公开(公告)号：WO2004002627A8

公开(公告)日：2005-03-17

申请号：PCT/US0320542

申请日：2003-06-30

Applicant: HARVARD COLLEGE ,  STONE HOWARD A ,  ANNA SHELLY L ,  BONTOUX NATHALIE ,  LINK DARREN ROY ,  WEITZ DAVID A ,  GITLIN IRINA ,  GARSTECKI PIOTR ,  DILUZIO WILLOW ,  WHITESIDES GEORGE M ,  KUMACHEVA EUGENIA

Inventor： STONE HOWARD A ,  ANNA SHELLY L ,  BONTOUX NATHALIE ,  LINK DARREN ROY ,  WEITZ DAVID A ,  GITLIN IRINA ,  GARSTECKI PIOTR ,  DILUZIO WILLOW ,  WHITESIDES GEORGE M ,  KUMACHEVA EUGENIA

IPC: B01F3/08 ,  B01F5/06 ,  B01F13/00 ,  B01L3/00 ,  B05B7/04

CPC classification number: B01L3/5027 ,  B01F3/0807 ,  B01F5/0682 ,  B01F5/0688 ,  B01F13/0062 ,  B01F2215/0431 ,  B01F2215/045 ,  B05B7/0408 ,  B05B7/0416 ,  B05B7/0441 ,  Y10S516/924 ,  Y10S516/927 ,  Y10T29/49002 ,  Y10T137/0324 ,  Y10T137/0329 ,  Y10T137/206 ,  Y10T137/87346 ,  Y10T436/2575

Abstract: A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.

Abstract translation: 提供了用于在流体中聚焦和/或形成类似或不同尺寸的不连续部分的微流体方法和装置。 该设备可以简单地使用简单的技术从容易获得的廉价材料制造。

公开(公告)号：WO2003092654A1

公开(公告)日：2003-11-13

申请号：PCT/US2003/013707

申请日：2003-05-01

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  EDWARDS, David, A. ,  STONE, Howard, A.

Inventor： EDWARDS, David, A. ,  STONE, Howard, A.

IPC: A61K9/12

CPC classification number: A61K9/0075 ,  A61K9/0078 ,  A61K31/355 ,  A61K31/685 ,  A61K31/715

Abstract: Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as viral infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be a surfactant and, optionally, a carrier. The formulation may be administered as a powder where the particles consist basically of the material altering surface tension. The carrier may be a solution, such as an alcohol, although an aqueous solution may be utilized, or a material mixed with the material altering surface tension to form particles. These may include proteins such as albumin or polysaccharides such as dextran, which also has surface active properties, or polymers such as polyethylene oxide (PEO) or biodegradable synthetic polymers which can be used to encapsulate or deliver the materials to be delivered. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.

Abstract translation: 已经开发了用于肺部输送以治疗或减少诸如病毒感染，特别是结核病，SARS，流感和呼吸道合成病毒以及动物蹄和口蹄疫的感染性的制剂。 用于肺部给药的制剂包括显着改变诸如表面活性剂和任选的载体的肺粘液衬里液体的表面张力和表面弹性的物理性质的材料。 制剂可以粉末施用，其中颗粒基本上由改变表面张力的材料组成。 载体可以是溶液，例如醇，尽管可以使用水溶液，或与材料混合的材料改变表面张力以形成颗粒。 这些可以包括诸如白蛋白或多糖的蛋白质，例如还具有表面活性的葡聚糖，或聚合物如聚环氧乙烷（PEO）或可生物降解的合成聚合物，其可用于封装或递送待递送材料。 药物，特别是抗病毒剂或抗生素，可以任选地包括在制剂中。 这些可以与制剂一起施用或掺入制剂中。