能够通过该装置,但是将通过摩擦或涡流来减小流体速度和加速度。 可渗透结构可以是刚性的或柔性的。

    METHOD OF ATTACKING TARGET CELLS
    27.
    发明申请
    METHOD OF ATTACKING TARGET CELLS 审中-公开
    攻击目标细胞的方法

    公开(公告)号:WO2017031372A1

    公开(公告)日:2017-02-23

    申请号:PCT/US2016/047646

    申请日:2016-08-18

    Abstract: A method of killing cells of a targeted cell type in a patient body that utilizes nanoparticles (10) having a first portion (12), which when exposed to a target portion (14) of a targeted cell type (16), binds to the target portion and a second portion (10A), joined to the first portion, and comprised of a low resistivity material. The nanoparticles are introduced into a contact area where they contact cells of the targeted cell type. Contemporaneously, the contact area is exposed to a varying magnetic field of insufficient strength to increase the temperature of any part of the patient body by more than ten degrees Celsius, but which creates a current (20) at the nanoparticles sufficient to disrupt function of the targeted cell type.

    Abstract translation: 一种利用具有第一部分(12)的纳米颗粒(10)杀死患者体内靶细胞类型的细胞的方法,当暴露于靶细胞类型(16)的靶部分(14)时,其结合到 目标部分和第二部分(10A),其连接到第一部分,并且由低电阻率材料构成。 将纳米颗粒引入接触区域,在接触区域接触靶细胞类型的细胞。 同时,接触区域暴露于强度不足的变化的磁场,以将患者身体的任何部分的温度增加超过十摄氏度,但是在纳米颗粒处产生足以破坏患者体内功能的电流(20) 靶细胞类型。

    TRANSPORTING AND TRANSFERRING FLUID
    28.
    发明申请
    TRANSPORTING AND TRANSFERRING FLUID 审中-公开
    运输和转移流体

    公开(公告)号:WO2008060350A2

    公开(公告)日:2008-05-22

    申请号:PCT/US2007020107

    申请日:2007-09-17

    CPC classification number: B63B27/24 Y10T137/0318 Y10T137/6906

    Abstract: A method and system for transporting fluid is described. The method includes coupling a transit vessel to a terminal vessel associated with at least one terminal. The transit vessel and the terminal vessel are coupled at an open sea or lightering location, which may be selected based upon operational conditions. Then, cryogenic fluid is transferred between the transit vessel and the terminal vessel, while the transit vessel and terminal vessel are moving in substantially the same direction. Once the transfer is complete, the terminal vessel decouples from the transit vessel and moves a terminal to provide the cryogenic fluid to the terminal. The cryogenic fluid may include liquefied natural gas (LNG) and/or liquefied carbon dioxide (CO 2 ).

    Abstract translation: 描述了用于输送流体的方法和系统。 该方法包括将运输船舶耦合到与至少一个终端相关联的终端船舶。 过境船和终端船耦合在公海或驳船位置,其可以基于操作条件来选择。 然后,在运输船和终端船之间转移低温流体,同时运输船和终端船以基本上相同的方向运动。 一旦转移完成,终端船将从过境船上卸下并移动一个终端,将低温流体提供给终端。 低温流体可以包括液化天然气(LNG)和/或液化二氧化碳(CO 2/2)。

    METHOD AND APPARATUS FOR FLUID FLOW TESTING
    29.
    发明申请
    METHOD AND APPARATUS FOR FLUID FLOW TESTING 审中-公开
    流体流动测试方法与装置

    公开(公告)号:WO2004111605A3

    公开(公告)日:2005-10-20

    申请号:PCT/US2004016686

    申请日:2004-05-27

    CPC classification number: G01M10/00

    Abstract: This invention relates generally to testing apparatus and methodology for measuring fluid dynamic properties of structures within fluid flows. One embodiment includes a fluid induced motion testing apparatus of the type which includes a test rig (21) suitable for holding a test body (1) in a fluid body. The apparatus may include any of an actuator (8) suitable for producing a force upon the test body (1); a turbulence generator (65) located in the fluid body up current from the test body (1) suitable for generating a turbulent flow field with uniform turbulence intensity across the fluid body-test body interface, the turbulent flow field including dominate vortical structures, the axis of the vortical structures about parallel to the longitudinal axis of the test body (1); or a test body adjuster suitable for adjusting the test body (1) relative to the fluid current in four or more increments, thereby enabling multiple headings of the test body (1) to be tested against the current of the fluid body. This invention also relates to designing and constructing offshore structures and to producing hydrocarbon resources using offshore structures designed using the testing apparatus and methodology.

    Abstract translation: 本发明一般涉及用于测量流体流体内结构的流体动力特性的测试装置和方法。 一个实施例包括一种类型的流体感应运动测试装置,其包括适合于将测试体(1)保持在流体体中的测试台(21)。 该装置可以包括适于在测试体(1)上产生力的致动器(8)中的任何一个; 位于流体内的湍流发生器(65),其从测试体(1)起向上流动,适于产生跨越流体体 - 测试体界面的均匀湍流强度的紊流流场,湍流场包括主旋涡结构, 涡旋结构的轴线平行于测试体(1)的纵向轴线; 或测试体调节器,其适于以四个或更多个增量相对于流体流量调节测试体(1),从而使得可以针对流体体的电流来测试测试体(1)的多个标题。 本发明还涉及使用测试装置和方法设计的使用海上结构设计和构造海上结构和生产碳氢化合物资源。

    METHOD AND APPARATUS FOR FLUID FLOW TESTING
    30.
    发明申请
    METHOD AND APPARATUS FOR FLUID FLOW TESTING 审中-公开
    流体流动测试方法与装置

    公开(公告)号:WO2004111605A2

    公开(公告)日:2004-12-23

    申请号:PCT/US2004/016686

    申请日:2004-05-27

    IPC: G01N

    CPC classification number: G01M10/00

    Abstract: This invention relates generally to testing apparatus and methodology for measuring fluid dynamic properties of structures within fluid flows. One embodiment includes a fluid induced motion testing apparatus of the type which includes a test rig suitable for holding a test body in a fluid body. The apparatus may include any of an actuator suitable for producing a force upon the test body; a turbulence generator located in the fluid body up current from the test body suitable for generating a turbulent flow field with uniform turbulence intensity across the fluid body-test body interface, the turbulent flow field including dominate vortical structures, the axis of the vortical structures about parallel to the longitudinal axis of the test body; or a test body adjuster suitable for adjusting the test body relative to the fluid current in four or more increments, thereby enabling multiple headings of the test body to be tested against the current of the fluid body. This invention also relates to designing and constructing offshore structures and to producing hydrocarbon resources using offshore structures designed using the testing apparatus and methodology.

    Abstract translation: 本发明一般涉及用于测量流体流体内结构的流体动力特性的测试装置和方法。 一个实施例包括一种类型的流体感应运动测试装置,其包括适于将测试体保持在流体体内的测试台。 该装置可以包括适于在测试体上产生力的致动器中的任何一个; 位于流体中的湍流发生器,其来自测试体的上流,其适于产生跨越流体体 - 测试体界面的均匀湍流强度的湍流流场,湍流场包括主旋涡结构,涡旋结构的轴线约为 平行于测试体的纵向轴线; 或测试体调节器,其适于以四个或更多个增量相对于流体流量调节测试体,从而使测试体的多个标题相对于流体的电流进行测试。 本发明还涉及使用测试装置和方法设计的使用海上结构设计和构造海上结构和生产碳氢化合物资源。

Patent Agency Ranking