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    METHODS FOR THE MODULATION OF OLEOSIN EXPRESSION IN PLANTS
    24.
    发明申请
    METHODS FOR THE MODULATION OF OLEOSIN EXPRESSION IN PLANTS 审中-公开
    用于调节植物油脂蛋白表达的方法

    公开(公告)号：WO2006037228A1

    公开(公告)日：2006-04-13

    申请号：PCT/CA2005/001529

    申请日：2005-10-06

    Applicant: SEMBIOSYS GENETICS INC. ,  SILOTO, Rodrigo, M. ,  MOLONEY, Maurice, M.

    Inventor： SILOTO, Rodrigo, M. ,  MOLONEY, Maurice, M.

    IPC: C12N15/82

    CPC classification number: A23D9/00 ,  C12N15/8247 ,  C12N15/8251

    Abstract: Methods to modulate oleosin expression levels in plants are provided. Specifically, methods for preparing seed derived products from seed, in which the composition of seed storage reserves, notably the seed lipid and protein contents, have been altered. In particular the present invention provides methods for preparing seed derived products from seed, in which the seed reserves have been altered by modulation of oleosin gene expression and more particularly the suppression of oleosin gene expression.

    Abstract translation: 提供了调节植物中油质蛋白表达水平的方法。 具体地说，种子储存储备的组成，特别是种子脂质和蛋白质含量已经被改变的用于制备种子衍生产品的方法。 特别地，本发明提供了从种子制备种子衍生产品的方法，其中通过调节油质蛋白基因表达而改变种子储备，更具体地说是抑制油质蛋白基因表达。

    MODIFIED OLEOSINS
    25.
    发明申请
    MODIFIED OLEOSINS 审中-公开
    改性油脂

    公开(公告)号：WO2004113376A1

    公开(公告)日：2004-12-29

    申请号：PCT/CA2004/000904

    申请日：2004-06-18

    Applicant: SEMBIOSYS GENETICS INC. ,  MOLONEY, Maurice, M. ,  SILOTO, Rodrigo, Marins

    Inventor： MOLONEY, Maurice, M. ,  SILOTO, Rodrigo, Marins

    IPC: C07K14/415

    CPC classification number: C07K14/415 ,  C07K2319/00 ,  C12N15/8221 ,  C12N15/8257

    Abstract: The present invention describes novel polypeptide structures based on oleosin molecules which are capable of being targeted to oil bodies in plants. The modified oleosin polypeptides are obtained by performing modifications in the hydrophobic domain encoding sequence of an oleosin cDNA. The present invention describes methods to obtain such polypeptides in vivo . The novel oleosins may be used to deliver a recombinant (non-oleosin) protein to oil bodies.

    Abstract translation: 本发明描述了能够靶向植物油体的基于油质蛋白分子的新型多肽结构。 通过在油质蛋白cDNA的疏水结构域编码序列中进行修饰来获得修饰的油质蛋白多肽。 本发明描述了在体内获得这种多肽的方法。 新的油质蛋白可用于将重组（非油质蛋白）蛋白递送至油体。

    POLYUNSATURATED FATTY ACID PRODUCTION IN HETEROLOGOUS ORGANISMS USING PUFA POLYKETIDE SYNTHASE SYSTEMS
    27.
    发明申请
    POLYUNSATURATED FATTY ACID PRODUCTION IN HETEROLOGOUS ORGANISMS USING PUFA POLYKETIDE SYNTHASE SYSTEMS 审中-公开
    使用多不饱和脂多糖合成酶系统进行异构体生物聚合脂肪酸生产

    公开(公告)号：WO2007106905A2

    公开(公告)日：2007-09-20

    申请号：PCT/US2007/064106

    申请日：2007-03-15

    Applicant: MARTEK BIOSCIENCES CORPORATION ,  SEMBIOSYS GENETICS INC. ,  METZ, James, G. ,  KUNER, Jerry, M. ,  LIPPMEIER, James, Casey ,  MOLONEY, Maurice, Martin ,  NYKIFORUK, Cory, Lee

    Inventor： METZ, James, G. ,  KUNER, Jerry, M. ,  LIPPMEIER, James, Casey ,  MOLONEY, Maurice, Martin ,  NYKIFORUK, Cory, Lee

    IPC: A01H1/00 ,  C12N9/04 ,  C12N15/82 ,  C12N5/04

    CPC classification number: C12N9/1029 ,  C12N9/93 ,  C12N15/8247 ,  C12P7/6427 ,  C12P7/6472 ,  Y02P20/52

    Abstract: Disclosed are novel acyl-CoA synthetases and novel acyltransferases, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified organisms (microorganisms and plants) comprising the same, and methods of making and using the same. Also disclosed are genetically modified organisms (e.g., plants, microorganisms) that have been genetically modified to express a PKS-like system for the production of PUFAs (a PUFA PKS system or PUFA synthase), wherein the organisms have been modified to express an acyl-CoA synthetase, to express an acyl transferase, to delete or inactivate a fatty acid synthase (FAS) expressed by the organism, to reduce competition for malonyl CoA with the PUFA synthase or to increase the level of malonyl CoA in the plant or plant cell, and in one aspect, to inhibit KASII or KASIII. Additional modifications, and methods to make and use such organisms, in addition to PUFAs and oils obtained from such organisms, are disclosed, alone with various products including such PUFAs and oils.

    Abstract translation: 公开了新型酰基辅酶A合成酶和新型酰基转移酶，编码该酰基转移酶的核酸分子，重组核酸分子和包含该核酸分子的重组宿主细胞，包含该核酸分子的转基因生物（微生物和植物），以及制备和使用 一样。 还公开了经遗传修饰以表达用于生产PUFA（PUFA PKS系统或PUFA合酶）的PKS样系统的遗传修饰生物体（例如，植物，微生物），其中生物体被修饰以表达酰基 -CoA合成酶，以表达酰基转移酶，以删除或失活由生物表达的脂肪酸合成酶（FAS），以减少与PUFA合酶的丙二酰辅酶A竞争或增加植物或植物细胞中丙二酰辅酶A的水平 ，并且在一个方面，抑制KASII或KASIII。 除了PUFA和从这些生物获得的油之外，还公开了另外的修饰和制造和使用这些生物体的方法，其中包括各种产品，包括这种PUFA和油。

    METHODS FOR THE PRODUCTION OF APOLIPOPROTEINS IN TRANSGENIC PLANTS
    28.
    发明申请
    METHODS FOR THE PRODUCTION OF APOLIPOPROTEINS IN TRANSGENIC PLANTS 审中-公开
    转基因植物中载脂蛋白生产方法

    公开(公告)号：WO2005047455A3

    公开(公告)日：2005-07-21

    申请号：PCT/CA2004001960

    申请日：2004-11-15

    Applicant: SEMBIOSYS GENETICS INC ,  MOLONEY MAURICE M ,  REID ALEXANDRA

    Inventor： MOLONEY MAURICE M ,  REID ALEXANDRA

    IPC: A01H1/00 ,  A01H5/00 ,  A01H5/10 ,  A61K38/17 ,  A61P3/06 ,  C07K14/775 ,  C12N20060101 ,  C12N15/12 ,  C12N15/82 ,  C12P21/02

    CPC classification number: C07K14/775 ,  C12N15/8257

    Abstract: Methods for the production of an apolipoprotein in plants are described. In one embodiment, the present invention provides a method for the expression of apolipoprotein in plants comprising : (a) providing a chimeric nucleic acid construct comprising in the 5' to 3' direction of transcription as operably linked components: (i) a nucleic acid sequence capable of controlling expression in plant cells; and (ii) a nucleic acid sequence encoding an apolipoprotein polypeptide; (b) introducing the chimeric nucleic acid construct into a plant cell; and growing the plant cell into a mature plant capable of setting seed wherein the seed expresses apolipoprotein.

    Abstract translation: 描述了在植物中生产载脂蛋白的方法。 在一个实施方案中，本发明提供了用于在植物中表达载脂蛋白的方法，其包括：（a）提供嵌合核酸构建体，所述嵌合核酸构建体包含作为可操作地连接的组分的5'至3'转录方向：（i） 能够控制植物细胞中表达的序列; 和（ii）编码载脂蛋白多肽的核酸序列; （b）将嵌合核酸构建体导入植物细胞中; 并将植物细胞培育成能够固定种子的成熟植物，其中种子表达载脂蛋白。

    METHODS FOR THE PRODUCTION OF INSULIN IN PLANTS
    29.
    发明申请
    METHODS FOR THE PRODUCTION OF INSULIN IN PLANTS 审中-公开
    在植物中生产胰岛素的方法

    公开(公告)号：WO2004111244A3

    公开(公告)日：2005-02-03

    申请号：PCT/CA2004000896

    申请日：2004-06-17

    Applicant: SEMBIOSYS GENETICS INC ,  MOLONEY MAURICE M ,  BOOTHE JOSEPH ,  KEON RICHARD ,  NYKIFORUK CORY ,  VAN ROOIJEN GIJS

    Inventor： MOLONEY MAURICE M ,  BOOTHE JOSEPH ,  KEON RICHARD ,  NYKIFORUK CORY ,  VAN ROOIJEN GIJS

    IPC: A01H1/00 ,  C07K14/62 ,  C12N15/82 ,  A01H5/00

    CPC classification number: C07K14/62 ,  C12N15/8257

    Abstract: Methods for the production of insulin in plants are described. In one embodiment, the present invention provides a method for the expression of insulin in plants comprising: (a) providing a chimeric nucleic acid construct comprising in the 5' supl; to 3' direction of transcription as operably linked components: (i) a nucleic acid sequence capable of controlling expression in plant seed cells; and (ii) a nucleic acid sequence encoding an insulin polypeptide; (b) introducing the chimeric nucleic acid construct into a plant cell; and (c) growing the plant cell into a mature plant capable of setting seed wherein the seed expresses insulin.

    Abstract translation: 描述了在植物中产生胰岛素的方法。 在一个实施方案中，本发明提供了一种用于在植物中表达胰岛素的方法，包括：（a）提供嵌合的核酸构建体，其包含在5' 至3'转录方向作为可操作连接的组分：（i）能够控制植物种子细胞中表达的核酸序列; 和（ii）编码胰岛素多肽的核酸序列; （b）将嵌合核酸构建体引入植物细胞; 和（c）将植物细胞生长成能种植种子的成熟植物，其中种子表达胰岛素。

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