公开(公告)号：WO2021262844A1

公开(公告)日：2021-12-30

申请号：PCT/US2021/038674

申请日：2021-06-23

Applicant: CHEMIMAGE CORPORATION ,  TREADO, Patrick, J. ,  GOMER, Heather, E. ,  STEWART, Shona ,  SMITH, Aaron, G.

Inventor： TREADO, Patrick, J. ,  GOMER, Heather, E. ,  STEWART, Shona ,  SMITH, Aaron, G.

IPC: H04N5/33 ,  A61B5/00 ,  G01N33/483 ,  A61B5/1455 ,  A61B5/0261

Abstract: Methods for improved tissue perfusion monitoring are disclosed. A method includes collecting hyperspectral image data from an image sensor positioned to collect interacted photons from a tissue region resulting from illumination of the tissue sample at a plurality of wavelengths in the visible, near infrared, or shortwave infrared regions. Hypercubes are generated based on the collected hyperspectral image data. The hypercubes are analyzed to identify one or more of the plurality of wavelengths resulting in contrast in the hyperspectral images. One or more regions in the tissue region with altered perfusion states are identified based on the contrast in the hyperspectral images. A tissue perfusion monitoring computing device and non-transitory medium are also disclosed.

公开(公告)号：WO2021236615A1

公开(公告)日：2021-11-25

申请号：PCT/US2021/032931

申请日：2021-05-18

Applicant: CHEMIMAGE CORPORATION ,  STEWART, Shona ,  SMITH, Aaron ,  TREADO, Patrick, J.

Inventor： STEWART, Shona ,  SMITH, Aaron ,  TREADO, Patrick, J.

IPC: A61B17/24

Abstract: Methods and systems of identifying oral cancer in vivo are disclosed. An oral cavity of a patient is illuminated with a plurality of illuminating photons. A plurality of interacted photos are received from the oral cavity. The interacted photons may have been absorbed, reflected, scattered or emitted by the oral cavity. The interacted photons are filtered into first and second polarized multi-passband wavelengths using first and second tunable conformal filters, respectively. A detector captures the first and second polarized multi-passband wavelengths. A processor automatically discriminates between cancerous tissue and non-cancerous tissue in an image resolved from the first and second polarized multi-passband wavelengths.

公开(公告)号：WO2009021178A1

公开(公告)日：2009-02-12

申请号：PCT/US2008/072617

申请日：2008-08-08

Applicant: CHEMIMAGE CORPORATION ,  MAIER, John ,  COHEN, Jeffrey ,  STEWART, Shona

Inventor： MAIER, John ,  COHEN, Jeffrey ,  STEWART, Shona

IPC: C12Q1/00

CPC classification number: G06K9/00127

Abstract: A method to diagnosis disease states of unknown samples is provided wherein a test Raman date set for unknown samples is generated A reference Raman database is also provided where the database contains a plurality of reference Raman data sets and a plurality of reference Raman difference data sets The reference Raman difference data set is generated by determining a difference between a first reference Raman data set and a second reference Raman data set First and second reference Raman data sets are associated with first and second known samples and associated with one or more of first and second known disease states and first and second known clinical outcomes A diagnosis is provided of whether the unknown sample has first or second disease states by comparing the test Raman data set to said plurality of reference Raman difference data sets in the reference Raman database using a chemometπc technique

Abstract translation: 提供了一种用于诊断未知样品的疾病状态的方法，其中生成针对未知样品的测试拉曼日期。还提供了参考拉曼数据库，其中数据库包含多个参考拉曼数据集和多个参考拉曼差异数据集 通过确定第一参考拉曼数据集和第二参考拉曼数据集之间的差异来生成参考拉曼差异数据集。第一和第二参考拉曼数据集与第一和第二已知样本相关联，并与第一和第二参考拉曼数据集中的一个或多个相关联 已知疾病状态和第一和第二已知临床结果通过使用化学计量技术将参考拉曼数据库中的测试拉曼数据集与所述多个参考拉曼差异数据集进行比较来提供未知样本是否具有第一或第二疾病状态的诊断

公开(公告)号：WO2006007064A2

公开(公告)日：2006-01-19

申请号：PCT/US2005/016141

申请日：2005-05-06

Applicant: CHEMIMAGE CORPORATION ,  STEWART, Shona ,  NELSON, Matthew, P. ,  DEMUTH, Joseph, E. ,  TREADO, Patrick, J.

Inventor： STEWART, Shona ,  NELSON, Matthew, P. ,  DEMUTH, Joseph, E. ,  TREADO, Patrick, J.

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01J3/0297 ,  G01N21/65

Abstract: The disclosure relates to a substrate material for the improved detection, resolution and imaging of biological material for spectroscopic characterization by Raman of optical imaging spectroscopy. The substrate provides a uniform, optically flat, highly reflective surface which can be made hydrophobic to prevent spreading of the sample and facilitating its optical evaluation. Moreover, the substrate can be coated with a material that does not emit Raman scattered photons when exposed to said illuminating photons. The principles disclosed herein allow a low spectroscopic background particularly suitable for examining small samples or samples having low concentrations of the suspected component.

Abstract translation: 本公开涉及用于通过光学成像光谱的拉曼的光谱表征的生物材料的改进的检测，分辨和成像的基底材料。 衬底提供均匀的光学平坦的高反射表面，其可以被制成疏水性以防止样品的扩散并且便于其光学评估。 此外，当暴露于所述照射光子时，衬底可以涂覆有不发射拉曼散射光子的材料。 本文公开的原理允许低光谱背景特别适合于检查具有低浓度可疑成分的小样品或样品。

公开(公告)号：WO2006007063A2

公开(公告)日：2006-01-19

申请号：PCT/US2005016140

申请日：2005-05-06

Applicant: CHEMIMAGE CORP ,  MAIER JOHN S ,  NEISS JASON H ,  STEWART SHONA

Inventor： MAIER JOHN S ,  NEISS JASON H ,  STEWART SHONA

IPC: G01J3/51

CPC classification number: G01J3/28 ,  G01J3/0227 ,  G01J3/027 ,  G01J3/0286 ,  G01J3/44

Abstract: In one embodiment the disclosure relates to a method and a system for determining the corrected wavelength of a photon scattered by a sample. The method includes the steps of determining a wavelength of a photon scattered from a sample exposed to illuminating photons and passed through a tunable filter and correcting the determined wavelength of the photon as a function of the temperature of the tunable filter and as a function of the bandpass set point of the tunable filter. The step of correcting the determined wavelength can further include determining an offset and adding the offset to the determined wavelength of the photon.

Abstract translation: 在一个实施例中，本公开涉及用于确定由样本散射的光子的校正波长的方法和系统。 该方法包括以下步骤：确定从暴露于照射光子并通过可调谐滤光器的样品散射的光子的波长，并根据可调谐滤光器的温度校正所确定的光子的波长，并且作为 可调谐滤波器的带通设置点。 校正所确定的波长的步骤可以进一步包括确定偏移并将该偏移添加到所确定的光子的波长。

公开(公告)号：WO2007050602A3

公开(公告)日：2009-05-14

申请号：PCT/US2006041471

申请日：2006-10-24

Applicant: CHEMIMAGE CORP ,  MAIER JOHN S ,  TREADO PATRICK J ,  NELSON MATTHEW ,  MCCLELLAND LINDY ,  STEWART SHONA

Inventor： MAIER JOHN S ,  TREADO PATRICK J ,  NELSON MATTHEW ,  MCCLELLAND LINDY ,  STEWART SHONA

IPC: G01J3/44 ,  G06F19/00 ,  H04B10/08 ,  H04B17/00

CPC classification number: G01N21/65 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/274 ,  G01N2021/656

Abstract: A system and method to automatically obtain spectra for samples. The method involves a two phase process including a photobleaching phase and a spectral acquisition phase. In the photobleaching phase, a series of spectral data sets of a sample are collected. A relative difference is determined between the background of subsequent spectral data sets is determined and compared to a predetermined threshold value. If threshold difference is less than the relative difference between the background of subsequent spectral data sets, the steps of collecting a series of spectra data sets is automatically repeated. In the spectrum acquisition phase, a series of Raman data sets of the sample are collected until a target SNR is obtained.

Abstract translation: 自动获取样品光谱的系统和方法。 该方法涉及包括光漂白相和光谱采集阶段的两相过程。 在漂白漂白阶段，收集样品的一系列光谱数据集。 在确定后续光谱数据集的背景并将其与预定阈值进行比较之间确定相对差。 如果阈值差小于随后的光谱数据集的背景之间的相对差，则自动重复收集一系列光谱数据集的步骤。 在频谱采集阶段，收集样本的一系列拉曼数据集，直到获得目标SNR。

公开(公告)号：WO2006091853A3

公开(公告)日：2008-05-08

申请号：PCT/US2006006663

申请日：2006-02-24

Applicant: CHEMIMAGE CORP ,  MAIER JOHN S ,  STEWART SHONA ,  COHEN JEFFREY ,  NELSON MATTHEW

Inventor： MAIER JOHN S ,  STEWART SHONA ,  COHEN JEFFREY ,  NELSON MATTHEW

IPC: A61B6/00

CPC classification number: G01N21/65 ,  A61B5/0075 ,  A61B5/0084 ,  G01N2021/6484 ,  G01N2021/656 ,  G01N2201/08

Abstract: A method and system to differentiate a tissue margins during various medical procedures. A region containing a biological tissue is irradiated, with a substantially monochromatic light. Raman spectroscopic data is obtained from the irradiated region. A boundary between a neoplastic portion and a non-neoplastic portion, in the region containing the biological tissue, is differentiated by evaluating the Raman spectroscopic data for at least one Raman spectroscopic value characteristic of either the neoplastic portion or the non-neoplastic portion. The neoplastic portion is selected for physical manipulation based on the differentiation of the boundary between the neoplastic portion and the non-neoplastic portion.

Abstract translation: 在各种医疗过程中区分组织边缘的方法和系统。 用基本上单色的光照射含有生物组织的区域。 从照射区域获得拉曼光谱数据。 在包含生物组织的区域中的肿瘤部分和非肿瘤部分之间的边界通过评估肿瘤部分或非肿瘤部分的至少一个拉曼光谱值特征的拉曼光谱数据来区分。 基于肿瘤部分和非肿瘤部分之间的边界的分化，选择肿瘤部分用于物理操作。

公开(公告)号：WO2007050602A2

公开(公告)日：2007-05-03

申请号：PCT/US2006/041471

申请日：2006-10-24

Applicant: CHEMIMAGE CORPORATION ,  MAIER, John, S. ,  TREADO, Patrick, J. ,  NELSON, Matthew ,  MCCLELLAND, Lindy ,  STEWART, Shona

Inventor： MAIER, John, S. ,  TREADO, Patrick, J. ,  NELSON, Matthew ,  MCCLELLAND, Lindy ,  STEWART, Shona

IPC: H04B10/08 ,  H04B17/00

CPC classification number: G01N21/65 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/274 ,  G01N2021/656

Abstract: A system and method to automatically obtain spectra for samples. The method involves a two phase process including a photobleaching phase and a spectral acquisition phase. In the photobleaching phase, a series of spectral data sets of a sample are collected. A relative difference is determined between the background of subsequent spectral data sets is determined and compared to a predetermined threshold value. If threshold difference is less than the relative difference between the background of subsequent spectral data sets, the steps of collecting a series of spectra data sets is automatically repeated. In the spectrum acquisition phase, a series of Raman data sets of the sample are collected until a target SNR is obtained.

Abstract translation: 自动获取样品光谱的系统和方法。 该方法涉及包括光漂白相和光谱采集阶段的两相过程。 在漂白漂白阶段，收集样品的一系列光谱数据集。 在确定后续光谱数据集的背景并将其与预定阈值进行比较之间确定相对差。 如果阈值差小于随后的光谱数据集的背景之间的相对差，则自动重复收集一系列光谱数据集的步骤。 在频谱采集阶段，收集样本的一系列拉曼数据集，直到获得目标SNR。

公开(公告)号：WO2006007064A3

公开(公告)日：2006-04-20

申请号：PCT/US2005016141

申请日：2005-05-06

Applicant: CHEMIMAGE CORP ,  STEWART SHONA ,  NELSON MATTHEW P ,  DEMUTH JOSEPH E ,  TREADO PATRICK J

Inventor： STEWART SHONA ,  NELSON MATTHEW P ,  DEMUTH JOSEPH E ,  TREADO PATRICK J

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01J3/0297 ,  G01N21/65

Abstract: The disclosure relates to a substrate material for the improved detection, resolution and imaging of biological material for spectroscopic characterization by Raman of optical imaging spectroscopy. The substrate provides a uniform, optically flat, highly reflective surface which can be made hydrophobic to prevent spreading of the sample and facilitating its optical evaluation. Moreover, the substrate can be coated with a material that does not emit Raman scattered photons when exposed to said illuminating photons. The principles disclosed herein allow a low spectroscopic background particularly suitable for examining small samples or samples having low concentrations of the suspected component.

Abstract translation: 本公开涉及一种用于改进的光学成像光谱术的拉曼光谱表征的生物材料的检测，分辨率和成像的基底材料。 基材提供均匀的，光学平坦的高度反射表面，其可以制成疏水性的，以防止样品扩散并促进其光学评估。 此外，衬底可以涂覆有当暴露于所述照射光子时不发射拉曼散射光子的材料。 本文公开的原理允许特别适用于检查小样品或具有低浓度可疑成分的样品的低光谱背景。

公开(公告)号：WO2006007063A3

公开(公告)日：2006-01-19

申请号：PCT/US2005/016140

申请日：2005-05-06

Applicant: CHEMIMAGE CORPORATION ,  MAIER, John, S. ,  NEISS, Jason, H. ,  STEWART, Shona

Inventor： MAIER, John, S. ,  NEISS, Jason, H. ,  STEWART, Shona

IPC: G01J3/44 ,  G01N21/65

Abstract: In one embodiment the disclosure relates to a method and a system for determining the corrected wavelength of a photon scattered by a sample. The method includes the steps of determining a wavelength of a photon scattered from a sample exposed to illuminating photons and passed through a tunable filter and correcting the determined wavelength of the photon as a function of the temperature of the tunable filter and as a function of the bandpass set point of the tunable filter. The step of correcting the determined wavelength can further include determining an offset and adding the offset to the determined wavelength of the photon.